Clinical trials: Intraoperative Fluid Management
Hemodynamic
Three Different GHDT ( Goal Hemodynamic Directed Therapy) Strategies for Intraoperative Fluid Management Optimization During Major Abdominal Surgery: A Randomized Controlled Trial
Major oncological surgery is among the most complex procedures, involving patients with a combination of high-risk factors that can significantly influence immediate postoperative outcomes and quality of life.
- Trial name
- SMART FLUID (NCT06871150)
- Testing
- Flotrac sensor, HPI, HPI-AFM
- Where
- 3 sites in Italy
- Volunteers
- 150 people
- Sponsor
- ASST Sette Laghi
Acute Normovolemic Hemodilution, Cardiac Surgery
Impact of Pleth Variability Index-Guided Acute Normovolemic Hemodilution on Intraoperative Fluid Management and Postoperative Complications in Cardiac Surgery
Acute normovolemic hemodilution (ANH) is a widely used blood conservation strategy in cardiac surgery aimed at reducing intraoperative blood loss and the need for allogeneic blood transfusion.
- Conditions
- Acute Normovolemic Hemodilution, Cardiac Surgery, Postoperative Complication, Pleth Variability Index
- Trial name
- NCT07466082
- Testing
- acute normovolemic hemodilution, PVI dependant acute normovolemic hemodilution
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Bursa City Hospital
Liver Transplantation, End-stage Liver Disease (ESLD)
Restrictive Fluid Management In Liver Transplantation (REFIL) - Pilot
Hypothesis: A Canadian multicentre clinical trial is feasible. Study Design: Multicenter internal pilot parallel arm randomized controlled trial.
- Trial name
- REFIL-1 (NCT05647733)
- Testing
- Low splanchnic blood volume restrictive fluid management strategy, Optimized cardiac output liberal fluid management strategy, Phlebotomy
- Where
- 4 sites in Canada
- Volunteers
- 138 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Bladder Cancer, Urinary Diversion
Effects of Noradrenaline Administration Combined With Restrictive Intraoperative Fluid Substitution on Perioperative Outcome in Patients Undergoing Radical Cystectomy
Perioperative fluid management in abdominal surgery is a subject of controversy and current standard fluid therapy is not evidence based. Compensating decreasing blood pressure by volume substitution is common praxis.
- Trial name
- NCT01276665
- Testing
- restrictive intraoperative fluid substitution, assessment of the pelvic venous pressure
- Where
- Switzerland
- Volunteers
- 190 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Surgical Blood Loss, Hemorrhage
The Cryopreserved vs. Liquid Platelets Trial
This trial is a phase III multicentre blinded randomised controlled clinical non-inferiority trial of cryopreserved platelets vs. conventional liquid-stored platelets for the management of surgical bleeding.
- Trial name
- CLIP II (NCT03991481)
- Testing
- Cryopreserved platelets, Liquid-stored platelets
- Where
- 6 sites in Australia
- Volunteers
- 388 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Crohn's Disease, Ulcerative Colitis
An Assessment of Goal-Directed Intraoperative Fluid Management in Hand Assisted Laparoscopic Colectomy
The purpose of this study is to find out if guided fluid administration with the esophageal monitor is superior to standard fluid administration and whether use of the hetastarch or lactated ringers offers different benefits with…
- Conditions
- Crohn's Disease, Ulcerative Colitis, Rectal Cancer, Colon Cancer
- Trial name
- NCT00467922
- Testing
- Hextend, Lactated Ringers
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Corewell Health West
Obesity, Abdominal Surgery
Intraoperative Goal-directed Fluid Management
The investigators propose to determine esophageal Doppler goal-directed fluid requirements in lean, overweight, obese, and morbidly obese patients with the goal of developing a body mass index (BMI)-specific fluid replacement…
- Conditions
- Obesity, Abdominal Surgery, Hysterectomy, Genital Prolapse
- Trial name
- NCT00554944
- Testing
- Esophageal probe
- Where
- United States
- Sponsor
- The Cleveland Clinic
Obesity
Obesity and Goal-directed Intraoperative Fluid Therapy
The purpose of the study is to compare non-obese patients (BMI≤ 30 kg/m2)versus obese patients (BMI> 30 kg/m2) in regard of their respective needs for intraoperative fluid therapy during laparoscopic surgery.
- Trial name
- NCT01052519
- Testing
- Goal directed fluid therapy
- Where
- Austria
- Volunteers
- 90 people
- Sponsor
- Medical University of Vienna
Anesthesia
Impact of Intraoperative Fluid Management on Electrolyte and Acid-base Variables
During major surgical procedures, intravascular volume is maintained with the administration of isotonic fluids such as Lactated Ringers (LR), Normal Saline (NS) or Normosol-R.
- Trial name
- NCT03054922
- Testing
- Normal Saline, Lactated Ringer, Normosol-R Inj
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Nationwide Children's Hospital
Fluid Overload
Body Composition Monitoring(BCM) for Determination of the Fluid Status in Patients Undergoing General Anesthesia
The purpose of this study is to evaluate a recently developed device, which measures body composition (i.e. the water content of the body) in the perioperative setting.
- Trial name
- BCM (NCT01945541)
- Testing
- Body Composition Monitoring
- Where
- Austria
- Volunteers
- 73 people
- Sponsor
- Medical University of Vienna
Intraoperative Fluid Management
Intraoperative Different Fluid Therapy Protocols
We aimed to evaluate the relationship between different intraoperative fluid therapy protocols and postoperative renal damage and mortality.
- Trial name
- NCT06188299
- Testing
- Restricted Fluid Administration
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara City Hospital Bilkent
Other Complications of Esophagostomy
Outcome Study of Restrictive vs. Liberal Intraoperative Fluid Management Guided by PPV in Esophagectomy
The purpose of this study is to determine whether intraoperative restrictive fluid management guided by pulse pressure variation produces a better effect on the postoperative lung function, kidney function, inflammatory response…
- Trial name
- PPV (NCT01933451)
- Testing
- Intraoperative fluid therapy
- Where
- Taiwan
- Volunteers
- 7 people
- Sponsor
- National Taiwan University Hospital
Major Abdominal Surgery, Perioperative Haemodynamic Monitoring
Continuous Central Venous Oxygen Saturation Assisted Intraoperative Hemodynamic Management
Patients who are scheduled for: elective oesophageal tumour resection, total gastrectomy, pancreas resection, major vascular, total cystectomy will be recruited.To investigate effects of central venous pressure (CVP) and central…
- Conditions
- Major Abdominal Surgery, Perioperative Haemodynamic Monitoring, Perioperative Fluid Management, Perioperative Vasopressor Requirement
- Trial name
- NCT02337010
- Testing
- CeVOX, CVP, Fluid bolus
- Where
- Hungary
- Volunteers
- 79 people
- Sponsor
- Domonkos Trásy
Peritoneal Neoplasms, Hyperthermic Intraperitoneal Chemotherapy
Efficacy of Intraoperative Use of 20% Albumin Combined With Ringer Lactate Versus Ringer Lactate During Cytoreductive Surgery With Hyperthermic Intraperitoneal Chemotherapy
Introduction Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is considered as the standard of care for the treatment of peritoneal metastases.
- Conditions
- Peritoneal Neoplasms, Hyperthermic Intraperitoneal Chemotherapy, Intraoperative Care, Fluid Therapy
- Trial name
- ALBUCHIP (NCT06351475)
- Testing
- Intra-operative albumin administration, Control
- Where
- 8 sites in France
- Volunteers
- 140 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Intracranial Aneurysm, Brain Edema
Goal-Directed Intraoperative Fluid Management Using FloTrac© Monitoring in High-Risk Neurosurgical Patients
This is a prospective, randomized controlled trial to determine if using FloTrac/EV1000 system in neurosurgical patients undergoing craniotomies for aneurysm repair or tumor resection complicated by cerebral edema, or complex…
- Conditions
- Intracranial Aneurysm, Brain Edema, Scoliosis, Surgery
- Trial name
- NCT02701582
- Testing
- Phenylephrine, Epinephrine, Albumin
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- NYU Langone Health
Acute Lung Injury (ALI), Acure Respiratory Distress Syndrome (ARDS)
Effect of Intraoperative Fluid Restriction on Postoperative Outcomes in Video-assisted Thoracic Surgery (VATS)
The objective of this study is to compare the effects of two intraoperative fluid regimens - restrictive versus liberal (standard)- on postoperative outcomes (e.g.
- Conditions
- Acute Lung Injury (ALI), Acure Respiratory Distress Syndrome (ARDS), Sepsis
- Trial name
- NCT00854386
- Testing
- liberal fluid administration, restrictive fluid administration
- Where
- 2 sites in Israel
- Volunteers
- 200 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Fluid Management
Hemodynamic Optimization Based on a Dynamic Elastance Protocol
In this study investigators explore the effects of a dynamic elastance guided protocol compared to a stroke volume variation fluid therapy on lactate levels during major abdominal surgery.
- Trial name
- NCT05187273
- Testing
- Elastance Group
- Where
- Italy
- Volunteers
- 46 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Surgery
Intraoperative Fluid Management Based on Arterial Pulse Pressure Variation During High-Risk Surgery
Hypovolaemia and tissue hypoperfusion can pass undetected during and after major surgery. The resulting systemic inflammatory response and organ dysfunction, often not clinically apparent for several days, may lead to increased…
- Trial name
- NCT00479011
- Testing
- fluid management based on arterial pulse pressure variation
- Where
- Brazil
- Volunteers
- 33 people
- Sponsor
- Santa Casa de Passos
Anemia, Fluid Management
Comparison of Pulse Hemoglobin and Pleth Variability Index
The purpose of this study is to investigate whether a validated sensor that is able to measure how much oxygen-carrying molecules called hemoglobin using pulse hemoglobin and Pleth Variability Index (PVI)] are in your blood…
- Trial name
- Pleth (NCT01602978)
- Where
- United States
- Volunteers
- 299 people
- Sponsor
- Loma Linda University
Free Tissue Flaps
PVI Based Intraoperative Fluid Management in Head and Neck Free Flap Reconstructive Surgeries
Intraoperative fluid given according to BMI in group B and according to pulse oximeter- derived pleth variability index(MASIMO RAINBOW PULSE CO OXIMETRY) in group G.
- Trial name
- NCT03116178
- Testing
- Group G -PVI( Masimo co oximeter) guided fluid therapy, Group B- Body weight guided intravenous fluid @6-8ml/kg
- Volunteers
- 80 people
- Sponsor
- Rajiv Gandhi Cancer Institute & Research Center, India