Clinical trials: Intracytoplasmic Sperm Injection
Exposure to Toxins from Smoking, Female Infertility
Presence of Toxins from Smoking in the Follicular Fluid of Women Undergoing Intracytoplasmic Sperm Injection Treatment
Smoking is associated with many adverse health effects like circulatory disorders, pulmonary diseases or heart diseases. It was also shown that smoking correlates with a significantly higher risk for miscarriage, preterm birth or…
- Trial name
- NCT03414567
- Where
- Germany
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Infertility Treatment Center Dortmund
IVF
Prolonged Protocol of Early Follicular or Mid Luteal Phase
Due to the injection of gonadotropin releasing hormone agonist (GnRH-a) before controlled ovarian hyperstimulation (COH), the scheme of prolonged early follicular period protocol has obvious advantages in achieving ideal egg…
- Trial name
- NCT04522479
- Testing
- Change the injection time of long acting GnRH-a
- Where
- China
- Volunteers
- 1,150 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Infertility, Reproductive Issues
Impact of a Predetermined Day 5 ET vs. a Predetermined Day 6 ET on Clinical Pregnancy Rate After ICSI Treatment
The aim of this prospective multicenter study is to investigate the influence of a predetermined embryo transfer on day 6 compared to a predetermined embryo transfer on day 5.
- Trial name
- NCT06447077
- Where
- Germany
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- Infertility Treatment Center Dortmund
Polycystic Ovarian Syndrome
Letrozole Combined With Gonadotropins (Gn) for Ovarian Stimulation Undergoing in Vitro Fertilization/Intracytoplasmic Sperm Injection (IVF/ICSI) in Patients With Polycystic Ovary Syndrome (PCOS)
The purpose of this study is to determine whether letrozole combined with gonadotropins are effective in the ovarian hyperstimulating for IVF/ICSI in patients with PCOS.
- Trial name
- NCT00894608
- Testing
- letrozole + gonadotropins, GnRHa + gonadotropins
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Yunyang Medical College
Female Infertility
Intracytoplasmic Morphologically Selected Sperm Injection and Advanced Maternal Age
The objective of this study was to evaluate the advanced maternal age as a rationale for performing intracytoplasmic morphologically selected sperm injection (IMSI).
- Trial name
- IMSIAMA (NCT01620346)
- Testing
- Intracytoplasmic sperm injection (ICSI), Intracytoplasmic morphologically selected sperm injection
- Where
- Brazil
- Volunteers
- 66 people
- Sponsor
- Sapientiae Institute
Infertility
Automation of Gamete Preparation, Intracytoplasmic Sperm Injection (ICSI), Embryo Culture, and Vitrification
Patients suffering from infertility may seek assisted conception treatment. In a full treatment cycle, the sperm and eggs (gametes) from the intended parents will be looked after by skilled laboratory staff (embryologists) who…
- Trial name
- NCT06074835
- Testing
- Gamete preparation, ICSI, embryo culture and vitrification robot assistant, Routine Manual ICSI Workflow
- Where
- Mexico
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Conceivable Life Sciences
Subfertility, Assisted Reproduction
Role of Follicular Output Rate in the Prediction of in Vitro Fertilization and Intracytoplasmic Sperm Injection in Women With Unexplained Infertility
300 women with unexplained infertility who are already decided to be treated with ICSI will be recruited from Cairo university hospitals and Dar Al-Teb subfertility centre.
- Trial name
- NCT02154958
- Where
- 2 sites in Egypt
- Volunteers
- 300 people
- Sponsor
- Cairo University
Infertility
Adding Insulin to IVF Culture Media Significantly Improve Outcome
Add insulin to a single step culture media for IVF embryo culture from day 0 to day 5/6 of In Vitro culture and detect the the effect upon embryo quality and implantation potential.
- Trial name
- NCT02420171
- Testing
- Adding insulin to In Vitro culture media
- Where
- 2 sites in Egypt
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Ibn Sina Hospital
Polycystic Ovary Syndrome
Myo-Inositol for Ovarian Stimulation and ICSI Outcomes in Women With PCOS
Polycystic ovary syndrome (PCOS) is a common endocrine disorder that may affect ovarian function, insulin sensitivity, and fertility.
- Trial name
- NCT07779850
- Testing
- Myo-Inositol, Folic Acid
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Kafrelsheikh University
Infertility
Supplementing Intracytoplasmic Sperm Injection Handling Medium With Latrunculin A (ICSI-LA)
Vienna Consensus has identified 10% damage rate after ICSI as a competency value. Despite the highest quality embryologists doing ICSI, degeneration sometimes occurs due to oocyte factors such as the fragile membrane, etc.
- Trial name
- NCT03678818
- Testing
- Medium Supplemented with Latrunculin A
- Where
- 2 sites in Egypt
- Volunteers
- 300 people
- Sponsor
- Ibn Sina Hospital
Conventional IVF, ICSI
Child Follow-up in Women Treated With Conventional IVF or ICSI
To compare the physical, mental and motor development of babies born from pregnancy using ICSI technique and and conventional IVF in non-male factor infertile couples.
- Trial name
- NCT04866524
- Testing
- Developmental score according to The Ages & Stages Questionnaires®, Third Edition - ASQ®-3, Physical development and General Health, Developmental Red flags
- Where
- Vietnam
- Volunteers
- 322 people
- Sponsor
- Mỹ Đức Hospital
in Vitro Fertilization, Ovulation Induction
Trial Comparing Start Stimulation of Recombinant Follicle Stimulating Hormone (rFSH) on Cycle Day 2 Versus Cycle Day 5 in In Vitro Fertilization (IVF)
Background of the study: Milder stimulation protocols have the advantage of being less expensive and more patient-friendly. Moreover, recent evidence suggests that mild stimulation protocols lead to lower embryo aneuploidy rates…
- Trial name
- LITE (NCT00823472)
- Testing
- Mild stimulation
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Infertility, Female, Abortion, Habitual
Effects of PGS in Infertile Female Patients With RPL
Recurrent pregnancy loss (RPL) is a multifactorial disorder which affects about 1% of all couples and challenges both patients and clinicians technically and emotionally.
- Trial name
- NCT02223221
- Testing
- IVF/ICSI, PGS, Without PGS
- Where
- China
- Volunteers
- 189 people
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
Reproductive Techniques, Assisted
Endometrial Volume and Sub-endometrial Vascularity as Predictors of In-vitro Fertilization Success
100 patients aged 21-40 years old, diagnosed as primary or secondary infertility These patients are then assigned to receive ICSI treatment (ovulation induction, .
- Trial name
- NCT02381821
- Testing
- 3 D ultrasound and Doppler examination, GnRH agonist
- Volunteers
- 82 people
- Sponsor
- Cairo University
Polycystic Ovary Syndrome, Infertility
Myo-inositol Therapy on the Dynamics of Embryo Development in Patients Suffering From PCOS Undergoing ICSI Treatment
The purpose of this study is to analyse the activity of myo-inositol on pregnancy rate, embryo development dynamics and oestradiol and progesterone concentration in blood serum and Superoxide Dismutase (SOD) and catalase…
- Trial name
- NCT02385396
- Testing
- Inofolic: myo-inositol and folic acid
- Where
- Poland
- Volunteers
- 217 people
- Sponsor
- Medical University of Lublin
Polycystic Ovary Syndrome, Infertility
Progesterone Primed Ovarian Stimulation Protocol Versus Antagonist Protocol for PCO Patient
this study is designed to compare the Progesterone primed ovarian stimulation protocol versus the antagonist protocol as a method to stimulate PCO patients in ICSI cycles to decrease cost and decrease OHSS.
- Conditions
- Polycystic Ovary Syndrome, Infertility, IVF
- Trial name
- NCT05847660
- Testing
- Progesterone antagonist, conventional antagonist protocol
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Infertility
ICSI Versus Conventional IVF in Non-male Factor Couples
Conventionally, ICSI was initially developed and has been shown to be an effective treatment for male factor infertility. It is increasingly being used for patients without a male factor diagnosis, despite the lack of clinical…
- Trial name
- NCT03428919
- Testing
- ICSI, IVF
- Where
- Vietnam
- Volunteers
- 1,064 people
- Sponsor
- Mỹ Đức Hospital
Male Infertility, Female Infertility
Patient-Centered Implementation Trial for Single Embryo Transfer
Background: The number of multiple pregnancies is considered to be the most important adverse effect of in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI).
- Conditions
- Male Infertility, Female Infertility, Pregnancy
- Trial name
- NCT00315029
- Testing
- evidence based decision aid, Possible reimbursement 4th IVF/ICSI cycle when necessary
- Where
- 2 sites in Netherlands
- Volunteers
- 230 people
- Sponsor
- Radboud University Medical Center
Infertile Patients
the Effect of Hyaluronic Acid Intrauterine Wash on Endometrial Receptivity and Pregnancy Outcome
Hyaluronic acid intrauterine wash is done for infertile females undergoing intracytoplasmic sperm injection on the day of oocyte retrieval.
- Trial name
- NCT06937645
- Testing
- Hyaluronic Acid (HA), platlet rich plasma (PRP)
- Where
- Iraq
- Volunteers
- 120 people
- Sponsor
- Al-Nahrain University
In Vitro Fertilization, Infertility
Sibling Oocyte Study of Medium for In Vitro Fertilization/Intracytoplasmic Sperm Injection (IVF/ICSI) With no Human Serum Albumine
The purpose of this study is to determine if a new medium with no human serum albumine added is as good as the media conventionally used for IVF/ICSI.
- Trial name
- NCT00541892
- Testing
- Medium with no human serum albumine added, Conventional medium
- Where
- Norway
- Sponsor
- Sykehuset Telemark