Clinical trials: Intracranial Hemorrhages
Stroke, Traumatic Brain Injury
Validation of the FOUR Coma Scale in Russia.
The purpose of this study is to examine the validity of the Russian version of the FOUR Full Outline of UnResponsiveness (hereafter FOUR) scale in adult ICU patients with an acute cerebral insufficiency clinic (hereinafter…
- Conditions
- Stroke, Traumatic Brain Injury, Subarachnoid Hemorrhage
- Trial name
- FOUR-RUS (NCT04018989)
- Where
- 3 sites in Russia
- Volunteers
- 260 people
- Sponsor
- Russian Federation of Anesthesiologists and Reanimatologists
Intracerebral Hemorrhage
Chinese Multicenter Cohort Study of Intracerebral Hemorrhage
Spontaneous intracerebral hemorrhage is a severe form of stroke associated with high mortality and long-term disability. The Chinese Multicenter Cohort Study of Intracerebral Hemorrhage (CASA) is a prospective observational…
- Trial name
- CMCS-ICH (NCT07833410)
- Where
- China
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Xiangya Hospital of Central South University
Acute Subdural Hematoma, Acquired Brain Injury
A Comparative Analysis of Prognostic Factors for Functional Outcomes in Patients With Acute Subdural Hematoma
Acute subdural hematoma (ASDH) is the most common intracranial traumatic lesion that requires surgical intervention. Although there is extensive published research on acute subdural, there remains uncertainty regarding mortality…
- Trial name
- NCT06364059
- Testing
- Decompressive craniectomy with evacuation of subdural hematoma
- Where
- Czechia
- Volunteers
- 175 people
- Sponsor
- Charles University, Czech Republic
Cerebral Hemorrhage
Multimodal Monitoring in Patients With Spontaneous Intracerebral Hemorrhage
Spontaneous intracerebral bleeding also known as spontaneous intracerebral hemorrhage (sICH) constitute 10-15 % of all apoplexies.
- Trial name
- NCT02326571
- Where
- Denmark
- Volunteers
- 8 people
- Sponsor
- Christian Kærsmose Friberg
Cerebral Vasospasm, SAH
Continuous Neurophysiological Monitoring Detection of Cerebral Vasospasm in Aneurysmal Subarachnoid Hemorrhage Subjects
Aneurysmal subarachnoid hemorrhage (bleeding on the brain due to a ruptured aneurysm) is a serious condition with a high morbidity (incidence of having ill health) and mortality (death).
- Conditions
- Cerebral Vasospasm, SAH, Aneurysm
- Trial name
- NCT01343537
- Testing
- Neuro Monitoring
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- State University of New York - Upstate Medical University
Hypertensive Intracerebral Hemorrhage, Intraventricular Hemorrhage
Neuroinflammatory Response in Patients With ICH and IVH Treated With rtPA
This study compares the neuroinflammatory response in patients with hypertensive ICH associated with IVH treated with intraventriculary applied rtPA, and the control group.
- Conditions
- Hypertensive Intracerebral Hemorrhage, Intraventricular Hemorrhage, Brain Injuries
- Trial name
- NCT03452722
- Testing
- intraventricual recombinant tissue plasminogen activator application
- Volunteers
- 88 people
- Sponsor
- University of Rijeka
Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia
Cerebral Nimodipine Concentrations Following Oral, Intra-venous and Intra-arterial Administration
Nimodipine reduces the risk of poor outcome and delayed cerebral ischemia in patients suffering aneurysmal subarachnoid haemorrhage (SAH), but its mode of action is unknown.
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia, Vasospasm, Cerebral
- Trial name
- NCT04649398
- Testing
- Nimodipine
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Brain Aneurysm, Intracranial Hemorrhages
Outcome Study of the Pipeline Embolization Device With Vantage Technology in Unruptured Aneurysms
In this project the investigators study the safety and efficacy of the pipeline embolization device with vantage technology in treatment of unruptured brain aneurysms
- Conditions
- Brain Aneurysm, Intracranial Hemorrhages, Stroke
- Trial name
- PEDVU (NCT05626504)
- Testing
- Pipeline Embolization Device with Vantage Technology
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- King's College Hospital NHS Trust
Trauma, Brain, Hemorrhage Cerebral
Research of Optimal Cerebral Perfusion Pressure Diagnosis
The research will investigate the hypothesis that timely identification of the optimal value of the cerebral perfusion pressure (optCPP) or optimal arterial blood pressure (optABP) is possible after detecting informative episodes…
- Trial name
- optCPP (NCT06028906)
- Testing
- Multimodal physiological monitoring and cerebral autoregulation monitoring
- Where
- Lithuania
- Volunteers
- 80 people
- Sponsor
- Vilnius University
Hypertensive Intracerebral Hemorrhage
Efficacy and Safety Study of Urapidil Alone or With Esmolol in Treating Acute Hypertensive Intracerebral Hemorrhage
The objective of this study is to investigate the efficacy and safety of urapidil monotherapy versus the combination of esmolol in treating participants with acute hypertensive intracerebral hemorrhage through a prospective…
- Trial name
- NCT06635707
- Testing
- Urapidil, Urapidil and Esmolol
- Volunteers
- 600 people
- Sponsor
- Qianfoshan Hospital
Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia
Subarachnoid Hemorrhage and Soluble Epoxide Hydrolase Inhibition Trial
Soluble epoxide hydrolase (sEH) is the metabolizing enzyme of epoxyeicosatrienoic acids (EETs), which may play a role in reducing neuroinflammation and regulating cerebral blood flow after subarachnoid hemorrhage (SAH).
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia, Vasospasm, Cerebral, Endothelial Dysfunction
- Trial name
- SUSHI (NCT03318783)
- Testing
- GSK2256294
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Oregon Health and Science University
Aneurysms, Arteriovenous Malformations
Neurosurgical Outcome Network
The evaluation of neurosurgical outcomes varies from center to center, and the predictive factors that determine these outcomes are not fully known or shared.
- Conditions
- Aneurysms, Arteriovenous Malformations, Cavernomas, Skull Base Tumors
- Trial name
- NEON (NCT06724029)
- Where
- 27 sites in Italy
- Volunteers
- 4,500 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Stroke, Intracerebral Haemorrhage
The Planetary Outcomes After Intracranial Haemorrhage Study
Over twelve million strokes occur worldwide every year, and stroke is the second most common cause of death globally. Strokes happen because blood supply to the brain is damaged.
- Conditions
- Stroke, Intracerebral Haemorrhage, Subarachnoid Haemorrhage (SAH)
- Trial name
- PLOT-ICH (NCT06731751)
- Testing
- Management of spontaneous intracranial haemorrhage
- Volunteers
- 1,000 people
- Sponsor
- University of Cambridge
Chronic Subdural Hematoma
Middle Meningeal Artery Embolization for Chronic Subdural Hematoma
Endovascular middle meningeal artery (MMA) embolization is an emerging treatment for chronic subdural hematoma (cSDH). There is preliminary data to suggest that this minimally invasive therapy may be more efficacious and equally…
- Trial name
- NCT04065113
- Testing
- Middle Meningeal Artery Embolization with polyvinyl alcohol particles (PVA), Drainage of Subdural Hematoma
- Where
- United States
- Sponsor
- Washington University School of Medicine
Brain Lesion, Head Trauma
Feasibility Study of Cortical Recording Depolarizations in Brain-injured Patients, and Their Use as Biomarkers of New Lesions.
The progression of brain lesions after severe head trauma or subarachnoid hemorrhage results from extra cranial aggression which is well controlled in intensive care and intracranial aggression which is less well known and…
- Conditions
- Brain Lesion, Head Trauma, Subarachnoid Hemorrhage
- Trial name
- SD-ICU (NCT04585503)
- Testing
- Electrode implantation
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Hospices Civils de Lyon
Infant, Newborn, Infant, Low Birth Weight
Antenatal Phenobarbital to Prevent Neonatal Intracranial Hemorrhage
This large randomized trial tested whether phenobarbital given to a pregnant woman about to deliver a premature infant would prevent brain injuries in their newborns.
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- Phenobarbital (NCT00009620)
- Testing
- Phenobarbital, Saline
- Where
- 11 sites in United States
- Volunteers
- 610 people, healthy volunteers welcome
- Sponsor
- NICHD Neonatal Research Network
Intracerebral Hemorrhage Basal Ganglia
Efficacy and Safety of NeuroEndoscopic Surgery for IntraCerebral Hemorrhage
To compare the efficacy and safety of neuroendoscopic hematoma removal and standard conservative treatment for patients with spontaneous supratentorial deep intracerebral hemorrhage.
- Trial name
- NESICH (NCT05539859)
- Testing
- Endoscopic surgery, Medical management
- Where
- 4 sites in China
- Volunteers
- 560 people
- Sponsor
- Southwest Hospital, China
Aneurysmal Subarachnoid Hemorrhage, Cerebral Vasospasm
Use of Simvastatin for the Prevention of Vasospasm in Aneurysmal Subarachnoid Hemorrhage
The purpose of this study is to test whether treatment with a drug called Simvastatin prevents and improves outcome in patients who have Subarachnoid bleeding.
- Trial name
- NCT00487461
- Testing
- Simvastatin 40 mg, Simvastatin 80 mg
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Illinois at Chicago
Subdural Hematoma, Subdural Hematoma, Chronic
Study On Histoacryl Used For Embolization Of Middle Meningeal Artery (MMA) In Chronic Subdural Hematoma (CSDH) (HARMONY)
The aim of the study is to proof the effectiveness of Histoacryl® on preventing recurrence or progression of subdural hematoma after embolization of the middle meningeal artery.
- Trial name
- HARMONY (NCT07258069)
- Testing
- Histoacryl®
- Where
- 6 sites in Japan
- Volunteers
- 178 people
- Sponsor
- Aesculap AG
Subarachnoid Hemorrhage, Subarachnoid Hemorrhage, Aneurysmal
Prevention of Vasospasm in SAH Through CSF Treatment
The pathophysiological mechanisms of aneurysmal subarachnoid haemorrhage (aSAH) involve early brain injury (EBI) and delayed cerebral ischemia (DCI).
- Conditions
- Subarachnoid Hemorrhage, Subarachnoid Hemorrhage, Aneurysmal, Vasospasm, Cerebral, Aneurysmal Subarachnoid Hemorrhage
- Trial name
- PREVAIL (NCT04490161)
- Testing
- intravenous reinstallation of cerebrospinal fluid
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Medical University Innsbruck