Clinical trials: Intra-dialytic Hypotension
Dialysis Hypotension
Steroids on Intra-dialytic Hypotension
Symptomatic hypotension during (or immediately following) hemodialysis complicates 5 to 30 percent of all dialysis treatments and is associated with increased morbidity and mortality.
- Trial name
- NCT03465007
- Testing
- Hydrocortisone, Normal saline
- Where
- Jordan
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of Jordan
Hypotension, End Stage Renal Disease
Pharmacokinetic and Pharmacodynamic Effects of MTR107 in End-Stage Renal Disease (ESRD) Patients
MTR107 effect on blood pressure throught the dialysis procedure and its ability to prevent Intra dialytic Hypotension
- Conditions
- Hypotension, End Stage Renal Disease, Intra Dialytic Hypotension
- Trial name
- NCT00448071
- Testing
- MTR107
- Where
- 2 sites in Israel
- Volunteers
- 12 people
- Sponsor
- Wolfson Medical Center
Intradialytic Hypotension, Hypervolemia
Pilot Study Using a Pulse Oximeter Derived Photo-plethysmographic Waveform to Guide Hemodialysis Ultrafiltration
The purpose of this study is to use the photo-plethysmographic [PPG] waveform signal to guide the dialysis and ultrafiltration [UF] of chronic maintenance hemodialysis patients, and to further the investigators understanding of…
- Trial name
- NCT02264522
- Testing
- Place dialysis chair into position 3., Decrease dialysate temperature., Decrease ultrafiltration rate by 25%.
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Intelomed, Inc.
Acute Kidney Injury, Intra-dialytic Hypotension
Low Dialysate Temperature During SLED
Objectives: This study is evaluating the hemodynamic effects of lowering the dialysate temperature in acute kidney injury (AKI) patients submitted to sustained low efficiency dialysis (SLED) in a single large center.
- Trial name
- NCT03397992
- Testing
- Changing dialysate temperature
- Volunteers
- 38 people
- Sponsor
- Washington University School of Medicine
End Stage Renal Disease (ESRD), Hemodialysis
Effect of Dialysis Techniques on Blood Pressure and Cardiac Function During Dialysis
Online hemodiafiltration confers a reduced mortality risk. However, it is not clear why HDF improved survival. To gain more insight in this issue, the effect of 4 dialysis techniques (differing in dialysate temperature and the…
- Conditions
- End Stage Renal Disease (ESRD), Hemodialysis, Hemodiafiltration, Intradialytic Hypotension
- Trial name
- HOLLANT (NCT03249532)
- Testing
- standard hemodialysis, cool hemodialysis, low volume hemodiafiltration
- Where
- 3 sites in Netherlands
- Volunteers
- 40 people
- Sponsor
- Amsterdam UMC, location VUmc
Hemodialysis Complication, Fluid Overload
Dialysate Sodium Lowering Trial
This is a pilot randomized clinical trial in which patients treated with 3X per weekly conventional hemodialysis will be treated to a dialysate sodium 135 mEq/L vs.
- Conditions
- Hemodialysis Complication, Fluid Overload, Dialysis Disequilibrium, Intra-dialytic Hypotension
- Trial name
- DeSaLT (NCT03144817)
- Testing
- Dialysate Sodium Lowering
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Tufts Medical Center
Hypotension of Hemodialysis, Hypotension
Measuring Cardiovascular Stress in Patients on Hemodialysis Study II
The overall goal is to evaluate the predictive accuracy of a measure of autoregulatory adequacy derived from CVInsight and compare it with other measures in recognizing hypotensive events during hemodialysis..
- Conditions
- Hypotension of Hemodialysis, Hypotension, Estimated Dry Weight, Myocardial Injury
- Trial name
- NCT02182089
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Intelomed, Inc.
Intradialytic Hypotension
The Effect of On-Line Hemodiafiltration Versus High Flux Hemodialysis on Hemodynamic Parameters in Patients With Intra-Dialytic Hypotension
Rationale and objectives 1. Patients on On Line Hemodiafiltration (OL- HDF) are more stable hemodynamically with less Intra Dialytic Hypotension (IDH) episodes compared to conventional hemodialysis (HD).
- Trial name
- NCT02719223
- Testing
- NICaS
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Western Galilee Hospital-Nahariya
Hemodialysis Complication
Coffee in Hemodialysis and Headache
Coffee is the most consumed drink worldwide, sometimes needed to boost energy and other times to entertain social connectivity. Caffeine is mostly present unbound in the plasma, only 10 to 30% of caffeine binds to plasma…
- Trial name
- CoffeeHD (NCT04057313)
- Testing
- Coffee
- Where
- Lebanon
- Volunteers
- 156 people
- Sponsor
- Saint-Joseph University
Intra-dialytic Hypotension
Mannitol - Potential Role in Hemodialysis Initiation for Reduction of Intra-dialytic Hypotension
Kidney failure can result from a variety of conditions and can be temporary or permanent. Hemodialysis is available as a replacement treatment to perform the work that the kidneys normally do.
- Trial name
- NCT01520207
- Testing
- Mannitol (20%), 0.9% saline
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Brigham and Women's Hospital
Intradialytic Hypotension
The Clinical Study of Improving the Thirst and Hypotension of Hemodialysis Patients
This clinical study is to observe the improvement of MHD (maintenance hemodialysis) patients, quality of life，after applying therapy combining Auriculotherapy and Shengmai capsule.
- Trial name
- NCT02583802
- Testing
- Ear pills, Shengmai capsule
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Beijing University of Chinese Medicine
Intra-dialytic Hypotension
IDH in Diabetic Haemodialysis Patients and Association With Dialytic Age
Intradialytic hypotension (IDH ) is a serious and the most frequent complication of hemodialysis of the hemodialysis .Diabetes is associated with autonomic neuropathy which contribute to intradialytic hypotension
- Trial name
- NCT03870594
- Testing
- glycated hemoglobin
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Mahmoud Mohamed Fawzy
Intradialytic Hypotension, End Stage Renal Failure on Dialysis
Adjusting Fluid Removal Based on Blood Volume in Hemodialysis: A Randomized Study
As kidney function declines, the ability to maintain water balance is impaired and is most often treated with hemodialysis. The removal of excess water in hemodialysis often leads to a sudden drop of blood pressure and causes…
- Trial name
- NCT01988181
- Testing
- BVM-UF biofeedback, Fresenius 5008 HD machine (Fresenius Medical Care, Bad Homburg, Germany)
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- University of Calgary
Hypotension of Hemodialysis
Early Warning of Intradialytic Hypotension in Hemodialysis Patients
In this study, the investigators will monitor patients undergoing hemodialysis treatment with a non-invasive wearable PPG-based device.
- Trial name
- NCT04680039
- Testing
- Continuous monitoring
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Biobeat Technologies Ltd.
Peri-dialytic Cardiac Rhythms, Intradialytic Hypotension
Trial of Variable Dialysate Bicarbonate
QTc prolongation and premature ventricular contractions (PVCs) are common in hemodialysis (HD) patients and are associated with sudden cardiac death.
- Conditions
- Peri-dialytic Cardiac Rhythms, Intradialytic Hypotension, Electrolyte Changes, pH Changes
- Trial name
- NCT05814146
- Testing
- Dialysate bicarbonate concentration, Dialysate bicarbonate concentration - telemetry monitoring
- Where
- United States
- Volunteers
- 141 people
- Sponsor
- Brigham and Women's Hospital
Hemodialysis-Induced Symptom, Intra-dialytic Hypotension
To Evaluate the Effects of Heating Device (Electronic Moxibustion) in Patients With Intradialytic Hypotension
The aim of this study is to investigate the effects of heating device among otherwise stable patients with intradialytic hypotension
- Trial name
- NCT03856151
- Testing
- "HEALTHY BOX" Powered heating pad (electronic moxibustion)
- Where
- Taiwan
- Volunteers
- 32 people
- Sponsor
- Chang Gung Memorial Hospital
Hemodialysis Complication, Hypotension of Hemodialysis
Hemodialysis.-Induced Hypotension Therapy for End Stage Kidney Disease
Bradykinin is a potent vasodilator that is formed by the activation of the kallikrein-kinin system. We and others have shown that bradykinin increased during hemodialysis; however, the role of bradykinin in dialysis-induced…
- Trial name
- Hinder (NCT05297786)
- Testing
- Lanadelumab Injection [Takhzyro]
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Vanderbilt University Medical Center
Intradialytic Hypotension
A Preliminary Randomized Study of Tianjiu (Auto-moxibustion) Effects in Patients With Intradialytic Hypotension
Intradialytic hypotension (IDH) is a most frequent complication of hemodialysis (HD) and may contribute to cardiovascular events and high mortality.
- Trial name
- NCT02210377
- Testing
- Tianjiu
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- Chang Gung Memorial Hospital
Intra-dialytic Hypotension
Trial of Dialysate Sodium in Chronic Hospitalized Hemodialysis Patients
Intra-dialytic hypotensive (IDH) events can be defined as an abrupt decline in blood pressure that cause symptoms and/or require an intervention. They are common, affecting up to one third of maintenance HD sessions.
- Trial name
- NCT02145260
- Testing
- Lower dialysate sodium (138 mmol/L; using Renasol hemodialysis concentrate), Higher dialysate sodium (142 mmol/L; using Renasol hemodialysis concentrate)
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Brigham and Women's Hospital
Dialysis Amyloidosis, Hypotension
Studying the Effect of Dialysate Temperature on Toxin Removal and Hypotension
Hemodialysis (HD) is widely used treatment for end stage renal diseases (ESRD) patients. The chief aims of HD are solute and fluid removal.
- Trial name
- NCT02064153
- Testing
- Cool dialysate, Warm dialysate
- Where
- Singapore
- Volunteers
- 14 people
- Sponsor
- National University Hospital, Singapore