Clinical trials: Intensive Care Unit Patients, active
Fluid Overload
Controlled Fluid Removal in Critical Ill Patients With Fluid Overload in the Intensive Care Unit.
This study evaluates the benefits and harms of goal directed fluid removal with furosemide versus placebo in critical ill adult patients with fluid overload in the intensive care unit.
- Trial name
- GODIF (NCT04180397)
- Testing
- Furosemide, Isotonic saline
- Where
- 29 sites in Australia, Czechia and 7 more
- Volunteers
- 1,000 people
- Sponsor
- Morten H. Bestle
Trauma Injury
Retrospective Assessment of Referral of a Major Trauma Patient
The aim of this study is to find out whether major trauma patients from the Val d'Oise are referred to the appropriate trauma centre for their care and to assess the quality of triage within the Val d'Oise department.
- Trial name
- SAMU-TRAUMAS (NCT06551350)
- Testing
- Data Collection
- Where
- France
- Volunteers
- 461 people
- Sponsor
- Hôpital NOVO
Post-Intensive Care Syndrome (PICS)
Long-Term Outcomes and Post-Intensive Care Syndrome: Investigating the Associations Between Metabolic Signatures and Physical Functioning in Critically Ill Patients
Despite being young, healthy, and physically fit, some intensive care unit (ICU) patients experience significantly worse functional recovery after critical illness than older patients with multiple comorbidities although a poor…
- Trial name
- TOPICS (NCT07170527)
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- ARH van Zanten, MD PhD
Drug Overdose, Metformin
Clinical and Biological Signs of Dapagliflozin Overdose in ICU Patients With Metformin Poisoning
This study looks at patients admitted to intensive care for drug poisoning involving metformin, a common diabetes medication. Researchers will compare two groups: patients who overdosed on metformin alone and those who took both…
- Conditions
- Drug Overdose, Metformin, Dapagliflozin, Lactic Acidosis
- Trial name
- NCT07193069
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier de Saint-Denis
Diabetes Mellitus, Blood Sugar
Accuracy and Safety of the Syai Tag System for Continuous Glucose Monitoring in Intensive Internal Care Unit
Researchers at the Department of Intensive Internal Medicine and the Department of Endocrinology and Diabetology will conduct a study to verify the accuracy and safety of the new Syai Tag system for continuous glucose monitoring…
- Conditions
- Diabetes Mellitus, Blood Sugar, Sepsis, Critically Ill Intensive Care Unit Patients
- Trial name
- NCT07448805
- Testing
- continuous glucose monitor
- Where
- Slovenia
- Volunteers
- 100 people
- Sponsor
- University Medical Centre Maribor
Medical Errors, Electronic Medical Records
Pictographs for Preventing Wrong-Patient Errors in NICUs
Newborns in the neonatal intensive care unit (NICU) are at high risk for wrong-patient errors. Effective 2019, The Joint Commission requires that health systems adopt distinct methods of newborn identification as part of its…
- Trial name
- NCT03960099
- Testing
- Pictograph in Banner and Verification Alert
- Where
- 4 sites in United States
- Volunteers
- 6,250 people
- Sponsor
- Columbia University
Subarachnoid Hemorrhage, Aneurysmal, Brain Injuries, Traumatic
Prospective Observational Multimodal Neuromonitoring in Adult NSICU Patients
This is a prospective observational cohort study of adult patients admitted to the Neurosciences Intensive Care Unit (NSICU) at UT Southwestern Medical Center.
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Brain Injuries, Traumatic, Cerebral Hemorrhage, Ischemic Stroke
- Trial name
- NCT07577713
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Texas Southwestern Medical Center
Acute Respiratory Distress Syndrome, Prone Position
Early Verticalization of the Patient With Acute Respiratory Distress Syndrome: Assessment of Feasibility and Safety.
Acute Respiratory Distress Syndrome (ARDS) is defined according to the Berlin definition (1) as diffuse lung damage occurring in patients with a predisposing risk factor.
- Trial name
- STAND_ARDS1 (NCT04472260)
- Testing
- Verticalization and Prone position
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Sepsis
Effect of Xuebijing InjecTion on Outcomes in Sepsis Patients Under Real-World Conditions（EXIT-SEP REAL）
Xuebijing injection (XBJ) showed proven efficacy in the EXIT-SEP trial (NCT03238742), lowering 28-day mortality. However, its real-world effectiveness requires validation due to the trial's strict criteria.
- Trial name
- EXIT-SEP REAL (NCT07069894)
- Where
- China
- Volunteers
- 5,400 people
- Sponsor
- Southeast University, China
Platelets/Albumin and Aki
Platelets to Albumin Ratio for Prediction of Acute Kidney Injury in Patients Admitted to the Intensive Care Unit
To evaluate the role of platelet to albumin ratio to detect Acute kidney injury in patients admitted to intensive care
- Trial name
- NCT06554977
- Testing
- Laboratory
- Volunteers
- 140 people
- Sponsor
- Assiut University
Mechanical Ventilation, Intensive Care (ICU)
Effects of PERMISSive Lung-protective Ventilation on Outcome in Critically Ill Invasively Ventilated Patients
RATIONALE Lung-protective ventilation using a lower respiratory rate (RR) is an appealing strategy to reduce ventilation intensity, which may require permissive hypercapnia.
- Trial name
- PERMISS pilot (NCT07077174)
- Testing
- Permissive lung-protective ventilation, Conventional lung-protective ventilation
- Where
- 5 sites in Netherlands, Spain
- Volunteers
- 56 people
- Sponsor
- Reinier de Graaf Groep
Ventilator Weaning, Airway Extubation
Can a Pain Monitor Predict When Postoperative Intensive Care Unit Patients Are Ready to Breathe on Their Own? A Pilot Study
The goal of this observational study is to learn if a chest monitor that tracks heart rhythm can help predict whether adults on a breathing machine after surgery will be able to breathe on their own once the breathing tube is…
- Conditions
- Ventilator Weaning, Airway Extubation, Respiration, Artificial
- Trial name
- NCT07771101
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Hospital
Post Intensive Care Syndrome (PICS), PTSD - Post Traumatic Stress Disorder
ICU-VR Prior to ICU Admission
Rationale: A substantial proportion of the Intensive Care Unit (ICU) survivors develop psychological impairments due to their ICU admission.
- Trial name
- NCT06642636
- Testing
- Intensive Care Unit-specific Virtual Reality
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Denzel Drop
Delirium
Melatonin for Treatment of Delirium in Critically Ill Adult Patients
The purpose of this study is to determine the feasibility of conducting a randomized controlled trial (RCT) with melatonin for treatment of delirium in critically ill adult patients.
- Trial name
- DELIRE-ICU (NCT05713877)
- Testing
- Melatonin
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Hyperoxia / High FiO₂ Exposure, Uric Acid/Albumin Ratio (UAR)
Association Between Early FiO₂ Exposure and Changes in the Uric Acid/Albumin Ratio in Septic ICU Patients
This prospective, non-interventional study aims to investigate the relationship between early oxygen exposure and oxidative stress in adult intensive care unit (ICU) patients diagnosed with sepsis or septic shock.
- Trial name
- NCT07332637
- Testing
- Oxygen Exposure (Fraction of Inspired Oxygen, FiO₂) - Standard of Care (Observational, No Experimental Intervention)
- Volunteers
- 110 people
- Sponsor
- Istinye University
Ventilated Patient in Intensive Care
Weighted Blanket to Improve Sedation and Comfort During Ventilator Weaning
Patients in the ICU who are being taken off of a breathing machine (ventilator weaning) commonly experience anxiety, agitation, sleep disruption, and physiologic stress.
- Trial name
- NCT07710469
- Testing
- Weighted blanket, Standard hospital linens
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Massachusetts General Hospital
Pressure Injury, Intensive Care Unit (ICU)
Arterial Blood Gas Levels, Oxygen Saturation, and Pressure Injury Risk in ICU Patients
The purpose of this study is to examine the relationship between arterial blood gas (ABG) parameters and oxygen saturation (SpO₂) levels and the risk of pressure injury development in patients hospitalized in intensive care…
- Trial name
- NCT07691710
- Where
- Turkey (Türkiye)
- Volunteers
- 122 people
- Sponsor
- Istanbul University
Sepsis, Bloodstream Infections
Blood DdPCR for Early Identification and Dynamic Surveillance of Pathogenic Bacteria in ICU Septic Patients: a Single-centre, Prospective, Observational Study
The purpose of this study is to investigate the efficacy of droplet digital PCR (ddPCR) in identifying pathogenic organisms in ICU sepsis patients, aiming to find a method that allows early identification of pathogenic organisms…
- Conditions
- Sepsis, Bloodstream Infections, Critically Ill Intensive Care Unit Patients
- Trial name
- NCT06791889
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Critical Illness, ICU Patients
Intensive Care Unit Rehabilitation Protocols
The aim of this study was to investigate the effects of NMES combination applied in addition to bicycle ergometry on mobility, functional status, muscle strength and hemodynamic responses in ICU patients.
- Trial name
- ICU-Rehab (NCT07179718)
- Testing
- neuromuscular electrical stimulation, bicycle ergometer
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Hacettepe University
Cancer, Critical Care, Cancer Critically Ill
Admission, Triage, and Discharge Criteria for Oncological Patients in the Intensive Care Unit
This study will create one agreed set of rules to help doctors decide which people with cancer should be treated in an intensive care unit (ICU), and when they are well enough to leave it.
- Trial name
- ONCO-TRIAD (NCT07809490)
- Testing
- No Intervention: Observational Cohort
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Onco Critical Care Society