Clinical trials: Intensive Care Unit (ICU)
Pressure Ulcer, Nursing Care
The Effect of Three Different Nasogastric Tube Fixation Materials on Pressure Injury
This randomized controlled experimental study aims to comparatively determine the effects of three different nasogastric tube fixation materials (elastic plaster, medical silk plaster, transparent waterproof plaster) on pressure…
- Trial name
- NCT06819800
- Testing
- Transparent Waterproof Flaster, Medical Silk Flaster, Elastic Flaster
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Bezmialem Vakif University
Sepsis, Acute Kidney Injury
Comparison of Balanced Crystalloids and Normal Saline in Septic Patients
In this prospective randomized controlled trial, investigators attempt to study the effects of acetated Ringer's solution on the prognosis and renal function of patients with sepsis in intensive care unit compared with normal…
- Conditions
- Sepsis, Acute Kidney Injury, Septic Shock, Sepsis, Severe
- Trial name
- NCT03685214
- Testing
- 0.9% saline, lactated Ringer's solution
- Where
- China
- Volunteers
- 500 people
- Sponsor
- ZhiYong Peng
Epilepsy, Neurologic Disorder
Cenobamate in the Intensive Care Unit
The CENOBITE study will be conducted as a multi-center trial involving X leading centers from the Critical Care EEG Monitoring Consortium (CCEMRC).
- Trial name
- CENOBITE (NCT06352723)
- Testing
- Cenobamate
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Sepsis, Bloodstream Infection
Rapid Molecular Diagnosis of Sepsis in the Intensive Care Unit
Rapid diagnosis of sepsis is crucial for treatment and survival. Currently, blood culture takes 48 hours-5 days to complete. After starting antimicrobial treatment blood culture results are not reliable.
- Trial name
- RADOS (NCT06624618)
- Where
- Netherlands
- Volunteers
- 300 people
- Sponsor
- Maastricht University Medical Center
Septic Shock
Association Between Muscle L3 CT Scan Muscle Derived Parameters of Muscle Function Upon Intensive Care Unit Admission and 3 Months Mortality After ICU Discharge for Patients Admitted for Septic Shock. The SIMS Study
Muscle dysfunction in intensive care units is associated with significant morbidity and mortality. During septic shock, there is an increased catabolism and systemic inflammation resulting in quantitative and qualitative muscle…
- Trial name
- SIMS (NCT07483710)
- Testing
- Evaluation of muscle dysfunction in intensive care units for septic schock patients
- Where
- 4 sites in France
- Volunteers
- 196 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Delirium
DeltaScan Validation Study for the Assessment of Delirium in the ICU and on Wards
Rationale: Delirium is associated with prolonged hospitalization, an increased risk of dementia, institutionalization and mortality, as well as increased costs.
- Trial name
- Val3 (NCT03966274)
- Where
- Netherlands
- Volunteers
- 434 people
- Sponsor
- UMC Utrecht
Complications of Surgical and Medical Care: General Terms, Adverse Reaction to Drug
The Thai Surgical Intensive Care Study (Thai-SICU Study)
The study observed the 28 days mortality of 9 participated University base surgical intensive care unit (SICU) as well as the occurrence of adverse events in SICU.
- Conditions
- Complications of Surgical and Medical Care: General Terms, Adverse Reaction to Drug, Sequelae of External Causes of Morbidity and Mortality, Critical Illness
- Trial name
- THAI-SICU (NCT01354197)
- Where
- 9 sites in Thailand
- Volunteers
- 4,652 people
- Sponsor
- Royal College of Anesthesiologists of Thailand
Anisocoria
Anisocoria in the Intensive Care Unit (AICU Study)
This retrospective single-center cohort study aims to determine the prevalence of acute "new onset" pupillary abnormalities in adult intensive care unit patients, assess their clinical impact, identify the contexts leading to…
- Trial name
- NCT06964997
- Where
- Switzerland
- Volunteers
- 920 people
- Sponsor
- University Hospital, Basel, Switzerland
ICU Hospitalization, Chronic Pain
Chronic Pain After Intensive Care Unit: Clinical Predictors
Thanks to medical advances, more patients now survive their stay in the Intensive Care Unit (ICU). However, many people who leave the ICU face long-term health problems, known as Post-Intensive Care Syndrome (PICS).
- Trial name
- NCT07117396
- Where
- Greece
- Volunteers
- 92 people
- Sponsor
- Attikon Hospital
Severe Influenza, Intensive Care (ICU)
Early Corticosteroids in Severe Influenza Pneumonia
This is a Phase III, multicentre, randomized, controlled, double-blind, superiority trial aiming to evaluate the efficacy of dexamethasone versus placebo in patients admitted to intensive care or intermediate care with influenza…
- Conditions
- Severe Influenza, Intensive Care (ICU), Reanimation, Infectious Diseases
- Trial name
- ECSIP (NCT07786662)
- Testing
- Dexametasone
- Where
- 48 sites in France
- Volunteers
- 544 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Pneumonia
Study of the Characteristics of Acute Mycoplasma Resuscitation: ECRAN-PLASMA Study
The ECRAN-PLASMA study aims to analyze the characteristics of patients with Mycoplasma pneumoniae or Chlamydia pneumoniae pneumonia hospitalized in intensive care units (ICU), continuous monitoring units (USC), or intensive…
- Trial name
- ECRAN-PLASMA (NCT07479355)
- Testing
- Infectious disease epidemiology
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Mechanical Ventilation Complication
National Approach to Standardize and Improve Mechanical Ventilation
This is a pre-post implementation cohort study. This is a data driven quality improvement project which aims to improve the care of mechanically ventilated patients through the implementation of a bundle of evidence based…
- Trial name
- NASAM (NCT03790150)
- Testing
- Evidence-based practices
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 27,966 people
- Sponsor
- King Abdullah International Medical Research Center
Aspiration, Pediatric Intensive Care Unit
Aspiration Training Given With Different Methods
Parents whose children are in intensive care have to cope with many stressors in terms of psychological, physical, economic and social aspects.
- Trial name
- NCT05950425
- Testing
- Aspiration training
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Ulcer
Comparison of Esomeprazole and Famotidine for Stress Ulcer Prophylaxis in Neurosurgical Intensive Care Unit
Although stress ulcer is a complication that can cause mortality and morbidity in critical patients, there is still lack of consensus about its prophylaxis. There is also few data available from Taiwan.
- Trial name
- NCT00633035
- Testing
- esomeprazole 40 mg, famotidine 20 mg
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Far Eastern Memorial Hospital
Sepsis - to Reduce Mortality in the Intensive Care Unit
Efficacy and Safety of Oral Nicotinamide as an Adjunctive Therapy in Patients With Sepsis
Sepsis is a severe, life-threatening condition caused by an abnormal host response to infection, which includes systemic inflammation, oxidative stress, and increasing organ dysfunction.
- Trial name
- NCT07655791
- Testing
- Nicotinamide 1000 mg
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Premature Birth, Newborn
Pain Management in Neonatal Intensive Care Units by Studying the Autonomic Balance
Fight against the pain caused by the disease or by the diagnostic and therapeutic procedures is a daily and essential concern for the caregiver neonatologist.
- Trial name
- NIPE-DOL (NCT02764424)
- Testing
- NIPE (MDoloris®)
- Where
- France
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Intensive Care Unit, Respiratory Insufficiency
Low Creatinine Level and Respiratory Failure
Low creatinine levels may be a sign of muscle atrophy or weakness, and therefore predictive for respiratory insufficiency in the Intensive care unit (ICU) patients.
- Conditions
- Intensive Care Unit, Respiratory Insufficiency, Muscle Weakness
- Trial name
- NCT04368325
- Testing
- Serum creatinine levels
- Where
- Croatia
- Volunteers
- 107 people
- Sponsor
- Osijek University Hospital
Infection, Bacterial Infection
Procalcitonin Level to Discontinue Antibiotics on ICU Patients With no Obvious Site of Infection
The purpose of this study is to test whether a U.S. Food and Drug Administration (FDA) approved laboratory test (PCT Kryptor) can help doctors make better decisions on the need for antibiotic therapy in ICU patients with…
- Conditions
- Infection, Bacterial Infection, Sepsis
- Trial name
- NCT00407147
- Testing
- Procalcitonin assay - B.R.A.H.M.S PCT sensitive Kryptor
- Where
- 3 sites in United States
- Volunteers
- 11 people
- Sponsor
- Brahms AG
No High Risk of Hemorrhage
Efficacy of the Association Mechanical Prophylaxis + Anticoagulant Prophylaxis on Venous Thromboembolism Incidence in Intensive Care Unit (ICU)
This multicentre open-label randomized parallel-group trial aims to compare the association of intermittent pneumatic compression of the lower limbs + elastic stockings + anticoagulant prophylaxis to anticoagulant prophylaxis…
- Trial name
- CIREA2 (NCT00740987)
- Testing
- Intermittent pneumatic compression of the lower limbs
- Where
- 15 sites in France, Monaco
- Volunteers
- 621 people
- Sponsor
- University Hospital, Brest
Respiratory Failure, Mechanical Ventilation Complication
Effect of Sedation Strategy on Duration Mechanical Ventilation in Patient After Cardiac Surgery
There is a direct relationship between the sedative agent and the duration of ventilation.
- Conditions
- Respiratory Failure, Mechanical Ventilation Complication, Sedation Complication
- Trial name
- NCT05451121
- Testing
- Propofol, Dexmedetomidine, Propofol and dexmedetomidine
- Where
- Ukraine
- Volunteers
- 356 people
- Sponsor
- Anesthesia Research Group UA