Clinical trials: Integrated Treatment
Opioid Use Disorder, Alcohol Use Disorder
Comparing Treatments for HIV-Infected Opioid and Alcohol Users in an Integrated Care Effectiveness Study
The purpose of this study is to learn how best to treat substance use disorders in an HIV clinic setting. Specifically, the purpose of this pilot study is to learn if extended-release naltrexone (XR-NTX) would be a feasible and…
- Trial name
- CHOICES (NCT01908062)
- Testing
- Extended Release Naltrexone, Treatment As usual
- Where
- 2 sites in United States, Canada
- Volunteers
- 51 people
- Sponsor
- Oregon Health and Science University
Spasticity
A Study to Assess the Safety and Efficacy of IPN10200 in Adult Participants With Upper Limb Spasticity.
The purpose of the study is to assess the safety and efficacy of increasing doses of Corabotase (also known as IPN10200) with the aim to evaluate the Pharmacodynamics (PD) profile of Corabotase and to establish the total…
- Trial name
- LANTIMA (NCT04752774)
- Testing
- Corabotase, Dysport
- Where
- 81 sites in United States, Austria and 12 more
- Volunteers
- 240 people
- Sponsor
- Ipsen
HIV Positive
Integrated Treatment and Prevention for People Who Inject Drugs
The purpose of this study is to determine the feasibility of a future trial that will assess whether an integrated intervention combining psychosocial counseling and supported referrals for antiretroviral therapy (ART) at any CD4…
- Trial name
- NCT02935296
- Testing
- Integrated Intervention
- Where
- 3 sites in Indonesia, Ukraine and 1 more
- Volunteers
- 1,281 people
- Sponsor
- HIV Prevention Trials Network
Hepatocellular Carcinoma Non-resectable, Hepatocellular Carcinoma Recurrent
QUILT-3.072: NANT Hepatocellular Carcinoma (HCC) Vaccine
This is a phase 1b/2 study to evaluate the safety and efficacy of metronomic combination therapy in subjects with advanced, unresectable, and untransplantable HCC.
- Trial name
- NCT03563170
- Testing
- ETBX-011, GI-4000, haNK for infusion
- Where
- United States
- Sponsor
- ImmunityBio, Inc.
Rectal Neoplasms
Neoadjuvant Chemotherapy With PD-1 Inhibitors Combined With SIB-IMRT in the Treatment of Locally Advanced Rectal Cancer
This study aims to evaluate the efficacy and safety of tislelizumab combined with simultaneous integrated boost intensity-modulated radiotherapy in treating locally advanced rectal cancer.
- Trial name
- NCT06017583
- Testing
- Tislelizumab, Capecitabine, Oxaliplatin
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Yong Zhang,MD
Hypomagnesemia
Feasibility of Using an Integrated Consent Model to Compare Two Standard of Care Regimens for the Management of Hypomagnesemia From Anti-Cancer Therapies
Hypomagnesemia (hMg) is a common side effect of important anti-cancer therapies such as epidermal growth factor receptor inhibitors (EGFRIs) and platinum-containing anti-cancer drugs.
- Trial name
- OTT 15-03 (NCT02690012)
- Testing
- Magnesium Oxide, Magnesium Citrate
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Ottawa Hospital Research Institute
Musculoskeletal Pain, Pain
Brief Cognitive Behavioral Therapy for Chronic Pain to Improve Functioning Among Veterans
Chronic pain is very common among primary care Veterans and can seriously impact overall patient functioning and well-being. Currently, behavioral treatments for pain management are not often provided in primary care because they…
- Trial name
- NCT04724694
- Testing
- Brief CBT for Chronic Pain, Treatment as usual
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder, Substance Use Disorder
Present- Versus Past-focused Therapy for PTSD and Substance Use Disorder
This study compares Creating Change, a new past-focused behavioral therapy for posttraumatic stress disorder (PTSD)/substance use disorder (SUD), to Seeking Safety, an evidence-based present-focused behavioral therapy for…
- Conditions
- Posttraumatic Stress Disorder, Substance Use Disorder, Alcohol Use Disorder
- Trial name
- NCT01274741
- Testing
- Creating Change (CC), Seeking Safety (SS)
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- VA Boston Healthcare System
Post-stroke Depression
Integrated Rehabilitation in Treating Post-stroke Depression
Post-stroke depression (PSD) is a common complication of stroke that leads to dysfunction and reduces the quality of life. PSD exacerbates cognitive dysfunction, delays the recovery process, and increases the disability…
- Trial name
- IRTPD (NCT05187975)
- Testing
- Acupuncture
- Where
- China
- Volunteers
- 202 people
- Sponsor
- The Third Affiliated hospital of Zhejiang Chinese Medical University
Unintentional Burn Injury, Depression
Integrated Case Management for Burns Care in Pakistan
To test whether a culturally adapted multicomponent intervention for improving burns care and patient/family rehabilitation is effective in improving survival among burn victims in Pakistan and is cost-effective.
- Conditions
- Unintentional Burn Injury, Depression, Anxiety, Burns
- Trial name
- BURNS (NCT06559501)
- Testing
- Integrated case manager care
- Where
- 11 sites in Pakistan
- Volunteers
- 1,045 people
- Sponsor
- Pakistan Institute of Living and Learning
Transition, Emergencies
The LEARNING WISDOM Phase II Scale up Project
Inspired by the Acute Care for Elders program at Mount Sinai Hospital, this study aims to improve care for elderly patients in four hospitals of Chaudière-Appalaches.
- Conditions
- Transition, Emergencies, Health Care Utilization, Frailty
- Trial name
- NCT04093245
- Testing
- GEM nurse, pre- and post-hospitalization medication list reconciliation, systematic discharge summaries
- Where
- Canada
- Volunteers
- 4,000 people
- Sponsor
- Laval University
Polyneuropathy, Inflammatory Demyelinating, Chronic
Real-world Study of Treatment Outcomes in Chronic Inflammatory Demyelinating Polyneuropathy/Polyradiculoneuropathy (CIDP)
This study is an observational, ambispective, descriptive, non-interventional study of people with a chronic inflammatory demyelinating polyneuropathy/polyradiculoneuropathy (CIDP) diagnosis in the United States with residual…
- Trial name
- ORBIT-CIDP (NCT06968975)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Sanofi
Chronic Migraine Headache
Efficacy of Traditional Integrated Islamic Psychotherapy and Cognitive Behavioural Therapy for Migraine: A Randomized Controlled Trial
his randomized controlled trial aims to evaluate the efficacy of Cognitive Behavioral Therapy (CBT) and Traditional Integrated Islamic Psychotherapy (TIIP) as psychological interventions for individuals with chronic migraine.
- Trial name
- CBT TIIP (NCT07802912)
- Testing
- Cognitive Behavioral Therapy (CBT), Traditional Integrated Islamic Psychotherapy (TIIP), Medication Group
- Where
- Pakistan
- Volunteers
- 45 people
- Sponsor
- GIFT University
Prostate Cancer, Radiotherapy Side Effect
Protons vs. Photons for High-risk Prostate Cancer
The purpose of this study is to assess late gastro-intestinal side-effects comparing proton therapy to photon therapy in high-risk prostate cancer patients receiving whole pelvic irradiation.
- Trial name
- NCT05350475
- Testing
- Proton therapy, Photon therapy
- Where
- 7 sites in Denmark
- Volunteers
- 102 people
- Sponsor
- University of Aarhus
Trachoma, Lymphatic Filariasis
Safety Study of Combined Azithromycin, Ivermectin and Albendazole for Trachoma and Lymphatic Filariasis
Trachoma and lymphatic filariasis (LF) are two 'Neglected Tropical Diseases' (NTDs), infectious diseases that affect millions of poor people in countries in the developing world.
- Trial name
- AZIVAL2 (NCT01903057)
- Testing
- azithromycin, ivermectin, albendazole
- Where
- Mozambique
- Volunteers
- healthy volunteers welcome
- Sponsor
- Emory University
Depression
Evaluation of an Integrated Microfinance and Depression Care Program for Women
The study evaluates LIFE-DM, an integrated microfinance and collaborative care intervention by comparing it to enhanced treatment as usual (national guideline antidepressant care and referral to microfinance resources) in…
- Trial name
- LIFE-DM (NCT02069301)
- Testing
- Integrated Depression/Microfinance Group, Treatment as Usual, Livelihood Support
- Where
- 4 sites in Vietnam
- Volunteers
- 166 people
- Sponsor
- RAND
Smoking Cessation, Second Hand Tobacco Smoke
The "Quit-for-Kids" Project: to Increase Abstinence and Protect Children From Tobacco Smoke Exposure
This project aims to test the effectiveness of an integrated intervention of brief cessation advice (AWARD), Nicotine Replacement Therapy, and Instant Messaging support compared with waitlist control participants among adult…
- Trial name
- NCT06127589
- Testing
- Brief cessation advice (AWARD), Nicotine Replacement Therapy (NRT), Instant messaging Support (IM)
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Hypertension, Cardiovascular Disease
Regional Innovation in Chronic Disease and Elderly Care
This project aims to develop a community-based health promotion intervention model for populations at potential risk of metabolic syndrome.
- Conditions
- Hypertension, Cardiovascular Disease, Hyperlipidemia, Hyperglycemia
- Trial name
- NCT07578090
- Where
- Taiwan
- Volunteers
- 1,000 people
- Sponsor
- Fu Jen Catholic University
Cardiovascular Diseases, Diabetes Mellitus, Type 2
The Japan Diabetes Optimal Integrated Treatment Study for 3 Major Risk Factors of Cardiovascular Diseases
(Intervention study) The objective of the study is to confirm the superiority of the intensive therapy to the conventional therapy concerning the prevention of the incidence or exacerbation of vascular complications caused by…
- Trial name
- J-DOIT3 (NCT00300976)
- Testing
- Lifestyle consultation: weight control, diet, exercise
- Where
- Japan
- Volunteers
- 2,542 people
- Sponsor
- Japan Foundation for the Promotion of International Medical Research Cooperation
Traumatic Brain Injury
A TMU/NIH Integrated Research Project Translation of Basic Research to Clinical Diagnosis and Treatment of Mild Traumatic Brain Injury (mTBI)
This integrated research project is cooperated by an fully-experienced team of Taipei Medical University and National Institutes of Health.
- Trial name
- NCT01266356
- Where
- Taiwan
- Volunteers
- 500 people
- Sponsor
- Taipei Medical University WanFang Hospital