Clinical trials: Insulin Sensitivity
Insulin Resistance
Effect of Dietary Polyphenols on Insulin Sensitivity
A large and growing segment of the population is prediabetic. Dietary interventions that improve insulin sensitivity may be important in preventing the progression to full-blown diabetes in these individuals.
- Trial name
- NCT00668928
- Testing
- Polyphenols (flavon-3-ol monomers and oligomers)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- United States Department of Agriculture (USDA)
Impairment of Oral Perception, Insulin Resistance
The Effect of Artificial Sweeteners (AFS) on Sweetness Sensitivity, Preference and Brain Response in Adults
The purpose of this study is to investigate the effects of dietary exposure to artificial sweeteners on taste sensitivity, preference and brain response in adults.
- Trial name
- AFS-adult (NCT02335021)
- Testing
- Sucralose, Sucrose, Sucralose + maltodextrin
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Yale University
Type 2 Diabetes
Effect of High-intensity Low-volume Training on Insulin Sensitivity in Type 2 Diabetes
High intensity interval training is applied for several diseases. Hypothesis: High intensity interval training improves insulin sensitivity in patients with type 2 diabetes.
- Trial name
- HIT (NCT02039934)
- Testing
- High intensity interval training
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- German Diabetes Center
Obesity; Familial
Assessment of the Health Improvement of Obese Patients After Fecal Microbiota Transplantation (FMT)
Search for mechanisms of the effect of fecal microbiota transplantation on patients with obesity
- Trial name
- NCT04579263
- Testing
- Fecal microbiota
- Where
- 2 sites in Russia
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Federal Research and Clinical Center of Physical-Chemical Medicine
Exercise, Insulin Sensitivity
Myocellular Signalling in Skeletal Muscle
The study will investigate myocellular signalling in skeletal muscle after insulin-stimulation and exercise in healthy young men
- Trial name
- NCT03203317
- Testing
- Insulin, Exercise
- Where
- Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Obesity
Effect of Vitamin D3 Supplementation on Insulin Resistance and Cardiovascular Risk Factors in Obese Adolescents
The prevalence of obesity has reached epidemic proportions nationally as well as internationally. Currently, 16 % of American adolescents are obese.
- Trial name
- NCT00858247
- Testing
- Vitamin D3
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Obesity
High-intensity Intermittent Training for Obese Individuals
The most appropriate and effective exercise interventions for weight loss remain a matter of continued discussion and there is a need to identify sustainable exercise programs which successfully promote weight loss and benefit…
- Trial name
- NCT01143376
- Testing
- High intensity training, short springs, Moderate intensity exercise
- Where
- Norway
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Obesity, Diabetes
Insulin Sensitivity of the Human CNS System: fMRI Study With Intranasal Insulin Application
The purpose of the study is to investigate whether insulin sensitivity and insulin resistance of the human brain is comparable in all insulin sensitive parts of the brain and whether correlates to other phenotypic information…
- Trial name
- NCT01797601
- Testing
- Human Insulin
- Where
- Germany
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Hypertension, Impaired Glucose Tolerance
Clinical Trial To Evaluate The Effect Of Valsartan On Insulin Sensitivity In Subjects With Impaired Glucose Tolerance
THE PURPOSE OF THIS STUDY IS TO DETERMINE IF 24 WEEKS OF TREATMENT WITH VALSARTAN (80 MG - 320 MG) IMPROVES INSULIN SENSITIVITY IN SUBJECTS WITH HIGHER THAN NORMAL GLUCOSE LEVELS USING A TEST CALLED THE EUGLYCEMIC CLAMP.
- Trial name
- NCT00241072
- Testing
- valsartan
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Novartis
Dietary Intervention, Gut Microbiota
Phenolic Dependent And Independent Effects Of Whole Grain Sorghum On Immunometabolism
Sorghum is a nutrient-dense ancient grain that, when eaten as a whole grain, provides health-beneficial dietary fiber, protein, and phenolics.
- Conditions
- Dietary Intervention, Gut Microbiota, Insulin Sensitivity/Resistance, Obesity & Overweight
- Trial name
- NCT07832071
- Testing
- Whole grain sumac sorghum, Whole grain white sorghum, White rice
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nebraska Lincoln
Pre-diabetes
The Insulin Sensitivity Using Aerobic Interval Conditioning
The Insulin Sensitivity using Aerobic Interval Conditioning (ISAIC) trial will compare traditional aerobic training (AER) to interval training (INT) in sedentary, overweight/obese men at risk for pre-diabetes.
- Trial name
- ISAIC (NCT01286922)
- Testing
- Behavioral: exercise
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Insulin Resistance
Effects of Intranasal Insulin Administration on Tissue Specific Insulin Sensitivity
Recent research has suggested that intranasally administered insulin can reach the brain quickly without passing through circulation and evoke increased insulin sensitivity and tissue glucose consumption during insulin…
- Trial name
- NASO-PET (NCT02933645)
- Testing
- Actrapid, [18F]-FDG PET-CT, Hyperinsulinemic euglycemic clamp
- Where
- Finland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Obesity, Non-Alcoholic Fatty Liver Disease
Effect of Timed-Restricted Eating on Metabolic Health
We aim to determine the effect of combined isocaloric time restricted eating and meal timing on metabolic health, liver fat, functional brain networks, inflammation, and sleep pattern/quality in subjects with obesity and insulin…
- Conditions
- Obesity, Non-Alcoholic Fatty Liver Disease, Insulin Resistance
- Trial name
- TREAT (NCT06061042)
- Testing
- Early time restricted eating, Late time restricted eating
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Insulin Sensitivity
Influence of Brain Insulin Sensitivity on Peripheral Insulin Sensitivity
The researchers will investigate if brain insulin action influences peripheral insulin sensitivity in healthy humans.
- Trial name
- NCT01847456
- Testing
- human insulin as nasal spray
- Where
- Germany
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Type 2 Diabetes
High Intensity Interval Training (HIT) in Patients With Type 2 Diabetes
The purpose of this study is to determine the effect of High Intensity Interval Training (HIT) on insulin sensitivity in skeletal muscle in patients with type 2 diabetes.
- Trial name
- HIT_T2DM (NCT01732705)
- Testing
- High intensity interval training
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Insulin Sensitivity
"Effect of Central Insulin Administration on Whole-body Insulin Sensitivity in Women"
The human brain is an insulin sensitive organ. Brain insulin action modulates peripheral insulin sensitivity in young lean men. As a underlying mechanism, the investigators previously detected suppression of endogenous glucose…
- Trial name
- NCT03929419
- Testing
- intranasal insulin
- Where
- Germany
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Insulin Resistance, Type 2 Diabetes Mellitus
T-IR- Study to Understand the Effects of Testosterone and Estrogen on the Body's Response to the Hormone Insulin
The purpose of this research study is to understand the effects of testosterone and estrogen on the body's response to the hormone insulin.
- Conditions
- Insulin Resistance, Type 2 Diabetes Mellitus, Obesity, Androgen Deficiency
- Trial name
- T-IR (NCT01686828)
- Testing
- Acyline, Testosterone 1.62% gel, Letrozole
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Washington
Diabetes, Gestational
Insulin Sensitivity and Secretion During Pregnancy and Post Partum in Women With Gestational Diabetes.
Aim of the study: To define insulin requirement during pregnancy and to identify the rapid changes in insulin sensitivity around parturition and the first 6 months post partum.
- Trial name
- NCT02770079
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Type 2 Diabetes Mellitus With Features of Insulin Resistance
Effects of Chronic Dietary Exposure to Branched Chain Amino Acids
Branched-chain amino acids (BCAA) belong among nutrients strongly linked with insulin sensitivity (IS) measures. Their exact effect on IS appears to be dependent on various conditions that remain to be better defined .
- Trial name
- NCT02684929
- Testing
- branched chain amino acids
- Where
- Czechia
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Overweight and Obesity
SIT LESS 4: How Does Reducing Sitting Time Improve Glucose and Lipid Metabolism?
Research has shown that replacing sitting time with low intensity physical activity (such as slowly walking and standing) has beneficial effects on metabolic health, like insulin sensitivity, comparable to improvements after…
- Trial name
- SITLESS4 (NCT03912922)
- Testing
- Activity regime
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center