Clinical trials: Insulin Resistance, open to volunteers
Cardiovascular Diseases, Adiposity
The Influence of Chardonnay Marc Intake on Gut and Cardiometabolic Health
Recently a dietary recommendation of 400 - 600 mg/ day has been proposed for the reduced risk of developing cardiovascular disease.
- Conditions
- Cardiovascular Diseases, Adiposity, Cardiometabolic Syndrome
- Trial name
- NCT06476795
- Testing
- Chardonnay Marc
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Obesity, Insulin Resistance
Small Extracellular Vesicles and Insulin Action
The goals of this research study are to: 1) understand why some people with obesity are protected from developing conditions such as type 2 diabetes and cardiovascular disease while others are more likely to develop…
- Conditions
- Obesity, Insulin Resistance, Metabolically Healthy Obesity, Obesity, Metabolically Benign
- Trial name
- SEV (NCT05933707)
- Testing
- People with Metabolically Unhealthy Obesity - Low Calorie Diet
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
HR+/HER2-negative Breast Cancer, Metastatic Breast Cancer
Evexomostat Plus PI3K or AKT Inhibitor and Fulvestrant in Patients With a PI3K Alteration and HR+/Her2- Breast Cancer
This is a Phase 1b/2, open-label, parallel-arms pilot study in men and post-menopausal women with hormone receptor positive (HR+), HER2- advanced or metastatic breast cancer with an alteration in the PI3K pathway, including a…
- Trial name
- Amelia-1 (NCT05455619)
- Testing
- Evexomostat
- Where
- 10 sites in United States
- Volunteers
- 52 people
- Sponsor
- SynDevRx, Inc.
Dietary Intervention, Gut Microbiota
Phenolic Dependent And Independent Effects Of Whole Grain Sorghum On Immunometabolism
Sorghum is a nutrient-dense ancient grain that, when eaten as a whole grain, provides health-beneficial dietary fiber, protein, and phenolics.
- Conditions
- Dietary Intervention, Gut Microbiota, Insulin Sensitivity/Resistance, Obesity & Overweight
- Trial name
- NCT07832071
- Testing
- Whole grain sumac sorghum, Whole grain white sorghum, White rice
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nebraska Lincoln
Metabolic Syndrome, Diabetes
Evaluation of a Novel Self-Sampling Earwax Tool for Chronic Disease Biomarkers [TREARS STUDIES II]
Trears Biomarkers: A New Way to Manage Chronic Diseases Trears Biomarkers are changing how we care for chronic diseases by focusing on patients' needs.
- Conditions
- Metabolic Syndrome, Diabetes, Hypertension, Obesity and Obesity-related Medical Conditions
- Trial name
- Trears-II (NCT06932601)
- Volunteers
- 258 people
- Sponsor
- Trears
Type 1 Diabetes Mellitus, T1DM
Type 1 Diabetes Extension Study
This is a multi-center, prospective, non-interventional study that focuses on the long- term effects following participation in selected ITN new-onset Type1 Diabetes Mellitus studies with immunomodulatory agents (T1DM, T1D).
- Conditions
- Type 1 Diabetes Mellitus, T1DM, T1D
- Trial name
- T1DES (NCT02734277)
- Where
- 12 sites in United States
- Volunteers
- 111 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Chronic Kidney Diseases, Diabetes Mellitus
Automated Insulin Delivery in Adults With Advanced Kidney Disease
Diabetes is the leading cause of kidney failure in the UK. Many people with diabetes and advanced kidney failure inject themselves with insulin and do finger-prick blood glucose tests.
- Trial name
- AIDkidney (NCT06463483)
- Testing
- Medtronic 780G System, Continuous Glucose Monitoring
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Imperial College London
Congenital Hypothyroidism, Metabolic Syndrome
Metabolic Risk Assessment in Prepubertal Children With Congenital Hypothyroidism
We propose a multicenter prospective study to define the prevalence and severity score of metabolic syndrome in a prepubertal pediatric cohort with congenital hypothyroidism, compared to a healthy and normal-weight pediatric…
- Trial name
- IpoMet (NCT07126353)
- Testing
- prospective observational study (clinical, hormonal and auxological data)
- Where
- Italy
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Buzzi Children's Hospital
Metabolic Dysfunction-Associated Steatotic Liver Disease, Non-Alcoholic Steato-Hepatitis (NASH)
How Abnormal Function of Fat Tissue in Type 1 Diabetes Contributes to Fat in the Liver
Steatotic liver disease associated with metabolic dysfunction (MASLD) is a disease caused by excess fat storage in the liver. Excessive fat delivery to the liver and MASLD typically occurs in people with abdominal obesity and…
- Conditions
- Metabolic Dysfunction-Associated Steatotic Liver Disease, Non-Alcoholic Steato-Hepatitis (NASH), Type 1 Diabetes Mellitus
- Trial name
- AGL14 (NCT07133854)
- Testing
- Imaging PET/MRI, Stable isotope infusions, meal test
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Obesity, Non-Alcoholic Fatty Liver Disease
Effect of Timed-Restricted Eating on Metabolic Health
We aim to determine the effect of combined isocaloric time restricted eating and meal timing on metabolic health, liver fat, functional brain networks, inflammation, and sleep pattern/quality in subjects with obesity and insulin…
- Conditions
- Obesity, Non-Alcoholic Fatty Liver Disease, Insulin Resistance
- Trial name
- TREAT (NCT06061042)
- Testing
- Early time restricted eating, Late time restricted eating
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Diabetes, Pre-diabetes
Effect of Oral L-arginine 3.32 g a Day on Oxidative Stress Influencing Beta Cell Function and Insulin Resistance.
The objective of this clinical trial is to explore whether L-arginine supplementation with 3.32g/day may enhance antioxidant defenses in overweight and obese patients with pre-diabetes and metabolic syndrome, possibly providing…
- Conditions
- Diabetes, Pre-diabetes, Metabolic Syndrome
- Trial name
- L-BIOARG (NCT06686069)
- Testing
- bioarginina zero
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Federico II University
Metabolic Syndrome
Probiotics and Gut Health
This study evaluates the effects of probiotic consumption on inflammatory outcomes and measures of gut health. Participants will be given yogurt with probiotics for one period and yogurt without probiotics for another, with a…
- Trial name
- PRO (NCT03418857)
- Testing
- Yogurt smoothie with BB-12, Yogurt smoothie
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Penn State University
Perioperative Care, Intermittent Fasting
Intermittent Fasting Versus Carbohydrate Drinks Before Surgery
The purpose of this study is to investigate whether time-restricted feeding, a form of intermittent fasting, before surgery improves insulin resistance around the time of surgery, compared to carbohydrate drinks and standard…
- Conditions
- Perioperative Care, Intermittent Fasting, Carbohydrate Loading, Preoperative Fasting
- Trial name
- PRINCESS (NCT05760339)
- Testing
- Time-restricted feeding, Carbohydrate loading
- Where
- Netherlands
- Volunteers
- 75 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Cardiometabolic Syndrome, Hiv
The Role of Ectopic Fat and Heart Attack Risk in HIV
This study is designed to investigate differences between people living with HIV (PLWHIV) and general populations on how the body utilises and stores energy.
- Trial name
- BHIVA (NCT06784154)
- Testing
- Non-interventional
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Liverpool
Metabolic Syndrome (MetS), Inflammation
Comparing a Healthy Beef-Centric Diet to a Healthy U.S.-Style Diet on Metabolic Health Outcomes in Pre-Diabetic Adults
This randomized study will be conducted to compare the effect of a healthy beef-centric diet to a healthy U.S.-style dietary pattern on inflammation and other metabolic health outcomes in a metabolic syndrome and/or pre-diabetic…
- Conditions
- Metabolic Syndrome (MetS), Inflammation, Pre-Diabetes
- Trial name
- NCT07269847
- Testing
- Healthy Beef-Centric Diet, Healthy U.S.-Style Dietary Pattern
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- National Cattlemen's Beef Association, a contractor to the Beef Checkoff
Brain Insulin-sensitivity, Brain Vascular Function
Effects of Wild Blueberry Consumption on Brain Function in Elderly
Impaired brain vascular function precedes the development of reduced cognitive performance, while brain insulin-resistance is associated with cognitive decline.
- Conditions
- Brain Insulin-sensitivity, Brain Vascular Function, Cerebral Blood Flow
- Trial name
- NCT07177781
- Testing
- Wild blueberry powder
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Metabolic Syndrome, IBS - Irritable Bowel Syndrome
Applications of a Functional Dairy Product in Diet Therapy
The aim of the study will be to evaluate the effectiveness of dietary therapy using a functional dairy product, using fermented milk with selected probiotic cultures, in individuals with irritable bowel syndrome and metabolic…
- Trial name
- SUPRIMDIET (NCT07793487)
- Testing
- new functional milk drink, conventional, acidified milk drink
- Where
- Poland
- Volunteers
- 80 people
- Sponsor
- Warsaw University of Life Sciences
M-health, Metabolic Syndrome
Exercise-Targeted Smart Lifestyle Management
To investigate the effects of simple dietary management and diet combined with exercise capacity-targeted intelligent lifestyle management on improving metabolic indicators in patients with overweight/obesity and metabolic…
- Conditions
- M-health, Metabolic Syndrome, Lifestyle Alteration, Lifestyle (Sedentary Behavior and Physical Activity)
- Trial name
- NCT07535333
- Testing
- Dietary Prescription, Personalized Exercise Prescription, Metabolic Syndrome Prevention and Education
- Volunteers
- 435 people
- Sponsor
- China National Center for Cardiovascular Diseases
Cardiometabolic Syndrome, Type 2 Diabetes
Circadian Intervention to Improve Cardiometabolic Health
The overall goal is to examine the efficacy of a circadian intervention in people with overweight and obesity and habitual short sleep duration (HSSD).
- Conditions
- Cardiometabolic Syndrome, Type 2 Diabetes, Sleep, Time Restricted Feeding
- Trial name
- TOCS (NCT05943626)
- Testing
- Circadian Intervention
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Utah
Metabolic Syndrome, Postmenopausal Symptoms
Circadian Rhythms in Postmenopausal Women
This is a randomized, parallel two-arm clinical trial design to study the efficacy of time-restricted feeding on metabolic risk in postmenopausal women, who may be particularly vulnerable to disruption of circadian eating rhythms…
- Trial name
- NCT04893226
- Testing
- Time-Restricted Feeding (TRF)
- Where
- United States
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Julie Pendergast