Clinical trials: Insulin Hypoglycemia
Insulin Hypoglycemia, Type 1 Diabetes Mellitus
G-Pen Compared to Glucagen Hypokit for Severe Hypoglycemia Rescue in Adults With Type 1 Diabetes
This is a multi-center, randomized, controlled, single-blind, two-way crossover efficacy and safety study in subjects with Type 1 diabetes mellitus.
- Conditions
- Insulin Hypoglycemia, Type 1 Diabetes Mellitus, Severe Hypoglycemia
- Trial name
- NCT03738865
- Testing
- G-Pen, Novo Glucagon
- Where
- 7 sites in United States, Austria and 1 more
- Volunteers
- 132 people
- Sponsor
- Xeris Pharmaceuticals
Diabetes Mellitus
Effect of Pulsatile IV Insulin on Circulating Risk Markers of Vascular and Metabolic Complications in Pts With Diabetes
The purpose of this study is to determine the effect of Pulsatile Intravenous Insulin therapy on circulating blood markers. These blood markers are selected due to their correlation to and possible pathogenetic roles in vascular…
- Trial name
- NCT00361907
- Testing
- Effect of Pulsatile IV insulin on diabetic pt blood markers, Effect of Pulsatile IV Insulin on blood markers
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Florida Atlantic University
Type 1 Diabetes
Closed-loop Control of Glucose Levels (Artificial Pancreas) for 60 Hours in Adults With Type 1 Diabetes
Closed-loop strategy is composed of three components: glucose sensor to read glucose levels, insulin pump to infuse insulin and a dosing mathematical algorithm to decide on the required insulin dosages based on the sensor's…
- Trial name
- NCT01966393
- Testing
- 60-hours intervention
- Where
- Canada
- Volunteers
- 23 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Diabetes, Diabetes Mellitus, Type 1
French Observational Survey to Assess Hypoglycaemia in Insulin-treated Diabetic Patients
This non-interventional study is conducted in Europe. The study is both retrospective and prospective. The purpose of the study is to assess the frequency of hypoglycaemia (low blood glucose) in insulin-treated patients with type…
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- DIALOG (NCT01628341)
- Testing
- insulin
- Where
- France
- Volunteers
- 4,424 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes Mellitus, Hypoglycemia
How to be Safe With Alcoholic Drinks in Diabetes
The purpose of this study is to show that during and after drinking beer a treatment strategy by insulin bolus and reduction of basal rate reduces the rate of hyperglycaemia without an increase of hypoglycaemic events compared to…
- Trial name
- BEER (NCT02518022)
- Testing
- Insulin
- Where
- Germany
- Sponsor
- Kinderkrankenhaus auf der Bult
Diabetes Mellitus, Lipohypertrophy
Lipohypertrophy Monitoring Study
The investigators intend to audit the impact of optimal injection technique education delivered through a multimodal tailored approach augmented with a digital 'tailorable' patient learning platform on clinical parameters and…
- Conditions
- Diabetes Mellitus, Lipohypertrophy, Hypoglycemia
- Trial name
- LiMo (NCT04659330)
- Testing
- Online education (BdandMe) for injection technique, 4mm needles
- Where
- Belgium
- Volunteers
- 171 people
- Sponsor
- University Hospital, Antwerp
Diabetes Mellitus 2 Type
Comparison of Two Insulin Regimens in Optimally-controlled Patients With DM2.
Intensive Insulin Therapy (IIT) may be given in Type 2 Diabetes (T2DM) in two different ways : as Basal/bolus therapy (B/B) in four-five injections per day . as Modern Premixed Insulins( MPI's) three times per day .
- Trial name
- NCT01627509
- Where
- 2 sites in Israel
- Volunteers
- 40 people
- Sponsor
- Sheba Medical Center
Diabetes
Comparison of Insulin Glargine and NPH Insulin at Night and at Hypoglycemia in Type 2 Diabetes
Long-acting insulin injected at bedtime may cause hypoglycemia (low blood sugar) in the night in patients with diabetes. The aims of the study are 1) to compare the dynamic characteristics of long-acting insulin analog glargine…
- Trial name
- ClampHOE901 (NCT00468364)
- Testing
- insulin glargine, NPH insulin
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- University of Giessen
Nocturnal Hypoglycemia, Type 1 Diabetes
Prevalence of Nocturnal Hypoglycemia in Children on a Type 1 Diabetes (TID) Insulin Regimen Using a Continuous Glucose Monitoring System (CGMS)
This study will help determine the frequency and magnitude of nocturnal hypoglycemia (low blood sugar at night during sleep), in children with type 1 diabetes who are on a standard insulin regimen, by using a Continuous Glucose…
- Trial name
- NCT00542334
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Children's Hospital of Eastern Ontario
Neonatal Hypoglycemia, Gestational Diabetes Mellitus (GDM)
COntinuous Glucose Monitoring in nEwborns of Mothers With Insulin-Treated Gestational Diabetes Mellitus
The purpose of this study is to determine whether continuous glucose monitoring (CGM) improves the detection and management of neonatal hypoglycaemia in newborns of mothers with insulin-treated gestational diabetes.
- Trial name
- COMET-GDM (NCT07462793)
- Testing
- Dexcom ONE Continuous Glucose Monitoring System
- Where
- Poland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Institute of Mother and Child, Warsaw, Poland
Type 1 Diabetes, Continuous Glucose Monitoring
Effect of Different Plasma Insulin Levels on the Accuracy of Continuous Subcutaneous Glucose Monitoring
Achieving near-normoglycaemia has been established as the main objective for most patients with diabetes. However, it is well known that intensification of treatment is associated with an increase in the frequency of…
- Conditions
- Type 1 Diabetes, Continuous Glucose Monitoring, Hypoglycemia
- Trial name
- NCT01714895
- Testing
- High insulin eu-hypoglycemic clamp, Low insulin eu-hypoglycemic clamp
- Where
- Spain
- Volunteers
- 14 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Type 1 Diabetes (T1D), Pregnancy
Automated Insulin for Management of Intrapartum Glycemia
The goal of this clinical trial is learn if automated insulin delivery (AID) systems can be used for glucose management during labor/delivery for pregnant people with type 1 diabetes (T1D).
- Conditions
- Type 1 Diabetes (T1D), Pregnancy, Pre-Gestational Diabetes
- Trial name
- AIMING (NCT06883344)
- Testing
- Automated insulin delivery (AID) system, Intravenous (IV) insulin
- Where
- 3 sites in United States
- Volunteers
- 150 people
- Sponsor
- University of California, San Francisco
Type 1 Diabetes Mellitus, Hypoglycemia
Exercise Physiology Study
People with type 1 diabetes often find exercise very difficult to manage, because of the high risk for low blood glucose levels.
- Trial name
- NCT03090451
- Testing
- Aerobic Exercise
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Oregon Health and Science University
Type 1 Diabetes Mellitus
Combined Basal-bolus Insulin and Post-exercise Carbohydrate Feeding Strategy in T1DM
The investigators hypothesise that reducing basal insulin dose (Glargine, Lantus, Sanofi-Aventis, or Detemir, Levemir, Novo Nordisk), whilst employing current carbohydrate feeding and rapid-acting insulin dose recommendations…
- Trial name
- NCT02204839
- Testing
- Basal insulin dose
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Northumbria University
Hyperglycemia, Critically Ill Patients
Impact of 2 Blood Glucose Levels on Hospital Mortality in Patients Admitted in ICU
During hospitalization in the intensive care unit (ICU), the occurrence of a blood glucose imbalance is frequent and associated with increased mortality.
- Trial name
- INSUREA (NCT00591071)
- Testing
- Strict glycemic control, Conventional glycemic control
- Where
- 2 sites in France
- Volunteers
- 440 people
- Sponsor
- Poissy-Saint Germain Hospital
Diabetes
Point-of-Care Glucose Testing and Insulin Supplementation
Capillary point-of-care (POC) testing is advocated as a valuable aid in the management of diabetes and hyperglycemia in the hospital setting.
- Trial name
- POC (NCT01702311)
- Testing
- Bedtime insulin Aspart (Novolog)
- Where
- 2 sites in United States
- Volunteers
- 235 people
- Sponsor
- Emory University
Diabetes, Diabetes Mellitus, Type 1
A Survey on Hypoglycaemia Among Insulin-treated Patients With Diabetes
This survey is conducted in South America. The aim of this survey is to investigate hypoglycaemia among Insulin-treated patients with diabetes.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT02230631
- Testing
- No treatment given
- Where
- Brazil
- Volunteers
- 704 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes
Insulin Analogues and Severe Hypoglycaemia
Severe hypoglycaemia is hampering the lives of many diabetic patients. The effect on the occurrence of severe hypoglycaemia during two different insulin regimens are to be investigated.
- Trial name
- NCT00346996
- Testing
- insulin levemir / aspart, human insulin /insulin isophane
- Where
- Denmark
- Volunteers
- 179 people
- Sponsor
- Lise Tarnow
Type 1 Diabetes
Continuous Glucose Monitoring and Hypoglycemia Unawareness in Type 1 Diabetes
Looking for strict normoglycemia in type 1 diabetes increases the risk of hypoglycemia, exposing to hypoglycemia unawareness. It has been shown that the early correction of hypoglycemia can help recovering the perception of…
- Trial name
- NCT03605979
- Where
- France
- Volunteers
- 11 people
- Sponsor
- CHU de Reims
Blood Glucose, Low, Hypoglycemia
EFFECTS OF MOXIFLOXACIN AND GEMIFLOXACIN ON BLOOD GLUCOSE AND ECG MORPHOLOGY OF EUGLYCEMICS:A CLINICAL STUDY
EFFECTS OF MOXIFLOXACIN AND GEMIFLOXACIN ON BLOOD GLUCOSE LEVEL OF EUGLYCEMICS:A PRE-CLINICAL AND CLINICAL STUDY. Our aim and objectives are to: 1.
- Trial name
- CT (NCT04692623)
- Testing
- Moxifloxacin 400mg, Gemifloxacin 320 MG
- Where
- Pakistan
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Shaheed Benazir Bhutto University Sheringal Dir Upper