Clinical trials: Inflammatory Response After Surgery
Aortic Stenosis
The Effects of High Spinal Anesthesia on Heart Function, Stress Response and Pain Control in Aortic Valve Surgery
This study is looking at the effects of high spinal anesthesia (also known as total spinal anesthesia) combined with general anesthesia versus general anesthesia alone on the following: Stress response: Patients undergoing aortic…
- Trial name
- NCT00348920
- Testing
- High Spinal and General Anesthesia
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- University of Manitoba
The Effect of BIS Closed-loop Target Control on Postoperative Operation
Effects of BIS Closed Loop Target Controlled Infusion on Perioperative Inflammatory Response and Prognosis of Elderly Patients Undergoing Laparoscopic Radical Gastrectomy for Gastric Cancer
The purpose of this study is to find the elderly patients with laparoscopic gastric cancer radical is suitable the BIS closed round target control level of anesthesia depth of sedation, can decrease the elderly laparoscopic…
- Trial name
- NCT05173909
- Testing
- BIS closed-loop target controlled infusion
- Where
- China
- Volunteers
- 73 people
- Sponsor
- Zhonghua Chen,MD
Delivery, Cesarean Delivery
Comparison of Inflammatory Responses Subsequent to Different Cesarean Section Techniques
In this study, the investigators aimed to find out whether there are any differences in inflammatory reactions occured subsequent to two different cesarean delivery techniques; modified Misgav-Ladach vs Pfannenstiel-Kerr…
- Conditions
- Delivery, Cesarean Delivery, Inflammation
- Trial name
- C/S (NCT02976311)
- Testing
- cesarean section(C/S) via the modified Misgav-Ladach technique, cesarean section via the Pfannenstiel-Kerr technique
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Kayseri Education and Research Hospital
Locally Advanced Rectal Cancer, Abdominoperineal Resection
Inflammation After Laparoscopic Robot-assisted Surgery for Locally Advanced Rectal Cancer
The intention of the study is to explore metabolic and inflammatory parameters in the pelvis and systemically after abdominoperineal resection (APR) for locally advanced rectal cancer (LARC) in patients that have received…
- Trial name
- APR-IMM (NCT04324567)
- Where
- Norway
- Volunteers
- 55 people
- Sponsor
- Oslo University Hospital
Video-Assisted Thoracic Surgery
Hemodynamic and Inflammatory Responses in Thoracic Surgery
Video-assisted thoracoscopic surgery (VATS) for thoracic surgery is practical, has been shown to reduce postoperative discomfort, and has improved cosmetic results when compare to open thoracotomy.
- Trial name
- NCT02647775
- Testing
- multi-port VATS, single-port VATS
- Where
- Taiwan
- Volunteers
- 63 people
- Sponsor
- Chang Gung Memorial Hospital
Systemic Inflammatory Response Syndrome
INFLACOR - Clinical and Genetic Predictors of Inflammation Related Complications After Heart Surgery
The aim of the study is to evaluate a clinically and economically most effective diagnostic algorithm for prediction of inflammatory response related complications in patients undergoing heart surgery with use of cardiopulmonary…
- Trial name
- INFLACOR (NCT01020409)
- Testing
- cardiac surgery with CPB use
- Where
- Poland
- Volunteers
- 525 people, healthy volunteers welcome
- Sponsor
- Medical University of Gdansk
Bariatric Surgery Candidate
Effects of Alveolar Recruitment Strategies on Arterial Oxygenation and Postoperative Inflammatory Response During Laparoscopic Bariatric Surgery: A Randomised Control Trial.
even though the advancement of ambulatory bariatric surgeries, yet the precise spot of recruitment manoeuvres as a secure and efficient approach to enhance the respiratory efficacy of obese patients is still obscured.
- Trial name
- NCT05960071
- Testing
- protective lung strategy with recruitment manoeuvre (RM) - steady PEEP, protective lung strategy with recruitment manoeuvre (RM) - decreasing PEEP
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Alexandria University
Sepsis, Primary Myopathies
Muscle Force Assessment in the Intensive Care Unit and in Primary Myopathies
The primary aim of the project is to apply the non-invasive stimulated muscle force assessment system to i) intensive care unit patients and ii) patients with primary myopathy or subclinic myopathy (e.g., Duchenne muscular…
- Trial name
- NCT00735384
- Where
- Switzerland
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Myocardial Ischemia, Inflammatory Response
Remote Ischemic Preconditioning and Postoperative Myocardial Ischemia
High-risk abdominal surgery is frequently complicated by postoperative complications, such as sepsis, pneumonia or anastomotic dehiscence.
- Trial name
- MICOLON2 (NCT03460938)
- Testing
- Remote ischemic preconditioning
- Where
- Netherlands
- Volunteers
- 90 people
- Sponsor
- St. Antonius Hospital
Healthcare Associated Infectious Disease, Sternal Superficial Wound Infection
Optimizing Prevention of Healthcare-Acquired Infections After Cardiac Surgery
Our Aim is to identify patient risk factors and clinical practices associated with healthcare-acquired infections (HAIs) after cardiac surgery.
- Conditions
- Healthcare Associated Infectious Disease, Sternal Superficial Wound Infection, Sepsis, Pneumonia
- Trial name
- HAI (NCT02068716)
- Where
- United States
- Volunteers
- 911,754 people
- Sponsor
- Dr. Donald Likosky
Laparotomy, Laparotomy Surgery
Saudi Emergency Laparotomy Audit
The Saudi Emergency Laparotomy Audit (SELA) is a national, multicenter observational clinical audit designed to evaluate outcomes and quality of care for patients undergoing emergency laparotomy in Saudi Arabia.
- Conditions
- Laparotomy, Laparotomy Surgery, Emergency Treatment, Abdominal Diseases
- Trial name
- SELA (NCT07429929)
- Testing
- Emergency Laparotomy
- Where
- Saudi Arabia
- Volunteers
- 10,000 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Cardiac Arrest, Extracorporeal Circulation
Cytokine Adsorption in Post-cardiac Arrest Syndrome in Patients Requiring Extracorporeal Cardiopulmonary Resuscitation
Almost all patients with refractory cardiac arrest, who are primarily stabilized under ongoing cardiopulmonary resuscitation by transcutaneous implantation of a venoarterial extracorporeal membrane oxygenation system (va-ECMO for…
- Conditions
- Cardiac Arrest, Extracorporeal Circulation, Extracorporeal Membrane Oxygenation, Cytokine Storm
- Trial name
- CYTER (NCT03685383)
- Testing
- Cytosorb removal column in eCPR, standard eCPR (va-ECMO)
- Where
- Germany
- Volunteers
- 41 people
- Sponsor
- University Hospital Freiburg
Postoperative Cognitive Dysfunction
Cognitive Dysfunction Following Cardiac Surgery
Postoperative cognitive dysfunction (POCD) is the most common complication after cardiac surgery. This prospective study was conducted to investigate the mechanisms of development of POCD following cardiac surgery taking into…
- Trial name
- CDCS (NCT02767713)
- Testing
- Dexamethasone
- Volunteers
- 171 people
- Sponsor
- Clinical Hospital Center, Split
Systemic Inflammatory Response Syndrome
Immunophenotyping of Patients With Postoperative SIRS
The purpose of this study is to develop an immune-phenotype based prediction of postoperative SIRS in patients undergoing open heart surgery.
- Trial name
- NCT02957175
- Testing
- Immunophenotyping
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Bonn
Obesity
Mechanisms Underlying Postoperative Insulin Resistance and Inflammation
Having an operation places an enormous burden on the body, leading to the development of inflammation and so called 'insulin resistance'.
- Trial name
- NCT01470534
- Testing
- carbohydrate drink, Muscle biopsy, Blood sampling
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- University of Nottingham
Adductor Canal Block, Total Knee Replacement Surgery
Coupling of IPACK Block With Adductor Canal Block Versus Adductor Canal Block Alone on Pain, Functional Recovery and Inflammatory Response After Knee Replacement
The aim of this study is to compare the Competency of coupling of IPACK Block with Adductor Canal Block versus Adductor Canal Block Alone on Postoperative Pain after total knee replacement as well as Functional Recovery and…
- Conditions
- Adductor Canal Block, Total Knee Replacement Surgery, Functional Recovery
- Trial name
- NCT07096375
- Testing
- Adductor Canal Block (ACB) + iPACK Block
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Colorectal Cancer
Preoperative Nutritional Status and Postoperative Outcomes in Colorectal Cancer
The aim of this study was to evaluate the effect of preoperative nutritional status, dietary inflammatory index, and systemic inflammatory response on postoperative outcomes.
- Trial name
- NCT06016829
- Testing
- Nutrition Risk Screening 2002 (NRS-2002), Global Leadership Initiative on Malnutrition (GLIM), Measurement of body composition with computed tomography (CT)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 121 people
- Sponsor
- Hacettepe University
Wounds and Injuries
Effect of Leukoreduced Blood Transfusions on Infection Following Trauma
The purpose of this study is to determine if leukoreduced blood transfusions reduce the risk of infection following trauma. Specifically, the investigators intend to evaluate whether there are clinically relevant differences in…
- Trial name
- NCT00135291
- Testing
- Leukoreduced blood transfusion
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Washington
Postoperative Pain, Inflammatory Response
Bilateral Ultrasound Guided Quadratus Lumborum Versus Lumbar Epidural Block on Postoperative Analgesia, and Inflammatory Response in Abdominal Surgery
This study aims at comparing the effects of bilateral ultrasound-guided quadratus lumborum block versus lumbar epidural block on postoperative analgesia and inflammatory response following major lower abdominal cancer surgery.
- Trial name
- NCT03958942
- Testing
- Ultrasound quadratus lumborum block with bupivacaine 25%, lumbar epideural block with bupivacaine 25%
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Heart Diseases
Database of Tissue Samples to Understand the Inflammatory Response After Cardiac Surgery
The aim of this study is to collect non-individual related blood samples for the compelling of a unique database of tissue samples to understand the inflammatory responds after cardiac surgery on an on-going basis.
- Trial name
- NCT02488876
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- RWTH Aachen University