Clinical trials: Inflammatory Response
Crohn Disease
An Open-Label Extension and Long-term Efficacy and Safety Monitoring Study of Patients With Crohn's Disease Previously Included in the Loss of RESponse to Ustekinumab Treated by Dose Escalation Study
The aim of the study is to assess the long-term efficacy and safety of a ustekinumab 90mg subcutaneous (SC) every 4 weeks (Q4w) regimen in patients with Crohn's disease previously enrolled in the REScUE study (NCT04245215)…
- Trial name
- REScUE-OLE (NCT05299931)
- Testing
- Ustekinumab
- Where
- Belgium
- Volunteers
- 41 people
- Sponsor
- Belgian Inflammatory Bowel Disease Research and Development (BIRD) VZW
Invasive Candidiasis, Candidemia
Risk Of Severe Hepatic Injury In Patients With Invasive Candidiasis Treated With Echinocandins
The purpose of this study is to estimate the relative risk of severe hepatic injury in hospitalized patients with invasive candidiasis and candidemia who received anidulafungin, compared to patients who received caspofungin…
- Trial name
- NCT01213823
- Testing
- Does not apply
- Volunteers
- 536 people, healthy volunteers welcome
- Sponsor
- Pfizer
Pain, Hyperalgesia
Evaluation of the Effect of Ketamine on Remifentanil-induced Hyperalgesia
The aim of this study was to determine if the addition of ketamine reduces remifentanil-induced hyperalgesia, improves its analgesic effect, inhibits IL(interleukin)-6 and IL-8 (inflammatory cytokines), and stimulates IL-10 (an…
- Conditions
- Pain, Hyperalgesia, Inflammatory Response
- Trial name
- NCT01301079
- Testing
- Ketamine, Saline
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Federal University of São Paulo
Septic Shock, Sepsis
Discordance Between Capillary Refill Time and Oxygen Extraction Ratio in Septic Shock
In septic shock, restoring large-vessel (macrocirculatory) perfusion-reflected by a normal capillary refill time (CRT)-does not always mean that oxygen use at the tissue level has recovered.
- Trial name
- DISCO-SHOCK (NCT07774962)
- Testing
- Capillary refill time (CRT), Oxygen extraction ratio (O₂ER) assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Istanbul University - Cerrahpasa
Septic Shock
Vasopressin for Septic Shock Pragmatic Trial
Life-threatening low blood pressure due to a serious infection is called "septic shock." Septic shock is treated with vasopressors, medications that raise blood pressure.
- Trial name
- VASSPR (NCT06217562)
- Testing
- Vasopressin, Recommendation to use a lower initiation threshold for vasopressin, Recommendation to use a higher initiation threshold for vasopressin
- Where
- 13 sites in United States
- Volunteers
- 3,959 people
- Sponsor
- Intermountain Health Care, Inc.
Septic Shock
Metabolic Cluster Analysis in Septic Shock Patients
Observational study including septic shock patients within 24 hours of ICU admission, monitored with a cardiac output estimation system, with ongoing resuscitation.
- Trial name
- ACMEcat (NCT06500156)
- Testing
- Fluid challenge
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Corporacion Parc Tauli
Acute Lung Injury, Acute Respiratory Distress Syndrome
Influence of Acute Respiratory Distress Syndrome (ARDS) and Severe Sepsis on sRAGE Levels in ICU Patients
sRAGE, the soluble form of the receptor for advanced glycation end products, is a novel marker of alveolar epithelial type I cell injury, but is also involved in acute systemic inflammation.
- Conditions
- Acute Lung Injury, Acute Respiratory Distress Syndrome, Severe Sepsis, Septic Shock
- Trial name
- NCT00811629
- Testing
- sRAGE
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Clermont-Ferrand
Sepsis
Quantification of Dilutional Anemia in the Initial Phase of Sepsis Management: Preliminary Retrospective Study
This is a single-center retrospective study conducted at Mercy hospital, aiming to investigate the correlation between changes in hemoglobin (Hb) levels and the volume of vascular refill administered during the first 48 hours.
- Trial name
- QUADS (NCT06242561)
- Testing
- Data collection from sepsis management
- Where
- France
- Volunteers
- 208 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Polyneuropathies
The Impact of IVIG Treatment on Critical Illness Polyneuropathy and/or Myopathy in Patients With MOF and SIRS/Sepsis
Critical illness polyneuropathy and/or myopathy (CIPNM) is a severe complication of critical illness. Retrospective data suggest that early application of IgM-enriched intravenous immunoglobulin (IVIG) may prevent or mitigate…
- Trial name
- CIPNM (NCT01867645)
- Testing
- IgM-enriched Intravenous Immunoglobulins, Human Albumin
- Where
- Austria
- Volunteers
- 38 people
- Sponsor
- Medical University of Vienna
Thoracic Diseases, Surgery
Comparative Analysis of the Lung Inflammatory Response After Thoracic Surgery With Single or Double Lung Ventilation: a Randomized, Pilot, Trial
The goal of this clinical trial is to compare in patients undergoing thoracic procedures the lung inflammatory response in on one-lung ventilation and two-lung ventilation strategies The main question to answer is: Lung…
- Trial name
- NCT05982639
- Testing
- two lung ventilation, one lung ventilation
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Universidade do Extremo Sul Catarinense - Unidade Academica de Ciecias da Saude
Shock, Septic
Vasopressin Hemodynamic Response as a Septic Shock Subphenotype Indicator
The goal of this observational study is to learn about blood pressure response to the vasopressor drug vasopressin in people with septic shock.
- Trial name
- NCT06426407
- Testing
- Vasopressin
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- The Cleveland Clinic
Covid19, Cytokine Storm
Intramuscular Effect of Polymerized Type I Collagen on the Cytokine Storm in COVID-19 Patients
SARS-CoV-2 infection induces a hyperinflammatory syndrome, causing the acute respiratory distress syndrome, massive lung cell destruction and, as a plausible sequelae, pulmonary fibrosis in COVID-19 patients.
- Conditions
- Covid19, Cytokine Storm, Regulation of Inflammatory Response, Pulmonary Fibrosis
- Trial name
- NCT04517162
- Testing
- Collagen-Polyvinylpyrrolidone
- Where
- Mexico
- Volunteers
- 90 people
- Sponsor
- Janette Furuzawa Carballeda
Seasonal Allergic Rhinitis
Evaluation of Nasal Inflammatory Biomarkers
This research aims to establish a panel of inflammatory biomarkers of the early (Histamine, Tryptase, ProstaglandineD2) and late (Interleukin-4, Interleukin-5, Interleukin-6, Interleukin-13, Eotaxin, Tumor necrosis factor-a…
- Trial name
- NCT03450031
- Testing
- NAC (no drug/no device)
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- Fraunhofer-Institute of Toxicology and Experimental Medicine
Severe Sepsis, Septic Shock
Clinical Trial of the Optimal Endpoint of Early Sepsis Resuscitation
The purpose of this study is to determine if there is equivalence between two different methods of treating patients with severe bloodstream infection called sepsis.
- Trial name
- LactATES (NCT00372502)
- Testing
- Modified EGDT, Standard EGDT
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- National Institute of General Medical Sciences (NIGMS)
Pediatric Cardiac Surgery, Complication of Extracorporeal Circulation
A Pilot Study Comparing Anti-Inflammatory Effects Of TXA Versus EACA In Pediatric Congenital Heart Surgery
The purpose of this study is to compare anti-inflammatory effects of two anti-fibrinolytic drugs (Tranexamic acid versus Epsilon-aminocaproic acid) in pediatric patients undergoing pediatric cardiac surgery.
- Trial name
- TXAEACA (NCT02656472)
- Testing
- Tranexamic acid, Epsilon Aminocaproic Acid
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Wake Forest University Health Sciences
Septic Shock, Polymyxin B Hemoperfusion
Safety and Efficacy of Heparin Dosing Score Protocol for Polymyxin-B Hemoperfusion
Polymyxin B hemoperfusion (PMX-HP) is mainly used to remove endotoxins in septic shock patients with intra-abdominal infections.
- Trial name
- NCT03177330
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Fluid and Electrolyte Imbalance
Volume Kinetics of Fluid Resuscitation in Early Sepsis
The recommended volume resuscitation for patients with early sepsis-induced hypoperfusion is at least 30 ml/kg of crystalloid administered within the first three hours.
- Trial name
- NCT06499701
- Testing
- Ringer's Lactate
- Where
- 2 sites in Romania
- Volunteers
- 13 people
- Sponsor
- Institutul de Urgenţă pentru Boli Cardiovasculare Prof.Dr. C.C. Iliescu
Septic Shock
Effects of Dobutamine on Microcirculation, Regional and Peripheral Perfusion in Septic Shock Patients
The investigators hypothesize that dobutamine is able to revert negative redistribution of flow by inducing a selective vasodilatory effect on hypoperfused territories, particularly at the sublingual and gastric mucosa, and at…
- Trial name
- NCT01271153
- Testing
- Dobutamine
- Where
- Chile
- Volunteers
- 20 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Cardiogenic Shock, Septic Shock
Levosimendan Versus Dobutamine in Shock Patients
The purpose of the study is to compare the efficacy of levosimendan with that of dobutamine in patients with unstable hemodynamics (shock).
- Trial name
- NCT00093301
- Testing
- Levosimendan, Dobutamine
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- Wentworth Area Health Services
Early Onset Neonatal Sepsis
Management of Early Onset Neonatal Septicaemia: Selection of Optimal Antibacterial Regimen for Empiric Treatment
A prospective two-center antibiotic regimen switch study will be conducted to compare the clinical efficacy of two antibiotic regimens - penicillin/gentamicin versus ampicillin/gentamicin - in the empirical treatment of early…
- Trial name
- NCT00487019
- Where
- 2 sites in Estonia
- Volunteers
- 281 people
- Sponsor
- University of Tartu