Clinical trials: Inflammatory Bowel System
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Ulcerative Colitis, Ulcerative Colitis Chronic
A Study of Eltrekibart and Mirikizumab in Adult Patients With Moderately to Severely Active Ulcerative Colitis
The main purpose of this study is to determine the safety and efficacy of eltrekibart and mirikizumab in adult participants with moderately to severely active ulcerative colitis (UC).
- Trial name
- NCT06598943
- Testing
- Eltrekibart, Mirikizumab
- Where
- 207 sites in United States, Argentina and 19 more
- Volunteers
- 143 people
- Sponsor
- Eli Lilly and Company
Inflammatory Bowel Disease, Colitis, Ulcerative
A Study to Generate Real-world Evidence of Guselkumab Effectiveness in Inflammatory Bowel Disease in Germany
The purpose of this study is to characterize participants with Crohn's Disease (CD) and Ulcerative Colitis (UC) treated with Guselkumab in a real-world setting, and to assess the clinical effectiveness (how well the treatment…
- Conditions
- Inflammatory Bowel Disease, Colitis, Ulcerative, Crohn's Disease
- Trial name
- GORGEOUS (NCT07102368)
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- Janssen-Cilag G.m.b.H
Crohn's Disease, Ulcerative Colitis
Study of the Role of Pomegranate Juice Ellagitannins in the Modulation of Inflammation in Inflammatory Bowel Disease
The aim of this research is to study the effects of a pomegranate juice on calprotectin levels in patients suffering of inflammatory bowel disease (IBD) in clinical remission.
- Trial name
- POME2016 (NCT03000101)
- Testing
- 100% pomegranate juice
- Where
- Italy
- Volunteers
- 18 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Gastro-Intestinal Disorder, Crohn Disease
NAZA - Nottingham/Astra ZenecA Prospective IBD Cohort Study
The goal of this observational study is to learn about the comparisons of inflammatory markers between IBD and non-IBD (control) participants.
- Conditions
- Gastro-Intestinal Disorder, Crohn Disease, Ulcerative Colitis, Inflammatory Bowel Diseases
- Trial name
- NAZA (NCT06956703)
- Where
- United Kingdom
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Digestive System Diseases, Inflammatory Bowel Disease, Ulcerative Colitis Type
Intestinal Organoids
Over the last decade, the use of mini-organ or organoids has been increasingly developed in fundamental research. Indeed, digestive organoids represent an essential advance compared to classical culture systems (epithelial cell…
- Conditions
- Digestive System Diseases, Inflammatory Bowel Disease, Ulcerative Colitis Type, Crohn Disease
- Trial name
- BIOÏDES (NCT05294107)
- Testing
- additional biopsies
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Rennes University Hospital
Inflammatory Bowel Disease (IBD), Irritable Bowel Syndrome (IBS)
Enabling Microbiomics- Driven Personalized Nutrition
The goal of this observational research study is to determine how diet contributes to various gastrointestinal related conditions.
- Conditions
- Inflammatory Bowel Disease (IBD), Irritable Bowel Syndrome (IBS), Celiac Disease, Diarrhea
- Trial name
- EMPOWER (NCT06657001)
- Where
- United States
- Volunteers
- 4,001 people
- Sponsor
- Mayo Clinic
Inflammatory Bowel Diseases, Crohn's Disease
A 5-year Longitudinal Observational Study of Patients Undergoing Therapy for Inflammatory Bowel Disease
TARGET-IBD is a 5-year, longitudinal, observational study of adult and pediatric patients (age 2 and above) being managed for Inflammatory Bowel Disease (IBD) in usual clinical practice.
- Conditions
- Inflammatory Bowel Diseases, Crohn's Disease, Ulcerative Colitis, Indeterminate Colitis
- Trial name
- TARGET-IBD (NCT03251118)
- Where
- 37 sites in United States
- Volunteers
- 15,000 people
- Sponsor
- Target PharmaSolutions, Inc.
Post-Acute COVID-19 Syndrome, ME/CFS
Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related…
- Conditions
- Post-Acute COVID-19 Syndrome, ME/CFS, Rheumatic Arthritis, Juvenile Rheumatoid Arthritis (JRA)
- Trial name
- NCT04806620
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Brain Inflammation Collaborative
Inflammatory Disorder of Immune System, Spondylitis, Ankylosing
Effects of Phytocannabinoids on Immune Response and Autophagy During Chronic Immune-mediated Inflammatory Diseases
Cannabis, in addition to its psychotropic properties, could have anti-inflammatory and immunomodulatory effects. Phytocannabinoids (pCBs) are a group of molecules naturally secreted by the cannabis plant.
- Conditions
- Inflammatory Disorder of Immune System, Spondylitis, Ankylosing, Arthritis, Rheumatoid, Arthritis, Psoriatic
- Trial name
- pCB-IMIDs (NCT06842316)
- Testing
- 1 blood sample, 40 mL (collection during a blood test, part of the standard of care for this disease)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Primary Sclerosing Cholangitis, Liver and Intrahepatic Bile Duct Disorder
Vancomycin in Primary Sclerosing Cholangitis in Italy
Primary sclerosing cholangitis (PSC) is chronic fibroinflammatory disease of the liver. There is still no medical therapy proven to halt the progression of PSC or prevent its serious complications.
- Conditions
- Primary Sclerosing Cholangitis, Liver and Intrahepatic Bile Duct Disorder, IBD
- Trial name
- VanC-IT (NCT05876182)
- Testing
- Oral Vancomycin
- Where
- Italy
- Volunteers
- 84 people
- Sponsor
- University of Milano Bicocca
Crohn Disease
EXL01 in the Maintenance of Steroid-induced Clinical Response/Remission in Participants With Mild to Moderate Crohn's Disease
A Phase 1, 2-part, multicentre study to evaluate the safety and preliminary efficacy of the oral administration of EXL01 in the maintenance of corticosteroid-induced clinical response/remission in participants with mild to…
- Trial name
- MAINTAIN (NCT05542355)
- Testing
- EXL01, SoC corticosteroid - Induction Period, SoC corticosteroid - Tapering
- Where
- 5 sites in Belgium, Poland
- Volunteers
- 8 people
- Sponsor
- Exeliom Biosciences
Ulcerative Colitis, Digestive System Diseases
Study of a Monoclonal Antibody KHK4083 in Moderate Ulcerative Colitis
The purpose of this study is to determine the safety and tolerability of administration of multiple ascending doses of KHK4083 and to select the highest dose tolerated by subjects with moderately active Ulcerative Colitis (UC)…
- Conditions
- Ulcerative Colitis, Digestive System Diseases, Colitis, Ulcerative, Colitis
- Trial name
- NCT02647866
- Testing
- KHK4083
- Where
- 23 sites in United States, Czechia and 5 more
- Volunteers
- 66 people
- Sponsor
- Kyowa Kirin, Inc.
Ulcerative Colitis
A Study Evaluating the Effects of GLPG3970 Given as an Oral Treatment for 6 Weeks in Adults With Ulcerative Colitis
The primary objective of this study was to evaluate the effect of GLPG3970 compared to placebo on the signs and symptoms of Ulcerative Colitis (UC) in participants with moderately to severely active UC.
- Trial name
- SEA TURTLE (NCT04577794)
- Testing
- GLPG3970
- Where
- 15 sites in Georgia, Moldova and 2 more
- Volunteers
- 31 people
- Sponsor
- Lakefront Biotherapeutics NV
Inflammatory Bowel Diseases, Sarcopenia
Phenotyping of Adult Crohn's Focusing on Sarcopenia
Inflammatory bowel disease (IBD) includes two idiopathic chronic relapsing and remitting inflammatory conditions affecting the gastrointestinal (GI) tract: Crohn's disease (CD) and ulcerative colitis (UC)Malnutrition and…
- Conditions
- Inflammatory Bowel Diseases, Sarcopenia, Digestive System Disease, Nutrition, Healthy
- Trial name
- PACS (NCT05572203)
- Testing
- Intrinsically labelled protein
- Where
- United Kingdom
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Digestive System Disease, Inflammatory Bowel Diseases
Comparative Study of Intestinal Color Ultrasound and Capsule Endoscopy in Monitoring Crohn's Disease
The disease activity index under intestinal color ultrasound was evaluated by SUS-CD, and the disease activity index under capsule endoscopy was evaluated by CECDAI.
- Conditions
- Digestive System Disease, Inflammatory Bowel Diseases, Crohn Disease, Crohn Disease of Small Intestine
- Trial name
- NCT05636657
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Digestive System Disease, Inflammatory Bowel Diseases
Optoacoustic Characterization of Postprandial Intestinal Blood Flow
Inflammatory activities in the gastrointestinal tract are accompanied by an increase in blood flow in the intestinal wall layers of the respective organs.
- Trial name
- NEPOMUC (NCT05160077)
- Testing
- Multispectral optoacoustic tomography (MSOT)
- Where
- Germany
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Inflammatory Bowel Diseases, Crohn Disease
Real Life Remote Monitoring of Mild, Moderate and Severe Infectious Complications in IBD by Patient Reported Assessment
Inflammatory bowel disease (IBD) is a chronic relapsing immune mediated inflammatory disease (IMID) of the gastrointestinal tract. Like all IMIDs (e.g.
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis, IBD
- Trial name
- NCT04151420
- Testing
- Remote monitoring tool (infections questionnaire) validation
- Where
- 2 sites in Netherlands
- Volunteers
- 584 people
- Sponsor
- Maastricht University Medical Center
Transition, Diabetes
Healthcare Transition of Adolescents With Chronic Health Conditions
At least 12% of children have a chronic disease that requires regular medical follow-up after patients reach legal maturity. This international study aims to provide prospective evidence for improving health and wellbeing…
- Conditions
- Transition, Diabetes, Kidney Diseases, Liver Diseases
- Trial name
- NCT04631965
- Testing
- Transition support service
- Where
- 2 sites in Australia, Finland
- Volunteers
- 503 people
- Sponsor
- University of Helsinki
Crohn Disease
Biologics and Partial Enteral Nutrition Study
Crohn's disease (CD) is a chronic, incurable condition associated with inflammation in the gut lining. It causes diarrhoea, severe abdominal pain, poor nutrition and adversely affects the quality of life of sufferers.
- Trial name
- BIOPIC (NCT04859088)
- Testing
- Partial Enteral Nutrition
- Where
- 4 sites in United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- NHS Greater Glasgow and Clyde