Clinical trials: Inflammation Plaque, Atherosclerotic
Inflammation, Atheromatous Plaques
Multimodal Imaging Assessment of the Inflammatory Atheromatous Plaque
The present study aims at assessing the ability of 68Ga-NODAGA-RGD PET/CT for the detection of inflammatory atheromatous plaques in the carotid arteries, compared to 18F-FDG PET/CT, MRI and US and to determine the contribution of…
- Conditions
- Inflammation, Atheromatous Plaques, Carotid Artery Diseases
- Trial name
- NCT01608516
- Testing
- 68Ga-NODAGA-RGD PET/CT
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Lausanne Hospitals
Inflammation, Community Acquired Pneumonia (CAP)
Targeting Vascular INflammation in Patients With Community-Acquired Pneumonia
The goal of this clinical trial is to learn if icosapent ethyl (Vascepa) works to lessen the amount of inflammation in adults diagnosed with Community-Acquired Pneumonia (CAP).
- Conditions
- Inflammation, Community Acquired Pneumonia (CAP), Inflammation Plaque, Atherosclerotic
- Trial name
- TIN-CAP (NCT06710080)
- Testing
- Icosapent Ethyl 1000 MG Oral Capsule [Vascepa]
- Where
- Canada
- Volunteers
- 168 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Atherosclerosis, Coronary, Diabetes Mellitus
Fat Around Heart Arteries as a Measure of Inflammation in Patients With Diabetes
In this prospective study, the objective is to investigate inflammation in the arteries of the heart. A heart CT scan (CCTA) will be used to measure inflammation by assessing the fat tissue surrounding the arteries of the heart.
- Conditions
- Atherosclerosis, Coronary, Diabetes Mellitus, Diabetes Mellitus Type 2, Inflammation
- Trial name
- PCAT-DM (NCT06644651)
- Where
- Denmark
- Volunteers
- 314 people
- Sponsor
- Odense University Hospital
Calcific Coronary Arteriosclerosis, Coronary Stenosis
Whole Blood Transcriptomic Signal According to Coronary Atherosclerotic Plaque Burden Assessed by CT Angiography
The present clinical study aims to identify transcriptomic patterns derived from whole blood samples related to coronary atherotic burden.
- Conditions
- Calcific Coronary Arteriosclerosis, Coronary Stenosis, Coronary Plaque, Aortic Calcification
- Trial name
- CORPLAQ-TRAIT (NCT06194526)
- Where
- 2 sites in Argentina
- Volunteers
- 200 people
- Sponsor
- MultiplAI Health Limited
Coronary Stenosis, Periodontal Diseases
Periodontal Disease, Inflammation and Acute Coronary Syndromes
Recent studies have shown that the systemic inflammation caused by periodontal disease (PD) can determine important changes in the coronary arteries, favoring atherosclerosis progression and development of acute coronary…
- Conditions
- Coronary Stenosis, Periodontal Diseases, Acute Coronary Syndrome, Non-ST Elevation Myocardial Infarction
- Trial name
- ATHERODENT (NCT03395041)
- Testing
- cardiac imaging tests
- Where
- Romania
- Volunteers
- 149 people
- Sponsor
- Cardio Med Medical Center
Acute Coronary Syndrome, Carotid Atherosclerotic Plaque With Inflammation
Comparison of High-dose Rosuvastatin Versus Low-dose Rosuvastatin Plus Ezetimibe on Carotid Plaque Inflammation in Patients With Acute Coronary Syndrome
Combination therapy of ezetimibe with a low-dose statin is occasionally used to avoid statin-related side effects in clinical practice among patients with atherosclerotic cardiovascular disease.
- Trial name
- NCT04056169
- Testing
- high-dose rosuvastatin, low-dose rosuvastatin plus ezetimibe
- Where
- 2 sites in South Korea
- Volunteers
- 50 people
- Sponsor
- Yuhan Corporation
Inflammation Plaque, Atherosclerotic, Coronary Disease
Comparison of Fimasartan Versus Amlodipine Therapy on Carotid PlaquE Inflammation
The purpose of this study is to evaluate the effects of angiotensin receptor 1 blocker versus calcium channel blocker on atherosclerotic plaque inflammation using serial FDG PET/CT imaging of carotid artery.
- Conditions
- Inflammation Plaque, Atherosclerotic, Coronary Disease, Renin-Angiotensin System
- Trial name
- FACE (NCT02378064)
- Testing
- 6-month treatment
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- CHEOL WHAN LEE, M.D., Ph.D
Atherosclerosis, Atherosclerotic Plaque
Indocyanine Green Fluorescence Uptake in Human Carotid Artery Plaque
This will be a pilot study of 9 patients undergoing standard-of-care clinically indicated carotid endarterectomy. The nine patients will receive an injection of Indocyanine green (ICG) at a dose of 0.25 mg/kg (maximum 25 mg) as…
- Conditions
- Atherosclerosis, Atherosclerotic Plaque, Carotid Stenosis
- Trial name
- BRIGHT-CEA (NCT01873716)
- Testing
- Indocyanine green
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Massachusetts General Hospital
Atherosclerosis, Inflammation
Anti-inflammatory Effect of Atorvastatin in Atherosclerotic Plaques Assessed by FDG-PET Imaging
The purpose of this study is to determine whether HMG-CoA reductase inhibitor, atorvastatin attenuates inflammation in atherosclerotic plaques detected by 18F-fluorodeoxyglucose(FDG) PET.
- Trial name
- NCT00920101
- Testing
- Atorvastatin, Lifestyle counseling
- Where
- Japan
- Volunteers
- 30 people
- Sponsor
- National Defense Medical College, Japan