Clinical trials: Infertility of Uterine Origin
Infertility of Uterine Origin
Deceased Uterine Transplant in Absolute Uterine Infertility (AUIF)
Our study will explore the feasibility of initiating a deceased donor uterine transplant program in addition to the existing living donor IRB at BWH.
- Trial name
- NCT04026893
- Testing
- Uterine Transplant from Deceased Donor
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Mayer Rokitansky Kuster Hauser Syndrome, Uterine Agenesis
The University of Pennsylvania Uterus Transplant for Uterine Factor Infertility Trial
Options for childbearing are limited for the thousands of women in the United States who suffer from absolute uterine factor infertility. Uterine transplantation is an emerging treatment that provides hope for these individuals.
- Conditions
- Mayer Rokitansky Kuster Hauser Syndrome, Uterine Agenesis, Infertility, Female, of Uterine Origin, Uterine Factor Infertility
- Trial name
- UNTIL (NCT03307356)
- Testing
- Uterine Transplant
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Infertility of Uterine Origin
Platelet Rich Plasma for Insufficient Endometrium
To determine the effectiveness of an intrauterine PRP infusion on endometrial thickness and in vitro fertilization (IVF) outcomes in a population of infertile women with a history of unresponsive thin endometrium.
- Trial name
- PIER (NCT05538338)
- Testing
- Platelet Rich Plasma Intrauterine infusion, Normal saline Intrauterine infusion
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Reproductive Medicine Associates of New Jersey
Mayer Rokitansky Kuster Hauser Syndrome, Absence of Uterus
Uterine Transplant for Women With Absolute Uterine Factor Infertility (AUFI)
Absolute Uterine Factor Infertility (AUFI) is due to congenital or surgical absence of a uterus or the presence of a nonfunctional uterus.
- Conditions
- Mayer Rokitansky Kuster Hauser Syndrome, Absence of Uterus, Infertility of Uterine Origin
- Trial name
- NCT05263076
- Testing
- Uterine Transplant
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- John Goss
Infertility of Uterine Origin, Implantation Failure
International Non-selection Study for ERA® Test in Patients With Previous Implantation Failures
Women´s period comprises different hormonal stages, being one of them the stage for maximum receptivity and proper embryo implantation.
- Trial name
- NCT06097559
- Testing
- Endometrial fluid and biopsy collection
- Where
- 8 sites in Argentina, Panama and 2 more
- Volunteers
- 738 people, healthy volunteers welcome
- Sponsor
- Igenomix
Infertility, Infertility,Female
The Role of Granulocyte Colony Stimulating Factor in Embryo Transfer Outcomes
The goal of this clinical trial is to test the effect of granulocyte colony-stimulating factor (G-CSF, A.K.A. Filgrastim) in infertility patients undergoing in vitro fertilization (IVF) treatment.
- Conditions
- Infertility, Infertility,Female, Infertility; Female, Nonimplantation, Infertility Unexplained
- Trial name
- NCT06174298
- Testing
- Granulocyte Colony-Stimulating Factor (Filgrastim), Standard Embryo Transfer Media
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- Newlife Fertility Centre
Female Infertility, Female Infertility Due to Ovulatory Disorder
Comparative Study on the Efficacy of Ovarian Stimulation Protocols on the Success Rate of ICSI in Female Infertility
The study will describe the effectiveness of ovarian stimulation in correlation with female infertility causes in a Lebanese population: a comparative study using 5 protocols of ovulation induction (treatment with "A"…
- Conditions
- Female Infertility, Female Infertility Due to Ovulatory Disorder, Premature Ovarian Failure, Polycystic Ovary Syndrome
- Trial name
- CS-EOSP-ICSI (NCT04071574)
- Testing
- Human Chorionic Gonadotropin (hCG), Gonadotropins, GNRH-A Triptorelin
- Where
- Lebanon
- Volunteers
- 200 people
- Sponsor
- Lebanese University
Infertility, Female, of Uterine Origin, Endometrial Fibrosis
Clinical Study of in Situ Regeneration of Endometrium
Thin endometrium will lead to hypomenorrhea，infertility and recurrent pregnancy loss and there are few effective methods to increase the endometrial thickness and improve the fertility outcomes.
- Trial name
- NCT04233892
- Testing
- CBD-bFGF, Collagen/BMMNCs, Estrogen
- Where
- China
- Volunteers
- 345 people
- Sponsor
- Yali Hu
Infertility of Uterine Origin
Clinical Study of PGT-A Versus PGT-A+ERA
Patients who have shown previous implantation failures, despite transferring good quality and chromosomally normal embryos (diagnosed by PGT-A), could have a displaced Window of Implantation (WOI) and consequently, alterations in…
- Trial name
- PGT-A&ERA (NCT03530254)
- Testing
- PGT-A, ERA Test
- Where
- 15 sites in United States, Argentina and 10 more
- Volunteers
- 368 people
- Sponsor
- Igenomix
Infertility of Uterine Origin
Endometrial Rejuvenation Study
To evaluate the response of the endometrial lining after subcutaneous administration of the medication AMD3100. This medication mobilizes stem cells and will be used in a population of infertile women with a thin endometrium who…
- Trial name
- NCT04045821
- Testing
- AMD3100, Normal saline, dilation and curettage
- Where
- 3 sites in United States
- Volunteers
- 3 people
- Sponsor
- Reproductive Medicine Associates of New Jersey
Infertility, Female, Infertility of Uterine Origin
Progesterone Levels and Endometrial Compaction in Frozen-Thawed Embryo Transfer Cycles
This study is intended to determine whether there is a correlation between endometrial compaction and serum progesterone levels on the day of frozen embryo transfers by using transvaginal sonography for the endometrial assessment.
- Conditions
- Infertility, Female, Infertility of Uterine Origin, Implantation; Placenta
- Trial name
- NCT04554654
- Testing
- transvaginal ultrasound,
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Cem Demirel
Infertility of Uterine Origin
Development of a Microbiome Non-invasive Diagnosis Tool
Although the endometrium tissue has been traditionally considered free of bacteria, recent studies have documented the presence of an endometrial microbiome.
- Trial name
- ERA-niMIC (NCT03330444)
- Testing
- Endometrial biopsy and endometrial fluid collection
- Where
- 13 sites in United States, Argentina and 6 more
- Volunteers
- 452 people, healthy volunteers welcome
- Sponsor
- Igenomix
Infertility, Female, Infertility of Uterine Origin
Autologous Bone Marrow-derived Mesenchymal Stem Cells for Atrophic Endometrium in Patients With Repeated IVF Failures
Investigators will examine safety and efficiency of the cell product of autologous bone marrow-derived mesenchymal stem cells (MSC) for patients with repeated IVF failures and hypoplastic or/and fibrosis process of endometrium
- Conditions
- Infertility, Female, Infertility of Uterine Origin, Asherman Syndrome
- Trial name
- NCT03166189
- Testing
- bone marrow-derived MSC and HRT, hormonal replacement therapy
- Where
- Russia
- Volunteers
- 46 people
- Sponsor
- D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology
Infertility of Tubal Origin, Infertility, Female
Hysteroscopic Evaluation of Fallopian Tubal Patency
Hysteroscopy is an important tool in the evaluation of sterility. Assessing tubal patency during hysteroscopy seems highly relevant, particularly when it allows for a low cost, fast, gentle, and accurate way of gathering…
- Conditions
- Infertility of Tubal Origin, Infertility, Female, Fallopian Tube Occlusion, Uterus Abnormal
- Trial name
- NCT04077242
- Testing
- Hysteroscopic Fallopian tube assessment using the "Parryscope" technique, Hysteroscopic Fallopian tube assessment using the "Tubal flow" technique
- Where
- Austria
- Volunteers
- 60 people
- Sponsor
- Medical University of Vienna