Clinical trials: Infertility, Female
Acute Ovarian Failure, Infertility
Biorepository in Participants Who Undergo OTC for Gonadotoxic Therapy
Background: Medical advances have improved survival rates for many cancers and other illnesses. This means that more people are coping with the long-term effects of these treatments. Some treatments can cause female infertility.
- Conditions
- Acute Ovarian Failure, Infertility, Early Menopause And Infertility In Females After Treatment For Childhood Cancer
- Trial name
- NCT05440617
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Adenomyosis of Uterus, Implantation Failure
Linzagolix in Adenomyosis and Recurrent Implantation Failure
Adenomyosis is associated with impaired endometrial receptivity and reduced implantation rates in assisted reproduction, even when using high-quality embryos.
- Conditions
- Adenomyosis of Uterus, Implantation Failure, Infertility Female, Embryo Transfer
- Trial name
- LINZA-RIF (NCT07698561)
- Testing
- Linzagolix 200 mg (Yselty)
- Where
- 3 sites in Spain
- Volunteers
- 30 people
- Sponsor
- Vida Fertility Institute
Infertility,Female
Social Egg Freezing: Will Health Professionals Offer it ?
In 2021, the revision of bioethics laws opened the door to elective egg freezing. This gives women, between their 29th and 37th birthdays, the opportunity to freeze their eggs in order to combat age decline fertility.
- Trial name
- NCT06529224
- Testing
- Online questionnaire
- Where
- France
- Volunteers
- 1,551 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Infertility, Female, Pregnancy Related
Low TGF-β and Embryo Implantation in the Context of Assisted Reproductive Technology: Confirmation of a Biomarker Predictive of Success and Characterization of the Immune Microenvironment.
Infertility affects about one in seven couples in France. Beyond the medical and personal challenges, it has major societal implications.
- Trial name
- ImmuNoFertilit (NCT07859930)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Female Infertility
Uterine Transplant in Absolute Uterine Infertility (AUIF)
This study will examine the feasibility of initiating a uterine transplant program for Absolute Uterine Factor Infertility (AUFI) at Brigham and Women's Hospital.
- Trial name
- NCT02741102
- Testing
- Uterine Transplant
- Where
- United States
- Sponsor
- Brigham and Women's Hospital
Female Infertility, Uterine Fibroid
The Effects of Uterine Fibroids on Pregnancy in Women
Female fertility may be affected by uterine fibroids, although this association has not been elucidated. This retrospective cohort study aims to evaluate the impact of fibroids on women fertility.
- Trial name
- NCT06020924
- Testing
- No intervention
- Where
- China
- Volunteers
- 1,658 people, healthy volunteers welcome
- Sponsor
- Wenwen Wang
Male Factor Infertility, Female Factor Infertility
The Clinical Study of Sex Chromosome Variants
Purpose/Lay Summary: Background: Chromosomes are the structures inside of each cell that carry our genetic material (genes). Certain differences in the sex chromosomes are known to cause various diseases, such as infertility…
- Trial name
- NCT01661010
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Infertility (IVF Patients), Infertility
Intra-ovarian CAPA-IVM vs Standard IVM
This prospective study compares two approaches to obtaining mature oocytes for fertility treatment within the same participant. Immature oocytes are first retrieved from the right ovary and matured in the laboratory using a…
- Conditions
- Infertility (IVF Patients), Infertility, Infertility Female
- Trial name
- IO-CAPA (NCT07858435)
- Testing
- CAPA-IVM, In-House CAPA-IVM Pre-Maturation Medium, Minimal-Stimulation OS-IVF
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- New Hope Fertility Center
Female Infertility, Environmental Exposure
Detection of Microplastics in Human Granulosa Cells and in the Follicular Fluid of Women Undergoing ICSI Treatment
Plastic products have been used ubiquitously in the modern world for many decades - for example as packaging materials, textile fibers or molded parts.
- Trial name
- MP2021 (NCT05179993)
- Testing
- Microplastics
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Infertility Treatment Center Dortmund
Functional Hypothalamic Amenorrhea, FHA
A Study to Investigate Mibavademab in Adult Women With Functional Hypothalamic Amenorrhea
This study is researching an experimental drug called mibavademab (also called "study drug"). The study is focused on participants with a condition called Functional Hypothalamic Amenorrhea (FHA).
- Trial name
- KYRIAD (NCT07235917)
- Testing
- Mibavademab
- Where
- 11 sites in United States
- Volunteers
- 34 people
- Sponsor
- Regeneron Pharmaceuticals
Infertility, Female, Ovulation Induction
Oral GnRH Antagonist (Linzagolix) Versus Injectable GnRH Antagonist in Controlled Ovarian Stimulation for In Vitro Fertilization: A Randomized Controlled Non-Inferiority Trial With a Concurrent Comparator Cohort Undergoing Progestin-Primed Ovarian Stimulation (PPOS)
Women undergoing IVF/ICSI who are candidates for a GnRH-antagonist protocol are randomly assigned 1:1 to oral linzagolix or the standard injectable GnRH antagonist (ganirelix or cetrorelix).
- Trial name
- NCT07732348
- Testing
- Ganirelix ; Cetrorelix, Medroxyprogesterone Acetate ; Micronized Progesterone, Linzagolix
- Volunteers
- 120 people
- Sponsor
- Centro A.M.B.R.A. (Associazione Medici e Biologi per la Riproduzione Assistita)
Infertility Female, Frozen Embryo Transfer (FET)
FET-LET-2x2: Clinical Pregnancy Rates After Frozen Embryo Transfer in Natural and Modified Natural Cycles
The goal of this clinical trial is to learn whether different natural approaches to preparing the uterus for frozen embryo transfer (FET) can improve pregnancy success in women undergoing in vitro fertilization (IVF) treatment.
- Trial name
- FET-LET-2x2 (NCT07425990)
- Testing
- Letrozole (Aromatase Inhibitors), Choriogonadotropin alpha (r-hCG), Progesterone
- Where
- Serbia
- Volunteers
- 120 people
- Sponsor
- University of Novi Sad
Infertility, Infertility, Female
Half-dose vs Conventional-dose Cetrorelix in ICSI Cycles
This prospective cohort study aims to compare the effectiveness of half-dose (0.125 mg/day) versus conventional-dose (0.25 mg/day) cetrorelix in GnRH antagonist ICSI cycles regarding clinical pregnancy rate in women with BMI ≥25…
- Conditions
- Infertility, Infertility, Female, Anovulation
- Trial name
- NCT07836400
- Volunteers
- 160 people
- Sponsor
- Assiut University
Infertile Females or Females With Ovarian Insufficiency, Pre - Delivery Pregnant Women
The Effect of a Mindfulness-Based Stress Reduction Program on Pregnancy Adaptation, Stress, and Fetal Anxiety Levels in Women Who Conceived After Infertility Treatment
Infertility treatment is a long and challenging process. Women who become pregnant after this process may experience stress, anxiety and intense concerns about the baby's health alongside their happiness.
- Trial name
- MBSR-PAFS (NCT07307196)
- Testing
- MBSR
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
Female Infertility
AI-Assisted Euploid Embryo Selection for Single-Blastocyst Transfer in Women of Advanced Maternal Age
This single-center prospective randomized controlled study will enroll 500 infertile women aged 35 years or older who meet the criteria for fresh day-5 single-blastocyst transfer.
- Trial name
- NCT07833345
- Testing
- AI-assisted morphological assessment combined with euploidy prediction using EmbryoInsights™ Plus, AI-assisted morphological assessment using EmbryoInsights™
- Where
- China
- Volunteers
- 500 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Infertility, Female, Ovarian Reserve
hCG Priming in Women With Diminished Ovarian Reserve
The aim of this randomized controlled trial is to further examine the possible effects of low dose human chorionic gonadotropin (hCG) priming for eight weeks in women with diminished ovarian reserve (DOR) undergoing in vitro…
- Conditions
- Infertility, Female, Ovarian Reserve, In Vitro Fertilization (IVF)
- Trial name
- NCT07108621
- Testing
- Choriongonadotropin alfa (hCG)
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- Kristine Loessl
Endometriosis, Adenomyosis of Uterus
Artificial Intelligence Into Ultrasound Diagnostics in Reproductive Medicine
The goal of this observational study is to develop and validate artificial intelligence (AI)-based algorithms that support ultrasound diagnosis of endometriosis, adenomyosis, myometrial masses, uterine malformations, and impaired…
- Conditions
- Endometriosis, Adenomyosis of Uterus, Leiomyoma (Uterine Fibroids), Uterine Neoplasms
- Trial name
- AUDRIE (NCT07810920)
- Where
- Hungary
- Volunteers
- 1,600 people
- Sponsor
- Semmelweis University
Polycystic Ovary Syndrome, Infertility, Female
Effect of ALA Combined With Letrozole on Polycystic Ovary Syndrome Clinical Outcome in Infertile Females
This research study aims to investigate the effect of adding Alpha lipoic acid (ALA) supplement to letrozole treatment in infertile women with polycystic ovary syndrome (PCOS).
- Trial name
- NCT06418347
- Testing
- Alpha lipoic acid, Letrozole
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Ain Shams University
Infertility, Infertility, Female
Developmental Epidemiological Study of Children Born Through Reproductive Technology
DESCRT will be a long-term study that both looks back in time, at successful pregnancies, and forward in time at early pregnancy and long-term as these children grow.
- Conditions
- Infertility, Infertility, Female, Infertility, Male, Infertility Primary
- Trial name
- DESCRT (NCT03799107)
- Where
- United States
- Volunteers
- 2,020 people
- Sponsor
- University of California, San Francisco
Infertility, Female
Impact of a Web-Based Mind-Body Awareness Program on Women Undergoing Infertility Treatment
The goal of this two-group parallel randomized controlled study is to determine the effect of a web-based mind-body-based awareness program based on Meleis Transition Theory on fertility awareness and readiness levels in women…
- Trial name
- NCT06585137
- Testing
- Web-Based Mind-Body Based Awareness Program
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Hacettepe University