Clinical trials: Infertile Patients, active
Infertility (IVF Patients), Infertility
Follitropin Delta in Long GnRH-agonist Protocol
The REWAG study ("Real-world Evaluation of Women undergoing Agonist protocol with Follitropin delta") is a non-interventional observational study conducted across several fertility centers in Germany.
- Conditions
- Infertility (IVF Patients), Infertility, Infertility Drugs
- Trial name
- REWAG (NCT06995261)
- Where
- 4 sites in Germany
- Volunteers
- 350 people
- Sponsor
- Prof. Dr. med. M.Sc. Georg Griesinger
Infertility Assisted Reproductive Technology
The Feasibility of taVNS on Pregnancy Outcomes of Infertility Patients Undergoing IVF
To assess the feasibility of taVNS on pregnancy outcomes of infertility subjects undergoing IVF, the primary aim of this trial will focus on encompassing recruitment, compliance, and preliminary engagement outcomes.
- Trial name
- NCT06742788
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Xijing Hospital
Diminished Ovarian Reserve, Female Infertility
Hippo-Related Competing Endogenous RNA (ceRNA) Network Dysregulation and In Vitro Fertilization (IVF) Outcomes in Women With Diminished Ovarian Reserve
Diminished Ovarian Reserve (DOR) is an important cause of female infertility and is associated with poor ovarian response and lower pregnancy rates during In Vitro Fertilization (IVF).
- Conditions
- Diminished Ovarian Reserve, Female Infertility, In Vitro Fertilization
- Trial name
- DOR-HIPPO-IVF (NCT07658846)
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Assiut University
Infertility, Female, Luteinizing Hormone (LH)
Extra Luteinizing Hormone Improve Embryo Quality in IVF Patients With Low LH During Long GnRH-Agonist Treatment
This randomized controlled trial aims to evaluate whether supplementation with exogenous luteinizing hormone (LH) can improve embryo quality in patients undergoing in vitro fertilization (IVF) with a long gonadotropin-releasing…
- Trial name
- ELH-IVF (NCT07128394)
- Testing
- Recombinant Luteinizing Hormone (rLH), Recombinant Follicle-Stimulating Hormone (rFSH), Gonadotropin-Releasing Hormone Agonist (GnRH-a)
- Where
- China
- Volunteers
- 590 people
- Sponsor
- Nanjing University
Assisted Hatching, Advanced Age
The Impact of Assisted Hatching on Pregnancy Outcomes After Vitrified-Warmed Embryo Transfer in Advanced-age Patients
The goal of this clinical trial is to evaluate the effect of laser assisted hatching (LAH) on pregnancy outcomes, with live birth rate as the primary outcome, in advanced age infertile women aged ≥35 years who are undergoing…
- Trial name
- NCT07490561
- Testing
- Laser assisted hatching
- Volunteers
- 916 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Female İnfertility
Mobile Health Support Before Oocyte Pick-Up in Infertile Women
This study aims to evaluate the effect of the OPUCARE system, a structured mobile health application used before oocyte pick-up (OPU), on medication adherence and quality of life in infertile women.
- Trial name
- OPUCARE (NCT07690969)
- Testing
- OPUCARE, Routine clinical care
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istinye University
Azoospermia, Nonobstructive, Teratospermia
Study of Tolerability, Safety, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of the Medicinal Product MediReg®
The study is open to patients with severe forms of male infertility (non-obstructive disorders of spermatogenesis, including azoospermia).
- Conditions
- Azoospermia, Nonobstructive, Teratospermia, Oligospermia, Men Infertility
- Trial name
- MARS (NCT06869863)
- Testing
- Medicinal product MediReg® (Human Mesenchymal Stromal Cell Secretome), lyophilizate for preparation of solution for injection in patients with severe spermatogenesis disorders, Clostilbegit (clomiphene) 50 mg 1 tablet x 1 p a day - 3 months, Triovit - 1 tablet x 1 p a day - 3 months, Folic acid - 1 tablet x 1 p a day - 3 months.
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- Lomonosov Moscow State University Medical Research and Educational Center
Fertility Issues, Emotional Stress
Frame Support Study
This is a randomized, controlled pilot study evaluating an intervention of non-significant risk. Potential subjects will be women who have completed an initial new patient consultation at one of the participating fertility…
- Trial name
- NCT07083700
- Testing
- Frame Access
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Inception Fertility Research Institute, LLC
IVF Patients, Female Infertility
Endometrial Immune Profile Changes After Autologous Intrauterine PRP Treatment
The success rate after treatment by in-vitro fertilisation (IVF) strongly depends on the endometrial receptivity, which in turn is strictly connected to the endometrial immune profile.
- Trial name
- NCT07535190
- Testing
- Platelet rich plasma (PRP)
- Where
- Bulgaria
- Volunteers
- 50 people
- Sponsor
- Nadezhda Women's Health Hospital
Infertility, Mental Health
Patient Empowerment Project (PEP) Study
The Patient Empowerment Project (PEP) will be integrated into the intake process at a fertility clinic to prepare clinical staff for any patient sensitivities or preferences and provide extra support if needed.
- Trial name
- PEP (NCT07725458)
- Testing
- Patient Empowerment Program (PEP)
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Inception Fertility Research Institute, LLC
Anxiety, Stress
Aromatherapy for Mental Health Promotion in IVF Patients
The experience of infertility can cause significant emotional instability, especially for patients awaiting In Vitro Fertilization (IVF) treatment, generating anxiety, stress, and depressive symptoms.
- Conditions
- Anxiety, Stress, Depression Disorder, Quality of Life
- Trial name
- NCT07480668
- Testing
- Lavender essential oil Inhalation, Synthetic lavender aroma inhalation
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Federal University of Minas Gerais
Fertility Issues
Testicular Tissue Cryopreservation (TTC)
The "Testicular Tissue Cryopreservation" study is open to a subset of patients facing disease or treatment regimens that could lead to infertility (gonadotoxic therapies).
- Trial name
- TTC (NCT06387498)
- Testing
- Testicular tissue biopsy and cryopreservation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Colorado, Denver
Infertility
In Vitro Fertilisation Versus Intracytoplasmic Sperm Injection in Patients Without Severe Male Factor Infertility
Over recent decades, the use of intracytoplasmic sperm injection (ICSI) has increased, even among patients without severe male factor infertility.
- Trial name
- INVICSI (NCT04128904)
- Testing
- IVF, ICSI
- Where
- 6 sites in Denmark
- Volunteers
- 824 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Poor Response to Ovulation Induction, Infertility, Female
Autologous Platelet Rich Plasma Intraovarian Infusion for Poor Responders
Autologous platelet rich plasma (PRP) intraovarian infusion may improve ovarian response to controlled ovarian stimulation as well as the hormonal profile of poor ovarian response infertile women subjected to intracytoplasmic…
- Conditions
- Poor Response to Ovulation Induction, Infertility, Female, Ovarian Insufficiency, Ovarian Failure
- Trial name
- PRPPOR (NCT05181748)
- Testing
- Autologous platelet rich plasma
- Where
- Greece
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Genesis Athens Clinic
Infertility (IVF Patients), Oocyte Competence
The EPIC Study: Exploring Paternal Age and the Influence on Blastocyst Culture
This study aims to assess the effect of age of the male partner and the reproductive ability of sperm prepared via sperm selection devices (Zymot) compared to routine embryologist selected sperm after density gradient…
- Conditions
- Infertility (IVF Patients), Oocyte Competence, Sperm DNA Fragmentation, Paternal Age
- Trial name
- EPIC (NCT06629766)
- Testing
- Microfluidic sperm separation device, Density grade centrifugation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Reproductive Medicine Associates of New Jersey
ICSI, Testicular Sperm Extraction in Azoospermic Patients
Comparison of Two Types of Calcium (Ca²⁺) Ionophore Treatments for Oocyte Activation in Cases of Suboptimal Fertilization Potential
This study aims to investigate the effectiveness and safety of assisted oocyte activation (AOA) using Ca²⁺ ionophores in cases of total fertilization failure (TFF) due to oocyte activation deficiency (OAD).
- Conditions
- ICSI, Testicular Sperm Extraction in Azoospermic Patients, Male Infertility, PGT-A
- Trial name
- (Ca²⁺) (NCT07570342)
- Testing
- Group 1: Oocyte Activation (OA) CultActive, Group 2: Oocyte Activation (OA) Ionomycin, Group 3: Control
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Urologic Diseases, Urologic Cancer
Bank of Biological Material From Patients and Healthy Donors for the Study of Urological and Uro-oncological Pathologies
The project aims to collect fresh biological material derived both from surgical resections performed in diseases, neoplastic and otherwise, of urological relevance at the level of the prostate, bladder, kidney, testicle and…
- Conditions
- Urologic Diseases, Urologic Cancer, Infertility
- Trial name
- NCT06187870
- Testing
- Collection of biological data
- Where
- Italy
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Infertile Patient Undergoing ICSI Procedure
Advanced Sperm Selection in ICSI: A Comparative Study of PICSI and ZyMot
our study explores the effectiveness of two advanced sperm selection techniques-PICSI and the ZyMot microfluidic device-in improving outcomes of Intracytoplasmic Sperm Injection (ICSI).
- Trial name
- NCT07240779
- Testing
- picsi dish
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Sunrise Fertility Center
Infertility (IVF Patients)
Pilot Study of Discarded Blastocysts
The goal of this observational study is to determine multiomics patterns related to global embryo quality to help overcome the limitations of conventional embryo quality assessment.
- Trial name
- DECODE (NCT07429097)
- Testing
- Multiomics analysis
- Where
- Norway
- Volunteers
- 150 people
- Sponsor
- Igenomix
Thin Endometrium, Female Infertility
Intrauterine G-CSF Infusion for Thin Endometrium
Thin endometrium is a condition in which the lining of the uterus is too thin during preparation for embryo transfer. This may reduce the chance of pregnancy and live birth in patients undergoing frozen-thawed embryo transfer.
- Trial name
- GIFT (NCT07692672)
- Testing
- Granulocyte Colony-Stimulating Factor(G-CSF), Normal Saline
- Volunteers
- 620 people
- Sponsor
- Nanjing University