Clinical trials: Infective Endocarditis
Infective Endocarditis
Characteristics of Infective Endocarditis in East China
This was a retrospective observational study of consecutive cases of definite or possible infective endocarditis (IE) as per the modified Duke criteria between January 2008 and December 2015, which was performed at the Second…
- Trial name
- NCT04977518
- Testing
- no intervention
- Volunteers
- 183 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Infective Endocarditis
Early Clinical, Laboratory and Microbiological Predictors of Treatment Outcomes in Infective Endocaridtis
The investigators conduct a prospective observational study on consecutive patients being admitted to a tertiary care-centre with infective endocarditis.
- Trial name
- CRP-IE (NCT02466139)
- Volunteers
- 102 people
- Sponsor
- Government Medical College, Kozhikode
Endocarditis, Bacterial
Short-course Antibiotic Treatment in Gram-positive Cocci Infective Endocarditis
Background: it is well known that most serious complications of infective endocarditis (IE) appear in the so-called "critical phase" of the disease, which are the first days after diagnosis.
- Trial name
- SATIE (NCT04222257)
- Testing
- Antibiotics
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Carmen Olmos Blanco
Bacteremia, Infective Endocarditis
Reducing Risk for Infective Endocarditis
This clinical trial is studying if bacteria found in a participant's bloodstream after brushing their teeth can be prevented with a dental cleaning and more education on how to best brush and care for their teeth.
- Trial name
- PIE-B (NCT05721781)
- Testing
- Oral Hygiene instruction, Dental Cleaning
- Where
- 6 sites in United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Bacterial Endocarditis, Bacteremia
Daptomycin in the Treatment of Subjects With Infective Endocarditis or Bacteremia Due to S. Aureus
The purpose of this study is to compare the safety and efficacy of daptomycin, an antibiotic, to standard therapy in subjects who have infective endocarditis or bacteremia due to Staphylococcus aureus (S. aureus).
- Trial name
- NCT00093067
- Testing
- daptomycin
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Infective Endocarditis
Betalactam Pharmacokinetics in Endocarditis Patients
Infectious endocarditis (IE) is associated with mortality rates of 10-12%. Adequate antibiotic therapy is crucial for survival and is administered in high doses due to the severity of the disease.
- Trial name
- NCT04647331
- Where
- 4 sites in Sweden
- Volunteers
- 150 people
- Sponsor
- Uppsala University
Cardiac Sarcoidosis, Infective Endocarditis
A Prospective Diagnostic Trial of Al[¹⁸F]F-NOTA-folate PET in Patients With Suspected Cardiac Sarcoidosis and Infective Endocarditis
The goal of this prospective diagnostic study is to evaluate the imaging characteristics, diagnostic performance, radiation dosimetry, and safety of Al[¹⁸F]F-NOTA-folate PET imaging in patients with suspected cardiac sarcoidosis…
- Trial name
- FOL-CARD (NCT07814222)
- Testing
- Al[¹⁸F]F-NOTA-folate PET imaging, [15O]water PET imaging, Echocardiography
- Where
- Finland
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Staphylococcal Infection
A Study of MK-3009 in Japanese Patients With Skin or Blood Stream Infections Caused by Methicillin-resistant Staphylococcus Aureus (MK-3009-002)
The study investigates the efficacy and safety of MK-3009 in participants with skin infections, septicemia and right-sided infective endocarditis (RIE) caused by methicillin-resistant Staphylococcus aureus (MRSA).
- Trial name
- NCT00770341
- Testing
- Daptomycin 4 mg/kg, Comparator: vancomycin, Daptomycin 6 mg/kg
- Volunteers
- 122 people
- Sponsor
- Merck Sharp & Dohme LLC
Pulmonary Valve; Failure, Percutaneous Pulmonary Valve Implantation
Transcatheter Pulmonary Valve Implantation With SAPIEN 3 Valve
Background Transcatheter pulmonary valve implantation (TPVI) is indicated to treat right ventricular outflow tract dysfunction in patients with congenital heart diseases.
- Conditions
- Pulmonary Valve; Failure, Percutaneous Pulmonary Valve Implantation, Infective Endocarditis, Congenital Heart Disease
- Trial name
- EUROPULMS3 (NCT05264181)
- Testing
- Percutaneous pulmonary valve implantation
- Where
- France
- Volunteers
- 600 people
- Sponsor
- Centre Chirurgical Marie Lannelongue
Infective Endocarditis
Vancomycin, Gentamycin in Infective Endocarditis
Infective endocarditis is a microbial infection of the endocardial surface of the heart.
- Trial name
- NCT03688659
- Testing
- Vancomycin and gentamycin
- Volunteers
- 30 people
- Sponsor
- Assiut University
Infective Endocarditis
Rationale, Design and Methods for the Early Surgery in Infective Endocarditis Study (ENDOVAL)
Background: Prognosis of infective endocarditis is poor and has remained steady over the last four decades. Several nonrandomized studies suggest that early surgery could improve prognosis.
- Trial name
- ENDOVAL (NCT00624091)
- Testing
- Cardiac surgery, State-to-the-art treatment
- Where
- Spain
- Volunteers
- 216 people
- Sponsor
- Instituto de Ciencias del Corazon
Endocarditis
Cardiac Computed Tomography (CT) Scan Compared to Transesophageal Echocardiogram (TEE) in Endocarditis
The purpose of this study is to assess the effectiveness of cardiac CT versus TEE in endocarditis patients.
- Trial name
- NCT00995384
- Testing
- CT Scan
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Corewell Health East
Infective Endocarditis
CBCT vs OPT on the Oral Health Status at 12 Months of Patients Hospitalized for Infective Endocarditis.
1. Infective Endocarditis (IE) is a rare and serious disease with high morbidity and mortality; 2. Streptoccoci of oral origin are the second more frequent microorganisms responsible for IE; 3.
- Trial name
- 3D STARS (NCT06269679)
- Testing
- CBCT
- Where
- 10 sites in France
- Volunteers
- 170 people
- Sponsor
- Nantes University Hospital
Infective Endocarditis, Bacterial Infections
Healthrelated Quality of Life and Experiences of a Heart Rehabilitation Programme After Care for Infective Endocarditis.
How does health develop after Infective endocarditis (IE)? Can the health of patients with IE be improved by participation in the physical exercise training within cardiac rehabilitation program? Participants will: Answer…
- Conditions
- Infective Endocarditis, Bacterial Infections, Cardiac Rehabilitation, Patient Participation
- Trial name
- NCT06704048
- Testing
- Cardiac rehabilitation
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Region Halland
IV Drug Usage, Infective Endocarditis
Cardiac Surgery Peer Recovery Support Program
The purpose of the study is to develop and implement an addiction recovery support program for cardiac surgery patients admitted with a diagnosis of infective endocarditis secondary to IV drug addiction.
- Conditions
- IV Drug Usage, Infective Endocarditis, Substance Use Disorders
- Trial name
- NCT03590106
- Testing
- Peer Recovery Support Program
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Rochester
Infective Endocarditis
Research Interest Antiphospholipid in Predicting Embolic Risk During Infective Endocarditis
EMBOL-EI (Research Interest antiphospholipid antibody for embolic risk prediction in infective endocarditis) is a prospective cohort study with a biological collection.
- Trial name
- EMBOL-EI (NCT02887079)
- Where
- 2 sites in France
- Volunteers
- 186 people
- Sponsor
- Central Hospital, Nancy, France
Infective Endocarditis
Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Streptococcus
Infective endocarditis (IE) is a serious infection with a significant burden for patients and hospitals (in France, median length of hospital stay = 43 days), partly due to the long duration of intravenous (IV) antibacterial…
- Trial name
- NCT02701595
- Testing
- Amoxicillin, Conventional IV treatment of streptococci/enterococci IE following European guidelines 2015 including amoxicillin, gentamicin, amicillin, vancomycin, penicillin G, ceftriaxone, netilmicin
- Where
- 45 sites in France
- Volunteers
- 324 people
- Sponsor
- University Hospital, Tours
Surgical Valve Replacement, Dental
Impact of Preoperative Dental Screening in Reducing Infective Endocarditis Risk in Surgical Valve Replacement Patients
In Odense University Hospital preoperative dental screening (PDS) protocol for patients treated with surgical valve replacement was changed from mandatory to targeted PDS to from march 2024.
- Conditions
- Surgical Valve Replacement, Dental, Endocarditis
- Trial name
- DENSVAR (NCT06403839)
- Testing
- No preoperative dental screening
- Where
- Denmark
- Volunteers
- 1,000 people
- Sponsor
- Odense University Hospital
Intracardiac Thrombus, Intracardiac Mass
AngioVac Aspiration Therapy Registry
As a structured, multinational retrospective registry the AVATAR Registry addresses the following scientific aspects through systematic data collection, centralized quality control, and robust statistical analysis in patients…
- Conditions
- Intracardiac Thrombus, Intracardiac Mass, Intravascular Thrombosis, Vegetation; Heart
- Trial name
- AVATaR (NCT07769320)
- Testing
- Retrospective analysis of assigned treatment
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Charite University, Berlin, Germany
Infective Endocarditis
Accuracy of Metagenomic Blood Sampling to Identify Pathogen in Infective Endocarditis Patients
Infective Endocarditis is an infection, usually a bacterium, which attacks the heart and can cause valves to leak and produces a bacterial mass which can break off from the valves and block the blood supply to important organs.
- Trial name
- AMetIP (NCT06309680)
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London