Clinical trials: Infective Endocarditis
Endocarditis Infective, Endocarditis, Bacterial
Dalbavancin Therapy for Infective Endocarditis
This study compares two treatment strategies for antibiotic therapy in endocarditis. The aim of the study is to determine which treatment is more effective overall and better tolerated by patients.
- Trial name
- EndoDalba (NCT07699211)
- Testing
- Dalbavancin administration, Standard of Care (Investigator Choice)
- Where
- 9 sites in Germany
- Volunteers
- 184 people
- Sponsor
- Stefan Hagel
Infective Endocarditis
Partial Oral Antimicrobials to Treat Infective Endocarditis in People Who Inject Drugs
Infective endocarditis (IE) is a serious infection associated with significant morbidity and mortality. Recent studies demonstrated an increased risk of infective endocarditis in people who inject drugs (PWIDs).
- Trial name
- NCT04544306
- Testing
- Partial oral antimicrobial therapy
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Infective Endocarditis, Cardiac Surgery
SURgical Registry of ENDocarditis EuRope
This is a prospective, multicentric, european registry of patients with infective endocarditis undergoing cardiac surgery. Patient demographics, clinical data and laboratory values will be collected, as well as treatment outcomes…
- Conditions
- Infective Endocarditis, Cardiac Surgery, Outcomes
- Trial name
- SURRENDER (NCT05563662)
- Testing
- Cardiac surgery
- Where
- 2 sites in Germany
- Volunteers
- 10,000 people
- Sponsor
- University Hospital, Essen
Endocarditis, Infective
Ampicillin and Ceftriaxone for the Treatment of Enterococcus Faecalis Infective Endocarditis.
Phase IV, open-label, randomized and multicenter clinical trial to prove that patients with Enterococcus faecalis infective endocarditis treated with an antibiotic treatment as a continuous infusion is non-inferior to the…
- Trial name
- DOBLEI (NCT06423898)
- Testing
- Ampicillin plus ceftriaxone in continuous infusion, Ampicillin plus ceftriaxone in intermittent infusion of 14 days, after which the treatment may be changed
- Where
- 18 sites in Spain
- Volunteers
- 284 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Infective Endocarditis
Phase 4 Efficacy and Safety Study of Cubicin® With and Without Combination Therapy in S. Aureus Infective Endocarditis (SAIE)
multicenter, randomized, double blind study to describe the safety and efficacy of daptomycin (6 mg/kg q24h) with and without concomitant initial gentamicin combination therapy in the treatment of SAIE
- Trial name
- NCT00638157
- Testing
- daptomycin, daptomycin and gentamicin
- Where
- 4 sites in United States
- Volunteers
- 24 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Infective Endocarditis, Congenital Heart Disease
Infective Endocarditis in Percutaneous Pulmonary Revalvulation: Comparison Between Melody and Sapien Valves
Percutaneous pulmonary valve revalvulation (PPVR) has emerged as an alternative to surgery for the treatment of congenital heart disease with right ejection pathway dysfunction.
- Conditions
- Infective Endocarditis, Congenital Heart Disease, Percutaneous Pulmonary Valve Implantation
- Trial name
- Endopulm (NCT06186258)
- Testing
- percutaneous pulmonary valve implantation (PPVI)
- Where
- 18 sites in France, Germany and 5 more
- Volunteers
- 300 people
- Sponsor
- Centre Chirurgical Marie Lannelongue
Endocarditis, Bacteremia
Efficacy and Safety of Dalbavancin Compared to Standard of Care Antibiotic Therapy for the Completion of Treatment of Patients With Complicated Bacteremia or Infective Endocarditis
This study will compare dalbavancin to standard of care (SOC) antibiotic therapy for the completion of therapy in patients with complicated bacteremia or infective endocarditis.
- Trial name
- NCT03148756
- Testing
- Dalbavancin, Standard of Care
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- AbbVie
Endocarditis
Early Surgery Versus Conventional Treatment in Infective Endocarditis
There have been no prospective clinical studies in infective endocarditis comparing early surgery with the conventional treatment strategy based on current guidelines.
- Trial name
- EASE (NCT00750373)
- Testing
- Valve surgery with removal of vegetations
- Where
- 2 sites in South Korea
- Volunteers
- 76 people
- Sponsor
- Asan Medical Center
Valvular Endocarditis
Surgical Management of Valvular Endocarditis
This study aims to achieve the following objectives objective 1 : To review the Investigators' experience of surgical management of infective endocarditis (IE) and analyze the outcomes and associated prognostic factors objective…
- Trial name
- NCT04572529
- Testing
- Cardiac Valve replacement
- Volunteers
- 50 people
- Sponsor
- Assiut University
Infective Endocarditis, Heart Failure
Infective Endocarditis Surgery Using Conventional Prosthetic Valves Versus Cryopreserved Aortic Homograft
: Evidence suggested that autologous or allogeneic tissue is more suitable to synthetic material in an infected field. Given the unwillingness of some surgeons to use artificial foreign materials, such as conventional mechanical…
- Trial name
- IESCOPHO (NCT05253469)
- Testing
- Cryopreserved Aortic Homograft, Stented/Non stented xenograft, Mechanical prostheses
- Where
- France
- Volunteers
- 760 people
- Sponsor
- Centre Cardiologique du Nord
Infective Endocarditis
Detection of the Most Common Microorganism of Infective Endocarditis in Assiut University Hospital
Indocarditis is an endogenous infection acquired when organisms entering the blood stream establish on the heart valves, therefore, any bacteremia can potentially result in endocarditis.
- Trial name
- NCT03487653
- Testing
- microbiology:Blood culture and sensitvity test .Serology
- Volunteers
- 50 people
- Sponsor
- Safaa Samir
Infective Endocarditis, Cardiac Sarcoidosis
Evaluation of the Impact of a Patient Education Protocol on the Quality of 18F-FDG PET Imaging Indicated for Investigation of Cardiac Inflammation
The aim of this study is to assess the impact of implementing a patient education and preparation protocol for FDG PET (18F-FDG PET) imaging on the quality of imaging results.
- Trial name
- CARTEP (NCT07029295)
- Testing
- Sending a link to the video, Compliance questionnaire, Determination of beta-hydroxybutyrate (BHB) in capillary blood
- Where
- 2 sites in France
- Volunteers
- 138 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Infective Endocarditis (IE)
European Research Group on Outcomes of Surgical Treatment of Infective Endocarditis
The European Research Group on Outcomes of Surgical Treatment of Infective Endocarditis (ERGOSTE) is a nascent large surgical registry that would encompass most relevant aspects of IE in Europe in the contemporary era.
- Trial name
- ERGOSTE (NCT07108803)
- Where
- Italy
- Volunteers
- 2,500 people
- Sponsor
- Azienda Sanitaria Universitaria Giuliano Isontina (ASU GI)
Infective Endocarditis (IE)
Etiology of Endocarditis in Negative Blood Cultures
Infective endocarditis remains a serious disease that requires fast and specialized support in 2012. However, 24% of endocarditis unanswered etiology.
- Trial name
- ENDOC (NCT02816307)
- Testing
- blood samples
- Where
- France
- Volunteers
- 3,033 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Infective Endocarditis, Infection Staphylococcal
NExt-Generation Sequencing and Cell Culture-based Characterization of S. Aureus in Infective Endocarditis
Infective endocarditis is a deadly disease with a mortality rate between 20 and 40%. Antibiotic therapy is of utmost importance. It is primarily guided by microbial results from positive blood culture.
- Trial name
- NESSIE (NCT04257292)
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Jena University Hospital
Endocarditis, Bacterial, Infective Endocarditis
Phase 2 Study of Safety, Efficacy, and Pharmacokinetics of Higher Doses of Daptomycin and Vancomycin in MRSA Bacteremia
The overall goals of this study are to compare the safety and efficacy of daptomycin monotherapy 10 mg/kg/day and vancomycin monotherapy dosed to achieve vancomycin trough levels of 15 to 20 μg/mL for the treatment of…
- Trial name
- HDSAB (NCT00695903)
- Testing
- daptomycin, vancomycin
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Endocarditis
Stroke-free Survival Comparison Between Early Surgery and Conventional Therapy in Left Infective Endocarditis
The purpose of the EARLY study is to evaluate the efficacy and effectiveness of early surgery in patients with Infective Endocarditis (IE).
- Trial name
- NCT03411499
- Testing
- Early surgery, Conventional therapy
- Where
- Italy
- Volunteers
- 6 people
- Sponsor
- Maria Vittoria Hospital
Endocarditis Infective
Antibiotics Vs Antibiotics and Surgical ThERapy for Infective Endocarditis
Infective endocarditis (IE) is a deadly disease and the incidence is increasing. An important initial assessment of patients with IE includes whether surgical treatment is indicated; yet, appropriate data to guide this assessment…
- Trial name
- ASTERIx (NCT05061355)
- Testing
- Heart valve surgery
- Where
- 15 sites in Denmark, Germany and 2 more
- Volunteers
- 496 people
- Sponsor
- Emil Loldrup Fosbol
Infectious Endocarditis
Evaluation of an Antibiotic Regimen Pharmacokinetic Applicable to Enterococcus Faecalis Infective Endocarditis
The clinical trial is designed as a phase II, crossover clinical trial. It will be carried out in healthy volunteers, who will receive two different antibiotic regimen based on ceftriaxone.
- Trial name
- NCT03681431
- Testing
- Ceftriaxone 4g/ 24h, Ceftriaxone 2g/ 12h
- Where
- Spain
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Endocarditis Infective
San Matteo Endocarditis Registry STEADY
The general objective of this study is to deepen the knowledge of patients affected by endocarditis.
- Trial name
- NCT07346222
- Where
- Italy
- Volunteers
- 418 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia