Clinical trials: Infectious Endocarditis
Infections of the Implanted Material, Endocarditis
Diagnostic Accuracy of 18FDG-PET-CT for Pacing or Defibrillation Lead Infection
With aging of the general population and broadening indications, the number of pacemaker recipients is steadily increasing. The incidence of infections of the implanted material, a dreaded major complication, is also rising.
- Trial name
- ENDOTEP (NCT02251262)
- Testing
- Whole-body 18FDG-PET-CT scan
- Where
- 6 sites in France
- Volunteers
- 235 people
- Sponsor
- University Hospital, Bordeaux
Infective Endocarditis, Infection Staphylococcal
NExt-Generation Sequencing and Cell Culture-based Characterization of S. Aureus in Infective Endocarditis
Infective endocarditis is a deadly disease with a mortality rate between 20 and 40%. Antibiotic therapy is of utmost importance. It is primarily guided by microbial results from positive blood culture.
- Trial name
- NESSIE (NCT04257292)
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Jena University Hospital
Infectious Endocarditis
Evaluation of an Antibiotic Regimen Pharmacokinetic Applicable to Enterococcus Faecalis Infective Endocarditis
The clinical trial is designed as a phase II, crossover clinical trial. It will be carried out in healthy volunteers, who will receive two different antibiotic regimen based on ceftriaxone.
- Trial name
- NCT03681431
- Testing
- Ceftriaxone 4g/ 24h, Ceftriaxone 2g/ 12h
- Where
- Spain
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Bacterial Infections, Bone Diseases, Infectious
Fosfomycin I.v. for Treatment of Severely Infected Patients
The purpose of this European, multicentric, prospective, non-interventional study is to document and evaluate the efficacy and safety of the treatment of severely infected patients with intravenously administered fosfomycin…
- Conditions
- Bacterial Infections, Bone Diseases, Infectious, Osteomyelitis, Central Nervous System Bacterial Infections
- Trial name
- FORTRESS (NCT02979951)
- Where
- 50 sites in Austria, Germany and 3 more
- Volunteers
- 1,000 people
- Sponsor
- Infectopharm Arzneimittel GmbH
Endocarditis
Contribution of 18F-FDG PET-CT in the Diagnosis and the Detection of Peripheral Emboli of Infectious Endocarditis on Native Valves
The diagnosis of infectious endocarditis is not always easy and is based on several clinical and imaging arguments. Positron Emission Tomography - Computed Tomography (PET-CT) has been validated for endocarditis on prosthetic…
- Trial name
- NATIVTEP (NCT03695861)
- Testing
- Whole-body 18F-FDG PET-CT scan
- Where
- France
- Volunteers
- 31 people
- Sponsor
- University Hospital, Bordeaux
Bacteremia, Infective Endocarditis
Impact of the Blood Culture Technique on the Diagnosis of Infective Endocarditis
To evaluate the performance of a single high volume blood culture sampling strategy versus the actually used multiple sampling strategy for the diagnosis and categorization of infective endocarditis according to the Duke-Li…
- Trial name
- UniEndo (NCT03153384)
- Testing
- Blood Culture
- Where
- 8 sites in France
- Volunteers
- 269 people
- Sponsor
- Central Hospital, Nancy, France
Staphylococcus Aureus Bacteremia
Ceftobiprole in the Treatment of Patients With Staphylococcus Aureus Bacteremia
The purpose of this study was to compare the efficacy and safety of ceftobiprole medocaril versus a comparator in the treatment of patients with complicated Staphylococcus aureus bacteremia (SAB).
- Trial name
- NCT03138733
- Testing
- Ceftobiprole medocaril, Daptomycin
- Where
- 60 sites in United States, Argentina and 15 more
- Volunteers
- 390 people
- Sponsor
- Basilea Pharmaceutica
Endocarditis Infective
Study of the Prognosis of Infectious Endocarditis (EPEI)
Infectious endocarditis (IE) is the localization and proliferation of blood-borne germs in the endocardium. It remains a complicated disease to manage due to its low incidence, diagnostic difficulties, the change in epidemiology…
- Trial name
- EPEI (NCT03211975)
- Testing
- To study the evolution of the prognosis of infectious endocarditis on native valves and on prostheses
- Where
- France
- Volunteers
- 645 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Infective Endocarditis
Evolution of the Profile of Infectious Endocarditis in France in 2008 (EI2008)
Infective endocarditis (IE) is a rare (30 cases / million / year in France) and serious (20 % of deaths during hospitalization) disease .
- Trial name
- EI2008 (NCT03295045)
- Volunteers
- 484 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Staphylococcus Aureus Bacteremia, Staphylococcus Aureus Endocarditis
Direct Lysis of Staph Aureus Resistant Pathogen Trial of Exebacase
The purpose of this superiority study is to evaluate the efficacy and safety of exebacase in addition to standard of care antibiotics (SoCA) compared with SoCA alone for the treatment of patients with Staphylococcus aureus (S.
- Trial name
- DISRUPT (NCT04160468)
- Testing
- Exebacase
- Where
- 55 sites in United States
- Volunteers
- 259 people
- Sponsor
- ContraFect
Staphylococcus Aureus Endocarditis, Staphylococcus Aureus Septicemia
Dabigatran vs. Oral Anti-Xa Inhibitors in S. Aureus Bacteremia
This is an open-label randomized controlled trial which will enroll patients with S. aureus bacteremia who are already taking oral anticoagulant medications (apixaban, edoxaban, or rivaroxaban) for an approved indication (stroke…
- Conditions
- Staphylococcus Aureus Endocarditis, Staphylococcus Aureus Septicemia, Staphylococcus Aureus Bacteremia, Staphylococcus Aureus Bloodstream Infection
- Trial name
- DABI-SNAP (NCT06650501)
- Testing
- Dabigatran, Apixaban, edoxaban
- Where
- 3 sites in Canada
- Volunteers
- 300 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Infectious Endocarditis
Hyperbaric Oxygen Treatment in Humans With Gram Positive Cocci Endocarditis
Infectious endocarditis (IE) is defined as an infection anywhere on the endocardium, most often localised to the cardiac valves. It is an infection with an increasing incidence and in Denmark with 6-700 new cases annually.
- Trial name
- ENDOHOT (NCT04691440)
- Testing
- Hyperbaric oxygen
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Ole Hyldegaard
Staphylococcal Infection
A Study of MK-3009 in Japanese Patients With Skin or Blood Stream Infections Caused by Methicillin-resistant Staphylococcus Aureus (MK-3009-002)
The study investigates the efficacy and safety of MK-3009 in participants with skin infections, septicemia and right-sided infective endocarditis (RIE) caused by methicillin-resistant Staphylococcus aureus (MRSA).
- Trial name
- NCT00770341
- Testing
- Daptomycin 4 mg/kg, Comparator: vancomycin, Daptomycin 6 mg/kg
- Volunteers
- 122 people
- Sponsor
- Merck Sharp & Dohme LLC
Infectious Endocarditis
Characterization of Enterococcus Faecalis Endocarditis and Impact of Amoxicillin MIC Elevation on Patient Outcome
Infective endocarditis is a complex infection that can be life-threatening. These infections also cause anatomical lesions that can be severe.
- Trial name
- ENDO_ENTERO (NCT05530837)
- Where
- 2 sites in France
- Volunteers
- 281 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Endocarditis
Suppressive Antibiotic Therapy for Endocarditis
Endocarditis are deadly infections, which nowadays occurs mainly among older patients with multiple comorbidities. The incidence is notably high among patients with valvular prosthetic or implantable devices.
- Trial name
- SATIE (NCT06107309)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Strasbourg, France
MRSA Bloodstream Infection, MRSA Bacteremia
Expanded Access Study of Exebacase in COVID-19 Patients With Persistent MRSA Bacteremia
This is an open-label, expanded access study of exebacase used in addition to antistaphylococcal antibiotics in adult patients with persistent methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infections (BSI)…
- Conditions
- MRSA Bloodstream Infection, MRSA Bacteremia, MRSA Right-sided Endocarditis, Covid19
- Trial name
- NCT04597242
- Testing
- Exebacase
- Where
- 2 sites in United States
- Sponsor
- ContraFect
Septic Shock, Acute Respiratory Distress Syndrome
CytOSorb TreatMent Of Critically Ill PatientS Registry
Registry intended to provide a data repository and reporting infrastructure for the surveillance of CytoSorb device use in real-world critical care settings, and to serve as an objective, comprehensive, and scientifically-based…
- Conditions
- Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
- Trial name
- COSMOS (NCT05146336)
- Testing
- CytoSorb
- Where
- 28 sites in Austria, Germany and 4 more
- Volunteers
- 3,000 people
- Sponsor
- CytoSorbents, Inc
Transcatheter Aortic Valve Implantation, Dental
Impact of Preoperative Dental Screening in Reducing Infective Endocarditis Risk in Transcatheter Aortic Valve Implantation Patients
In Odense University Hospital preoperative dental screening (PDS) protocol for patients treated with Transcatheter Aortic Valve Implantation (TAVI) was changed from mandatory to targeted PDS to between June 2023 to october 2023.
- Conditions
- Transcatheter Aortic Valve Implantation, Dental, Endocarditis
- Trial name
- DENTAVI (NCT06330766)
- Testing
- No preoperative dental screening
- Where
- Denmark
- Volunteers
- 1,000 people
- Sponsor
- Odense University Hospital
Endocarditis, Prosthetic Material Related Infection
Individualized Diagnosis of Endocarditis and Its Therapy With a Focus on Infected Prosthetic materiAL
Infective endocarditis (IE) is a frequent and serious complication of implanted intracardiac prosthetic material, with a high morbidity and mortality.
- Trial name
- IDENTICAL (NCT02759978)
- Testing
- diagnostic workup
- Where
- Netherlands
- Volunteers
- 300 people
- Sponsor
- University Medical Center Groningen
Cardiac Implantable Electronic Device Infection
Cardiac Implantable Electronic Device RemOval Versus Full CoUrse Medical Treatment
The CIEDOUT study is an open label randomized trial in patients with possible cardiac implantable electronic device (CIED) infection.
- Trial name
- CIEDOUT (NCT06323668)
- Testing
- Cardiac implantable electronic device extraction
- Where
- Denmark
- Volunteers
- 180 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet