Clinical trials: Infection of Total Hip Joint Prosthesis
Hip Prosthesis Infection
Does the Type of Ventilation Affect the Risk for Infections After Hip Replacements?
Background: During hip replacement surgery, there is a risk that bacteria in the operating room can cause an infection. To try and reduce this risk, some operating rooms use a special system called laminar airflow (LAF), which…
- Trial name
- NCT05932823
- Testing
- Laminary airflow
- Volunteers
- 110,000 people
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Infection and Inflammatory Reaction
Pending Failure in Hard-hard Total Hip Arthroplasty
During last 6 years approximately 10.000 ceramic balls and 5.000 ceramic liners have been implanted in the region Emilia-Romagna in Italy (4 million Every single year approximately 60.000 hip prostheses are implanted in Italy.
- Trial name
- PF (NCT02427984)
- Testing
- Metal ions dosage and evaluation of local/systemic reaction, Noise registration and metal ions determination, Metal ions dosage, evaluation of local/systemic reaction, noise registration
- Where
- Italy
- Volunteers
- 148 people
- Sponsor
- Istituto Ortopedico Rizzoli
Infection of Total Hip Joint Prosthesis, Implants
Immunology of Failing Metal-on-Metal Hip Replacement
Metal-on-metal total hip replacement (MoM THR) has been targeted at younger patients with anticipated long-term survival since the bearing surfaces wear less than the traditional metal-on-plastic (MoP) replacements.
- Trial name
- NCT01517737
- Where
- 2 sites in United Kingdom
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
Infection of Total Hip Joint Prosthesis, Infection of Total Knee Joint Prosthesis
Phage Therapy in Prosthetic Joint Infection Due to Staphylococcus Aureus Treated With DAIR.
Pilot non comparative study assessing the clinical control of infection of DAIR + SAT +NaCl and DAIR + SAT + Phages anti-Staphylococcus aureus in patients with Staphylococcus aureus Prosthetic Joint Infection with an indication…
- Trial name
- PhagoDAIRI (NCT05369104)
- Testing
- Anti-Staphylococcus aureus Bacteriophages
- Where
- France
- Volunteers
- 64 people
- Sponsor
- Phagenix
Prosthesis-related Infections, Wound Complications
Evaluation of Wound Management With Negative Pressure Dressing Versus Standard Dressing After Revision Arthroplasty.
The purpose of this study is to determine the efficacy of a negative pressure wound therapy (NPWT) system after revision total knee and hip arthroplasty in patients at high risk for infection.
- Conditions
- Prosthesis-related Infections, Wound Complications, Joint Diseases, Musculoskeletal Diseases
- Trial name
- NCT02127281
- Testing
- Prevena
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- The Cleveland Clinic
Infection of Total Hip Joint Prosthesis
Evaluating Advantages of Prevena After Hip and Knee Arthroplasty
Determine the extent to which application of the Prevena vacuum system to clean surgical incisions immediately following surgical procedure (total hip or total knee arthroplasty) will reduce the rates of: readmission to hospital…
- Trial name
- NCT01854138
- Testing
- Prevena Incision Management System
- Where
- United States
- Volunteers
- 248 people
- Sponsor
- ProMedica Health System
Adverse Reactions to Metal Debris, Infection of Total Hip Joint Prosthesis
Imaging of Joint Replacement Complications by PET/CT
Total hip replacement is the well-established surgical method for treatment of hip osteoarthritis and related diseases. The outcome of the procedure is commonly satisfactory and most patients will not need any revision surgery.
- Conditions
- Adverse Reactions to Metal Debris, Infection of Total Hip Joint Prosthesis, Mechanical Loosening of Prosthetic Joint
- Trial name
- Propeli (NCT01970228)
- Testing
- 68Ga-citrate and 18F-FDG PET/CT imaging
- Where
- Finland
- Volunteers
- 12 people
- Sponsor
- Turku University Hospital
Sonication, Total Hip Replacement
Biofilm Investigation on Bearing Components of Explanted Hip Joint Prosthesis
In this study the investigators sonicate the bearing components of the explanted hip prosthesis which allows highly sensitive detection of in vivo biofilms (qualitatively and quantitatively).
- Conditions
- Sonication, Total Hip Replacement, Biofilm
- Trial name
- NCT02853461
- Testing
- Sonication, Microbiological analysis
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Charite University, Berlin, Germany
Hip Prosthesis Infection
Single-stage Surgery With Antibiotic-loaded Hydrogel Coated Implants Versus Two Stage Surgery for Secondary Prevention of Complex Chronic Periprosthetic Hip Joint Infection
Each year, around 1500 infected Total Hip Arthroplasties (THA) need non-conservative surgery, remaining an issue for patients and healthcare units.
- Trial name
- SINBIOSE-H (NCT04251377)
- Testing
- Defensive Antiadhesive Coating DAC®, Novagenit SRL
- Where
- 14 sites in France
- Volunteers
- 39 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Prosthesis-Related Infections, Hip Prosthesis Infection
Effect of Sonication on Periprosthetic Joint Infection Treatment Strategy.
It is not known in the literature how much sonication affects the patient's treatment. Another important issue is that the place of this method in diagnosis is not clear.
- Conditions
- Prosthesis-Related Infections, Hip Prosthesis Infection, Joint Infection, Biofilm
- Trial name
- NCT04304885
- Testing
- Sonication method
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Bezmialem Vakif University
Infection of Total Hip Joint Prosthesis
Orthopedic Digital Planning for Total Hip Arthroplasties
Preoperative planning has been carried out to allow for response preparedness . A layer technique is usually used with standard radiography .The investigators have a record of routine preoperative radiographs by standard…
- Trial name
- ORTHOPLAN (NCT02842684)
- Testing
- TraumaCad software
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Toulouse
Chronically Infected Total Hip of Knee Prosthesis
Cost-effectiveness Evaluation of One Stage Versus Two Stage Exchange for Chronically Infected Total Hip and Total Knee Prostheses
Chronic infection after total joint arthroplasty generally requires implant exchange. Two stage exchange is considered as the gold standard procedure. However, some authors suggest that one stage exchange may be as effective.
- Trial name
- IPRO (NCT02651961)
- Testing
- Exchange of total hip or knee arthroplasty on same time, Exchange of total hip or knee arthroplasty in two time
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Infection of Total Hip Joint Prosthesis, Infection of Total Knee Joint Prosthesis
Topical Vancomycin for Infection Prophylaxis in TJA
11% of the general population undergo total hip arthroplasty (THA) in their lifetime and 7% undergo total knee arthroplasty (TKA), with these rates expected to rise up to 50% by 2026.
- Trial name
- NCT04993027
- Testing
- Vancomycin Powder
- Volunteers
- 100 people
- Sponsor
- Alberta Hip and Knee Clinic
Prosthesis-Related Infections, Arthroplasty, Replacement, Hip
Exploring Novel Diagnostic Tools for Periprosthetic Joint Infection
Joint replacement is a valuable surgical intervention that improves quality of life, provides pain relief, and restores function of patients.
- Conditions
- Prosthesis-Related Infections, Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee
- Trial name
- VECTOR-PJI (NCT05582460)
- Testing
- Reporter Gene Assay, Flow Cytometry
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Rijnstate Hospital