Clinical trials: Infection Hip
Prosthetic Joint Infection, Prosthetic Infection
Susceptibility Testing of Biofilm to Guide Treatment of Periprosthetic Joint Infections
The overall purpose of this clinical treatment research project is to explore novel diagnostics that can guide the treatment of infections associated to orthopaedic implants, in order to improve patient outcomes and reduce the…
- Conditions
- Prosthetic Joint Infection, Prosthetic Infection, Hip Prosthesis Infection, Knee Prosthesis Infection
- Trial name
- NCT04488458
- Testing
- MIC or MBEC+MIC based treatment algorithm
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Vastra Gotaland Region
Periprosthetic Infection Total Hip Arthoplasty
Treatment of Acute Periprosthetic Total Hip Arthroplasty Infections
The purpose of this study is to determine the success rate of two treatments for infection after total hip replacement: single stage arthroplasty exchange (your surgeon will take out your original implants and replace them with a…
- Trial name
- NCT01712880
- Testing
- open debridement with modular exchange, one stage exchange
- Where
- United States
- Sponsor
- OrthoCarolina Research Institute, Inc.
Prosthetic Joint Infection
Abbreviated Protocol for Two-Stage Exchange
Study Type: A multi-site, parallel group, randomized trial. Study Objectives: The objective is to evaluate safety and determine preliminary efficacy of VT-X7 (Vancomycin and Tobramycin Exchanged over 7 Days).
- Trial name
- APEX (NCT04662632)
- Testing
- VT-X7 Treatment System with Tobramycin Sulfate, Standard of Care, Two-stage exchange arthroplasty
- Where
- 17 sites in United States
- Volunteers
- 76 people
- Sponsor
- Osteal Therapeutics, Inc.
Infection, Bacterial Infection
Leukocyte Depletion of Autologous Whole Blood
Leukocyte depletion of autologous whole blood prior to storage does not reduce infection rate (wound, urinary tract, other), use of antibiotic treatment and length of hospital stay but may increase retransfusion perioperatively…
- Conditions
- Infection, Bacterial Infection, Sepsis
- Trial name
- LDAWB-2001 (NCT00176124)
- Testing
- leukocyte depletion of whole blood, Leukocyte filtration/Depletion
- Where
- 3 sites in Germany
- Volunteers
- 1,089 people
- Sponsor
- Heidelberg University
Loosening, Prosthesis
Identification of Infections in Hip Arthroplasty Loosening.
Recent data showed that the rate of periprosthetic infections in patients undergoing a hip arthroplasty revision for aseptic loosening is higher than what can be ascertained with conventional methods.
- Trial name
- NCT04773054
- Testing
- Microbiological analysis of periprosthetic tissue, Histological analysis of periprosthetic tissue, Characterization of tissue microbiota
- Where
- Italy
- Volunteers
- 11 people
- Sponsor
- Istituto Ortopedico Rizzoli
Prosthetic Joint Infections of Hip, Bacteriophage Therapy
Bacteriophage Therapy for Staphylococcus Lugdunensis Prosthetic Joint Infection
This is a single-patient, phase I/II clinical trial that aims to evaluate the potential of a bacteriophage drug product to treat and prevent the recurrence of a Staphylococcus lugdunensis prosthetic joint infection of the hip.
- Trial name
- NCT07461337
- Testing
- Five phage anti-Staphylococcus aureus bacteriophage cocktail
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University of Calgary
Disorder of Hip Region
A Ten-state Cluster-randomized Controlled Trial of the Institute for Health Improvement's Project JOINTS
In 2011, IHI designed a new campaign to accelerate uptake of evidence-based practices that had been shown to prevent surgical site infections (SSI) associated with hip and knee arthroplasty.
- Trial name
- NCT02886741
- Testing
- Quality Improvement Campaign
- Volunteers
- 549 people
- Sponsor
- RAND
Urinary Catheters, Urinary Retention
Evaluating Nine-Year Sustainability After Implementing Evidence-Based Practices to Prevent Urinary Tract Infections and Overfilling of the Bladder in Patients With Hip Fracture
This study focuses on evaluating the long-term sustainability of a urinary catheter care bundle designed to prevent urinary tract infections and bladder distension in patients undergoing surgery for hip fractures.
- Conditions
- Urinary Catheters, Urinary Retention, Adherence, Documentation Skill
- Trial name
- NCT06893562
- Testing
- Safe Hands and Safe Bladder intervention
- Where
- Sweden
- Volunteers
- 750 people
- Sponsor
- Sahlgrenska University Hospital
Prosthetic-joint Infection
A Second Trial of the Abbreviated Protocol Two-Stage Exchange
Apex-2 is a multi-site, parallel group, randomized trial. Patients will be randomly assigned in a 1:1 ratio to the Experimental Arm or the Control Arm.
- Trial name
- Apex-2 (NCT05607030)
- Testing
- VT-X7 Treatment System, Two-stage exchange arthroplasty, SOC Antibiotics
- Where
- 19 sites in United States
- Volunteers
- 76 people
- Sponsor
- Osteal Therapeutics, Inc.
Delirium, Confusion
Improving Safety of Diagnosis and Therapy in the Inpatient Setting
To improve the safety of diagnosis and therapy for a set of conditions and undifferentiated symptoms for hospitalized patients, the investigators will employ a set of methods and tools from the disciplines of systems engineering…
- Conditions
- Delirium, Confusion, Mental Status Change, Back Pain
- Trial name
- PSLL2-0 (NCT04393909)
- Testing
- Diagnostic Uncertainty Educational Curriculum, Diagnostic Timeout, Patient Diagnostic (Dx) Questionnaire
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- Brigham and Women's Hospital
Radius; Deformity, Hip Osteoarthritis
Clinical Evaluation and Cost-effectiveness Analysis of 3D Digital Surgery in Traumatology
Digital surgery, in combination with patient specific instrumentation (PSI) is being used more and more in traumatology due to its proven benefits and applications.
- Conditions
- Radius; Deformity, Hip Osteoarthritis, Hip Arthritis, Hip Arthropathy
- Trial name
- NCT06603831
- Testing
- patients treated using 3D technology and Patient-Specific Instrumentation, Patients treated with conventional surgery, without using 3D technology
- Where
- Spain
- Volunteers
- 180 people
- Sponsor
- Corporacion Parc Tauli
Fractures, Bone, Stroke
Tele-Rehabilitation Pilot Evaluation Study
A proof of concept randomized controlled trial (RCT) only evaluated the National University of Singapore's (NUS) T-Rehab tele-rehabilitation (TR) system at a home setting where rehabilitation was provided on an individual level.
- Conditions
- Fractures, Bone, Stroke, Lower Limb Joint Replacement (Hip or Knee), Lower Limb Amputation
- Trial name
- NCT03409354
- Testing
- Tele-rehabilitation, Usual care
- Where
- Singapore
- Volunteers
- 14 people
- Sponsor
- National University of Singapore
Hip Prosthesis Infection
Early Discrimination of Periprosthetic Hip Infections Using Neural Networks (SEPTIC-ANNR)
The study is about the role of cellular neural networks-genetic algorithm in the diagnosis of periprosthetic hip infections. A retrospective case series of septic and aseptic loosening of primary hip arthroplasties is selected.
- Trial name
- SEPTIC-ANNR (NCT04119804)
- Testing
- cellular neural networks-genetic algorithm
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- Istituto Ortopedico Rizzoli
Hip Fractures, Covid19
COVID-19 Pandemic on Health Care and Rehabilitation Outcomes
Fragility fracture is easily associated with a clinical worsening of patients in terms of quality of life and disability in the medium and long term.
- Trial name
- HIP COVID (NCT04882670)
- Where
- Italy
- Volunteers
- 360 people
- Sponsor
- Istituto Ortopedico Rizzoli
Hip Osteoarthritis, Arthroplasty, Replacement, Hip
Preoperative Fasting and the Gut Microbiome Before Hip Replacement
Postoperative complications occur in 5-15% of patients undergoing elective primary total hip arthroplasty (THA), including periprosthetic joint infection (PJI), thrombosis, wound healing disorders, and metabolic dysregulation.
- Conditions
- Hip Osteoarthritis, Arthroplasty, Replacement, Hip, Postoperative Complications, Surgical Wound Infection
- Trial name
- PreFAST-Hip (NCT07651462)
- Testing
- Buchinger Fastenbox + intermittent fasting (20-day preoperative schedule)
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- Charite University, Berlin, Germany
Periprosthetic Joint Infection (PJI)
Is the EBJIS Definition of Prosthetic Joint Infection Meaningful in Our Clinical Practice?
This retrospective multi-center, multi-national cohort study is to validate the European Bone and Joint Infection Society (EBJIS) Definition of Prosthetic Joint Infection.
- Trial name
- NCT05117671
- Testing
- data collection to classify infection status
- Where
- 2 sites in Portugal, Switzerland
- Volunteers
- 1,554 people
- Sponsor
- University Hospital, Basel, Switzerland
Sepsis, Hip Fractures
The Association Between Preoperative Sepsis and the Mortality After Hip Fracture Surgery
The worldwide occurrence of hip fracture is high with an annual incidence of approximately 100 per 100.000 people. Mortality for patients undergoing hip fracture surgery is high with a 30-day mortality rate varying between 4.5…
- Trial name
- NCT03201679
- Testing
- Repair of hip fracture
- Volunteers
- 1,967 people
- Sponsor
- Bispebjerg Hospital
Hip Surgery
Preoperative Intravenous Omega 3 Fatty Acids Administration in Elderly Patients Undergoing Hip Surgery
The perioperative administration of n-3 fatty acids has been shown to lead to favorable effects on outcome in patients with severe surgical interventions by lowering the magnitude of inflammatory response and by modulating the…
- Trial name
- NCT00890123
- Testing
- Omegaven-IV FO
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Nizam's Institute of Medical Sciences University, India
Hip Prosthesis Infection
Does the Type of Ventilation Affect the Risk for Infections After Hip Replacements?
Background: During hip replacement surgery, there is a risk that bacteria in the operating room can cause an infection. To try and reduce this risk, some operating rooms use a special system called laminar airflow (LAF), which…
- Trial name
- NCT05932823
- Testing
- Laminary airflow
- Volunteers
- 110,000 people
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Hip Osteoarthritis, Hip Prosthesis Infection
Image Quality of EOSedge for Radiographic Evaluation of Hip Implant
EOSedge is a precise, low dose imaging system that delivers full body, high-quality images covering the full set of musculoskeletal and orthopedic exams.
- Trial name
- PreHIPEOS (NCT05615701)
- Testing
- EOSedge imaging
- Where
- France
- Volunteers
- 97 people
- Sponsor
- University Hospital, Montpellier