Clinical trials: Infection
Necator Americanus Infection
Establishing a Controlled Human Hookworm Infection Model at Leiden University Medical Center
Four healthy hookworm-naive volunteers will be exposed to 50 L3 Necator americanus larvae once and will retain infection for up to 2 years.
- Trial name
- CHHIL (NCT03126552)
- Testing
- Necator americanus L3 larvae
- Where
- Netherlands
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
HIV Infection Associated Kaposi Disease
Lenalidomide in Kaposi Disease Associated With HIV Infection
Lenakap : This multicenter, non randomized (single arm), open, phase II study aims to evaluated the efficacy of Lenalidomide in HIV-associated kaposi disease. Patients will be followed for 48 weeks.
- Trial name
- LENAKAP (NCT01282047)
- Testing
- Lenalidomide
- Where
- France
- Volunteers
- 12 people
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
HIV-1 Infection
Effects of Losartan and Antiretroviral Regimen Containing Raltegravir in Fibrosis Inflammation Mediators, Cardiovascular Risk and Neurocognitive Disorders in HIV Infected Patients Previously Effectively Treated
This is a open controlled trial in which 48 HIV-1 patients successfully treated with EFV/FTC/TDF will be randomized to one of 4 groups in equal proportion between arms (1:1).
- Trial name
- NCT01529749
- Testing
- EFV/FTC/TDF + Losartan, EFV/FTC/TDF, FTC/TDF + MK-0518
- Where
- Spain
- Volunteers
- 48 people
- Sponsor
- Felipe Garcia
HIV Infections
Trial About Hepatic Security of Antiretroviral Treatment Based on Kaletra Versus Nevirapine in Co-infected HIV/HCV Patients
In retrospective studies, acceleration of hepatic fibrosis has been seen in Nevirapine (NVP) treatment when compared with Protease Inhibitors (PI) boosted with ritonavir treatment in patients with Human Immunodeficiency Virus…
- Trial name
- NCT00661349
- Testing
- Lopinavir/ritonavir, Nevirapine
- Where
- 9 sites in Spain
- Volunteers
- 9 people
- Sponsor
- Germans Trias i Pujol Hospital
Infectious Diseases
Sensitivity Study of Diagnostic for Detection of Chagas Infection
This study is a multi-site trial assessing the sensitivity of Chagas Detect™ Plus rapid test versus standard reference tests (e.g. IFA, IHA, RIPA) for Chagas diagnosis.
- Trial name
- NCT02134548
- Where
- 2 sites in Bolivia, Chile
- Volunteers
- 1,601 people
- Sponsor
- InBios International, Inc.
HIV/AIDS, Medication Adherence
Centralized Off-Site Adherence Enhancement Program
Our proposal "Centralized Off-Site Adherence Enhancement Program" or "CARE" will develop and test an effective behavioral adherence intervention program for HIV patients with alcohol and/or substance abuse problems.
- Trial name
- CARE (NCT01409655)
- Testing
- cognitive-behavioral therapy
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of California, Los Angeles
HIV Testing
Implementation and Evaluation of an Electronic Alert to Encourage Targeted Screening for HIV Infection at Foch Hospital According to Socio-demographic Criteria
In 2013 in France, 29,000 people are reported to be unaware of their HIV status. HIV testing is a priority in France where one third of all diagnoses remain late despite 5 million annual tests.
- Trial name
- POP-UP (NCT03991767)
- Testing
- "POP-UP" electronic alert, Serology HIV
- Where
- France
- Volunteers
- 297 people
- Sponsor
- Hopital Foch
Influenza, Human
Special Drug Use Investigation for Relenza® (Zanamivir) (Prophylaxis)
The purpose of this post-marketing surveillance study is to collect information on efficacy and safety for prophylactic administration of zanamivir in clinical practice in family or persons living with patients with influenza…
- Trial name
- NCT01390792
- Testing
- Zanamivir hydrate
- Volunteers
- 622 people
- Sponsor
- GlaxoSmithKline
HIV Infections
A Study of Thalidomide in HIV-Infected Patients Who Are Receiving HAART
To ascertain the effect of thalidomide on immune responses to vaccination with polyvalent pneumococcal polysaccharide vaccine and tetanus toxoid in HIV-infected patients; particularly, on markers of immune activation and…
- Trial name
- NCT00002392
- Testing
- Thalidomide
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Rockefeller University
Sexually Transmitted Infections
Brief Intervention and/or Distribution of Free Condoms for Travelers
The objective of this study is to assess the impact of a structured intervention and/or free distribution of condoms during the pre-travel consultation on sexual risk behavior of young persons traveling alone.
- Trial name
- NCT01056536
- Testing
- Structured intervention for the prevention of sexually transmitted infections (STI)., Free condoms
- Where
- Switzerland
- Volunteers
- 1,681 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Surgical Site Infection
Air Barrier System for the Prevention of Surgical Site Infection
Airborne particles are present in all indoor environments including the operating room. Most of these particles come from the surgical staff moving around in the room, positioning of the patient during surgery, and the movement…
- Trial name
- ABS (NCT01610271)
- Testing
- Air Barrier System
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Nimbic Systems, LLC
Helicobacter Pylori Infection, Helicobacter Pylori Eradication Antibiotic
The Impact of Helicobacter Pylori Eradication on the Vaginal Microecology Change
This clinical controlled study enrolled 73 H. pylori（Helicobacter Pylori ）-infected female participants, stratified into reproductive-age and menopausal cohorts, alongside 10 non-infected controls.
- Trial name
- NCT07408271
- Testing
- rabeprazole-based triple therapy plus bismuth H. pylori eradication therapy
- Where
- China
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Hematologic Neoplasms, Gram-Negative Bacterial Infections
Ceftazidime-Avibactam PK/PD and Resistance in Hematology Patients
This is a prospective, single-arm, observational, exploratory clinical study to evaluate whether the standard fixed dose of ceftazidime-avibactam (CAZ-AVI) achieves sufficient drug exposure (pharmacokinetic/pharmacodynamic, or…
- Conditions
- Hematologic Neoplasms, Gram-Negative Bacterial Infections, Pseudomonas Aeruginosa Infection, Klebsiella Pneumoniae Infections
- Trial name
- CZA-TDM (NCT07703644)
- Testing
- Ceftazidime-avibactam, Therapeutic Drug Monitoring (TDM) and Microbiological Surveillance
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Sizhou Feng
Prosthesis-Related Infections, Arthroplasty
Dilute Betadine Lavage in the Prevention of Postoperative Infection
The purpose of this study is to examine the efficacy of a dilute betadine solution in reducing infectious complications in revision total knee arthroplasty.
- Trial name
- NCT01175044
- Testing
- Betadine Lavage, Saline Lavage
- Where
- 2 sites in United States
- Volunteers
- 505 people
- Sponsor
- Rush University Medical Center
Patient Preference, COVID-19
Patients' Experiences in a Medicalized Hotel for COVID-19 Acute Care Support
The 11th March 2020, the World Health Organization (WHO) declared the novel coronavirus Covid-19 as a pandemic. Urgent reorganization was required to give answers to the needs of this new illness.
- Trial name
- NCT04503434
- Where
- Spain
- Volunteers
- 517 people
- Sponsor
- Hospital Clinic of Barcelona
Malaria
Single-Blind, Placebo-Controlled, Randomized Study Testing Single Ascending Doses Of GSK369796 In Healthy Subjects
This study will examine safety of single doses of GSK369796 in healthy subjects, along with some test to examine how quickly GSK369796 gets in your blood, and how long it takes your body to get rid of it.
- Trial name
- NCT00675064
- Testing
- GSK369796
- Where
- United Kingdom
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
HIV/AIDS, Alcohol-Related Disorders
Common Elements Treatment Approach HIV Alcohol Reduction Trial in Zambia
This study, which is part of the Zambia Alabama HIV Alcohol Comorbidities Program funded by NIH-NIAAA, is designed to examine the efficacy of brief and in-depth cognitive behavioral therapy-based interventions to address…
- Conditions
- HIV/AIDS, Alcohol-Related Disorders, Mental Illness
- Trial name
- CHARTZ (NCT05121064)
- Testing
- Alcohol Brief Intervention, Common Elements Treatment Approach, Standard of Care
- Where
- 5 sites in Zambia
- Volunteers
- 680 people
- Sponsor
- University of Alabama at Birmingham
BK Virus (BKV) Viremia
BK Virus Infection (Viremia) Natural History in Renal Transplant Recipients
The objectives of this study is to establish the natural history of BK virus viremia and other possible opportunistic viral pathogens in renal transplants recipients.
- Trial name
- NCT01782209
- Where
- 6 sites in United States
- Volunteers
- 335 people
- Sponsor
- University of Alabama at Birmingham
Pandemic, COVID-19, Demodex Infestation
Could Wearing Face Mask Have Affected Demodex Parasite
This study aimed to examine whether wearing masks by healthy individuals during the Covid-19 pandemic created an environment for Demodex mites, by comparing it with the control group.
- Trial name
- NCT06185699
- Testing
- standard superficial skin biopsy (SSSB)
- Where
- Turkey (Türkiye)
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Nurhan Döner Aktaş
Hepatitis C Virus
Study of BMS-650032 With Peginterferon Alfa-2a Plus Ribavirin
The purpose of this study is to identify one or more doses of BMS-650032 that, when used in combination with pegylated-interferon alpha and ribavirin are safe and demonstrate sufficient activity against hepatitis C virus…
- Trial name
- NCT01030432
- Testing
- BMS-650032, Peginterferon Alfa-2a, Ribavirin
- Where
- 40 sites in United States, Argentina and 6 more
- Volunteers
- 285 people
- Sponsor
- Bristol-Myers Squibb