Clinical trials: Infants at Risk of Cerebral Palsy
Infant Development, Sensory Disorder
The Prechtl's General Movement Assessment, Hammersmith Infant Neurological Examination and Sensory Profile-2
In the Neonatal Intensive Care Unit (NICU), infants encounter many sensory stimuli (excessive noise, bright lights, painful medical applications, etc.) that are not present in the uterus.
- Conditions
- Infant Development, Sensory Disorder, Sensory Processing Disorder, Motor Delay
- Trial name
- highrisk (NCT05217199)
- Testing
- Measurements
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
Preterm, Sensory Disorders
Evaluation of The Effectiveness of The SAFE Early Intervention Program
In this study, it was aimed to examine the effect of SAFE, which is a sensory-based, activity-oriented early intervention approach applied in an enriched environment with family cooperation, on cognitive, language, motor and…
- Conditions
- Preterm, Sensory Disorders, Cerebral Palsy
- Trial name
- NCT06930482
- Testing
- Safe early intervention, early intervention approach based on neurodevelopmental treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Gazi University
Cerebral Palsy (CP), Infant ALL
Turkish Version of the Hammersmith Neonatal Neurological Examination (HNNE)
Infants at risk are defined as an infant with a history of adverse environmental and biological factors that may lead to neuromotor developmental problems.
- Conditions
- Cerebral Palsy (CP), Infant ALL, Neurological Development, Neonatal
- Trial name
- HNNE (NCT07182513)
- Where
- Turkey (Türkiye)
- Volunteers
- 126 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Cerebral Palsy
Impact of Early Intensive Stimulation on Bimanual Function in Infants at High Risk of Unilateral CP (BB-BIM)
The aim of this study is to measure the impact of early bimanual stimulation in babies with clinical signs of underuse of one hand. The observation focuses on the developmental curve of hands use.
- Trial name
- BB-BIM (NCT04899284)
- Testing
- Early Intensive Bimanual Stimulation
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Centre Médico-Chirurgical de Réadaptation des Massues Croix Rouge Française
EEG Sleep Spindles, Motor Outcome
Sleep Spindles Organization as an Early Neural Marker of Neuromotor Outcome
The goal of this observational study is to test the effectiveness of quantitative early biomarkers in the sleep electroencephalogram (EEG), namely sleep spindles, as predictors of early sensorimotor maturation and long-term motor…
- Conditions
- EEG Sleep Spindles, Motor Outcome, Cerebral Palsy, SMA1
- Trial name
- SONNO (NCT06256887)
- Where
- 3 sites in Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- IRCCS Fondazione Stella Maris
Cerebral Palsy, Preterm Infant
Early Identification of Infants at Risk of Cerebral Palsy
This observational study aims to early identify, through a rigorous and standardized follow-up, infants at high risk for Cerebral Palsy.
- Trial name
- NCT03211533
- Where
- Italy
- Volunteers
- 99 people
- Sponsor
- IRCCS Fondazione Stella Maris
Cerebral Palsy
Locomotor Learning in Infants at High Risk for Cerebral Palsy
The objective of this project is to characterize the evolution of locomotor learning over the first 18 months of life in infants at high risk for cerebral palsy (CP).
- Trial name
- NCT04561232
- Testing
- Prone and Upright Locomotor Training
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Children's Hospital of Philadelphia
Cerebral Palsy
Motor Training for Infants With Cerebral Palsy
The intervention in this study, Let's Move, is a motor intervention for infants at risk for cerebral palsy. We will test the feasibility and acceptability of the intervention as well as preliminary effectiveness.
- Trial name
- NCT04886895
- Testing
- Let's Move Motor Intervention
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Unilateral Cerebral Palsy
Multi Sensory Stimulation And Priming (MuSSAP) in Infants at Risk of Unilateral Cerebral Palsy
A pilot randomized clinical trial exploring the effect of a Multi Sensory Stimulation And Priming (MuSSAP) training on improving manual ability in infants at risk of developing unilateral Cerebral Palsy.
- Trial name
- MuSSAP (NCT05533476)
- Testing
- Multi Sensory Stimulation and Priming, Intensive Usual Care (Upper Limb)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Sint Maartenskliniek
Infants at Risk of Cerebral Palsy
A Randomized Controlled Trial of Hybrid Environmental Enrichment-Based Early Intervention in Infants at Risk of Cerebral Palsy
This randomized controlled trial aims to evaluate the effects of a hybrid environmental enrichment-based early intervention grounded in the Homeostasis-Enrichment-Plasticity (HEP®) Approach in infants at risk of cerebral palsy…
- Trial name
- NCT07116148
- Testing
- HEP-Based Early Intervention, Conventional Early Intervention
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Medipol University
Cerebral Palsy, Developmental Delay
SmarToyGym: Smart Detection of Atypical Toy-oriented Actions in At-risk Infants
The study aims to develop a SmarToyGym where sensitized, wireless toys are strategically hung and placed within reach of infants to elicit toy-oriented body and arm/hand movements.
- Conditions
- Cerebral Palsy, Developmental Delay, Stroke, Fine Motor Delay
- Trial name
- NCT02813889
- Testing
- SmarToyGym
- Where
- 2 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Infant Development, Infant,Premature
Pacifier Activated Device and Mother's Voice in Infants at High-risk for Cerebral Palsy
The study seeks to determine the efficacy of non-nutritive suck (NNS) training using a pacifier-activated device (PAM) with mothers' voice to condition suck-strength and rhythmicity, in improving the feeding and developmental…
- Conditions
- Infant Development, Infant,Premature, Hydrocephalus, Neonatal Encephalopathy
- Trial name
- NCT03230032
- Testing
- pacifier-activated device
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Cerebral Palsy
Implementation of Early Detection and Early Intervention Service Delivery in Infants at Risk for Cerebral Palsy to Promote Infants' Psychomotor Development and Maternal Health
The BORNTOGETTHERE consists of improving health programs for early detection and surveillance of Cerebral Palsy (CP) by implementing the first International Clinical Practice Guidelines (Novak et al, 2017) in multiple sites in…
- Trial name
- BornTogether (NCT04622787)
- Testing
- Knowledge translation
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- University of Pisa
Cerebral Palsy, Cerebral Palsy (CP)
Coaching, Learning, Empowerment in Cerebral Palsy - a 6-Week Integrated PT/OT Caregiver "Primer" Bootcamp for Infants Diagnosed With or at High Risk for Cerebral Palsy
This study focuses on the caregiver's knowledge, comfort, and confidence in interacting with and supporting their infant with Cerebral Palsy (CP) or at high risk for Cerebral Palsy.
- Conditions
- Cerebral Palsy, Cerebral Palsy (CP), Cerebral Palsy Infantile, Infant
- Trial name
- CIRCLE-CP (NCT07469514)
- Testing
- Caregiver knowledge, Physical therapy, Occupational Therapy
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of California, San Francisco
Prematurity, Cerebral Palsy
NEO Rehab for Infants at Risk of Cerebral Palsy
Premature infants are at increased risk of developing cerebral palsy (CP). Early interventions for at risk infants have the potential to decrease disease severity and improve quality of life.
- Trial name
- NCT03372590
- Testing
- NICU-based rehabilitation bundle, Standard of care
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Virginia
Cerebral Palsy, Prematurity
NEO Rehab Program for Premature Infants at Risk for Cerebral Palsy
The goal of this project is to investigate the acceptability, feasibility and fidelity of an innovative NICU rehabilitation program that will include six multimodal, gestational age (GA) appropriate, parent-administered…
- Conditions
- Cerebral Palsy, Prematurity, Early Intervention, Family Centered Care
- Trial name
- NCT04330859
- Testing
- NeoRehab Bundle, Routine care
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Virginia
Infant, Cerebral Palsy
Early Support and Physiotherapy for Children and Their Motor Skills
The App-eMot-Quali project proposed here is the first phase in the implementation of a care pathway supported by a digital tool.
- Conditions
- Infant, Cerebral Palsy, Neonatal
- Trial name
- App-eMot-Quali (NCT04523441)
- Testing
- Focus group, Semi-directive interview
- Where
- France
- Volunteers
- 37 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Cerebral Palsy
Feasibility of an In-home Standing and Walking Intervention for Infants With and at High Risk of Cerebral Palsy
The purpose of this study is to evaluate the feasibility and begin to evaluate the effect of an intensive in-home standing and walking intervention for infants with or at high risk of cerebral palsy.
- Trial name
- NCT05781438
- Testing
- In-home standing and walking intervention
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Southern California
Cerebral Palsy
Study of Parental Stress and Care Consumption Until 24 Months Corrected Age of Infants at a High Risk of Developmental Delay, After Discharge From Neonatal Intensive Care
Cerebral palsy (CP) is the leading cause of motor disability in children, affecting 125,000 people in France and with 1800 new cases per year.
- Trial name
- DeStreSs (NCT05233371)
- Testing
- Parenting Stress Index (PSI), Collection of health care consumption, Assessment of parent satisfaction
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Autism, Cerebral Palsy
Near-infrared Spectroscopy and Electroencephalography to Assess Cortical Activation During Motor Tasks in Infants and Toddlers With and Without Cerebral Palsy
Background: New ways to study the brain as people move include near-infrared spectroscopy (NIRS) and electroencephalography (EEG).
- Trial name
- NCT03434080
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)