Clinical trials: Infantile Hemangiomas
Hemangioma, Infant
Topical Timolol 0.5% Solution for Proliferating Infantile Hemangiomas
The purpose of this study is to learn about a new potential use for topical timolol 0.5% aqueous solution that may help treat small uncomplicated infantile hemangiomas.
- Trial name
- NCT01147601
- Testing
- topical 0.5% Timolol
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Oregon Health and Science University
Healthy Subjects
A Comparative Study of the Pharmacokinetic Profiles of Timolol Maleate Ophthalmic Gel With Timolol Maleate Gel
The goal of this clinical trial is: 1)To evaluate the pharmacokinetic profiles and safety of 0.5% Timolol Maleate Ophthalmic Gel Forming Solution in healthy adult subjects after multiple dosing; 2)To compare the systemic exposure…
- Trial name
- NCT06813807
- Testing
- 0.5% TM
- Where
- China
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Auson Pharmaceuticals Inc.
Infantile Hemangioma
Study in Infants With Infantile Hemangioma to Compare Propranolol Gel to Placebo
There is an unsatisfied medical need for a first-line treatment of localized uncomplicated proliferating Infantile Hemangioma with a good benefit/risk profile.
- Trial name
- NCT01512173
- Testing
- propranolol gel
- Where
- 17 sites in France, Poland and 1 more
- Volunteers
- 82 people
- Sponsor
- Pierre Fabre Dermatology
Infantile Hemangioma
Optimizing Timolol Maleate Treatment of Infantile Hemangioma by Doppler Ultrasound Examination
The purpose of this study is to assess the safety and efficacy of Timolol Maleate treatment for different depth of infantile hemangioma based on B-ultrasonography.
- Trial name
- NCT03842631
- Testing
- Timolol Maleate 0.5% Oph Soln
- Where
- China
- Volunteers
- 150 people
- Sponsor
- XiaoXi Lin
Infantile Hemangioma
Assessing the Impact of Dosage Frequency of Propranolol on Sleep Patterns in Patients With Infantile Hemangiomas
The purpose of this study is to assess the baseline sleep pattern disruption for patients starting oral propranolol at the standard BID dosing regimen compared to the control (timolol) group and to determine if there is a…
- Trial name
- NCT05479123
- Testing
- Propranolol three times a day, Propranolol twice a day, Timolol
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- The University of Texas Health Science Center, Houston
Infantile Hemangioma (IH)
Abrupt Discontinuation Versus Gradual Tapering of Propranolol in Infantile Hemangioma
Infantile hemangioma is the most common benign vascular tumor in infancy. Oral propranolol is the first-line systemic treatment for infantile hemangiomas requiring therapy.
- Trial name
- PROIHSTOP (NCT07665177)
- Testing
- Abrupt Discontinuation of Propranolol, Gradual Tapering of Propranolol
- Where
- China
- Volunteers
- 110 people
- Sponsor
- West China Hospital
Infantile Hemangioma
Study to Demonstrate the Efficacy and Safety of Propranolol Oral Solution in Infants With Proliferating Infantile Hemangiomas Requiring Systemic Therapy
There is an unsatisfied medical need for a first-line treatment of proliferating IHs with a good benefit/risk profile. Based on the recent findings of encouraging results obtained with propranolol in a series of infants with…
- Trial name
- NCT01056341
- Testing
- Propranolol
- Where
- 59 sites in United States, Australia and 14 more
- Volunteers
- 512 people
- Sponsor
- Pierre Fabre Dermatology
Infantile Hemangioma, Capillary Hemangioma
A Prospective Study on the Incidence and Related Risk Factors of Infantile Hemangioma in China
Infant hemangioma(IH) is the most common benign vascular tumor of infancy with the estimated incidence varies 1% to 12%.However, in China, the incidence of infant hemangioma and related epidemiological data remains unclear.
- Conditions
- Infantile Hemangioma, Capillary Hemangioma, Capillary Hemangiomas, Hemangioma, Capillary Infantile
- Trial name
- IH (NCT03173352)
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Hemangioma, Propranolol
Role of Propranolol as Compared to Bleomycin in Management of Hemangioma
Infantile hemangiomas are widespread vascular tumours having incidence of 10% and most of them involute spontaneously. However, they are known to be located in proximity of vital organs and can have poor cosmetic and functional…
- Trial name
- NCT05327309
- Testing
- Bleomycin
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Shaheed Zulfiqar Ali Bhutto Medical University
Infantile Hemangioma
Nadolol Versus Propranolol in Children With Infantile Hemangiomas
The purpose of this study is to assess the efficacy and safety of oral propranolol versus nadolol in patients with Infantile Hemangiomas (IH) in a randomized, controlled, double-blinded study.
- Trial name
- NCT02505971
- Testing
- Nadolol, Propranolol
- Where
- Canada
- Volunteers
- 74 people
- Sponsor
- The Hospital for Sick Children
Hemangioma
Topical Timolol for Infantile Hemangioma in Early Proliferative Phase
Infantile hemangioma (IH) is the most common benign vascular tumor in pediatric population. Oral propranolol is the treatment of choice for complicated hemangiomas.
- Trial name
- NCT02731287
- Testing
- Timolol
- Where
- 2 sites in Spain
- Volunteers
- 70 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Infantile Hemangioma
Nadolol for Proliferating Infantile Hemangiomas
The purpose of this study is to explore the efficacy and safety of Nadolol in hemangiomas of infancy. The secondary objective is to assess the feasibility of conducting a randomized controlled trial comparing nadolol with…
- Trial name
- NCT01010308
- Testing
- Nadolol
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- The Hospital for Sick Children
Infantile Hemangioma, Very Low Birth Weight Infants
Timolol for the Prevention of Proliferation of Infantile Hemangioma (TiPPIH Trial)
The purpose of this trial is to see if a topical beta blocker is effective in preventing the proliferation of infantile hemangioma.
- Trial name
- TiPPIH (NCT01434849)
- Testing
- topical 0.5% Timolol maleate
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Alice K. Gong
Infantile Hemangioma (IH)
Oral Propranolol Versus Fractional Carbon Dioxide CO2 Laser Assisted Delivery of Topical Timolol for Treatment of Infantile Hemangioma
To assess and compare the efficacy of systemic beta-blocker therapy with the efficacy and safety of fractional carbon dioxide laser-assisted delivery of a topical beta-blocker solution in the treatment of infantile hemangioma.
- Trial name
- NCT07560332
- Testing
- Propranolol 1, Fractional CO2 laser with topical timolol
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Hemangioma
Topical Timolol Gel for the Treatment of Infantile Hemangiomas
We plan to conduct a study, to see how safe and effective timolol maleate 0.5% gel-forming solution is for infantile hemangiomas (IH) and the response of hemangiomas to timolol maleate 0.5% .
- Trial name
- NCT02145884
- Testing
- timolol maleate 0.5% gel
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Rady Children's Hospital, San Diego
Hemangioma
A Study of CCCTC-binding Factor (CTCF) in Infantile Hemangiomas
The purpose of this study is to evaluate the genotype of CTCF, a proven transcription factor, in patients with infantile hemangiomas and to monitor tumor growth.
- Trial name
- NCT00974129
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Yale University
Hemangioma
Immune Suppression Of Infants Treated With Steroids
The goal of this study is to clarify the degree of immune suppression in infants requiring therapy and to create guidelines for evaluation and prevention of infection in infants on oral steroids for hemangiomas.
- Trial name
- NCT00433940
- Testing
- Prednisolone
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Medical College of Wisconsin
Hemangiomas of Infancy
Hemangioma Growth During the First 6 Months of Life
One of the most important and unique characteristics of infantile hemangiomas is their dramatic growth during early infancy. Most hemangiomas are either absent at birth or barely evident as a small scratch or bruise-like area.
- Trial name
- NCT00911781
- Testing
- No intervention
- Where
- 2 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Hemangioma
Clinical Characteristics of Infantile Hemangioma
The primary purpose of this study is to identify the clinical characteristics of infantile hemangioma (IH) in our single center in China.
- Trial name
- NCT03331744
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- West China Hospital
Infantile Haemangiomas
Systemic Propranolol for the Treatment of Paediatric Patients With Infantile Hemangiomas
This is retrospective study. The patients treated with oral propranolol at a dose of 2.0 mg/kg per day. Growth parameters (height and weight) were measured at the beginning, the end of treatment and 2 years after treatment.
- Trial name
- NCT04651049
- Testing
- propranolol
- Volunteers
- 128 people
- Sponsor
- Qilu Hospital of Shandong University