Clinical trials: Induction of Labor
Induction of Labor
Dilapan-S Versus Double Balloon Catheter (CRB) for Preinduction of Labor at Term
Induction of labor (IOL) is a frequently performed procedure in obstetrics, aimed to achieve vaginal delivery when continuing the pregnancy is no longer advisable.
- Trial name
- NCT07010653
- Testing
- Higroscopic Cervical ripening, Cervical ripening via CRB
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Induction of Labor, Cervical Ripening
Balloon + Oxytocin Versus Oral Misoprostol to Induce Labor in Case of PROM (RUBAPRO2)
Premature rupture of membranes (PROM) at term complicates 6 to 22% of singleton pregnancies. Spontaneous labour occurs in 60-67% of these patients within 24h.
- Conditions
- Induction of Labor, Cervical Ripening, Premature Rupture of Fetal Membranes, Nulliparous
- Trial name
- RUBAPRO2 (NCT05568745)
- Testing
- Balloon for cervical ripening (Teleflex French Dufour catheter CH20 reference 174000), Oxytocin, Misoprostol Oral Tablet
- Where
- 5 sites in France
- Volunteers
- 152 people
- Sponsor
- University Hospital, Clermont-Ferrand
Labor Induction
Effect of Induction Admission of Shared Decision-Making on First Time Expectant Mothers', Self-efficacy, Anxiety, Birth Outcomes and Birth Satisfaction
Women's childbirth is regarded as a natural, normal and healthy process, and no interventional measures are required unless medically necessary.
- Trial name
- NCT07479524
- Testing
- decision aid
- Where
- Taiwan
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Lee Wan
Induced Labor, Cervical Ripening
Safety and Feasibility of the INGA Sensor System for Fetal and Uterine Monitoring During Cervical Ripening
The goal of this clinical trial is to learn about the safety and performance of the INGA Sensor System when used with the INGA balloon catheter during cervical ripening for labor induction in pregnant individuals at term.
- Conditions
- Induced Labor, Cervical Ripening, Cervical Ripening and Induction of Labor, Balloon Catheter for Labor Induction
- Trial name
- INGA-SENPe (NCT07846111)
- Testing
- Cervical ripening, labor Induction, uterus and fetal monitoring
- Where
- Estonia
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Aalto University
Ophthalmic Artery, Labor and Delivery
The Ophthalmic Artery Doppler Evaluation Prior to Labor Induction and Adverse Intrapartum Fetal Outcomes
The ophthalmic artery Doppler has been recently proposed as a potential "soft marker" for placental insufficiency in retrospective and observational studies, with similar clinical significance with respect to Uterine Artery (UA)…
- Conditions
- Ophthalmic Artery, Labor and Delivery, Induction of Labor, Intrapartum Fetal Distress
- Trial name
- OPHELIA (NCT07846137)
- Testing
- Ophthalmic Artery Doppler
- Volunteers
- 1,477 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Reflexology, Labor Induction
The Effect of Reflexology on Time to Delivery During Induction of Labor
This prospective, randomized controlled trial evaluates the effect of reflexology on maternal anxiety, labor duration, and pain in women undergoing labor induction with an extra-amniotic balloon (EAB).
- Conditions
- Reflexology, Labor Induction, Extra Amniotic Balloon
- Trial name
- NCT07168187
- Testing
- Reflexology
- Where
- Israel
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Wolfson Medical Center
Induction of Birth, Cervical Ripening
Open, Randomized Feasibility Trial on the Safety and Performance of the INGA Catheter for Labor Induction
This study investigates the safety and usability of the new INGA catheter for labor induction. Labor induction is common, with about one in three births being induced.
- Conditions
- Induction of Birth, Cervical Ripening, Cervical Ripening and Induction of Labor
- Trial name
- INGA-RCT (NCT07214948)
- Testing
- INGA Catheter, Currently used single balloon catheter
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Aalto University
Induction of Labor, Cervical Ripening
Safety and Usability of the Inga Catheter for Labor Induction (INGA-MDP)
The goal of this clinical study is to evaluate a new mechanical balloon catheter (INGA) used to prepare the cervix for labor induction in pregnant women at term.
- Conditions
- Induction of Labor, Cervical Ripening, Cervical Ripening and Induction of Labor
- Trial name
- INGA-MDP (NCT07414771)
- Testing
- Cervical ripening, labor induction
- Where
- 3 sites in Finland
- Volunteers
- 42 people
- Sponsor
- Aalto University
Induction of Birth, Cervical Ripening
Evaluation of the INGA Sensor System for Fetal and Uterine Monitoring During Cervical Ripening
The goal of this clinical trial is to learn about the safety and performance of the INGA Sensor System when used with the INGA balloon catheter during cervical ripening for labor induction in pregnant individuals at term.
- Conditions
- Induction of Birth, Cervical Ripening, Cervical Ripening and Induction of Labor, Balloon Catheter for Labor Induction
- Trial name
- INGA-SEN (NCT07432282)
- Testing
- Cervical ripening, labor Induction, uterus and fetal monitoring
- Sponsor
- Aalto University
Labor Induction, Cesarean Delivery
Induction of Labor After Cesarean Using Foley Alone vs. Concurrent Foley and Oxytocin
A randomized trial of patients undergoing a term (≥37 weeks) induction of labor with a history of one prior Cesarean delivery, wherein the provider intends to use a Foley catheter for cervical ripening.
- Trial name
- LIFT (NCT07006896)
- Testing
- Foley balloon, Oxytocin
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Pennsylvania
Nulliparous Women Who Scheduled for Labor Induction, Pregnancy
Ripening Approaches for Prompt Induction and Delivery - Sequential Versus Concurrent Dilapan-S and Misoprostol to Achieve Vaginal Delivery (RAPID-DS)
The purpose of this study is to compare the effectiveness of sequential versus combined multimodal cervical ripening strategies to achieve vaginal delivery within 24 hours among nulliparous patients with singleton, vertex…
- Trial name
- RAPID-DS (NCT07717502)
- Testing
- Sequential Cervical Ripening, Inpatient Combined Cervical Ripening
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- Ochsner Health System
Labor Induction
COOKACUPAIN 2 : Impact of Acupuncture on Delay of Delevery During Induced Labor With Cook's Balloon at the Beaumont Maternity in Roubaix
In France, labor induction rate is above 25.8%. Labor induction with Cook's balloon is a non-hormonal mechanical method. At Roubaix's maternity, midewifes can adminitred acupuncture therapy to help to manage this labor induction.
- Trial name
- COOKACUPAIN 2 (NCT07774442)
- Testing
- Acupuncture therapy
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier de Roubaix
Oxytocin, Labor Pain
The Stimulation To Induce Mothers Study
The investigators propose a parallel group randomized clinical trial of intrapartum nipple stimulation versus exogenous oxytocin infusion for nulliparous women undergoing induction of labor near term.
- Conditions
- Oxytocin, Labor Pain, Induction of Labor Affected Fetus / Newborn, Physiologic Effects of Drugs
- Trial name
- STIM (NCT05079841)
- Testing
- Electric breast pump, Exogenous oxytocin intravenous infusion without nipple stimulation.
- Where
- 3 sites in United States
- Volunteers
- 933 people, healthy volunteers welcome
- Sponsor
- Yale University
Labor Induction, Cesarean Birth
Implementation of a Disparities in Labor Outcomes Dashboard
This proposal will determine if a Disparities in Labor Outcomes dashboard can be used as an implementation strategy to increase compliance to an evidence-based set of interventions for labor induction in a two-site…
- Trial name
- NCT07756424
- Testing
- Disparities in Labor Outcomes Dashboard
- Where
- United States
- Volunteers
- 2,300 people
- Sponsor
- University of Pennsylvania
Nulliparous Patient With Unfavourable Cervix, Undergoing Labor Induction at Term ≥ 39SA
Prediction of Labor Induction Outcome in Nulliparous Women
Labor induction rates are increasing worldwide, yet nulliparous patients remain at high risk of failed induction and intrapartum cesarean delivery as well as prolonged labor which are associated with increased maternal morbidity…
- Trial name
- PREDISS (NCT07637318)
- Testing
- Vaginal sample
- Where
- France
- Volunteers
- 190 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Labor Induction
Pain Control for Cervical Ripening Balloon
No standard of care exists for pain management during cervical ripening balloon placement. The purpose of this study is to evaluate if vaginal topical lidocaine reduces pain related to cervical ripening balloon placement during…
- Trial name
- NCT07268118
- Testing
- topical vaginal application lidocaine gel
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Beth Israel Deaconess Medical Center
Labor Induction, Cervical Ripening and Induction of Labor
Cervical Ripening Balloon, 3 Hours vs 12 Hours Placement
The goal of this clinical trial is to learn if a shorter duration of cervical ripening balloon (CRB) placement can reduce the time to delivery in pregnant women undergoing induction of labor.
- Trial name
- NCT07689357
- Testing
- Cook Cervical Ripening Balloon 3 hours, Cook Cervical Ripening Balloon 12 hours
- Where
- Israel
- Volunteers
- 164 people
- Sponsor
- Rambam Health Care Campus
Induction of Labor, Vaginal Delivery
Efficacy and Safety of Oral Misoprostol 25 μg vs. Vaginal Dinoprostone in Induction of Labor at Term
Labor induction is a common medical technique. There is no consensus on which technique is better than the others. Misoprostol is an analogue of Prostaglandin E1 previously used off-label in labor induction.
- Conditions
- Induction of Labor, Vaginal Delivery, Cesarean Section
- Trial name
- MISODINO (NCT04955847)
- Where
- France
- Volunteers
- 706 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Pregnancy, Induction of Labor
Natural Cervical Ripening to Prevent Pharmacological Induction of Labor - a Pilot Study.
As of today, around 25% of all vaginal births happen after induction of labor (IOL). The internal guidelines of the University Hospital Zurich currently recommend pregnant women with a non-insulin dependent gestational diabetes…
- Conditions
- Pregnancy, Induction of Labor, Gestational Diabetes Mellitus (GDM)
- Trial name
- Cervinat (NCT07587632)
- Testing
- Membrane sweaping and Breast massage
- Where
- Switzerland
- Volunteers
- 74 people
- Sponsor
- University of Zurich
Pregnancy, Induction of Labor
Is Nipple Stimulation Effective for Inducing Labor and Acceptable to Patients, Nurses, and Providers?
In this study the investigators will be testing the use of the Symphony PLUS® breast pump for nipple stimulation. Typically, breast pumps are used to start breast milk production and collect breast milk in patients after…
- Trial name
- NSAIL (NCT07588529)
- Testing
- Electric breast pump for nipple stimulation, induction of labor
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Kansas Medical Center