Clinical trials: Induction of Anesthesia
Pre-Eclampsia
Restrictive Fluid Therapy in Severe Preeclampsia
Introduction: Pre-eclampsia is a multifactorial syndrome which occurs in hypertension and proteinuria in pregnant women over 20 weeks gestation.
- Trial name
- NCT02214186
- Testing
- Restrictive Fluid Therapy
- Where
- Brazil
- Volunteers
- 46 people
- Sponsor
- University of Sao Paulo General Hospital
Apneic Oxygenation
A "Less-rapid" Sequence Anesthetic Induction/Intubation Sequence? Does Apneic Oxygenation by Means of an Oxygenating Laryngoscope Blade Prolong the "Duration of Apnea Without Desaturation" in Paralyzed Non-obese and Morbidly Obese Patients?
The study will test the efficacy of the Pentax AWSTM video laryngoscope (VLS) equipped with a P Blade (Figure 1) as the means to provide Apneic Oxygenation (AO) and prolong Duration of Apnea Without Desaturation (DAWD) in…
- Trial name
- NCT02943629
- Testing
- Apneic oxygenation: Eight minute, Without apneic oxygenation, Apneic oxygenation: five minutes
- Sponsor
- Vanderbilt University
Blood Pressure Monitoring
Measurement Agreement Between IBP and NIBP During Induction of Anesthesia in High Risk Patients
The AGREE-BP study aims to evaluate how closely blood pressure measurements taken with an automated upper-arm cuff agree with measurements taken through a small plastic tube placed in an artery, called an arterial catheter…
- Trial name
- AGREE-BP (NCT07870356)
- Testing
- non-invasive oscillometric blood pressure monitoring
- Where
- Austria
- Volunteers
- 120 people
- Sponsor
- Medical University of Graz
Burst Suppression, General Anesthesia
Interrater Variability for the Identification of Anesthetic-induced Burst Suppression EEG
Burst suppression describes a specific EEG pattern that can generally indicate a too deep general anesthesia. The pathophysiology of anesthetic-induced Burst Suppression may be distinctly different from the pathophysiology of…
- Conditions
- Burst Suppression, General Anesthesia, Electroencephalogram
- Trial name
- NCT05508386
- Testing
- MATLAB-based interface, showing 50 EEG traces, classification of the EEG-pattern as Burst Suppression possible, yes, no.
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Hypotension
Haemodynamic Response to General Anaesthesia in Healthy Orthopaedic Patients
Continuous cardiovascular monitoring as part of management of high-risk surgical patients is widely practiced, however its role in low-risk surgical patients is unclear.
- Trial name
- HRespToAS (NCT02834000)
- Testing
- LiDCO rapid™ CNAP monitoring
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Post Induction Hypotension, Postoperative Morbidity
Preoperative Carotid Doppler Ultrasound Parameters for Prediction of Post-Induction Hypotension in Elective Non-Cardiac Surgery
This prospective observational study aims to evaluate the predictive value of preoperative carotid Doppler ultrasound parameters, including carotid velocity-time integral (carotid VTI) and corrected carotid flow time (ccFT), for…
- Trial name
- NCT07488182
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Necmettin Erbakan University
Anesthesia, General
Comparison of Sugammadex (Org 25969) With Neostigmine as Reversal Agents for Rocuronium or Vecuronium at Reappearance of T2 (P05960)
The purpose of this study was to demonstrate in adult participants faster recovery from a neuromuscular block induced by either rocuronium or vecuronium after reversal at reappearance of T2 (the amplitude of the first response of…
- Trial name
- NCT00451217
- Testing
- Sugammadex, Neostigmine
- Volunteers
- 198 people
- Sponsor
- Merck Sharp & Dohme LLC
Spinal (Fusion) Surgery, Total Intravenous Anesthesia
Comparison of Hemodynamic Responses During Anesthesia Induction Using Eleveld and Schnider
This randomized prospective study aims to compare the effects of two target-controlled infusion models, the Schnider and Eleveld models, on anesthetic depth and hemodynamic responses during anesthesia induction in adult patients…
- Conditions
- Spinal (Fusion) Surgery, Total Intravenous Anesthesia, Target Controlled Infusion of Propofol, Anesthesia Depth Monitoring
- Trial name
- NCT07586189
- Testing
- TCI Propofol Injection Models- Eleveld, TCI Propofol Injection Schnider
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul University
Tachycardia
Study Evaluating the Efficacy and Safety of Remifentanil in a Rapid Sequence Induction for Fragile Subjects
The primary objective is to determine whether, during a rapid sequence intubation by etomidate, and succinylcholine Sellick maneuver, the administration of remifentanil at 2 different dosages (0.5 and 1.0 microgram per kg body…
- Trial name
- NCT01259648
- Testing
- 0.5 µg/kg remifentanil, 1.0 µg/kg remifentanil, NaCl
- Where
- 2 sites in France
- Volunteers
- 75 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Anesthesia
EEG-fMRI Experiments During Anesthesia Induction With Propofol
This observational study aims to investigate healthy cortical and subcortical neural processes involved in generating intrinsic alpha oscillations during induction of general anesthesia with propofol.
- Trial name
- NCT06179719
- Testing
- Propofol, visual flickering stimulation at the alpha frequency
- Where
- 2 sites in Germany
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Altered State of Consciousness, General Anesthetics
Correlating EEG Dynamics With Consciousness Alteration Under Anesthesia
This prospective observational study is designed to investigate and compare the dynamic features of whole-brain electroencephalogram (EEG) during the induction of unconsciousness using various anesthetic agents with distinct…
- Trial name
- NCT07410702
- Testing
- Anesthetic Agents
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Huazhong University of Science and Technology
General Anesthetics
Changes in Autonomic Nervous Activity and Blood Pressure After Anesthesia Induction: Remimazolam Versus Propofol
The goal of this clinical trial is to compare the effects of changes in autonomic nervous activity on changes in blood pressure after anesthesia induction between propofol and remimazolam in patients undergoing low-risk surgery.
- Trial name
- NCT05635201
- Testing
- Anesthesia induction with propofol, Anesthesia induction with remimazolam
- Where
- South Korea
- Volunteers
- 78 people
- Sponsor
- Daegu Catholic University Medical Center
Hypotension on Induction
Carotid Artery Corrected Flow Time and Respiratory Variation of Blood Flow Peak Velocity for Prediction of Hypotension After Induction of General Anaesthesia in Adult Patients With Chronic Liver Disease
Baseline Measurements For the ultrasound parameters, it is the average of three readings In supine position . The investigators will continuously monitoring during induction and 10 minutes after.
- Trial name
- NCT07370103
- Where
- Egypt
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Pediatric, ED95
The ED95 of Single Intravenous Bolus Remimazolam Besylate in Pediatric Patients During General Anesthesia Induction
Due to the incomplete development of systems and low pain thresholds in the pediatric population, good general anesthesia is required during the perioperative period to ensure the smooth progress of the surgery.Propofol is often…
- Conditions
- Pediatric, ED95, Sedation, General Anesthesia
- Trial name
- NCT06061159
- Testing
- Remimazolam besylate
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Residual Neuromuscular Block, Neuromuscular Blockade Monitoring
Comparison of Sugammadex and Sugammadex-neostigmine Combination in the Antagonism of Moderate Neuromuscular Block
In this prospective randomized controlled study the investigators compare the sugammadex-neostigmine combination and single dose sugammadex in terms of side effects and cost for the antagonism of moderate neuromuscular block…
- Trial name
- NCT05228223
- Testing
- Neuromuscular monitoring, reverse of NMB with sugammadex, reverse of NMB with Sugammadex and neostigmin low dose
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Ankara City Hospital Bilkent
Immunotoxicity, Anesthesia
Anesthetic Depth Effects Upon Immune Competent Cells
Anesthesia depth affects the proliferation of lymphocytes to NK-cells and memory T-cells effect and the phagocytosis activity of macrophages in healthy patients.
- Conditions
- Immunotoxicity, Anesthesia, Inert Gas Narcosis
- Trial name
- BIS-MA (NCT02794896)
- Testing
- High dose propofol, fentanyl and sevoflurane, Low dose propofol, fentanyl and sevoflurane
- Where
- Germany
- Volunteers
- 16 people
- Sponsor
- Heidelberg University
Propofol Injection Pain in Children
Determining if the Buzzy® Personal Pain Relief Device Reduces Injection Pain of Propofol as Much as Intravenous Lidocaine in Children
Propofol is a drug commonly used for induction of general anesthesia in children as well as adults; however, propofol can cause pain on injection, possibly more frequently in children.
- Trial name
- NCT07770581
- Testing
- Buzzy device, Intravenous lidocaine
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Obesity
The Influence of Induction Anesthetic Agents on Serum Cortisol Concentration in Morbidly Obese Patients.
The effect of etomidate administration on the adrenal cortex in obese patients is still unclear. The objective of the study was to determine the influence of single dose of etomidate on cortisol secretion in morbidly obese.
- Trial name
- NCT01930019
- Testing
- Intravenous administration of the induction agent of general anesthesia (etomidate or thiopental)
- Where
- Poland
- Volunteers
- 82 people
- Sponsor
- Military Institute od Medicine National Research Institute
General Anesthesia, Prostate Cancer
Binaural Sound for Remimazolam Induction
It is important to decrease the time-to-loss of consciousness and anesthetics dose of remimazolam for general anesthesia induction.
- Conditions
- General Anesthesia, Prostate Cancer, Uterine Myoma
- Trial name
- NCT06099977
- Testing
- Binaural sound
- Where
- South Korea
- Volunteers
- 72 people
- Sponsor
- Gangnam Severance Hospital
Fasting Period, Intravascular Volume
The Impact of Preoperative Fasting Period on Cardiac Index Variability After Anesthesia Induction in Pediatric Patients
The minimum period of fasting recommended by the 'American Society of Anesthesiologists' for the preoperative period is 6 hours for solid foods and 2 hours for clear liquids.
- Trial name
- NCT03406481
- Where
- Turkey (Türkiye)
- Volunteers
- 85 people
- Sponsor
- Marmara University