Clinical trials: Induction Anesthesia
Lower Extremity Fracture
Atropine Versus Glycopyrrolate in Preventing Spinal Anesthesia Induced Hypotension in Lower Limb Surgeries
A study to compare between intravenous atropine and glycopyrrolate in preventing spinal anesthesia induced hypotension in patients undergoing major lower limb orthopedic surgeries.
- Trial name
- NCT03580889
- Testing
- Atropine, Glycopyrrolate, Normal Saline Flush, 0.9% Injectable Solution
- Where
- Nepal
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- B.P. Koirala Institute of Health Sciences
Cardiac Surgery
Post Operative Hemodynamic Function After Anesthetic Induction With Etomidate for Cardiac Surgery With ECC
Because of its hemodynamic safety, etomidate is widely used for anaesthesia induction of cardiac surgery. It can also cause adrenal insufficiency during the following 48 hours ( 11 betahydroxylase inhibition ).
- Trial name
- NCT00451776
- Testing
- etomidate, propofol
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Morbid Obesity, Opioid-Related Disorders
Recovery of Ventilation After General Anesthesia in Morbidly Obese Patients
This is an observational study of morbidly obese patients recovering from general anesthesia after weight-loss surgery. The investigators aim to assess ventilatory function and how this is influenced by the diagnosis of…
- Conditions
- Morbid Obesity, Opioid-Related Disorders, Surgery--Complications, Sleep Apnea Syndromes
- Trial name
- NCT03925610
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Stanford University
Post-induction Hypotension (PIH), Geriatric Patient
Incidence and Risk Factors of Post-Induction Hypotension in Geriatric Cancer Patients
This observational clinical study aims to investigate the incidence and risk factors of post-induction hypotension (PIH) in geriatric cancer patients undergoing surgery under general anesthesia.
- Conditions
- Post-induction Hypotension (PIH), Geriatric Patient, Oncologic Disease, Hemodynamic Effects of General Anesthesia
- Trial name
- NCT07294040
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Dolunay ARIK
General Anesthesia
Effects of Intravenous Lidocaine on ED50, ED95 and NTI Values of Propofol Induced Unconsciousness
The effect of intravenous lidocaine on ED50 and ED95 of propofol, which causes unconsciousness, is unclear. In addition, it is not clear whether the depth of anesthesia induced by propofol changes when lidocaine is used in…
- Trial name
- NCT05573191
- Testing
- Lidocaine, Normal saline
- Where
- 2 sites in China
- Volunteers
- 100 people
- Sponsor
- General Hospital of Ningxia Medical University
Anesthesia
A Study of Changes in Heart Function and Blood Flow in People Receiving Anesthesia
The purpose of this study is to understand changes in heart function (how the heart pumps blood) and blood flow in people who receive general anesthesia during surgery.
- Trial name
- NCT05954832
- Testing
- Echocardiography
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Anesthesia, Neurotoxicity
A Study to Compare the Long-term Outcomes After Two Different Anaesthetics
There is considerable evidence that most general anaesthetics modulate brain development in animal studies. The impact is greater with longer durations of exposure and in younger animals.
- Conditions
- Anesthesia, Neurotoxicity, Child Development
- Trial name
- TREX (NCT03089905)
- Testing
- Sevoflurane, Remifentanil, Dexmedetomidine
- Where
- 21 sites in United States, Australia and 2 more
- Volunteers
- 450 people
- Sponsor
- Murdoch Childrens Research Institute
Insomnia
Study on the Efficacy and Safety of Anesthesia-Induced Sleep Therapy for Refractory Insomnia
The incidence of refractory insomnia is rising annually, with traditional therapies offering limited efficacy. Anesthesia-Induced Sleep (AIS), involving anesthetic infusion like dexmedetomidine, is emerging.
- Trial name
- NCT07255027
- Testing
- Dexmedetomidine and conventional oral drug, Conventional oral drug therapy
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Airway Management, Positive End Expiratory Pressure
Airway Effects of PEEP During Anesthesia Induction.
This study investigates airway effects of PEEP during maskventilation at anesthesia induction. Four patient groups will be ventilated with different PEEP and driving pressures to evaluate time to open airway after start of…
- Conditions
- Airway Management, Positive End Expiratory Pressure, Mask-ventilation, Anesthesia Induction
- Trial name
- NCT02920879
- Testing
- PEEP-level, driving pressure
- Volunteers
- 120 people
- Sponsor
- Region Örebro County
Hemodynamics, Postoperative Recovery
Effect of Ciprofol Infusion for Induction and Maintenance on Hemodynamics and Postoperative Recovery
To study the Effect of Ciprofol Infusion for Induction and Maintenance of anesthesia on Hemodynamics and Postoperative Recovery in Patients Undergoing Thoracoscopic Lobectomy:a randomized, controlled trial.
- Conditions
- Hemodynamics, Postoperative Recovery, Anesthesia
- Trial name
- NCT05664386
- Testing
- propofol, ciprofol
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Xiumei Song
Anesthesia-induced Negative Hemodynamic Effects
Atropine-effect During Propofol/Remifentanil Induction
Remifentanil is a widely used potent intravenous opioid with the advantage of having a short time of action. Compared to other opiates however remifentanil generates more intense hemodynamic side-effects.
- Trial name
- NCT01871922
- Testing
- Atropine
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- University Medical Center Groningen
Hypotension During Surgery
Electrical Acupoint Stimulation Reduces Intrathecal Anesthesia Induced Hypotension
The parturients may suffer from hypotension after spinal anesthesia and the incidence could be as high as 70-80% when pharmacological prophylaxis is not used.
- Trial name
- EARTH (NCT05724095)
- Testing
- high frequency acupoint stimulation, low frequency acupoint stimulation, electrodes attached
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Zhihong LU
Gastric Ultrasonography, Gastric Insufflation
Ventilation and Gastric Insufflation During Three Levels of Inspiratory Pressure During Mask Ventilation
Pulmonary aspiration of gastric contents is one of the leading causes of general anesthesia-related mortality. Gastric insufflation during positive pressure mask ventilation increases the gastric volume, and consequently the risk…
- Conditions
- Gastric Ultrasonography, Gastric Insufflation, Mask Ventilation
- Trial name
- NCT05020548
- Testing
- peak inspiratory pressure 10 cmH2O, peak inspiratory pressure 15 cmH2O, peak inspiratory pressure 20 cmH2O
- Where
- Egypt
- Volunteers
- 111 people
- Sponsor
- Kasr El Aini Hospital
Emergence Delirium
Emergence Delirium in Children: Total Intravenous Anesthesia With Propofol and Remifentanil Versus Inhalational Sevoflurane Anesthesia
Emergence delirium (ED) refers to a wide variety of behavioural disturbances that are commonly seen in children following emergence from anesthesia.
- Trial name
- NCT00885443
- Testing
- Propofol, sevoflurane
- Where
- Canada
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Diabete Type 2, Regurgitation
Investigation of Gastric Emptying by Gastric Ultrasonography in Diabetic Patients Treated With GLP-1 Receptors
Treatment with semaglutide slows down gastric emptying , food remains in the stomach for a longer period of time. This slowing has important implications for anesthesia management.
- Conditions
- Diabete Type 2, Regurgitation, Pulmonary Aspiration During Anaesthetic Induction
- Trial name
- SAGUSE (NCT07506356)
- Where
- Switzerland
- Volunteers
- 38 people
- Sponsor
- University Hospital, Geneva
Middle Aged Patients, Sevoflurane
Minimal Alveolar Concentration of Sevoflurane Inducing Isoelectric Electroencephalogram
Sevoflurane can abolish movement or adrenergic response to noxious stimulus. In order to investigate the effect of sevoflurane on cerebral electrical activity, we determined the MAC of sevoflurane inducing isoelectric…
- Conditions
- Middle Aged Patients, Sevoflurane, General Anesthesia
- Trial name
- NCT01662622
- Testing
- Sevoflurane
- Where
- China
- Volunteers
- 31 people
- Sponsor
- Huazhong University of Science and Technology
Preeclampsia
ST- Depression on Electrocardiogram During Caesarean Section in Regional Anaesthesia in Women With Preeclampsia
The investigators examined whether there was a difference in the occurrence of ST depressions after injection of five or ten units of oxytocin, in preeclamptic patients delivered by caesarean section (CS) under regional…
- Trial name
- NCT01530230
- Testing
- oxytocin
- Where
- Sweden
- Volunteers
- 25 people
- Sponsor
- Uppsala University Hospital
Post Spinal Anesthesia Shivering
Nebulized vs. IV Ketamine in Preventing Shivering Post Spinal Anesthesia
Shivering is an involuntary muscle activity, often triggered by hypothermia, that can occur after anesthesia. This is known as postanesthetic shivering (PAS) and is a common issue that increases oxygen demand, raises the risk of…
- Trial name
- NCT07055828
- Testing
- Ketamine, Intranasal ketamine, Normal Saline
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Tanta University
General Anesthesia-Induced Altered Consciousness
Brain Activity and Changes in Consciousness During General Anesthesia
This study aims to investigate how general anesthetics alter brain activity and consciousness across different age groups. The study will evaluate four anesthetic agents with different mechanisms of action: propofol, remimazolam…
- Trial name
- NCT07836205
- Testing
- Propofol (Group P), Remimazolam group, Esketamine group
- Where
- China
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Beijing Chao Yang Hospital
Cardiac Congenital Defects
Volume Versus Pressure Ventilation on Lung Atelectasis
This prospective randomized comparative study, to assess post-operative lung atelectasis by comparing calculated lung score using ultrasound between pediatric patients intubated with LMA (laryngeal mask airway) under volume…
- Trial name
- NCT06076395
- Testing
- LMA (Laryngeal Mask Airway)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Kasr El Aini Hospital