Clinical trials: Indeterminate Thyroid Nodules
Thyroid Nodule, Thyroid Cancer
Clinical Validation of a Molecular Signature to Detect Cancer in Thyroid Nodules With Indeterminate Cytology
1. Principal objective: The primary objective of this study is to validate the diagnostic performance of a Dx15 molecular test based on molecular transcriptomic signatures previously identified in distincts cohorts of samples to…
- Trial name
- CITHY (NCT02225509)
- Testing
- FNA biopsy for thyroid nodule(s)
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Diaxonhit
Thyroid Nodule, Thyroid Cancer
Assessment the Cancer Risk of Indeterminate Thyroid Nodules Through Integration of Clinical, Ultrasonographic and Multiomic Features
Indeterminate thyroid nodules have a mild risk of malignancy (15-30%). The aim of our study is to individuate new biomarkers of thyroid carcinoma through multiomic analyses of blood samples and of specimen samples of patients…
- Trial name
- THYOMICS (NCT05428371)
- Testing
- Multiomic analyses of blood and surgical specimens
- Where
- Italy
- Volunteers
- 256 people
- Sponsor
- University of Cagliari
Thyroid
Randomized Trial Comparing Performance of Molecular Markers for Indeterminate Thyroid Nodules
The purpose of this study is to compare the performance of Afirma GSC and ThyroSeq v.3 in indeterminate thyroid nodules to determine which test can allow more patients to avoid unnecessary surgery and preserve quality of life.
- Trial name
- NCT02681328
- Testing
- Afirma GEC, ThyroSeq v.2, Afirma GSC
- Where
- United States
- Volunteers
- 328 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Indeterminate Bethesda III Thyroid Nodules
Radiofrequency Ablation for BIII Thyroid Nodules
The purpose of this observational chart review study is to evaluate the efficacy and safety of Radiofrequency Ablation (RFA) for treatment of indeterminate thyroid nodules before and after RFA procedure.
- Trial name
- NCT05189808
- Testing
- Radiofrequency Ablation
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Columbia University
Indeterminate Thyroid Nodules
Central Compartment Neck Dissection With Thyroidectomy
When a patient presents with a thyroid mass, part of the work-up may include a fine needle aspiration biopsy (FNAB). The results of the biopsy then help plan treatment.
- Trial name
- NCT01106443
- Testing
- Total Thyroidectomy + CLND, Total thyroidectomy - CLND, Hemi-thyroidectomy + CLND
- Where
- 2 sites in Canada
- Volunteers
- 128 people
- Sponsor
- University of Alberta
Thyroid Node, Indeterminate Cytology
Diagnostic Value of Molecular Cytological Analysis (CMA) and Shear Wave Elastography ShearWave (SWE) in Patients With a Thyroid Nodule With Indeterminate Cytology: Feasibility Study
The purpose of the study is to investigate the contribution of molecular cytological analysis (CMA) and shear wave elastography ShearWave (SWE) in the diagnosis of nodules with indeterminate cytology (IC)
- Conditions
- Thyroid Node, Indeterminate Cytology, Surgery Indication
- Trial name
- SWEETMAC (NCT01880203)
- Testing
- aspiration in thyroid node for Molecular Cytogenetic Analysis.
- Where
- 4 sites in France
- Volunteers
- 140 people
- Sponsor
- Centre Francois Baclesse
Thyroid Nodule
Protein Classifier for Thyroid Indeterminate Nodules
In multi-center, prospective, double-blind cohorts, PCT-DIA/MS protein classifier supported by artificial neural networks will be validated to classify thyroid indeterminate nodules.
- Trial name
- NCT04477798
- Testing
- PCT-DIA/MS
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Luo Dingcun
Indeterminate Thyroid Cytology
Clinical Validation of ThyroidPrint: A Gene Expression Signature for Diagnosis of Indeterminate Thyroid Nodules
A clinical trial is proposed, to clinically validate, in a US population, the diagnostic performance of a new genetic test (ThyroidPrint).
- Trial name
- NCT03309631
- Testing
- In vitro Diagnostic
- Where
- 6 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Thyroid Nodule
Multimodal Assessment of Malignancy in Atypia of Undetermined Significance in Thyroid Nodules Using Ultrasound and Cytology Whole-Slide Images
The prospective study aim to develop a multimodal deep learning model that integrates ultrasound images and cytological whole-slide images for more accurate malignant risk prediction of Bethesda III thyroid nodules.
- Trial name
- NCT07488325
- Testing
- Histopathology or cytopathology.
- Where
- China
- Volunteers
- 396 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Thyroid Gland
Diagnostic Value of 18F-Choline PET/CT in Patients With a Thyroid Nodule With an Indeterminate Cytology: Pilot Study
The purpose of the study is to investigate the contribution of PET-CT with F18-choline in the diagnosis of thyroid nodule with indeterminate cytology in order to guide the best indication of surgical resection.
- Trial name
- CHOCOLATE (NCT02784223)
- Testing
- Radiation : PET-CT with F18-choline examination
- Where
- France
- Volunteers
- 107 people
- Sponsor
- Centre Francois Baclesse
Thyroid Cancer
To Perform a Post-market Study of the Performance of the Idylla ThyroidPrint Assay Using Clinical Samples in Predicting the Nature of Indeterminate Thyroid Nodules (ITNs) Across Multiple Centers.
To perform a post-market study of the performance of the Idylla™ ThyroidPrint® Assay using clinical samples in predicting the nature of indeterminate thyroid nodules (ITNs) across multiple centers.
- Trial name
- NCT06849284
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Royal Cornwall Hospitals Trust
Indeterminate Thyroid Cytology
Validation of a Multi-Genetic Test for the Diagnosis of Indeterminate Thyroid Nodules
A clinical trial is proposed, to clinically validate the diagnostic performance of a new genetic test developed in Chile. It will determine the nature of thyroid nodules that have been informed as indeterminate by cytology…
- Trial name
- CT-DS (NCT03061318)
- Where
- 9 sites in Chile
- Volunteers
- 3,100 people, healthy volunteers welcome
- Sponsor
- Hernán González
Indeterminate Thyroid Nodules
Management of Indeterminate Thyroid Nodules Across Different World Regions
Thyroid carcinoma (TC) is the most common endocrine malignancy, affecting 0.2-1.5% of individuals worldwide. The rising incidence rate of TC is mostly related to the expanding use of high-quality imaging techniques, with an…
- Trial name
- NCT05851404
- Testing
- Thyroidectomy
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- University of Cagliari
Thyroid Nodule, Thyroid Neoplasm
Molecular Classifier for the Fine Needle-based Assessment of Malignancy Risk in Thyroid Nodules
This study evaluates the usefulness of molecular classifier to aid the diagnosis of malignancy in the material obtained by fine-needle aspiration biopsy (FNAB) of thyroid nodule.
- Conditions
- Thyroid Nodule, Thyroid Neoplasm, Thyroid Cancer
- Trial name
- ThyroPred-1 (NCT03392402)
- Where
- Poland
- Volunteers
- 599 people
- Sponsor
- Maria Sklodowska-Curie National Research Institute of Oncology
Low Risk, Papillary Thyroid Cancer
Radiofrequency Ablation for Management of Benign/Indeterminate Thyroid Nodules and Low Risk Papillary Thyroid Cancers
To track the outcomes of patients who have been treated with RFA and its long-term effectiveness, and to learn more about the quality of life of patients who have received RFA in this study.
- Conditions
- Low Risk, Papillary Thyroid Cancer, Radiofrequency Ablation
- Trial name
- NCT07140757
- Testing
- Questionnaire
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- M.D. Anderson Cancer Center
Thyroid Nodule
Radiofrequency Ablation in TIR3A Nodules With Negative Genetic Evaluation
The goal of this clinical trial is to demonstrate that TIR3A nodules with negative genetic test can be safely and effectively treated by radiofrequency ablation, with nodular shrinkage and improvement of clinical symptoms.
- Trial name
- NCT05765695
- Testing
- Radiofrequency ablation performed with a 19 gauge STARmed needle.
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Istituto Auxologico Italiano
Thyroid Neoplasms
Accuracy of FDG-PET Scanning to Diagnose Malignant Thyroid Nodules
The main purpose of this study is to see how well FDG-PET scans can determine the malignancy of thyroid nodules that have already been tested (and come back positive) by fine needle aspiration.
- Trial name
- NCT00537797
- Testing
- FDG-PET Scan
- Where
- 3 sites in United States
- Volunteers
- 84 people
- Sponsor
- Washington University School of Medicine
Thyroid Nodule
Myo-inositol and Selenium in Indeterminate Thyroid Nodules (TIR3a)
Thyroid nodules present a variable risk of malignancy depending on the cytological result obtained from the ultrasound-assisted thyroid fine needle aspiration biopsy.
- Trial name
- MYOSEL (NCT06736015)
- Testing
- Myo-Inositol 600 mg + Selenium 83 mcg
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Regina Elena Cancer Institute
Thyroid Nodule, Thyroid Neoplasms
FDG-PET/CT in Evaluation of Cytological Indeterminate Thyroid Nodules to Prevent Unnecessary Surgery (EfFECTS)
The purpose of this study is to determine whether the use of molecular imaging using FDG-PET/CT could prevent unnecessary diagnostic thyroid surgery in case of indeterminate cytology during fine-needle aspiration biopsy.
- Trial name
- EfFECTS (NCT02208544)
- Testing
- Diagnostic Thyroid Surgery, Ultrasound of the head and neck, FDG-PET/CT
- Where
- 15 sites in Netherlands
- Volunteers
- 132 people
- Sponsor
- Radboud University Medical Center