Clinical trials: Indeterminate Pulmonary Nodule
Lung Cancer, Precancerous Condition
Natural History of Lung Nodules Seen on CT Scans From Participants at High-Risk of Developing Lung Cancer
RATIONALE: Comparing lung CT scans from participants with lung nodules at high-risk for lung cancer may help doctors learn more about the disease and find better methods of treatment.
- Trial name
- NCT01540552
- Testing
- medical chart review, computed tomography, computer-aided detection/diagnosis
- Where
- Italy
- Volunteers
- 320 people
- Sponsor
- M.D. Anderson Cancer Center
Lung Abscess
Biomarkers for Diagnosis of Lung Nodules
A need exists for non-invasive testing to aid in clinical decision-making for Computerized Tomography (CT) scan detected lung nodules of indeterminate etiology.
- Trial name
- Nodule (NCT01085864)
- Where
- United States
- Volunteers
- 550 people
- Sponsor
- University of Colorado, Denver
Lung Cancer
Surveillance For New Lung Primaries
This clinical research protocol proposes to perform low dose helical computed tomographic (CT) scanning in 250 high-risk patients (125/year for two years) in order to detect lung carcinomas when they are small and subject to…
- Trial name
- NCT00205413
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Wisconsin, Madison
Solitary Pulmonary Nodule, Multiple Pulmonary Nodules
LungLB in Subjects Presenting With Indeterminate Pulmonary Nodules
Correlate performance of LungLB Test with outcome of a scheduled biopsy.
- Trial name
- NCT05171491
- Where
- 12 sites in United States
- Volunteers
- 425 people
- Sponsor
- LungLife AI
Lung Neoplasm
Biomarker Platform (Virtual Nodule Clinic) for the Management of Indeterminate Pulmonary Nodules
This clinical trial studies whether a biomarker platform, the Virtual Nodule Clinic, can be used for the management of lung (pulmonary) nodules that are not clearly non-cancerous (benign) or clearly cancerous (malignant)…
- Trial name
- NCT06638398
- Testing
- Computed Tomography, Diagnostic Procedure, Best Practice
- Where
- 5 sites in United States
- Volunteers
- 400 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Pulmonary Nodules, Lung Neoplasms
Longitudinal AI-Assisted Management of Indeterminate Pulmonary Nodules
Patients with indeterminate lung nodules often face a choice between continued CT surveillance and invasive investigation. This trial compares management with or without access to an AI report that matches nodules across real…
- Trial name
- NCT07895277
- Testing
- AI-Assisted Longitudinal CT Assessment and Pulmonary Nodule Management
- Where
- China
- Volunteers
- 6,000 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Lung Carcinoma, Solitary Pulmonary Nodule
18F-FSPG PET/CT in Imaging Patients With Newly Diagnosed Lung Cancer or Indeterminate Pulmonary Nodules
This clinical trial compares fluorine F 18 L-glutamate derivative BAY94-9392 (18F-FSPG) positron emission tomography (PET)/computed tomography (CT) to the standard of care fluorodeoxyglucose F-18 (18F-FDG) PET/CT in imaging…
- Conditions
- Lung Carcinoma, Solitary Pulmonary Nodule, Cigarette Smoking Behavior
- Trial name
- NCT02448225
- Testing
- Computed Tomography, fluorodeoxyglucose F-18, Fluorine F 18 L-glutamate Derivative BAY94-9392
- Where
- 2 sites in United States
- Volunteers
- 46 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Lung Cancer
Budesonide in Treating Patients With Lung Nodules at High Risk of Developing Lung Cancer
RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming, growing, or coming back. The use of budesonide may keep lung cancer from forming in patients with lung nodules.
- Trial name
- NCT00321893
- Testing
- Budesonide
- Where
- Italy
- Volunteers
- 225 people
- Sponsor
- National Cancer Institute (NCI)
Pulmonary Nodule
A Combined Biomarker Model for Risk Stratification of Indeterminate Pulmonary Nodules
This is a prospective, multicenter observational study aim at estimating the potential clinical utility of the CBM and at establishing the SOPs and protocols for a future randomized control trial.
- Trial name
- NCT06074133
- Testing
- Blood collection, Chest Computed Tomography
- Where
- 4 sites in United States
- Volunteers
- 103 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Lung Cancer
Lung Nodule Detection Using Ultra-long FOV PET/CT
Indeterminate lung nodules (6-15mm) are frequent findings in patients undergoing chest CT scanning, but adequate follow-up imaging is currently not in place to facilitate early detection, diagnosis and decision making regarding…
- Trial name
- NCT05463913
- Testing
- 18F-FDG, PET/CT imaging
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- University Medical Center Groningen
Lung Cancer, Solitary Pulmonary Nodule
4-[18F]Fluoroglutamine PET/CT in Imaging Patients With Newly Diagnosed Lung Cancer or Indeterminate Pulmonary Nodules
This clinical trial studies positron emission tomography (PET) imaging utilizing 18F-(2S,4R)4-fluoroglutamine, a glutamic acid derivative, to image patients with Newly Diagnosed Lung Cancer or Indeterminate Pulmonary Nodules.
- Conditions
- Lung Cancer, Solitary Pulmonary Nodule, Cigarette Smoking Behavior
- Trial name
- GLN (NCT03568799)
- Testing
- 18F-(2S,4R)4-fluoroglutamine
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Pulmonary Disease
DECAMP 1 PLUS: Prediction of Lung Cancer Using Noninvasive Biomarkers
DECAMP 1 PLUS aims to improve the efficiency of the diagnostic evaluation of patients with indeterminate pulmonary nodules (8-25 mm).
- Trial name
- NCT04165564
- Testing
- Institutional standard of care, Biosamples of airway and blood
- Where
- 19 sites in United States
- Volunteers
- 85 people
- Sponsor
- Boston University
Pulmonary Nodule Cm
Bronchoscopy Assisted by Electromagnetic Navigation (EMN) in the Diagnosis of Small Pulmonary Nodules
Due to CT screening, a lot of peripheral nodule not accessible to conventional endoscopy will be found. Electromagnetic navigation directed bronchoscopy (ENB) is a new technique needing validation.
- Trial name
- NCT01779388
- Testing
- Bronchoscopy
- Where
- Belgium
- Volunteers
- 120 people
- Sponsor
- European Lung Cancer Working Party
Lung Cancer, Pulmonary Nodule, Solitary
Safety and Long-term Effects of COVID-19 Vaccines in Patients With Pulmonary Tumor
The objective of this study is to assess the inoculation-related symptoms and long-term effects of COVID-19 vaccines in patients with lung cancer or pulmonary nodules in a real-world setting.
- Conditions
- Lung Cancer, Pulmonary Nodule, Solitary, Pulmonary Nodule, Multiple, COVID-19 Pneumonia
- Trial name
- CoVac-Lung (NCT04894682)
- Testing
- Vaccine inoculation against SARS-CoV-2
- Where
- China
- Volunteers
- healthy volunteers welcome
- Sponsor
- Guangdong Provincial People's Hospital
Indeterminate Pulmonary Nodule
Nodify Lung Testing for Pulmonary Nodules
The STRATIFY Study is an observational study for adults age 40 or older who have a lung nodule that is not clearly benign or cancerous. The study will enroll up to 1,000 participants at about 10-12 U.S.
- Trial name
- STRATIFY (NCT07858552)
- Volunteers
- 1,000 people
- Sponsor
- Biodesix, Inc.
Peripheral Solitary Pulmonary Nodule or Tuberculoma
Comparative Study of Nonintubated Uniport Thoracoscopic Surgery Using Thoracic Paravertebral Nerve Block Versus Intercostal Nerve Block for Peripheral Solitary Pulmonary Nodule Patients
The aim of this study is to study the safety and effectiveness of the effects on the perioperative pain control comparing between the thoracic paravertebral nerve block using the camera guided and the intrathoracic intercostals…
- Trial name
- NCT03086213
- Testing
- Propofol, Sulfentanyl, Dexmedetomidine
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Shenzhen Third People's Hospital
Lung Cancer
Early Cancer Detection Test - Lung Cancer China
Lung cancer is the most common cancer in China from both incidence and mortality rate point of view, with significantly lower 5-year survival rate than average. Early detection is the recognized solution.
- Trial name
- ECLC (NCT04216511)
- Testing
- Tumor autoantibody detection
- Where
- 3 sites in China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Bai Chunxue
Lung Nodule
Navigation Endoscopy to Reach Indeterminate Lung Nodules Versus Trans-Thoracic Needle Aspiration
This study will evaluate which procedure is the best for patients referred for biopsy of a lung nodule (growth in the lung) meeting the size and location requirements of the protocol.
- Trial name
- VERITAS (NCT04250194)
- Testing
- CT-Guided Biopsy, Navigation bronchoscopy
- Where
- 7 sites in United States
- Volunteers
- 288 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Lung Cancer
DECAMP-1: Diagnosis and Surveillance of Indeterminate Pulmonary Nodules
The goal is to improve the efficiency of the diagnostic follow-up of patients with indeterminate pulmonary nodules by determining whether biomarkers for lung cancer diagnosis that are measured in minimally invasive biospecimens…
- Trial name
- DECAMP-1 (NCT01785342)
- Testing
- Biosample and Imaging Collection
- Where
- 15 sites in United States
- Volunteers
- 489 people, healthy volunteers welcome
- Sponsor
- Boston University
Indeterminate Pulmonary Nodules, Lung Metastases
AI & Radiomics for Stratification of Lung Nodules After Radically Treated Cancer
This study will assess the utility of radiomics and artificial intelligence approaches to new lung nodules in patients who have undergone radical treatment for a previous cancer.
- Conditions
- Indeterminate Pulmonary Nodules, Lung Metastases, Second Primary Cancer, Lung Cancer
- Trial name
- AI-SONAR (NCT05375591)
- Testing
- Non-Interventional Study
- Where
- 2 sites in United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- Royal Marsden NHS Foundation Trust