Clinical trials: Incomplete Spinal Cord Injury (SCI)
Spinal Cord Injuries
Functional Electrical Stimulation During Cycling in People With Spinal Cord Injury
Neuroscience research that has identified potential for recovery (neuroplasticity) following incomplete SCI has changed clinical practice away from compensation strategies towards optimizing recovery.
- Trial name
- iCycle (NCT03834324)
- Testing
- FES
- Volunteers
- 11 people
- Sponsor
- University of Southampton
Incomplete Spinal Cord Injury (SCI), SCI - Spinal Cord Injury
FES-assisted Gait Training for Incomplete Spinal Cord Injury
Spinal cord injuries (SCI) impair neural communication, leading to difficulties in walking due to muscle weakness, altered reflexes, and impaired muscle activation below the injury.
- Trial name
- FES-SCI (NCT07645144)
- Testing
- FES-assisted gait training
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Stichting Reade
Spinal Cord Injury
Improving Spinal Cord Injury Rehabilitation Interventions by Retraining the Brain With Stimulation
The purpose of this study is to investigate whether combining a noninvasive method of brain stimulation, called Transcranial Direct Current Stimulation (tDCS), enhances the effect of training of the affected upper limbs in…
- Trial name
- NCT01539109
- Testing
- Rehabilitation, Noninvasive brain stimulation: tDCS
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Spinal Cord Injuries
Effects of Breathing Mild Bouts of Low Oxygen on Limb Mobility After Spinal Injury
Accumulating evidence suggests that repeatedly breathing low oxygen levels for brief periods (termed intermittent hypoxia) is a safe and effective treatment strategy to promote meaningful functional recovery in persons with…
- Trial name
- NCT02323945
- Testing
- AIH, Walk, Strength
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Spaulding Rehabilitation Hospital
Spinal Cord Injuries
High Intensity Exercise in Incomplete SCI
The goal of this study is to identify the comparative efficacy of high-intensity walking training in individuals with chronic, motor incomplete spinal cord injury as compared to lower-intensity walking exercise.
- Trial name
- NCT03714997
- Testing
- Walking training
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Indiana University
Spinal Cord Injuries
Brain-Controlled Spinal Stimulation Walking Therapy After Incomplete Spinal Cord Injury (SCI)
The purpose of this research is to test the effectiveness of a new therapy, called Brain-Computer Interface (BCI)-Transcutaneous Spinal Cord Stimulation (TSCS), for improving walking in people with an incomplete spinal cord…
- Trial name
- NCT06406855
- Testing
- Brain-Computer Interface-Triggered Transcutaneous Spinal Cord Stimulation (BCI-tSCS) System
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Miami
Incomplete Spinal Cord Injury
Amplify Gait to Improve Locomotor Engagement in Spinal Cord Injury
Spinal cord injury (SCI) affects ~42,000 Veterans. The VA provides the single largest network of SCI care in the nation. The lifetime financial burden of SCI can exceed $3 million. A major cost of SCI is impaired mobility.
- Trial name
- AGILE SCI (NCT04340063)
- Testing
- Gait training performed on a treadmill, Gait training performed in a Movement Amplification Environment
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injuries, Muscle Pareses
A Novel Combined Neuromodulation Therapy to Enhance Balance and Neuroplasticity
Many people with partial damages in their spinal cord (iSCI) have physical impairments such as muscle paralysis in legs which make standing balance difficult.
- Conditions
- Spinal Cord Injuries, Muscle Pareses, Fall
- Trial name
- NCT05940636
- Testing
- Activity-based rehabilitation+electrical stimulation
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- University Health Network, Toronto
Incomplete Spinal Cord Injury
Effects of Transcutaneous Spinal Direct Current Stimulation in Incomplete Spinal Cord Injury
The purpose of the study is to investigate the effects of a novel therapeutic approach with transcutaneous spinal direct current stimulation (tsDCS) to promote functional recovery and spasticity in chronic spinal cord injury…
- Trial name
- NCT03249454
- Testing
- Anodal tsDCS, Cathodal tsDCS
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- The University of Texas Health Science Center, Houston
Psychological Well-Being, Spinal Cord Injuries
Self-Management Program for AIS D SCI
About 25-51% of adults with acquired spinal cord injury (SCI) have "AIS D" SCI, the lowest severity grade of neurologic injury. Veterans with AIS D SCI generally have better outcomes in mobility, community integration, and…
- Trial name
- SCISM-D (NCT05800717)
- Testing
- SCI Self-Management for AIS D
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Spinal Cord Injuries
Locomotor Training With Exoskeleton EKSO-GT in Patients With Incomplete Motor Spinal Cord Injury in a Hospital Setting
The aim of this observational, non-controlled, non-profit study is to describe the responses to rehabilitative training with the robotic exoskeleton EKSO-GT in patients with incomplete motor Spinal Cord Injury (AIS C or D).
- Trial name
- NCT02600013
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- Montecatone Rehabilitation Institute S.p.A.
Spinal Cord Injuries (SCI)
Patient and Clinician Perceptions of Safe Ambulation in Incomplete Spinal Cord Injury
This observational cross-sectional study aims to investigate the relationship between patient and therapist perceptions of safe ambulation and objective clinical outcomes in individuals with incomplete spinal cord injury (iSCI).
- Trial name
- NCT07139652
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people
- Sponsor
- Ankara City Hospital Bilkent
Spinal Cord Injuries
Augmenting Reactive Stepping With FES After SCI
Up to 25 individuals living with chronic incomplete spinal cord injury (iSCI) who can stand but have limited ability to elicit a step without physical assistance or upper limb (U/L) support will be recruited for this study.
- Trial name
- NCT04309448
- Testing
- Perturbation-based balance training with functional electrical stimulation
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- University Health Network, Toronto
Spinal Cord Injuries, Incomplete
Protocol for Rapid Onset of Mobilization in Patients With Traumatic Spinal Cord Injury III (PROMPT-SCI III) Trial
This longitudinal cohort study will investigate the clinical benefits of early acute exercise therapy after mild spinal cord injury (SCI).
- Trial name
- PROMPT-SCI III (NCT07798310)
- Testing
- Cycling
- Where
- Canada
- Volunteers
- 107 people
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Spinal Cord Injury, Tetraplegia
Rehabilitation of the Upper Extremity With Enhanced Proprioceptive Feedback Following Incomplete Spinal Cord Injury
The purpose of this study is to determine if tetraplegic individuals with incomplete spinal cord injury (SCI) who remain unable to move their arms normally 1 year after their SCIs are able to sense and move the affected arm(s)…
- Conditions
- Spinal Cord Injury, Tetraplegia, Paresis, Plegia
- Trial name
- NCT00833105
- Testing
- AMES treatment
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- Oregon Health and Science University
Spinal Cord Injuries
Patient-therapist INTERaction During RObotic GAIT Rehabilitation After Spinal Cord Injury
INTERROGAIT will disentangle the role of Physical Therapist - Patient (Pht-Pt) interaction in robotic assisted gait rehabilitation in spinal cord injury patients.
- Trial name
- INTERROGAIT (NCT06531304)
- Testing
- Lokomat Robot Assisted Gait Training
- Where
- Italy
- Volunteers
- 55 people
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Spinal Cord Injury
Monoaminergic Modulation of Motor Function in Subacute Incomplete Spinal Cord Injury (SCI)
The primary goal of the proposed clinical trial is to investigate the combined effects of walking training and monoaminergic agents (SSRIs and TIZ) on motor function of individuals in sub-acute (2-7 mo) human motor incomplete…
- Trial name
- NCT01753882
- Testing
- Lexapro
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Shirley Ryan AbilityLab
Acute Spinal Cord Injury (SCI), Spinal Cord Diseases
NG004 in Incomplete Spinal Cord Injury Patients
This is a randomized, double-blind, placebo controlled, multicenter trial of NG004 in patients with acute traumatic incomplete cervical SCI.
- Conditions
- Acute Spinal Cord Injury (SCI), Spinal Cord Diseases, Spinal Cord Injuries, Trauma Nervous System
- Trial name
- SPROUT-2 (NCT07840196)
- Testing
- NG004
- Where
- 10 sites in Germany, Switzerland
- Volunteers
- 120 people
- Sponsor
- NovaGo Therapeutics AG
Spinal Cord Injuries
AAN Robotic Therapy in SCI
The purpose of this study is to demonstrate that a robot-aided rehabilitation protocol that follows the "assist-as needed" paradigm provide statistically significant improvements in arm and hand motor functions when compared to…
- Trial name
- NCT02803255
- Testing
- MAHI Exo-II
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- William Marsh Rice University
Spinal Cord Disease, Spinal Cord Injuries (Complete and Incomplete)
Spinal Cord Stimulation Combined With Motor Training in Non-Traumatic SCI: A Prospective Interventional Study
Interventional prospective longitudinal on the evaluation of spinal cord stimulation (SCS) assisted by motor rehabilitation training for restoring motor function in patients with non-traumatic spinal cord injury (SCI).
- Trial name
- Neuro-scs-002 (NCT07412808)
- Testing
- Spinal cord stimulation surgery (device implant) and motor rehabilitation
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Albano Luigi