Clinical trials: Implant Infection
Peri-Implantitis, Peri-implant Mucositis
Characterizing the Inflammation Around Dental Implants
The use of titanium dental implants has become a common modern treatment to restore teeth. Although the success rate of dental implants is high, inflammation around the dental implant still occurs.
- Conditions
- Peri-Implantitis, Peri-implant Mucositis, Implant Site Reaction, Implant Site Infection
- Trial name
- NCT05675241
- Testing
- Clinical examination of a dental implant, Radiological Examination, Peri-implant crevicular fluid sample collection
- Where
- Canada
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- McGill University
Transvenous Lead Extraction
Effectiveness, Complications, and Mortality of TLE in Patients.
The number of devices for cardiac pacing and defibrillation has increased in recent years. However, although they have improved in terms of quality and extended lifespan after implantation, they are not free from complications.
- Trial name
- EXTRACT (NCT05775783)
- Testing
- Transvenous lead extraction
- Where
- Poland
- Volunteers
- 702 people, healthy volunteers welcome
- Sponsor
- Medical University of Silesia
Knee Disease, Knee Infection
F18-MHF: Implants-Associated Infection Detection
Following intravenous injection of [F-18]MHF as a bolus, dynamic PET imaging of the lower limbs will be acquired for approximately 90 minutes. The acquired images will be processed and viewed on a MIMVista or similar workstation.
- Trial name
- NCT05889286
- Testing
- [F-18]MHF
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Emory University
Surgical Site Infection, Pancreatic Neoplasms
Comparison Between Wound Vacuum Dressing and Standard Closure to Reduce Rates of Surgical Site Infections
Pancreaticoduodenectomy is associated with high perioperative morbidity, with surgical site infection (SSIs) being one of the most common complications.
- Conditions
- Surgical Site Infection, Pancreatic Neoplasms, Pancreatic Cancer, Chemotherapy Effects
- Trial name
- NCT03021668
- Testing
- Prevena Peel & Place Dressing, Standard Closure of the Surgical Incision
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Johns Hopkins University
Aspiration Pneumonia, Tracheostomy Complication
Intra-laryngeal Implant for Treatment of Chronic Aspirations
This study evaluates the medical device Newbreez LD is designed to protect the lower airways from saliva, liquids and food aspirations in tracheotomized patients suffering from chronic aspirations that require specific care and…
- Trial name
- NCT03325725
- Testing
- NewBreez LD intra-laryngeal implant
- Where
- 2 sites in France
- Sponsor
- ProTiP Medical
Postoperative Wound Infection Deep Incisional Surgical Site, Prosthesis and Implants
Effect of Photodynamic Therapy on Skin Microbiome. Single Center Study (PHOMIC-II)
The overarching aim of this research project is to prevent orthopedic implant-associated infections. This study aims to investigate if PDT has an effect on bacterial skin colonization in order to improve skin antisepsis…
- Conditions
- Postoperative Wound Infection Deep Incisional Surgical Site, Prosthesis and Implants, Surgical Site Infection, Prosthetic Joint Infection
- Trial name
- NCT04618276
- Testing
- Photodynamic Therapy
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Wound Closure After Port Catheter Implantation
Comparison of Skin Adhesive to Subcuticular Suture Wound Closure After Port Placement
Port Wound Closure compares synthetic tissue adhesives with seam for cutaneous wound closure to port plant in terms of cosmetic results and time savings at comparable risk for wound infection.
- Trial name
- PWC (NCT02551510)
- Testing
- Suture, Experimental: Histoacryl®
- Where
- Germany
- Volunteers
- 128 people
- Sponsor
- Jena University Hospital
Cardiac Implantable Electronic Device Infection, Cardiovascular Infections
Improving Safety of Lead Extraction Procedures by Traction Force Sensing
Death and vascular tears occur in up to 1% of the patients undergoing lead extraction procedures. These complications are due to abnormal force vectors during the procedure.
- Trial name
- NCT03842124
- Testing
- Force gauge
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Mayo Clinic
Cytomegalovirus Retinitis, HIV Infections
Comparison of Two Drugs, Cidofovir and Ganciclovir, in Treating Patients With AIDS Who Have CMV Retinitis
To compare cidofovir with a commonly used treatment regimen, ganciclovir given by mouth (oral) and through an eye device (intraocular) , in order to determine the safety and effectiveness of cidofovir in preventing vision loss in…
- Trial name
- NCT00000894
- Testing
- Cidofovir, Probenecid, Ganciclovir
- Where
- 12 sites in United States
- Volunteers
- 300 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Bone Diseases
European Implant Cohort Study
The incidence of postoperative PJI is ranging from 0.5-2.5% for primary interventions and are reported up to 20% for revision procedure.
- Trial name
- EICS (NCT01633619)
- Where
- Switzerland
- Volunteers
- 4,000 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
CIED Related Infection
World-wide Randomized Antibiotic Envelope Infection Prevention Trial
Medtronic , Inc. is sponsoring the World-wide Randomized Antibiotic Envelope Infection Prevention Trial (WRAP-IT), a randomized, prospective, multi-center, single blinded, post-market, interventional clinical study.
- Trial name
- WRAP-IT (NCT02277990)
- Testing
- TYRX™ Absorbable Antibacterial Envelope
- Where
- 181 sites in United States, Austria and 23 more
- Volunteers
- 7,075 people, healthy volunteers welcome
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Cardiac Implantable Electronic Device Infections
Assessment of Diagnostic and Therapeutic Practices for Cardiac Implantable Electronic Devices Suspected Infections in Nancy University Hospital
The frequency of cardiac implantable electronic devices (CIED) is constantly increasing. Devices infections are one of the most serious complications in terms of morbidity and mortality.
- Trial name
- NCT04501835
- Testing
- Diagnostic and treatment evaluation
- Where
- France
- Volunteers
- 184 people
- Sponsor
- Central Hospital, Nancy, France
Wound Healing Disturbance of Port-A
Using a Thermal Imaging System to Evaluate the Wound of Port-A and the Relationship Between Thermal Images and Infection
Permanently implantable venous ports (Port-A) is very important to patients receiving chemotherapy. It not only provides a reliable route to administrate intravenous drugs, and it also requires minimal care when it is not in use.
- Trial name
- NCT02072265
- Testing
- Infrared thermal images
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Otitis Media
Postoperative Effects of Intranasal Fentanyl, IV and IM Morphine in Children Undergoing Myringotomy
The purpose of this study is to compare the difference in effect of three clinically common methods of providing pain medication during surgery for ventilating tubes placed for recurring ear infections.The methods are fentanyl…
- Trial name
- NCT01244126
- Testing
- Intranasal fentanyl, morphine IM, IV morphine
- Where
- United States
- Volunteers
- 171 people
- Sponsor
- Baylor College of Medicine
Breast Implant Infection
Infection After Implant-based Breast Reconstruction
Infections following postmastectomy breast reconstruction can compromise surgical outcomes and lead to significant morbidity. The aim of this study was to determine factors associated with infection following two-stage…
- Trial name
- NCT06187649
- Testing
- breast reconstruction
- Volunteers
- 5,000 people
- Sponsor
- Seoul National University Hospital
PJI
Analysis of Risk Factors for Recurrence of Periprosthetic Infection in Megaprostheses Implanted for Sarcoma of Bone
The goal of this observational study is to collect a large and homogeneous case report of periprosthetic infections in megaprostheses in patients with a history of bone sarcoma.
- Trial name
- NCT06784414
- Where
- 2 sites in Italy
- Volunteers
- 22 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Prostheses Infection
Efficacy and Tolerance of 4 Weeks of Tedizolid in Prosthetic Joint Infections Treated With Implant Removal
To evaluate the efficacy of 4 weeks of 200 mg/24h of tedizolid for prosthetic join infections caused by tedizolid susceptible microorganisms treated with implant removal in one or two stages at 6 months of followup after stopping…
- Trial name
- PROTEDI (NCT03746327)
- Testing
- Sivextro 200 milligrams Oral Tablet
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Chronic Otitis Media, Age Determined Bacteria
Bacterial Assessment of Middle Ear Fluid in Children Undergoing Ventilation Tube Placement Surgery
Children with chronic otitis media have more resistant bacteria that require surgical intervention to eradicate the infections. The study will evaluate the dominant bacteria and their sensitivities to antibiotics.
- Trial name
- NCT01157910
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Hillel Yaffe Medical Center
Prosthetic-joint Infection
SHort Interval Full Two-stage Implant Exchange
This study is a prospective bicentric feasibility study, which aims to evaluate the feasibility of a two-stage full implant exchange with early prosthesis reimplantation between 16 and 30 days after implants removal for hip or…
- Trial name
- SHIFT (NCT05642013)
- Testing
- Early prosthesis reimplantation, Retrospective analysis of medical records
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
Ventriculoperitoneal Shunt, Infection
Retrospective Analysis of Clinical Features in Ventriculoperitoneal Shunt Infectionsin Adults
The objectives of this study are: To describe the incidence of clinical features in adults with internal ventriculoperitoneal (VP) shunt infections, To determine the validity of laboratory parameters in adults with internal…
- Trial name
- NCT00524108
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- University of Pittsburgh