Clinical trials: Immunosenescence
Cancer Survivors, Healthy Participant
A Study to Evaluate the Effects of the Combination of GI-102 With GIB-7 on Biomarkers of Aging in Healthy Adults and Cancer Survivors
This Phase 2a clinical study (GIANTS-1) aims to evaluate a novel dual-combination strategy using GI-102 and GIB-7 to address key pathological features of aging, including immunosenescence (the aging of the immune system)…
- Conditions
- Cancer Survivors, Healthy Participant, Elderly
- Trial name
- GIANTS-1 (NCT07363057)
- Testing
- GI-102 in combination with GIB-7
- Where
- 2 sites in Australia
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- GI Innovation, Inc.
Respiratory Infection
Vitamin D Supplementation and Acute Respiratory Infection in Older Long-Term Care Residents
This study will test the role of high dose vitamin D supplementation in prevention of acute respiratory infection in older nursing home residents.
- Trial name
- NCT01102374
- Testing
- High Dose Vitamin D, Standard Dose Vitamin D, Usual Care
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- University of Colorado, Denver
Immune Deficiency
Efficacy of QBKPN Site-Specific Immunomodulator in Improving Innate Immune Function & Reducing Respiratory Tract Infection in Older Adults
This study is designed to test whether QBKPN SSI can improve immune function in older adults, including how well it can protect against respiratory and other infections, whether it improves the body's response to COVID-19…
- Trial name
- RESILIENCE (NCT05421325)
- Testing
- QBKPN SSI
- Where
- Canada
- Volunteers
- 72 people
- Sponsor
- Qu Biologics Inc.
Brain, Aging
Biobank and Brain Health in Bordeaux.
B cube is a new generation cohort to study the determinants and natural history of brain aging, using molecular epidemiology, in a representative sample (N=2000) of the general population from the age of 55 (the approximate age…
- Conditions
- Brain, Aging, Cognitive Aging, Immunosenescence
- Trial name
- B-cube (NCT05322343)
- Testing
- Questionnaires, Fasting blood sampling., Saliva collection and nasal or nasopharyngeal swab
- Where
- France
- Volunteers
- 2,050 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Fasting, Diet, Healthy
Therapeutic Fasting and Immune Aging
Immunosenescence is the age-related decline of the immune system, involving a state of chronic inflammation and a decrease in the diversity/adaptability of the lymphocyte repertoire.
- Trial name
- JÛVENILE (NCT05857241)
- Testing
- Fasting mimicking diet (FMD)
- Where
- 5 sites in France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Bladder Cancer, NMIBC
Age and Bladder Cancer Outcomes After BCG Treatment: A Multicenter Study
This study investigates whether a patient's age affects the outcomes of Bacillus Calmette-Guérin (BCG) treatment for high-grade bladder cancer.
- Trial name
- IATREP_NMIBC (NCT07798479)
- Testing
- Intravesical Bcg
- Volunteers
- 64 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Diabetes Mellitus, Type 2
The Effects of Henagliflozin on Glucose Fluctuation and Immunosenescence in Type 2 Diabetes Patients on Insulin Therapy
The goal of this clinical trial is to learn if SGLT2 inhibitor Henggliflozin works to improve glucose variability in type 2 diabetes and if Henggliflozin can benefit immunosenescence.
- Trial name
- HOLIDYA (NCT06818851)
- Testing
- Henggliflozin
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Immunosenescence
Exploratory Study on Infection and Immunosenescence Based on an Elderly Clinical Cohort
This prospective observational cohort study aims to investigate the relationship between immunosenescence and infectious diseases in older adults.
- Trial name
- NCT07672522
- Where
- China
- Volunteers
- 484 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Immunosenescence
The Effect of Prebiotic B-GOS on the Immune Function, Metabolism and Gut Microbiota of Elderly People
The purpose of this study is to determine the effects of prebiotic B-GOS on the immune function, metabolism and gut microbiota of elderly people
- Trial name
- PRIMES (NCT01303484)
- Testing
- Bi2muno® GOS, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Clasado
Influenza
Comparison of Immune Responses to Influenza Vaccine In Adults of Different Ages (SLVP015 2007-2017)
In this study the investigators are trying to understand how immune function declines in the elderly using annual influenza vaccinations as a model system. The longitudinal study began in 2007 and continued through early 2017.
- Trial name
- NCT01827462
- Testing
- Trivalent, inactivated influenza vaccine (TIV), Quadrivalent, inactivated influenza vaccine (IIV4), High-Dose Trivalent, inactivated influenza vaccine (TIV High-Dose)
- Where
- United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Stanford University
Covid19 Vaccine
Covid-19 Vaccine Response in Elderly Subjects
The objective of this research is to assess the amplitude and quality of the vaccine response against SARS-CoV-2, defined here by its characteristics established at 3 months, and its persistence over time, defined here at 9…
- Trial name
- MONITOCOVAGING (NCT04760704)
- Testing
- Specific antibody and cellular immune response after anti-SARS-CoV-2 vaccine administration
- Where
- France
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Hemodialysis
Functional Proteomics of Uremic Retention Solutes Associated With Immunosenescence, Inflammation and Impaired Adaptive Stress Response
This is a randomized controlled crossover trial (58) in order to characterize PBL damage and death rate in hemodialysis patients treated with membranes with different permeability, including protein-leaking dialysers.
- Trial name
- NCT07265635
- Testing
- HDF with PMMA, HDF
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Chronic Inflammation, Inflammaging
2021 PMT iAge® Intervention Trial by Edifice Health
This is a decentralized, double-blind, randomized, placebo-controlled study to assess the effectiveness of different dietary supplements in decreasing systemic chronic inflammation (SCI) and lowering inflammatory age (iAge®).
- Trial name
- NCT04983017
- Testing
- Dietary supplement
- Where
- 2 sites in United States
- Volunteers
- 781 people, healthy volunteers welcome
- Sponsor
- Edifice Health
Influenza Vaccination, Older Adults (65 Years and Older)
Influenza Vaccine Immunogenicity in Repeatedly Vaccinated Older Adults
The goal of this clinical trial is to compare immune responses to different influenza vaccine formulations in older adults and to understand how immune aging and repeated annual influenza vaccination affect these responses.
- Conditions
- Influenza Vaccination, Older Adults (65 Years and Older), Immunosenescence, Immunogenicity
- Trial name
- NCT07838298
- Testing
- Standard dose influenza vaccine, MF59 adjuvanted influenza vaccine, High dose influenza vaccine
- Where
- South Korea
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Korea University Guro Hospital
Immunity Disorders, Aging
The Impact of a Polyphenol-Rich Supplement on Epigenetic and Cellular Markers of Immune Age
This is a prospective, interventional, single-arm, open-label pilot study of 50 patients to evaluate the effect of a polyphenol-rich nutritional supplement on epigenetic and cellular markers of immune age.
- Conditions
- Immunity Disorders, Aging, Inflammation
- Trial name
- NCT05234203
- Testing
- HTB Rejuvenate
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Big Bold Health, PBC
Immunosenescence
Fasting-mimicking Diet and Immunosenescence
The objective of this study is to test a Fasting-Mimicking Diet (FMD) for its efficacy on improving immune response to flu vaccination in an older adult population (50-75 years of age).
- Trial name
- NCT02554188
- Testing
- Seasonal influenza (flu) vaccine, Diet
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Southern California
Healthy
Effect of TA-65MD on Healthy Volunteers
TA-65 MD® is pure, natural, plant-based compound that can help maintain or rebuild telomeres. A telomere is a region of repetitive DNA at the end of a chromosome, which protects the end of the chromosome from deterioration.
- Trial name
- TA-65MD (NCT02766790)
- Testing
- TA-65MD
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Telomerase Activation Sciences, Inc
Immunosenescence, Overweight
The Impact of Nicotinamide Mononucleotide Sustained-release Tablets on Immunosenescence and Metabolism in Middle-aged and Elderly Individuals With Metabolic Disorders.
This study evaluates whether nicotinamide mononucleotide (NMN) sustained-release tablets affect markers of immune system aging in adults aged 50 to 70 years with overweight or obesity and metabolic disorders.
- Conditions
- Immunosenescence, Overweight, Obesity, Metabolic Dysfunction-Associated Fatty Liver Disease
- Trial name
- NCT06907329
- Testing
- NMN
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Qing Su
Covid19, Geriatric Medicine
COVID-19 Serology and Immunosenescence
This study aims to determine how long COVID-19 neutralizing antibodies can be detected in an elderly institutionalized population presenting fragility factors.
- Conditions
- Covid19, Geriatric Medicine, Seroconversion, Immunosenescence
- Trial name
- SERO-CoV-OLD (NCT04563650)
- Testing
- blood sample
- Where
- France
- Volunteers
- 98 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Influenza, Herpes Zoster
Age Differences in Influenza and Herpes Zoster Vaccine Responses (INFLUENZA-SHINGRIX)
Vaccines are used to prevent infectious diseases worldwide. Unfortunately, many vaccines, like the flu vaccine, are less effective in older adults.
- Trial name
- NCT05082688
- Testing
- Herpes zoster vaccination (Shingrix, GSK), Influenza Vaccine (Fluarix Tetra Northern Hemisphere 2021 or 2022, GSK)
- Where
- Netherlands
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center