Clinical trials: Immunosenescence
Non Small Cell Lung Cancer
Immuno-effect of Tα1 for Stage I NSCLC
To explore the effect of thymosin alpha 1 (Tα1) on postoperative peripheral blood circulating tumor cells and immunosenescence in patients with early-stage non-small cell lung cancer (NSCLC).
- Trial name
- NCT06598839
- Testing
- Thymosin Alpha1
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Yousheng Mao
Renal Failure
Accelerated Immunosenescence and Chronic Kidney Disease
The aim of this study is to investigate the impact of renal function and dialysis techniques on the percentage of senescent T lymphocytes.
- Trial name
- IRIS (NCT02116270)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 222 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Axial Spondyloarthrithis, Inflammatory Diseases
EXercise Therapy in Axial SpA, Inflammation and Biologic Therapy (ExTASI-B)
The goal of this randomised controlled trial study is to investigate whether exercise (brisk walking, equal to 13 on a rating of perceived exertion scale; somewhat hard) can be used as an adjuvant therapy for people living with…
- Conditions
- Axial Spondyloarthrithis, Inflammatory Diseases, Arthritis
- Trial name
- ExTASI-B (NCT06669702)
- Testing
- 12-week home based exercise, Routine care
- Where
- 2 sites in United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Memory Disorders, Alzheimer's Disease
Prevention of Cognitive Decline in Alzheimer's Disease by Ingested Interferon Alpha
In this phase I-II parallel design, randomized, double-blind clinical trial we will determine if 3,000 or 30,000 units ingested hrIFN-a prevents deterioration of cognitive functioning in patients with dementia of Alzheimer's type…
- Trial name
- NCT00031018
- Testing
- Aricept, IFN-alpha2A
- Where
- United States
- Sponsor
- National Center for Research Resources (NCRR)
Influenza
Comparison of Immune Responses to Influenza Vaccine In Adults of Different Ages (SLVP015 2007-2017)
In this study the investigators are trying to understand how immune function declines in the elderly using annual influenza vaccinations as a model system. The longitudinal study began in 2007 and continued through early 2017.
- Trial name
- NCT01827462
- Testing
- Trivalent, inactivated influenza vaccine (TIV), Quadrivalent, inactivated influenza vaccine (IIV4), High-Dose Trivalent, inactivated influenza vaccine (TIV High-Dose)
- Where
- United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Stanford University
Influenza, Human
Tropical Influenza Control Strategies for the Elderly
TROPICS1 is a randomized, observer-blind, active comparator-controlled, single-center, Phase IV trial in 200 participants aged ≥65 years.
- Trial name
- TROPICS1 (NCT02655874)
- Testing
- Influenza vaccine, Tetanus-diphtheria-pertussis vaccine
- Where
- Singapore
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tan Tock Seng Hospital
Immunosenescence, Aging
The Immu-KNEE-ty Study
The goal of this observational study is to determine changes in immune functioning after total knee replacement surgery in elderly.
- Trial name
- NCT05920148
- Testing
- Knee arthroplasty
- Where
- Netherlands
- Volunteers
- 14 people
- Sponsor
- Wageningen University
Immunosenescence
Fasting-mimicking Diet and Immunosenescence
The objective of this study is to test a Fasting-Mimicking Diet (FMD) for its efficacy on improving immune response to flu vaccination in an older adult population (50-75 years of age).
- Trial name
- NCT02554188
- Testing
- Seasonal influenza (flu) vaccine, Diet
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Southern California
Immunosenescence, Uninfected Older
Interferon Reference for Older People - REFIPA Study
The diagnosis of respiratory viral infections is mainly based on PCR tests targeting the DNA or RNA of suspected viruses, including SARS-CoV-2, RSV and influenza viruses.
- Trial name
- REFIPA (NCT07239830)
- Testing
- Uninfected older adults
- Where
- France
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Immunodeficiency
Testing a Novel Dairy Protein to Counteract Immunosenescence
Aging populations experience a decline in adaptive immune system function also known as immunosenesence. Nutritional approaches to stimulate and strengthen the immune system are needed for this growing segment of the population.
- Trial name
- NCT03557463
- Testing
- Dairy protein
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Chronic Disease
Description of Immunosenescence Biomarkers and Nutritional Intervention to Evaluate the Implementation of Digital Tools
Descriptive comparative study of immunosenescence markers and their association with nutritional, metabolic, metabolomic and genetic characteristics in young (control), senior (age-associated immunosenescence), and populations…
- Trial name
- NCT05807243
- Testing
- Dietary intervention for healthy weight loss
- Where
- Spain
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- IMDEA Food
Brain, Aging
Biobank and Brain Health in Bordeaux.
B cube is a new generation cohort to study the determinants and natural history of brain aging, using molecular epidemiology, in a representative sample (N=2000) of the general population from the age of 55 (the approximate age…
- Conditions
- Brain, Aging, Cognitive Aging, Immunosenescence
- Trial name
- B-cube (NCT05322343)
- Testing
- Questionnaires, Fasting blood sampling., Saliva collection and nasal or nasopharyngeal swab
- Where
- France
- Volunteers
- 2,050 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Clinically Symptomatic Respiratory Illness
Effect of RTB101 on Illness Associated With Respiratory Tract Infections in the Elderly
The purpose of this study is to determine if RTB101 prevents illness associated with respiratory tract infections in people ≥65 years of age.
- Trial name
- NCT04139915
- Testing
- Dactolisib
- Sponsor
- Restorbio Inc.
Covid19, Non-specific Effects of Vaccines
Using BCG to Protect Senior Citizens During the COVID-19 Pandemic
Background: The virus SARS-CoV-2 has spread rapidly throughout the world. Seniors are at high risk of severe COVID-19 when infected.
- Conditions
- Covid19, Non-specific Effects of Vaccines, Heterologous Immunity, Morbidity
- Trial name
- NCT04542330
- Testing
- BCG-Denmark, Saline
- Where
- Denmark
- Volunteers
- 1,700 people, healthy volunteers welcome
- Sponsor
- Bandim Health Project
Immunosenescence
Pilot Study on Effect Size of Non-digestible Polysaccharides (NPS) on Immunity
The aim of the study is to estimate the effect size of a 5-week consumption period of different dietary non-digestible polysaccharides (NPS) on antibody response to influenza vaccination and cellular immunity of healthy…
- Trial name
- Fib-P-2012 (NCT01896154)
- Testing
- NPS
- Volunteers
- 239 people, healthy volunteers welcome
- Sponsor
- Clinical Research Center Kiel GmbH
Healthy
Entolimod on Immunosenescence in Healthy Geriatric Subjects Receiving Influenza Vaccination
Researchers are evaluating the safety and effectiveness of a single administration of entolimod when administered at the same time as the influenza vaccine (flu vaccine).
- Trial name
- NCT04176133
- Testing
- Entolimod, Influenza vaccine
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Robert J. Pignolo
Influenza
PRIMAGE (Probiotics, Immunity and Ageing)
Ageing dramatically affects immune function; this phenomenon is known as immunosenescence and partly explains the increased susceptibility for infection in older individuals.
- Trial name
- PRIMAGE (NCT01066377)
- Testing
- Prebiotic and probiotic mix
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Reading
Aging, High-intensity Interval Training
Can Exercise Ameliorate Immunosenescence and Thereby Reduce Relapse in Head and Neck Cancer Patients
Through the implementation of this three-year project, investigators expect to find a safe and effective exercise prescription for patients with oral cancer after surgery.
- Conditions
- Aging, High-intensity Interval Training, Head and Neck Cancers - Tonsils
- Trial name
- NCT06851988
- Testing
- HIIT & Record of physical activities at home., HIIT only
- Where
- Taiwan
- Volunteers
- 290 people
- Sponsor
- Chang Gung Memorial Hospital
Healthy Aged Volunteers
The Influence of Different Types of Physical Exercise on Immunosenescence in Elderly Persons
This study aims to identify the mechanisms by which physical exercise can counter inflammation and improve immune function in older persons.
- Trial name
- NCT04534049
- Testing
- Intensive Strength Training (IST), Strength Endurance Training (SET), Flexibility Training (FT)
- Where
- Belgium
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Immunosenescence, Metabolism
The Impact of Nicotinamide Mononucleotide Sustained-release Tablets on Immunosenescence and Metablism in Middle-aged and Elderly Individuals With Metabolic Disorders.
The ageing of our country is increasing and the ageing of the population has led to a significant increase in aging related diseases.
- Trial name
- NCT06907329
- Testing
- NMN
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Qing Su