Clinical trials: Immune
Immune Thrombocytopenia, Thrombocytopathy
Assesment of the Functional Activity of Platelets for the Differential Diagnosis of Thrombocytopathies
The purpose of this study is to develop a highly sensitive method for assessing the functional activity of platelets for use in the differential diagnosis of thrombocytopenia and platelet defects.
- Conditions
- Immune Thrombocytopenia, Thrombocytopathy, Acute Leukemia, Hemorrhagic Disorders
- Trial name
- NCT05654766
- Testing
- Flow cytometry, Platelet aggregation and plasma coagulation
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus
Immune-mediated Thrombocytopenic Purpura
Retrospective Study on Caplacizumab-treated Pediatric Patients With Immune-mediated Thrombocytopenic Purpura (iTTP)
The purpose of this multi-country, retrospective data collection study (chart review) is to describe the effectiveness and safety of caplacizumab in pediatric patients with iTTP.
- Trial name
- NCT05263193
- Testing
- Caplacizumab
- Where
- France
- Volunteers
- 4 people
- Sponsor
- Sanofi
Immunity Disorders, Aging
The Impact of a Polyphenol-Rich Supplement on Epigenetic and Cellular Markers of Immune Age
This is a prospective, interventional, single-arm, open-label pilot study of 50 patients to evaluate the effect of a polyphenol-rich nutritional supplement on epigenetic and cellular markers of immune age.
- Conditions
- Immunity Disorders, Aging, Inflammation
- Trial name
- NCT05234203
- Testing
- HTB Rejuvenate
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Big Bold Health, PBC
Immune Thrombocytopenia, Pregnancy Related
IVIg Plus Low Dose rhTPO for ITP in Pregnancy
Randomized, open-label, multicenter study to investigate the efficacy and safety of IVIg plus low-dose recombinant thrombopoietin in pregnant patients with corticosteroid or IVIg monotherapy-resistant ITP.
- Trial name
- NCT05634824
- Testing
- intravenous immunoglobulin plus low dose recombinant human thrombopoietin (rhTPO), intravenous immunoglobulin
- Volunteers
- 50 people
- Sponsor
- Peking University People's Hospital
Primary Immune Thrombocytopenia
Efficacy and Safety of QL0911 in Adult Patients With Chronic Primary Immune Thrombocytopenia
QL0911, a recombinant human thrombopoietin mimetic peptide-Fc fusion protein for injection, is a romiplostim (Nplate®) biosimilar for the treatment of primary immune thrombocytopenia (ITP).
- Trial name
- NCT05621330
- Testing
- QL0911
- Where
- China
- Volunteers
- 216 people
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Growth, Vitamin D Supplementation
Next-generation Effects of Vitamin D Supplementation in Pregnancy
Vitamin D deficiency is common among pregnant women, despite daily vitamin D supplements. This study aims to investigate if maternal vitamin D intake of 90 vs 10 µg affects the overall health, growth, and immune system of the…
- Conditions
- Growth, Vitamin D Supplementation, Immune System Diseases, Child Development
- Trial name
- NCT05616117
- Testing
- Intrauterine 90µg D-vitamin, Intrauterine 10µg D-vitamin
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Primary Immune Deficiency Disorder, Periodontitis
Investigation of Dental Health in Children With Neutrophil Defects: A Clinical Study
Title: Investigation of neutrophil defects associated with periodontal disease and tooth loss in children. A clinical study. Objectives: The primary objective of this study is: To investigate presence of periodontal disease and…
- Trial name
- GOSH (NCT03069079)
- Testing
- Oral hygiene advice, non surgical periodontal treatment
- Where
- 2 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- Queen Mary University of London
Idiopathic Thrombocytopenic Purpura, Thrombocytopenia
Romiplostim (AMG 531) Versus Medical Standard of Care for Immune (Idiopathic) Thrombocytopenic Purpura
This is a phase 3b, multi-center, randomized, Standard of Care (SOC)-controlled, open-label, 52-week treatment study to compare romiplostim to medical SOC for Idiopathic Thrombocytopenia Purpura (ITP), with a 6-month Safety…
- Conditions
- Idiopathic Thrombocytopenic Purpura, Thrombocytopenia, Thrombocytopenia in Subjects With Immune (Idiopathic) Thrombocytopenic Purpura (ITP), Thrombocytopenic Purpura
- Trial name
- NCT00415532
- Testing
- Medical Standard of Care for ITP, Romiplostim
- Volunteers
- 234 people
- Sponsor
- Amgen
Immune Deficiency, Diet, Healthy
Aerobic Training and Diet on the Immune System in Postmastectomy Patients Receiving Chemotherapy
The purpose of the study was to investigate the impact of aerobic exercise combined with diet protocol on the immune system in post-mastectomy patients receiving chemotherapy.
- Conditions
- Immune Deficiency, Diet, Healthy, Breast Cancer
- Trial name
- NCT05605808
- Testing
- Aerobic exercises, Diet protocol
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Cancer, IMMUNE CHECKPOINT INHIBITOR
Development of an EORTC Immune Checkpoint Inhibitor-specific Quality of Life Item List: Phase 1 & 2
Over the past 20 years, the views and experiences of patients in the field of oncology (through patient-reported outcomes, PROMs) have become increasingly important.
- Conditions
- Cancer, IMMUNE CHECKPOINT INHIBITOR, Quality of Life
- Trial name
- EORTC ICI (NCT05554432)
- Where
- France
- Volunteers
- 43 people
- Sponsor
- Institut Curie
Cardiovascular and Immune Responses to Yoga
Racial Differences in Yoga-Induced Responses
The purpose of this study is to 1) determine whether racial differences are evident in resting arterial stiffness and ambulatory blood pressure between African Americans and Caucasians 2) compare heart rate, blood pressure and…
- Trial name
- NCT05598073
- Testing
- Vinyasa yoga session
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Texas State University
Immune Thrombocytopenia
Newly Diagnosed Immune Thrombocytopenia Testing the Standard Steroid Treatment Against Combined Steroid & Mycophenolate
This is a study of two treatment pathways [Standard steroid treatment versus combined steroid and Mycophenolate (MMF)] for subjects with newly diagnosed Immune Thrombocytopenia (ITP).
- Trial name
- FLIGHT (NCT03156452)
- Testing
- Mycophenolate Mofetil, Prednisolone
- Where
- United Kingdom
- Volunteers
- 123 people
- Sponsor
- University Hospitals Bristol and Weston NHS Foundation Trust
Immune-Mediated Necrotizing Myopathy
Monotherapy IVIG Gamunex-C for HMG-CoA Reductase Auto-Antibody Positive Necrotizing Myopathy Treatment (The MIGHT Trial)
This is a phase 2, pilot, randomized, placebo-controlled trial of Gamunex-C IVIG as mono-therapy for HMGCoA reductase auto-antibody positive (HMGCR) necrotizing myopathy.
- Trial name
- NCT04450654
- Testing
- Gamunex-C, Albumin
- Where
- United States
- Sponsor
- University of Washington
Immune Thrombocytopenic Purpura
" Effect of Single-nucleotide Polymorphism of CD40 Gene rs1883832 C/T on the Risk of Immune Thrombocytopenic Purpura "
Immune thrombocytopenia is an acquired autoimmune disease, in which platelets are opsonized by auto-antibodies and destroyed by phagocytic cells .Genetic polymorphisms in the immune mediators have been suggested to play a pivotal…
- Trial name
- NCT05585944
- Testing
- Genotyping of rs1883832C/T related single-nucleotide polymorphism
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sohag University
Covid19, Immune Suppression
Differences in Immune Response Among HIV-1-infected Individuals With Previous or Current COVID-19 (CoVIHDis).
People living with HIV could have different susceptibility and outcome to the SARS CoV-2 infection. The risk of SARS CoV-2 infection in this population could be no related to HIV infection, immunodepression or antiretroviral…
- Conditions
- Covid19, Immune Suppression, HIV-1-infection
- Trial name
- CoVIHDis (NCT04526977)
- Testing
- Immune response study
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Asociacion para el Estudio de las Enfermedades Infecciosas
Immune Thrombocytopenia
A Clinical Study to Evaluate the Efficacy and Safety of LIV-GAMMA SN Inj.10% in Primary Immune Thrombocytopenia (ITP)
The purpose of this study is to evaluate the efficacy and safety of LIV-GAMMA SN Inj.10% administered for 2 days in adult subjects with primary immune thrombocytopenia (ITP).
- Trial name
- NCT05566990
- Testing
- LIV-GAMMA SN Inj.10%
- Where
- 11 sites in South Korea
- Volunteers
- 34 people
- Sponsor
- SK Plasma Co., Ltd.
Immune
Beverage for Immune Support
Evaluate the effects of a beverage supplement on immune health over an 8 week intervention using either a placebo or active supplement.
- Trial name
- NCT05566314
- Testing
- Amunizer
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Nutraceuticals Research Institute
ITP, Immune Thrombocytopenia
Baricitinib for Steroid-resistant/Relapse Immune Thrombocytopenia
Single-arm, open-label, single-center study to evaluate the efficacy and safety of baricitinib for the treatment of adults with steroid-resistant/relapse immune thrombocytopenia (ITP).
- Trial name
- BAITP (NCT05446831)
- Testing
- Baricitinib
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Peking University People's Hospital
Active Immune Response
Acute Effects of an Herbal Tea on Immune Surveillance and Activation.
A small cross-over trial on 24 people involving an herbal tea blend to test whether consuming 1 cup of tea triggers changes in the numbers of natural killer cells in the blood circulation as evidence of immune cell trafficking…
- Trial name
- NCT04491461
- Testing
- Herbal tea blend, Warm water
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Natural Immune Systems Inc
Immune Hepatitis
Characterization of the Relationship Between the Human Mesolimbic Reward System and Immune Functioning
The purpose of this study is to characterize the link between neurobehavioral measures of the mesolimbic reward system and immune functioning in healthy individuals, via fMRI neurofeedback modulation of mesolimbic reward system…
- Trial name
- NCT03951870
- Testing
- Neuromodulation via fMRI Neurofeedback task, Hepatitis B vaccination
- Where
- Israel
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center