Clinical trials: Idiopathic Normal Pressure Hydrocephalus
Idiopathic Normal Pressure Hydrocephalus
Improved Analysis Methods for Infusion Tests
Objective: Patients with Idiopathic Normal Pressure Hydrocephalus are improved with shunt surgery. To increase the accuracy of the diagnosis, supplementary tests that characterize the cerebrospinal fluid (CSF) dynamics are used.
- Trial name
- NCT01319136
- Where
- 2 sites in Sweden
- Volunteers
- 48 people
- Sponsor
- Umeå University
Idiopathic Normal Pressure Hydrocephalus (INPH)
A Placebo-Controlled Effectiveness in INPH Shunting (PENS) Trial
The Placebo-Controlled Effectiveness in Idiopathic Normal Pressure Hydrocephalus (iNPH) Shunting (PENS) trial is a multi-center blinded, randomized, placebo-controlled design investigation of cerebrospinal fluid (CSF) shunt…
- Trial name
- PENS (NCT03350750)
- Testing
- programmable CSF shunt valve
- Where
- 7 sites in United States, Canada and 1 more
- Volunteers
- 18 people
- Sponsor
- Johns Hopkins University
Freezing of Gait, Parkinson's Disease
Etiology-Phenotype-Outcome Pathway Study on Freezing of Gait (FOG)
This study is a prospective, multicenter, observational cohort (patient registry) designed to better understand freezing of gait (FOG), a disabling walking problem that can occur in Parkinson's disease and other related…
- Conditions
- Freezing of Gait, Parkinson's Disease, Parkinsonism, Vascular Parkinsonism
- Trial name
- NCT07386015
- Testing
- Observational Data Collection
- Where
- China
- Volunteers
- 700 people
- Sponsor
- Tianjin Huanhu Hospital
Rheumatoid Arthritis, Ankylosing Spondylitis
PatientSpot Formerly Known as ArthritisPower
Patient Power is a patient research network and database (registry) to collect prospective information about demographics, self-reported diagnoses and medications, and willingness to participate in research from participants with…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Fibromyalgia, Gout
- Trial name
- NCT03840928
- Where
- United States
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Global Healthy Living Foundation
Fecal Incontinence with Fecal Urgency, Urine Incontinence
Idiopathic Normal Pressure Hydrocephalus: Focus on Imaging and Clinical Symptoms.
LiNPH is a prospective single center clinical and radiological study.
- Conditions
- Fecal Incontinence with Fecal Urgency, Urine Incontinence, Diffusion Tensor Imaging, Leukoencephalopathies
- Trial name
- LiNPH (NCT04808076)
- Testing
- Shunt surgery
- Where
- Sweden
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Linkoeping University
The iNPH Patients Scheduled for VP or LP Shunt Procedures
Factors Associated With Post-induction Hypotension in iNPH Patient Undergoing VP and LP Shunt
This study is a retrospective work involving the review of patients who were scheduled for VP or LP shunt in Siriraj Hospital, Mahidol University, Thailand.
- Trial name
- NCT05183061
- Testing
- Ehedrine Norepineprine
- Where
- Thailand
- Volunteers
- 426 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Normal Pressure Hydrocephalus
Identifying Gait Changes From a CSF Tap Test Using a Smart Insole in iNPH
The goal of this clinical trial is to to evaluate various gait parameters by a sensor-embedded smart insole before and after the cerebrospinal fluid (CSF) tap test in idiopathic normal pressure hydrocephalus (iNPH) patients.
- Trial name
- NCT06722768
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Yonsei University
Idiopathic Normal Pressure Hydrocephalus
Integrated Multimodal Assessment to Optimize Diagnosis and Surgical Selection in Idiopathic Normal Pressure Hydrocephalus
Idiopathic normal pressure hydrocephalus (iNPH) is a neurological condition that can cause walking difficulties, cognitive impairment, and urinary incontinence.
- Trial name
- NPH-OPTIMIZE (NCT07427836)
- Where
- 2 sites in Italy
- Volunteers
- 116 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Hydrocephalus, Normal Pressure, Vascular Diseases
Vascular Risk Factors in INPH-patients
Idiopathic normal pressure hydrocephalus (INPH) is a treatable and a common disease of the elderly. The overall objective of this work is to describe cardio- and cerebrovascular risk factors and vascular disease in shunted…
- Conditions
- Hydrocephalus, Normal Pressure, Vascular Diseases, Brain Diseases, Central Nervous System Diseases
- Trial name
- NCT01850914
- Where
- Sweden
- Volunteers
- 860 people
- Sponsor
- Umeå University
Idiopathic Normal Pressure Hydrocephalus (INPH), Gait Disorders, Neurologic
Unsteady Gait in Older People May be a Common and Treatable Neurological Disease Associated With Increased Mortality
We live in an aging population and a third of the older population has a gait disorder that may cause institutionalization, and increased mortality.
- Conditions
- Idiopathic Normal Pressure Hydrocephalus (INPH), Gait Disorders, Neurologic, Gait Disorders in Old Age
- Trial name
- VESPR2 (NCT07137403)
- Where
- Sweden
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Umeå University
Brain Pulsatility, Idiopathic Normal Pressure Hydrocephalus (INPH)
Transcranial Ultrasound Assessment of Cerebral Pulsatility in Shunt Decision-making for Suspected Idiopathic Normal Pressure Hydrocephalus: a Prospective Cohort Study
This will be a single-center, prospective, analytical cohort study. All included patients will undergo transcranial ultrasound (TPI) with measurement of cerebral pulsatility parameters prior to subtractive lumbar puncture during…
- Trial name
- HYDROPULSE (NCT07285928)
- Where
- France
- Volunteers
- 110 people
- Sponsor
- University Hospital, Tours
Normal Pressure Hydrocephalus
European Study on Prediction of Outcome in Patients With Idiopathic Normal Pressure Hydrocephalus
The purpose of the study is to determine the predictive values and prognostic accuracies of CSF dynamic measures, the TAP -TEST (high-volume cerebrospinal fluid withdrawal), resistance to CSF outflow and compliance in the…
- Trial name
- NCT00874198
- Testing
- Ventriculo-peritoneal Shunt
- Where
- Germany
- Volunteers
- 156 people
- Sponsor
- International Neuroscience Institute Hannover
Idiopathic Normal Pressure Hydrocephalus (INPH), Brain Diseases
Ventriculomegaly and Gait Disturbance in the Senior Population in the Region of Västerbotten
Idiopathic normal pressure hydrocephalus (INPH) is a treatable disease of the elderly, typically causing gait impariment, dementia and urinary incontinence.
- Conditions
- Idiopathic Normal Pressure Hydrocephalus (INPH), Brain Diseases, Central Nervous System Diseases, Dementia
- Trial name
- VESPR (NCT05204745)
- Where
- Sweden
- Volunteers
- 6,500 people
- Sponsor
- Umeå University
Hydrocephalus, Shunt Malfunction
Comparison of Continuous Noninvasive and Invasive Intracranial Pressure Measurement--Celda Infusion Subprotocol
This research is being done to determine the accuracy of two noninvasive methods of measuring the pressure of the spinal fluid, also known as intracranial pressure (ICP).
- Trial name
- NCT01976559
- Testing
- Tympanic Membrane Displacement (TMD), DPOAE
- Where
- Sweden
- Volunteers
- 15 people
- Sponsor
- LifeBridge Health
Normal Pressure Hydrocephalus
Conservative Versus Surgical Management of Idiopathic Normal Pressure Hydrocephalus (INPH)
This study aims to provide class 1 evidence supporting or refuting the existence of normal pressure hydrocephalus.
- Trial name
- NCT00727142
- Testing
- Surgical treatment
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- University College London Hospitals
Idiopathic Normal Pressure Hydrocephalus
Study to Evaluate Efficacy of Shunt Operation for Idiopathic Normal Pressure Hydrocephalus
This study evaluates the efficacy of shunt operation for idiopathic normal pressure hydrocephalus, and determines the diagnostic value of noninvasive procedures commonly practiced in the clinic.
- Trial name
- NCT00221091
- Testing
- ventriculo-peritoneal shunt
- Where
- Japan
- Volunteers
- 110 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Idiopathic Normal Pressure Hydrocephalus (iNPH)
The Pilot Study of Medical Device-Neuclare for Patients With Idiopathic Normal Pressure Hydrocephalus (iNPH)
This clinical trial aims to explore the effectiveness and safety of gait improvemen of Neuclare, a science medical device, for patients with Idiopathic Normal Pressure Hydrocephalus (iNPH) Through methods such as Timed Up \& Go…
- Trial name
- NCT06478979
- Testing
- Neuclare
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Deepsonbio
Idiopathic Normal Pressure Hydrocephalus (INPH)
Walking Pattern Characteristics in Normal Pressure Hydrocephalus
20 patients who are diagnosed with NPH receive a set of 5 wearable gyroscopes (IMUs, ZurichMove sensors) for a period of 3 days for measurement and characterization of their walking in an ambulatory setting.
- Trial name
- NPH wearables (NCT04702035)
- Testing
- Characterization of walking pattern characteristics in an ambulatory setting using wearable IMUs (ZurichMOVE sensors)
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Normal Pressure Hydrocephalus
Computerized Neuropsychology in Idiopathic Normal Pressure Hydrocephalus (INPH)
A computerised neuropsychological test battery to be used as a standardised tool assessing the cognitive domains affected by idiopathic normal pressure hydrocephalus INPH was developed.
- Trial name
- NCT01265251
- Testing
- Computerized neuropsychological test, Conventional neuropsychological test
- Where
- Sweden
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Umeå University
Idiopathic Normal Pressure Hydrocephalus
Multi-omics Research of Idopathic Normal Pressure Hydrocephalus (iNPH)
The research is designed to study the prognostic factors of ventriculoperitoneal (VP) shunt for iNPH by multi-omics research
- Trial name
- NCT04998175
- Testing
- ventriculo-peritoneal shunt
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine