Clinical trials: INTENSIVE CARE
Critical Care, Intensive Care, Fluid Accumulation
CReep and Maintenance flUid Sodium Chloride ADministration rEduction in cRitically Ill adultS
This study is enrolling adult patients who require a prolonged stay in the intensive care unit (ICU). These patients often receive large amounts of intravenous fluids, which can contain more salt (sodium and chloride) than the…
- Conditions
- Critical Care, Intensive Care, Fluid Accumulation, Fluid and Electrolyte Imbalance, Critical Illness
- Trial name
- CRUSADERS (NCT07189091)
- Testing
- Glucose 5% for fluid creep, NaCl 0.9% (normal saline) for fluid creep, PlasmaLyte as maintenance fluid
- Where
- 4 sites in Belgium
- Volunteers
- 640 people
- Sponsor
- University Hospital, Antwerp
Fluid Overload
Controlled Fluid Removal in Critical Ill Patients With Fluid Overload in the Intensive Care Unit.
This study evaluates the benefits and harms of goal directed fluid removal with furosemide versus placebo in critical ill adult patients with fluid overload in the intensive care unit.
- Trial name
- GODIF (NCT04180397)
- Testing
- Furosemide, Isotonic saline
- Where
- 29 sites in Australia, Czechia and 7 more
- Volunteers
- 1,000 people
- Sponsor
- Morten H. Bestle
Acute Myeloid Leukemia, Myelodysplastic Syndromes
A Collaborative Palliative and Leukemia Care Model for Patients With AML and MDS Receiving Non-Intensive Therapy
This research study is evaluating the impact a collaborative palliative care and oncology team will have on end-of-life outcomes, quality of end-of-life care, and the quality of life, symptoms, and mood of patients with acute…
- Trial name
- NCT03310918
- Testing
- Palliative Care, Standard Leukemia care
- Where
- 2 sites in United States
- Volunteers
- 320 people
- Sponsor
- Massachusetts General Hospital
Graft Failure, Dialysis
Factors for Impairment of Renal Graft Function in Intensive Care
hypothesis = hospitalization in the intensive care unit (ICU) has an impact on the outcome of the renal graft, due to the therapeutic and exploratory procedures performed.
- Conditions
- Graft Failure, Dialysis, Chronic Kidney Failure
- Trial name
- RENAGRAF (NCT06191146)
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Cognitive Impairment, Mild, Quality of Life
Virtual Reality Stimulation to Enhance Cognitive Function of Intensive Care Unit Patients
An observational study will be conducted in the ICU (Intensive care unit) including patients with heart surgery (< 5 days) and prolonged ICU stay (> 5 days). Patients will receive 5 min Virtual reality stimulation per day.
- Trial name
- NCT03025373
- Testing
- Visuo-acoustic stimulation
- Where
- Switzerland
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Heart Failure, ICUAW
Intensive Care Unit-acquired Heart Failure in Critically Ill: the ICU-HF Study
Critically ill patients in intensive care units (ICUs) are exposed to a wide range of complications that can affect long-term morbidity and mortality.
- Trial name
- ICU-HF (NCT07094425)
- Testing
- transthoracic echocardiography
- Where
- 2 sites in Austria, Germany
- Volunteers
- 50 people
- Sponsor
- Charite University, Berlin, Germany
Intensive Care Unit, Mechanical Ventilation
Night-time Dexmedetomidine-esketamine Infusion and Sleep Quality in ICU Patients
Dexmedetomidine and ketamine are both suggested for sedation and analgesia in ICU patients. Recent studies suggest that low-dose dexmedetomidine or ketamine/esketamine may improve sleep quality of ICU patients.
- Conditions
- Intensive Care Unit, Mechanical Ventilation, Dexmedetomidine, Esketamine
- Trial name
- NCT05718024
- Testing
- Dexmedetomidine-esketamine, Routine sedation and analgesia
- Where
- China
- Volunteers
- 174 people
- Sponsor
- Peking University First Hospital
Brain Death
Determining ICU Staffs Conceptions, Opinions, Views, Experiences and Reflection of Brain Death and Organ Donation
The study aims to gather information regarding the individual perceptions, opinions, beliefs, and conceptual understanding of healthcare professionals working in the intensive care units at the University Hospital Basel, the…
- Trial name
- DISCOVER (NCT06640088)
- Where
- Switzerland
- Volunteers
- 338 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Neuromuscular Electrical Stimulation, Intensive Care Unit Acquired Weakness
Effects of Neuromuscular Electrical Stimulation on Muscle Mass and Strength in Critically Ill Patients After Cardiothoracic Surgery
The purposes of this study are 1) to determine whether neuromuscular electrical stimulation (NMES) is effective in preventing loss of muscle mass and strength and 2) to observe the time variation of MLT and strength from…
- Conditions
- Neuromuscular Electrical Stimulation, Intensive Care Unit Acquired Weakness, Muscle Wasting, Muscle Loss
- Trial name
- Catastim 2 (NCT02391103)
- Testing
- Compex 3 Professional (CefarCompex Medical AB) stimulator
- Volunteers
- 54 people
- Sponsor
- Medical University of Vienna
Information Retention
Telephone Follow-up From an Intensive Care Nursery
The first few weeks after leaving the Neonatal Intensive Care Unit (NICU) can be a difficult transition time for caregivers of a previously hospitalized infant.
- Trial name
- NCT00604240
- Where
- 2 sites in United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Christiana Care Health Services
Delirium
Incidence and Prognostic Value of Delirium in Patients With Acute Coronary Syndromes
The Purpose of this study is to evaluate the incidence of delirium in patients with acute coronary syndromes admitted to a Intensive Care Unit Patients.
- Trial name
- NCT02356523
- Testing
- Confusion Assessment Method
- Where
- Italy
- Volunteers
- 700 people
- Sponsor
- Ospedale San Donato
Acute Respiratory Failure
Effect Of Acute Inflammatory Mediators On Functional Limitations In Patients With Acute Respiratory Failure
This is a randomized, controlled, pilot study of two separate Cohorts of patients from the intensive care unit. Cohort I will enroll 50 patients and randomize to receive one physical therapy session per day or receive usual ICU…
- Trial name
- NCT01707303
- Testing
- Early ICU rehabilitation strategies, Usual Care
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Wake Forest University
Abdominal Surgery, Thoracic Surgery
Parent/Nurse Controlled Analgesia in the Neonatal Intensive Care Unit
The aim of this study is to examine the safety and effectiveness of 2 morphine delivery systems for post-surgical neonates. The investigators hypothesize that this study will be feasible to conduct, and that neonates receiving…
- Trial name
- PNCA (NCT01823497)
- Testing
- Morphine
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Medical College of Wisconsin
Agitated; State, Acute Reaction to Stress, Anxiety
Effect of Nature Based Sounds' Intervention on Agitation and Anxiety of Patients Admitted in Intensive Care Units.
Effect of nature based sounds' intervention on Agitation and Anxiety of patients admitted in Intensive Care Units of MMIMS\&R Hospital, Mullana, Ambala
- Trial name
- NCT03213782
- Testing
- Nature based sounds
- Volunteers
- 60 people
- Sponsor
- Maharishi Markendeswar University (Deemed to be University)
Fungal Infection
The Impact of Rapid Diagnostic Methods in the Diagnosis of Fungal Infections in Intensive Care Units of Assiut University Hospital
The diagnosis of invasive fungal disease remains challenging in the clinical laboratory. The use of matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) for the identification of filamentous…
- Trial name
- NCT05876962
- Volunteers
- 100 people
- Sponsor
- Assiut University
Sepsis
A Study of Meropenem Standard 30 Minute Infusion Versus Prolonged 3 Hour Infusion in Intensive Care Unit (ICU) Patients
Meropenem is a powerful antibiotic used in intensive care for people who have very serious infections. Meropenem is rapidly removed from the blood by the kidneys and it is very expensive.
- Trial name
- MERO001 (NCT00891423)
- Testing
- Meropenem short infusion, Meropenem extended infusion
- Where
- Australia
- Volunteers
- 10 people
- Sponsor
- Austin Health
Intensive Care
Bedside Measurement of Ventilation With or Without a One-way Valve During Lung Lavage
Surveillance of the lungs for bacteria is routinely undertaken in artificially ventilated patients as these individuals are at high risk of developing pneumonia.
- Trial name
- NCT01143961
- Testing
- CSC100 - Verso airway access adapter CareFusion
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Cardiff and Vale University Health Board
Infant, Premature, Diseases, Premature Birth of Newborn
Elevated Midline Positioning During Diaper Change in Preterm Infants
Diaper changing is one of the most frequent routine care procedures in the neonatal intensive care unit (NICU) and is known to cause physiological instability and behavioral stress responses in preterm infants.
- Conditions
- Infant, Premature, Diseases, Premature Birth of Newborn, Pain
- Trial name
- NCT07865897
- Testing
- 30-Degree Elevated Midline Positioning, Standard Lateral Position Diaper Change
- Volunteers
- 80 people
- Sponsor
- Akdeniz University
Cardiogenic Shock, Heart Failure
NIVIA-Hemodynamics
This is an investigator-initiated, single-center, single-arm prospective study to compare non-invasive hemodynamic assessment using transthoracic echocardiography (TTE) and lung ultrasound (LUS) and hemodynamic assessment using…
- Conditions
- Cardiogenic Shock, Heart Failure, Shock, Hemodynamic Instability
- Trial name
- NCT06330597
- Testing
- Echocardiography and lung ultrasound
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Palliative Care, Withdrawal of Life Support
End-of-life Care in Mechanically Ventilated Patients: Impact of a Comprehensive Palliative Care Protocol in the Intensive Care Setting
The ARREVE-3 trial will evaluate whether a structured palliative care protocol can improve end-of-life management for mechanically ventilated ICU patients in whom a decision to withdraw life-sustaining therapies has been made.
- Conditions
- Palliative Care, Withdrawal of Life Support, Intensive Care Medicine, Sedation
- Trial name
- ARREVE-3 (NCT07368010)
- Testing
- Protocol for palliative care and life-support withdrawal
- Where
- France
- Volunteers
- 720 people
- Sponsor
- Nantes University Hospital
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