Clinical trials: Hypoxic Conditions
Infarction, Middle Cerebral Artery, Middle Cerebral Artery Stroke
Multicenter Efficacy Study of Recombinant Human Erythropoietin in Acute Ischemic Stroke
The purpose of this randomized, double-blind, placebo-controlled multicenter study is to determine in a cohort of 506 patients with acute ischemic stroke in the middle cerebral artery territory, the effect of a three-day…
- Conditions
- Infarction, Middle Cerebral Artery, Middle Cerebral Artery Stroke, Stroke, Acute
- Trial name
- ESS (NCT00604630)
- Testing
- recombinant human erythropoietin alfa, 0.9% NaCl
- Where
- 9 sites in Germany
- Volunteers
- 522 people
- Sponsor
- Max-Planck-Institute of Experimental Medicine
Oxygen Deficiency, COPD Exacerbation
FreeDom: Innovative Strategy for the Management of COPD Exacerbations
The main objective of the study is to assess the "FreeDom" innovative strategy (FreeO2 at Domicile) to reduce hospitalization duration in patients with COPD exacerbation.
- Trial name
- NCT03396172
- Testing
- Control, FreeDom
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Laval University
Hypoxia, Desaturation of Blood
SpO2 Accuracy Low Saturation Validation of the OxySoftN Sensor
To compare prototype pulse oximeter saturation measurements, during normal to low saturation, to saturation measurements made by a multi-wavelength CO-oximeter, taken from arterial blood samples from healthy human subjects.
- Trial name
- NCT04811963
- Testing
- Non-Invasive Controlled Hypoxia
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Medtronic - MITG
Trauma, Cardiac Arrest
Airway Management Study in Physician Manned Helicopter Emergency Medical Services
An international airway management expert group has recently developed an Utstein-style template for uniform reporting of data from prehospital advanced airway management.
- Conditions
- Trauma, Cardiac Arrest, Emergencies
- Trial name
- AIRPORT (NCT01502111)
- Where
- Norway
- Volunteers
- 2,333 people
- Sponsor
- Norwegian Air Ambulance Foundation
Nocturnal Hypoxemia
Evaluation of POC Pulse-dose Demand Oxygen Delivery for Nocturnal Hypoxemia
The aim of this study is to describe the effect of the Inogen Rove 6 Portable Oxygen Concentrator on peripheral oxygen saturation in adults receiving supplemental oxygen at night and examine whether the device can adequately…
- Trial name
- NCT06000332
- Testing
- InogenOne Rove 6 Portable Oxygen Concentrator
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Inogen Inc.
Chronic Respiratory Failure, Acute Respiratory Failure
Validation Study of the EMILY AI Device in Acute and Chronic Respiratory Failure
Currently, there is no holistic solution for patients with respiratory diseases that includes oxygenation and management of a patient with respiratory disease, combining dynamic and automatic O2 administration and the detection…
- Trial name
- NCT06952816
- Testing
- Emily.AI
- Where
- 2 sites in Spain
- Volunteers
- 20 people
- Sponsor
- Aether Tech S.L.
Hypoxemia
HFLVV for Hypoxemia in Robot-assisted Cardiac Surgery
These robot-assisted cardiac surgeries usually require single-lung ventilation (SLV) to facilitate surgical exposure. SLV creates ventilation/perfusion mismatch and shunt (Qs:Qt) through the collapsed lung and leads to hypoxemia.
- Trial name
- NCT04926649
- Testing
- Differential ventilation to the non-dependent lung
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
COVID-19
Awake Prone Position for Early Hypoxemia in COVID-19
Prone positioning is a well studied and validated treatment for severe acute respiratory distress syndrome (ARDS), however there are no randomized studies on the use of prone positioning in the non-intubated patient.
- Trial name
- APPEX-19 (NCT04344587)
- Testing
- Self-prone position recommendation, Usual care
- Where
- 13 sites in United States, Spain
- Volunteers
- 305 people
- Sponsor
- Boston University
Hypoxemic Respiratory Failure
Correlation of Peak Tidal Inspiratory Flow Measured Before and After Extubation in Adult Patients With Hypoxemia
In this study, patients who are ready for extubation and indicated for high-flow nasal cannula therapy after extubation will be enrolled, the investigators would measure the patient peak tidal inspiratory flow (PTIF) pre and post…
- Trial name
- NCT04971148
- Testing
- HFNC flow set at patient peak tidal inspiratory flow, HFNC flow set at 1.33 times of patient peak tidal inspiratory flow, HFNC flow set at 1.67 times of patient peak tidal inspiratory flow
- Where
- 2 sites in United States, Spain
- Volunteers
- 5 people
- Sponsor
- Rush University Medical Center
Retinal Oxygenation, Retinal Blood Flow
Effect of Systemic Hypoxia and Hyperoxia on Retinal Oxygen Saturation
Adequate perfusion and oxygenation is essential for the function of the inner retina. Although it is known that oxygen tension is very well autoregulated in the retina, the physiological mechanisms behind this regulation process…
- Trial name
- NCT01692821
- Testing
- 100% oxygen breathing, 15% oxygen in N2 breathing, 12% oxygen in N2 breathing
- Where
- Austria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Perioperative/Postoperative Complications, Hypovolemia
Goal-directed Therapy in High-risk Surgery
There is growing evidence that the risk of postoperative complications can be decreased by optimizing the amount and type of infusion fluids given during surgery, steered by goal-directed therapy based on flow-related hemodynamic…
- Conditions
- Perioperative/Postoperative Complications, Hypovolemia, Hypoxia
- Trial name
- NCT01681238
- Testing
- Protocol group 2, Protocol group 1
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Guangzhou First People's Hospital
High Altitude Pulmonary Hypertension
Highlanders With High Altitude Pulmonary Hypertension (HAPH), 6 Minute Walk Distance (6MWD) Assessed at 3200m With and Without Supplemental Oxygen Therapy (SOT)
The investigators aim to study the effect of SOT in highlanders with high altitude pulmonary hypertension (HAPH) who permanently live >2500m on 6-minute walk distance (6MWD) assessed at 3200m.
- Trial name
- NCT06489743
- Testing
- 6-minute walk test (6MWT)
- Where
- Kyrgyzstan
- Volunteers
- 24 people
- Sponsor
- University of Zurich
Hypoxia, Anemia
Diastolic Deceleration Area in Early-onset FGR
DDA is a new Doppler parameter aiming to assess fetal well-being in-utero. Early-onset SGR is a specific subgroup of fetuses where the clinical application of this Doppler modality could play an important role in the detection of…
- Trial name
- NCT05820464
- Testing
- DDA Doppler
- Where
- Bulgaria
- Volunteers
- 300 people
- Sponsor
- Orthogyn Medical Center, Bulgaria
Hypoxia
Accuracy of the EvieMED Ring Pulse Oximeter in Profound Hypoxia
The goal of this study was to evaluate the accuracy of pulse oximeters over the range of 70-100% per the International Organization for Standardization (ISO) 80601-2-61:2019.
- Trial name
- NCT06459206
- Testing
- Pulse oximeter
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Movano Health
Sepsis, Bacteraemia
Optimising Diagnosis and Antibiotic Prescribing for Acutely Ill Children in Primary Care
Acute illness is the most common presentation of children attending ambulatory care settings. Serious infections (e.g. meningitis, sepsis, pyelonephritis, pneumonia) are rare, but their impact is quite large (increased morbidity…
- Conditions
- Sepsis, Bacteraemia, Meningitis, Abscess
- Trial name
- ERNIE2 (NCT02024282)
- Testing
- Use of C-reactive protein (CRP) point of care test, Brief intervention and parent leaflet, Finger Pulse Oximeter
- Where
- 2 sites in Belgium
- Volunteers
- 8,962 people
- Sponsor
- KU Leuven
Severe Obesity, Hypoxia
Use of Non-Invasive Positive Pressure Ventilation in Patients With Severe Obesity Undergoing Upper Endoscopy Procedures
The study evaluated the effect of non-invasive positive pressure ventilation (NIPPV) to decrease the incidence of desaturation events in patients with severe obesity undergoing upper endoscopy.
- Trial name
- NCT03529461
- Testing
- Non-invasive positive pressure ventilation through nasal mask, Rescue non-invasive positive pressure ventilation through nasal mask, Secondary rescue maneuvers
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Bristol Hospital
Cerebral Palsy, Hypoxic-Ischemic Encephalopathy
Early Virtual Intervention for Infants With CP Following HIE Diagnosis
This will be a five year study that will be a prospective, randomized, controlled trial (RCT) to assess the effect of a virtual early intervention care delivery model in the provision of therapy to enhance the neurodevelopmental…
- Conditions
- Cerebral Palsy, Hypoxic-Ischemic Encephalopathy, Brain Injuries, Perinatal Hypoxia
- Trial name
- RECOVER (NCT04913324)
- Testing
- Virtual Care
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- The Hospital for Sick Children
Anoxic Brain Injury
Safety and Efficacy Assessment of Autologous Bone-marrow Derived Adult Mesenchymal Stem Cell Therapy in Patients With Anoxic(or Hypoxic) Brain Injury Pilot Trial
The purpose of study is to evaluate the safety and efficacy of autologous bone marrow-derived stem cells therapy in patients with anaerobic (hypoxic) brain injury.
- Trial name
- NCT02210624
- Testing
- HYNR-CS inj.
- Where
- South Korea
- Volunteers
- 4 people
- Sponsor
- Hyun Young Kim
Hypoxemia
Comparison of the Non-rebreather Mask With the Double-trunk Mask
This study will compare the impact of the Double-Trunk Mask (DTM) with the Non-Rebreather Mask (NRM) on the blood gases of patients with severe hypoxemia.
- Trial name
- NCT04383821
- Testing
- Double-Trunk Mask, Non-Rebreather mask
- Where
- 3 sites in Belgium
- Volunteers
- 25 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Hypoxia, Esophageal Cancer
COMBO Endoscopy Oropharyngeal Airway in Sedated Gastrointestinal Endoscopy for Obese Patients
Hypoxia represents the prevailing adverse occurrence during the sedation of patients undergoing gastrointestinal endoscopy with propofol. This is particularly true for obese patients, who have a higher incidence of hypoxia.
- Conditions
- Hypoxia, Esophageal Cancer, Colon Cancer, Gastric Cancer
- Trial name
- NCT06804876
- Testing
- the COMBO Endoscopy Oropharyngeal Airway
- Where
- China
- Volunteers
- 107 people
- Sponsor
- Zhejiang University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.