Clinical trials: Hypotension During Surgery
Hypotension Drug-Induced
A Prospective Study of Vasopressor on Cerebral Oxygenation During General Anesthesia
The purpose of this study is to investigate whether norepinephrine(N), phenylephrine(P) or ephedrine(E) have different effect on cerebral oxygenation in abdominal surgery with propofol or sevoflurane.
- Trial name
- NCT06334549
- Testing
- Ephedrine-P, Phenylephrine-P, Norepinephrine-P
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Dalian Municipal Central Hospital
Hypotension, ENT Disease
Influence of the "Hypotension Probability Index" on Intraoperative and Postoperative Hypotension in ENT- and OM-Surgery
The aim of the project is to investigate whether the use of the HPI can reduce the number and duration of intra- and postoperative hypotension in ventilated patients during and two hours after extensive surgery in the head and…
- Conditions
- Hypotension, ENT Disease, Acute Kidney Injury, Anesthesia
- Trial name
- NCT04151264
- Testing
- Hypotension probability index (HPI)
- Where
- Germany
- Volunteers
- 75 people
- Sponsor
- University of Giessen
Hypotension, Spinal Anesthetics Causing Adverse Effects in Therapeutic Use
Use of Perfusion Index Change as a Predictor of Hypotension During Propofol Sedation in Adult Patients Undergoing Hip Surgery Under Spinal Anesthesia: A Prospective Observational Study
This observational study is to evaluate Perfusion Index Change as a Predictor of Hypotension During Propofol Sedation in Adult Patients Undergoing Hip Surgery Under Spinal Anesthesia.
- Trial name
- NCT03556969
- Testing
- Observation
- Where
- South Korea
- Volunteers
- 39 people
- Sponsor
- Samsung Medical Center
Hypotension During Surgery, Surgery-Complications
Incidence of Hypotension in the Post-anesthesia Care Unit (PACU).
The perioperative period poses a heightened risk of complications for patients, including hypotension. While the issue of intraoperative hypotension is well-documented in medical literature, the occurrence and causes of…
- Trial name
- NCT07022210
- Where
- Czechia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tomas Bata Hospital, Czech Republic
Protamine Allergy, Protamine Adverse Reaction
Serum Tryptase Levels During Cardiac Surgery, Diagnosis and Treatment Decisions for Allergic Reactions
The investigators aim to assess tryptase test efficacy for measuring the allergic response to protamine during cardiac bypass surgery.
- Trial name
- NCT02644785
- Testing
- protamine
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Mustafa Kemal University
Functional Endoscopic Sinus Surgery
Comparison Between Pregabalin and Magnesium Sulfate in Hypotensive Anaesthesia
Comparison between pregabalin and magnesium sulfate in hypotensive anaethesia
- Trial name
- NCT05442931
- Testing
- Pregabalin 150mg, Magnesium Sulfate, Nitroglycerin
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Minia University
Endovascular Carotid Surgery, Preoperative Hypotension
Compared Efficacy and Tolerance of Two Vasopressors Used to Treat Preoperative Hypotension During Carotid Surgery
The effects on brain perfusion of the two currently vasopressors used to treat accidental hypotension occurring during carotid surgery (i.e.
- Trial name
- VP-hTA-XCar (NCT01794273)
- Testing
- ephedrine and phenylephrine
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Clermont-Ferrand
Hypotension During Surgery
Electrical Acupoint Stimulation Reduces Intrathecal Anesthesia Induced Hypotension
The parturients may suffer from hypotension after spinal anesthesia and the incidence could be as high as 70-80% when pharmacological prophylaxis is not used.
- Trial name
- EARTH (NCT05724095)
- Testing
- high frequency acupoint stimulation, low frequency acupoint stimulation, electrodes attached
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Zhihong LU
Vasoplegia Syndrome, Vasoplegia
Femoral Versus Radial Invasive Arterial Pressure Monitoring in Cardiac Surgery Patients
Background: Acute circulatory failure, often presenting as arterial hypotension, is a major contributor to postoperative morbidity and mortality.
- Conditions
- Vasoplegia Syndrome, Vasoplegia, Cardiac Surgical Procedures, Arterial Pressure
- Trial name
- FERARI (NCT06952907)
- Testing
- Femoral artery catheterization for continuous invasive arterial blood pressure monitoring, Radial artery catheterization for continuous invasive arterial blood pressure monitoring
- Where
- 2 sites in France
- Volunteers
- 340 people
- Sponsor
- Guillaume BESCH
Hypertension, Hypotension
Intranasal Injection Versus Topical Administration of Epinephrin During Endoscopic Sinus Surgery
Intranasal injection of epinephrine is used routinely during endoscopic sinus surgery (ESS) to reduce bleeding in the nasal mucosa and thereby improve visualization of the surgical field.
- Conditions
- Hypertension, Hypotension, Tachycardia, Bradycardia
- Trial name
- NCT01075581
- Testing
- Epinephrin (Intranasal injection), Epinephrin (Topical administration)
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Hypotension During Surgery, Prevention of Hypotension
"Hypotension Probability Indicator" in TAVI/MitraClip for Hypotension Management
The study will investigate whether the use of Goal Directed Hemodynamic Therapy implemented with the HPI algorithm using a treatment algorithm will reduce the incidence of hypotension and improve treatment of hypotension.
- Trial name
- NCT06347211
- Testing
- Acumen IQ sensor with Hemosphere monitor incorporating the HPI algorithm
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Attikon Hospital
Magnesium Sulfate, Remifentanil
Anesthesia Techniques, Neuroprotection and Surgical Field in FESS Under Controlled Hypotension
This prospective, randomized controlled trial investigates the effect of four different anesthetic maintenance techniques on surgical field conditions, hemodynamic stability, and neuroprotection during functional endoscopic sinus…
- Conditions
- Magnesium Sulfate, Remifentanil, S 100beta, S100 Beta Protein, Human
- Trial name
- NCT07181564
- Testing
- Propofol / Remifentanil, Ketamine + Magnesium sulfate (drug combination), Sevoflurane and Remifentanil
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- University General Hospital of Patras
Hypotension During Surgery, NGAL
Controlled Hypotension and Renal Injury During Septoplasty
This prospective randomized single-blind study investigated the effects of two different mean arterial pressure (MAP) targets during controlled hypotension on renal injury in patients undergoing septoplasty.
- Conditions
- Hypotension During Surgery, NGAL, Kidney Injury
- Trial name
- NCT07662577
- Testing
- Controlled Hypotension (MAP 50-57 mmHg), Controlled Hypotension (MAP 58-65 mmHg)
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Hypotension, Cardiopulmonary Bypass
Pharmacokinetics and Pharmacodynamics of MTR105 in Hypotensive Cardiac Surgery Patients
The purpose of this study is to evaluate the safety, pharmacokinetic and the pharmacodynamic effects of escalating doses of MTR105 while weaning from bypass in a hypotensive population of cardiac surgery patients.
- Trial name
- NCT00482287
- Testing
- MTR105
- Where
- United States
- Sponsor
- Meditor Pharmaceuticals Ltd.
Hypotension During Surgery
Use of Hypotension Prediction Index to Reduce Intraoperative Hypotension in Major Thoracic Surgery
Intraoperative hypotension is linked to increased incidence of perioperative adverse events such as myocardial and cerebrovascular infarction and acute kidney injury.
- Trial name
- NCT05615168
- Testing
- "Acumen IQ" guided hemodynamic optimization, "Flotrac" guided hemodynamic optimization
- Where
- Croatia
- Volunteers
- 34 people
- Sponsor
- University Hospital Dubrava
Hemodynamic
Three Different GHDT ( Goal Hemodynamic Directed Therapy) Strategies for Intraoperative Fluid Management Optimization During Major Abdominal Surgery: A Randomized Controlled Trial
Major oncological surgery is among the most complex procedures, involving patients with a combination of high-risk factors that can significantly influence immediate postoperative outcomes and quality of life.
- Trial name
- SMART FLUID (NCT06871150)
- Testing
- Flotrac sensor, HPI, HPI-AFM
- Where
- 3 sites in Italy
- Volunteers
- 150 people
- Sponsor
- ASST Sette Laghi
Hypotension, Orthostatic, Total Hip Replacement
Study on Baroreceptor Function in Relation to Orthostatic Blood Pressure Regulation After Hip Surgery
The purpose of this observational study is to evaluate the baroreceptor function in relation to surgical inflammation and orthostatic intolerance after elective hip arthroplasty.
- Trial name
- NCT01866787
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Etomidate, Hypotension
The Safety of Etomidate - Propofol Mixture vs Propofol in Total Intravenous Anesthesia During Abdominal Surgery
The purpose of this study is to access the safety of etomidate - propofol mixture vs propofol in total intravenous anesthesia during abdominal surgery.
- Trial name
- NCT05810363
- Testing
- Etomidate - propofol mixture, Propofol
- Where
- China
- Volunteers
- 468 people, healthy volunteers welcome
- Sponsor
- Ailin Luo
Hypotension During Surgery, Perioperative Complication
Hypotension Predictive Index Effect on Intraoperative Hypotension During Pancreatic Surgery.
Intraoperative hypotension (IOH) is a sudden clinical phenomenon that occurs frequently during general anesthesia. Prevention of IOH has been linked to reduced postoperative organ damage and decreased incidence of perioperative…
- Trial name
- EHPI-Pan (NCT06097052)
- Testing
- Hypotension Predictive Index
- Where
- Italy
- Volunteers
- 48 people
- Sponsor
- Istituto Clinico Humanitas
Preoperative Fasting and Hypotension
Effect of the Duration of Preoperative Fasting on Hypotension Induced by General Anesthesia in the Elderly Person
This study aims to determine if prolonged fasting represents an independent risk factor for hypotension during induction of general anesthesia in the elderly.
- Trial name
- JEÛNE PREOP (NCT02891122)
- Where
- France
- Volunteers
- 56 people
- Sponsor
- University Hospital, Brest