Clinical trials: Hyposalivation
Oral Mucositis, Chemotherapy-induced Oral Mucositis
Ozone Therapy With Biomimetic Oral Care for Cancer-Related Oral Mucositis
Oral mucositis is a frequent and often debilitating complication of radiotherapy and chemotherapy, particularly in patients treated for head and neck cancers.
- Conditions
- Oral Mucositis, Chemotherapy-induced Oral Mucositis, Head and Neck Neoplasms
- Trial name
- OZOMUC (NCT07491536)
- Testing
- Gas Ozone Therapy, Biomimetic Oral Care Regimen
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Pavia
Sjogren's Syndrome
Assessment of Inflammatory Biomarkers Expressed in a Sjogren's Population: Effect of a Topical Steroid Intervention
The primary purpose of this study is to quantify the change in expression of biomarkers on the ocular surface of Sjogren's Syndrome participants after treatment with Maxidex.
- Trial name
- NCT00631358
- Testing
- Maxidex, No treatment
- Where
- 2 sites in Canada
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Sjogren's Disease
Evaluation of the Reproducibility Inter-observer of the Ultrasound Anomalies of the Salivary Glands in Sjogren's Disease
This aim of this study is to compare the reproducibility of reading of five international experts concerning the anomalies of the salivary glands. The reproducibility is measure on patients and not on recorded data.
- Trial name
- ETREINTE (NCT02358213)
- Testing
- Ultrasound
- Volunteers
- 21 people
- Sponsor
- University Hospital, Brest
Sjögren's Disease
a Salivary Cell-free RNA Liquid Biopsy Model for Non-invasive Diagnosis in Sjögren's Disease
The goal of this observational study is to learn whether salivary cell-free RNA (cfRNA) can be used as a non-invasive liquid biopsy test to help diagnose Sjögren's disease (SjD) and understand disease-related changes in the…
- Trial name
- cell-free RNA (NCT07824440)
- Where
- China
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Cancer of Head Neck, Radiation-Induced Xerostomia
Efficacy of Oral Moisturizing Jelly on Oral Health and Nutrition in Post-radiotherapy Head and Neck Cancer Patients
This randomized control trial aims to investigate the efficacy of oral moisturizing jelly in head and neck cancer patients with xerostomia.
- Conditions
- Cancer of Head Neck, Radiation-Induced Xerostomia, Dry Mouth
- Trial name
- NCT03035825
- Testing
- Oral moisturizing jelly, Artificial saliva
- Where
- Thailand
- Volunteers
- 73 people
- Sponsor
- Dental Innovation Foundation Under Royal Patronage
Xerostomia
Artificial Saliva Containing Cumin and Ginger Extract in Head and Neck Cancer Patients With Xerostomia
The objectives of this study are to evaluate efficacy and safety of artificial saliva containing cumin and ginger extract in head and neck cancer patients with xerostomia.
- Trial name
- NCT05872464
- Testing
- Artificial saliva containing cumin and ginger extract
- Volunteers
- 52 people
- Sponsor
- Chulalongkorn University
Dental Caries, Dry Mouth
Oral Health Intervention in Adult Primary Care
This study is a Stage III cRCT to test the efficacy of multi-level interventions at the practice- and provider-level to address low dental utilization (attendance) among Medicaid-enrolled older adults 55 years or older attending…
- Conditions
- Dental Caries, Dry Mouth, Periodontal Diseases, Bleeding Gum
- Trial name
- NCT06555029
- Testing
- EHR Changes, Medical Staff EHR Training, Clinician CSM theory-based didactic education and skills training, Standard ADA Oral Health Training
- Where
- United States
- Volunteers
- 929 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Quality of Life, Oral Mucositis
Efficacy of a Probiotic and Microbiological Analysis on Oral Complications in Patients With HNC
The study is a Clinical Trial and the main objective is to Evaluate the effects of probiotics on oral complications induced by antineoplastic therapies in patients with head and neck cancer, attended at the radiotherapy service…
- Conditions
- Quality of Life, Oral Mucositis, Dental Plaque, Periodontal Diseases
- Trial name
- HNC (NCT06122636)
- Testing
- The probiotic to be used in the intervention corresponds to PRODEFEN Plus manufactured by ITALFARMACO S.A. laboratory
- Where
- Spain
- Volunteers
- 62 people
- Sponsor
- University of Barcelona
Xerostomia
A Study of Patients With Dry Mouth and Sticky Saliva During Radiotherapy
The purpose of this study is to evaluate the clinical safety and effectiveness of Visco-ease dry mouth spray for the treatment of Radiotherapy Induced Xerostomia (RIX) in head and neck cancer patients.
- Trial name
- NCT02687087
- Testing
- Visco-ease
- Where
- United Kingdom
- Volunteers
- 44 people
- Sponsor
- NHS Greater Glasgow and Clyde
Sjögren's Syndrome
Evaluation of the Efficacy and the Mechanism of Chinese Herbal Formula SS-1 for Sjögren's Syndrome
To evaluate the efficacy of Chinese herbal medicine (SS-1) for the Sjögren's syndrome (SJS) patients.
- Trial name
- SS-1 (NCT02110446)
- Testing
- SS-1
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Chang Gung Memorial Hospital
Systemic Lupus Erythematosus, Systemic Sclerosis
An Clinical Study of YTS109 Cell Injection in Subjects With Recurrent/Refractory Autoimmune Disease
An exploratory clinical study of the safety and efficacy of YTS109 cell injection in subjects with recurrent/refractory autoimmune disease
- Conditions
- Systemic Lupus Erythematosus, Systemic Sclerosis, Inflammatory Myopathy, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
- Trial name
- NCT06379646
- Testing
- YTS109
- Where
- China
- Volunteers
- 6 people
- Sponsor
- China Immunotech (Beijing) Biotechnology Co., Ltd.
Sjögren's Syndrome
Proof of Concept Study to Evaluate the Efficacy and Safety of BMS-931699 (Lulizumab) or BMS-986142 in Primary Sjögren's Syndrome
The primary objective of this study is to evaluate the efficacy of treatment with either lulizumab or BMS-986142 versus placebo in subjects with moderate to severe primary Sjögren's syndrome as measured by the change from…
- Trial name
- NCT02843659
- Testing
- BMS-931699, BMS-986142
- Where
- 34 sites in United States, Australia and 9 more
- Volunteers
- 45 people
- Sponsor
- Bristol-Myers Squibb
Head and Neck Cancer
The Management of RT-induced Hyposalivation Using LLLT
The primary purpose is to evaluate the effectiveness of photobiomodulation laser application in the management of patients with radiotherapy-induced hyposalivation.
- Trial name
- REACH-LLLT (NCT05538169)
- Testing
- low-level laser diode (Pioon Laser)
- Where
- Saudi Arabia
- Volunteers
- 10 people
- Sponsor
- King Saud University
SARS-CoV-2, Systemic Lupus Erythematosus
Association Between Long-term Hydroxychloroquine Treatment and Outcome of a History of Symptoms Suggestive of COVID-19 Infection During the Epidemic Period in France in Patients With Autoimmune Disease
This epidemiological, transversal, cohort study aims to determine the potential influence of an active long-term hydroxychloroquine intake over the prevalence of a history of symptoms evocative of a COVID-19 infection in patients…
- Conditions
- SARS-CoV-2, Systemic Lupus Erythematosus, Rheumatoid Arthritis, Sjogren's Syndrome
- Trial name
- COVCALL (NCT04345159)
- Testing
- Questionnaire by phone call
- Where
- France
- Volunteers
- 572 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Head and Neck Cancer, Radiation Toxicity
Salivary Gland Surgery Before Radiation Therapy in Preventing Radiation-Caused Xerostomia in Patients With Head and Neck Cancer
RATIONALE: Moving a salivary gland out of the area that will undergo radiation therapy may protect the gland from side effects of radiation therapy and may prevent xerostomia (dry mouth).
- Conditions
- Head and Neck Cancer, Radiation Toxicity, Xerostomia
- Trial name
- NCT00068237
- Testing
- salivary gland transfer, Post-operative radiation therapy
- Where
- 12 sites in United States, Canada
- Volunteers
- 49 people
- Sponsor
- Radiation Therapy Oncology Group
Xerostomia, Dry Mouth
Xerostomia in Patients With a Life-limiting Condition or Frailty
Xerostomia, the subjective feeling of dry mouth, is a common symptom during the last year of life in patients with a life-limiting condition or frailty.
- Trial name
- NCT05506137
- Testing
- Pilocarpine
- Volunteers
- 120 people
- Sponsor
- Maastricht University Medical Center
Head and Neck Carcinoma, Xerostomia
Acupuncture-Like Transcutaneous Electrical Nerve Stimulation in Treating Radiation-Induced Xerostomia in Patients With Head and Neck Cancer
This randomized pilot clinical trial studies alternate schedules for acupuncture-like transcutaneous electrical nerve stimulation (ALTENS) in treating dry mouth (xerostomia) caused by radiation therapy (RT) in patients with head…
- Trial name
- NCT02474095
- Testing
- Quality-of-Life Assessment, Transcutaneous Acupoint Electrical Stimulation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Roswell Park Cancer Institute
Keratoconjunctivitis Sicca, Sjogren's Syndrome
Treatment of Dry Eye Syndrome With Cyclosporin A Eye Drops
This study will examine whether cyclosporin A eye drops alleviate dry eye syndrome, a disorder of tear deficiency or excessive tear evaporation. The condition damages the surface of the eye and causes discomfort.
- Trial name
- NCT00001731
- Testing
- Cyclosporin A
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Eye Institute (NEI)
Systemic Lupus Erthematosus, Systemic Vasculitis
Rare AutoImmune SElf-management Programme Development
The rare autoimmune rheumatic diseases (RAIRDs) are life-long multi-system diseases that are life or organ threatening. RAIRDs can impair quality of life similar to chronic diseases such as heart failure.
- Conditions
- Systemic Lupus Erthematosus, Systemic Vasculitis, Inflammatory Myositis, Systemic Sclerosis (SSc)
- Trial name
- RAISE (NCT06642870)
- Testing
- Non-interventional study
- Where
- United Kingdom
- Volunteers
- 360 people
- Sponsor
- University of the West of England
Rheumatoid Arthritis, Spondylitis, Ankylosing
Recombinant Herpes Zoster Vaccine in Patients With Autoimmune Rheumatic Diseases
Introduction: Patients with autoimmune rheumatic diseases (ARDs), rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), psoriatic arthritis (PAs), ankylosing spondylitis (AS), systemic lupus erythematosus (SLE), primary…
- Conditions
- Rheumatoid Arthritis, Spondylitis, Ankylosing, Spondyloarthritis, Systemic Lupus Erythematosus
- Trial name
- RZVRheum (NCT05879419)
- Testing
- Recombinant Herpes Zoster Vaccine (RZV), MTX Discontinuation, MMF Discontinuation
- Where
- Brazil
- Volunteers
- 2,005 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital