Clinical trials: Hypolactasia
Lactose Intolerance
MSOT for Assessment of Intestinal Transit Time in Lactose Intolerance Patients
The study aims to investigate gastrointestinal transit using multispectral optoacoustic tomography (MSOT) in a prospective diagnostic study involving patients suspected of primary or secondary lactose intolerance.
- Trial name
- NCT06617364
- Testing
- gastrointestinal transit time measurement using MSOT and ICG contrast agent
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Lactose Intolerance
Efficacy, Safety, and Tolerability Study of RP-G28 in Subjects With Lactose Intolerance
RP-G28 is being investigated for treatment of moderate to severe lactose intolerance and its potential to improve the tolerance of lactose (dairy products).
- Trial name
- NCT02673749
- Testing
- RP-G28
- Where
- United States
- Volunteers
- 377 people
- Sponsor
- Ritter Pharmaceuticals, Inc.
Lactose Intolerance, Adult Type
Testing the Capability of the Smart Underwear Device to Detect Increased Microbiome Activity Following Lactose Consumption
The goal of this Interventional study is to validate the Smart Underwear device's ability to detect lactose intolerance by comparing its results to self-reported symptoms in adult participants aged 18 and above, divided equally…
- Trial name
- NCT06724705
- Testing
- Lactose, Sucrose, Wear smart underwear
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Maryland, College Park
Lactose Intolerance
Effect of I31 Probiotic on Lactose Intolerance
This randomized study evaluates the usefulness of the I31 probiotic formula, against placebo, in the treatment of symptoms of lactose intolerance.
- Trial name
- NCT04164394
- Testing
- I31 Probiotic
- Where
- Mexico
- Volunteers
- 48 people
- Sponsor
- Hospital Juarez de Mexico
Lactose Intolerance
Effect of a Probiotic Formulation in Adults With Lactose Intolerance and Methanogenic Intestinal Overgrowth
Introduction: Lactose intolerance (LI) is characterized by specific gastrointestinal symptoms following the consumption of dairy products and lactose-containing foods, symptoms that may also be experienced by individuals with…
- Trial name
- LAC L-134/33 (NCT07652827)
- Testing
- Probiotic formulation
- Where
- Chile
- Volunteers
- 22 people
- Sponsor
- Universidad de Concepcion
Gastrointestinal Diseases, Cow's Milk Intolerance
Goat Milk Infant Formula Comfort Study
In this study, the investigators aim to assess that infants with mild symptoms have significantly less (severe) symptoms after 14 days goat milk-based formula use compared to infants using cow's milk-based formula supplemented…
- Trial name
- NCT06301139
- Testing
- Goat milk-based infant formula, Cow's milk-based infant formula with probiotic drops
- Where
- Spain
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Ausnutria Hyproca B.V.
Irritable Bowel Syndrome
Efficacy of a Low FODMAP Diet in the Absence of Lactose Malabsorption in Moderate to Severe ROME IV IBS.
Irritable bowel syndrome (IBS) is a frequently encountered disorder. According to the Rome IV criteria, it is characterized by abdominal pain associated with a change in stool frequency or con-sistency, or with symptomatic…
- Trial name
- NCT05120752
- Testing
- FODMAP diet
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Universitair Ziekenhuis Brussel
Hypolactasia
A Non-inferiority, Multicenter and Randomized, Single-Dose Study About a Treatment to Hypolactasia (LAILAI)
The study primary objective is to compare the clinical efficacy of two formulations in the supportive treatment of lactose intolerance.
- Trial name
- EF099 (NCT01145339)
- Testing
- Lactase
- Where
- 7 sites in Brazil
- Volunteers
- 140 people
- Sponsor
- Eurofarma Laboratorios S.A.
Lactose Intolerance, Adult Type
Comparing the Gastric Transit of Commercial Milk and A2 Milk
Cow's milk contains two types of β-casein: A1 and A2. The μ-opioid peptide BCM-7 is released from A1 but not from A2. BCM-7 is associated with slower gastrointestinal transit and hence increased gastrointestinal transit times.
- Trial name
- NCT05658861
- Testing
- Milk containing A1 and A2 beta-casein, Milk containing only A2 beta-casein
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Purdue University
Lactose Intolerance
Lactobreath: A Study to Diagnose Lactose Intolerance Using Breath Markers
Food intolerances affect many people and can cause discomfort and dietary challenges. One common cause is difficulty digesting certain carbohydrates called FODMAPs.
- Trial name
- Lactobreath (NCT06177938)
- Testing
- Lactose solution/Glucose solution
- Where
- Switzerland
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- ETH Zurich
Lactose Intolerance
Evaluation of the Efficacy, Durability, Safety, and Tolerability of RP-G28 in Patients With Lactose Intolerance
This is a multicenter, randomized, double-blind, placebo-controlled, parallel-group study conducted in the United States (US) to assess the efficacy of RP-G28 compared to placebo on symptom reduction related to lactose…
- Trial name
- NCT03597516
- Testing
- RP-G28
- Where
- 35 sites in United States
- Volunteers
- 557 people
- Sponsor
- Ritter Pharmaceuticals, Inc.
Lactose Intolerance
Comparison of the Colonic Metabolism in Patients With Lactose Intolerance and Healthy Controls
Most people are born with the ability to digest lactose, a dissacharide consisting of β-D-glucose and β-D-galactose, because of the presence of lactase at the brush border of the small intestine.
- Trial name
- NCT02171403
- Where
- Belgium
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Small Intestinal Bacterial Overgrowth, Lactose Intolerance
Clinical Utility of Breath Tests in GI
Bloating, gas, pain and diarrhea are common complaints. Routine investigations are negative; these patients are labeled as IBS. In these patients, whether testing for carbohydrate malabsorption or small intestinal bacterial…
- Conditions
- Small Intestinal Bacterial Overgrowth, Lactose Intolerance, Fructose Intolerance, Glucose Intolerance
- Trial name
- NCT03261856
- Where
- United States
- Volunteers
- 1,080 people
- Sponsor
- Augusta University
Lactose Intolerance
Screening of Lactose Intolerance Among IBS Patients Diarrhea Dominant
This cross-sectional study aims to determine the prevalence of lactose intolerance among patients with chronic diarrhea, assess its correlation with age and gender, and evaluate common symptoms in affected patients.
- Trial name
- NCT06931379
- Volunteers
- 70 people
- Sponsor
- Assiut University
Lactose Intolerants, Lactose Malabsorption
Milk Beta Caseins on Digestive Discomfort, Gastric Emptying
A1 and A2 β-casein are genetic variants of β-casein in cow's milk that differ by a single amino acid at position 67. Digestion of A1 β-casein may result in greater release of beta-casomorphin-7 (BCM-7), an opioid peptide that may…
- Conditions
- Lactose Intolerants, Lactose Malabsorption, Caseins
- Trial name
- Oral Naloxone (NCT07884123)
- Testing
- A1/A2 milk with oral naloxone, A1PF milk with oral naloxone
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Purdue University
Lactose Intolerance
Prevalence of Lactose Intolerance Following Stem Cell Transplantation
It is currently assumed that all patients are lactose intolerant post bone marrow transplantation. This pilot study is to assess what the incidence of lactose intolerance is after bone marrow transplantation in children.
- Trial name
- NCT00247806
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia
Lactose Intolerance
Effect of a Standard Meal on the Pharmacokinetic Profile of RP-G28 in Healthy Adult Male and Female Subjects
Randomized, open-label, 2-period, 2-sequence, crossover study to evaluate the effect of a standard meal on the pharmacokinetic (PK) profile of orally administered RP-G28.
- Trial name
- RP (NCT03563846)
- Testing
- RP-G28
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Ritter Pharmaceuticals, Inc.
Allergy
Althera® Versus Nutramigen / Cow's Milk Intolerance
The primary objective of this study is to demonstrate that ALTHERA® is equal or superior in efficacy than NUTRAMIGEN®
- Trial name
- NCT01727115
- Testing
- Infant Formula Feeding
- Where
- 14 sites in Belgium
- Volunteers
- 116 people
- Sponsor
- Société des Produits Nestlé (SPN)
Lactose Intolerance
Effects of Lactose on Fecal Microflora
The genetics of lactase divides the population into 2 phenotypes: Those who can(LP) and those who cannot(LNP)digest lactose. This division may help modify disease risks according to geographic population distribution.
- Trial name
- ELM (NCT00599859)
- Testing
- lactose
- Where
- Canada
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Lactose Intolerance, Ulcerative Colitis
Amount of Lactose Causing Symptoms in People With Lactose Intolerance and Ulcerative Colitis
The hypothesis underlying this study is that failure to recognise the role of lactose intolerance among patients with ulcerative colitis has led to inappropriate dietary advice and treatment with drugs that contain lactose as a…
- Trial name
- NCT00403923
- Testing
- Lactose in water
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- University Hospitals, Leicester