Clinical trials: Hypertonia, Muscle
Hyperhidrosis, Muscle Spasticity
Safety and Efficacy of BOTOX® (Botulinum Toxin Type A) in Korea
This post marketing surveillance study in Korea will evaluate the safety and efficacy of BOTOX (botulinum toxin Type A) in patients who receive treatment according to standard of care for primary axillary hyperhidrosis, focal…
- Conditions
- Hyperhidrosis, Muscle Spasticity, Glabellar Lines
- Trial name
- NCT02043145
- Testing
- botulinum toxin Type A
- Where
- South Korea
- Volunteers
- 727 people
- Sponsor
- Allergan
Spasticity, Muscle
Obturator Cryoneurotomy for Hip Adductor Spasticity
The purpose of the study is to measure the effects of obturator nerve cryoneurotomy, on clinical measures in adult (ages 19+) and paediatric (ages 12-18) patients with hip adductor spasticity, who will receive this procedure as a…
- Trial name
- NCT05147441
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Vancouver Island Health Authority
Stroke, Spasticity as Sequela of Stroke
Dynamic Lycra Orthosis as an Adjunct to Botulinum Toxin-A Injection for Post-stroke Spasticity
Upper extremity splints are one of the nonpharmacologic treatments used to treat hypertonicity after stroke. The purpose of splinting is to support, to position, to immobilize, to prevent contracture and deformities, to reduce…
- Conditions
- Stroke, Spasticity as Sequela of Stroke, Upper Limb Hypertonia
- Trial name
- NCT03546959
- Testing
- Lycra sleeve, Rehabilitation, Botulinum Toxin
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Marmara University
Stroke
Neurodynamics on Spasticity in Upper Extremity of Stroke Patients.
Data will be collected from 40 patients with hemiplegia, caused by stroke from DHQ hospital Jhelum. its an RCT Neurodynamics with conventional treatment to experimental group and conventional treatment alone to control group will…
- Trial name
- NCT03822923
- Testing
- Experimental group, Control group
- Where
- Pakistan
- Volunteers
- 41 people
- Sponsor
- Riphah International University
Cerebral Palsy, Spasticity
Dutch National ITB Study in Children With Cerebral Palsy
The objective of this study is to determine the efficacy and safety of treatment with intrathecal baclofen for severe spasticity in children with cerebral palsy.
- Trial name
- NCT00367068
- Testing
- baclofen, intrathecal, infusion pump for intrathecal baclofen, Synchromed, Medtronic
- Where
- Netherlands
- Volunteers
- 18 people
- Sponsor
- Maastricht University
Stroke
Early Treatment of Post-stroke Spasticity With Botulinum Toxin
This was a multicentric observational study with the aim to evaluate the effect of early treatment with botulinum toxin type A (BoNT-A) on post-stroke spasticity in adult patients.
- Trial name
- BTX_ST-ITA14 (NCT04404868)
- Testing
- Normal clinical practice
- Where
- Italy
- Volunteers
- 86 people
- Sponsor
- Universita di Verona
Stroke, Spastic Hemiplegia
The Effects of Neurorehabilitation Approaches Involving Different Upper Extremity Reactive Trainings in Stroke Patients
The goal of this clinical trial is to investigate the effectiveness of upper extremity training, which is expected for 5 seconds on the target during reaching forward, and to compare the effectiveness of neurorehabilitation…
- Trial name
- NCT06086314
- Testing
- reactive exercise training with ''FitPodz Light Trainer'' device in addition to a neurorehabilitation program, reactive exercise training with co-contraction with ''FitPodz Light Trainer'' device in addition to a neurorehabilitation program., neurorehabilitation program with functional reaching training without device.
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Pamukkale University
Spasticity, Multiple Sclerosis
A Study of the Safety and Effectiveness of Sativex®, for the Relief of Symptoms of Spasticity in Subjects, From Phase B, With Multiple Sclerosis (MS)
The purpose of this study is to determine whether Sativex® versus Placebo is effective in the relief of symptoms of spasticity in subjects with multiple sclerosis, who have been identified as having a capacity to respond to…
- Trial name
- NCT00681538
- Testing
- Sativex®
- Where
- United Kingdom
- Volunteers
- 572 people
- Sponsor
- Jazz Pharmaceuticals
Spinal Cord Injuries, Muscle Spasticity
Cyproheptadine and Chlorpromazine Effects on Spasticity
The main goal of this research is to understand the neuronal mechanisms that mediate the development of spasticity and motor dysfunction after spinal cord injury.
- Trial name
- NCT01509885
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Hypertonia
Grand Autohemo-Therapy With Oxygen-ozone on Patients With Hypertonia
The objective of this clinical study is to evaluate the influence of the Great autohemotherapy with oxygen-ozone (hyperbaric ozone therapy ) to describe the cardiovascular system in patients with resistant hypertension.
- Trial name
- HAB (NCT01902602)
- Where
- Germany
- Volunteers
- 19 people
- Sponsor
- Herrmann Apparatebau GmbH
Multiple Sclerosis, Spasticity
One Year, Open Label, Dose Escalation Long-term Safety Study in Multiple Sclerosis (MS) Subjects With Spasticity
Clinical protocol OS440-3003 is a multicenter, open-label, non-randomized, uncontrolled, dose escalation study to evaluate the safety and tolerability of Arbaclofen Extended Release Tablets over 1 year in Multiple Sclerosis (MS)…
- Trial name
- NCT01844232
- Testing
- arbaclofen
- Where
- 35 sites in United States, Russia and 1 more
- Volunteers
- 150 people
- Sponsor
- RVL Pharmaceuticals, Inc.
Spasticity
Definition, Assessment and Treatment of Spasticity According to Physiotherapists and Occupational Therapists in Flanders, Belgium: A Cross-sectional Qualitative Study.
The definition of spasticity described by Lance in 1980 provided a strong academic foundation for characterizing this neurological symptom.
- Trial name
- NCT06956534
- Testing
- Questionnaire and Physical Exam
- Where
- Belgium
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
Lower Limb Spasticity
Trial to Test the Effectiveness of Vibrotactile Stimulation for Lower Limb Spasticity
The goal of this clinical trial is to find out if Vibrotactile Stimulation (VTS) can help improve mobility and reduce spasticity (muscle stiffness) in people with lower limb spasticity.
- Trial name
- NCT07447934
- Testing
- Vibrotactile Stimulation (Static Use), Vibrotactile Stimulation (Dynamic Use), Vibrotactile Stimulation (Neurophysiological Mechanism)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Weill Medical College of Cornell University
Motor Neuron Disease, Amyotrophic Lateral Sclerosis
Levetiracetam for Cramps, Spasticity and Neuroprotection in Motor Neuron Disease
Levetiracetam (Keppra) is used to treat partial onset seizures. Its biological effects suggest it might also be useful in treating 3 aspects of human motor neuron diseases (MNDs) for which no effective therapy exists: cramps…
- Conditions
- Motor Neuron Disease, Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis, Progressive Muscular Atrophy
- Trial name
- NCT00324454
- Testing
- Levetiracetam
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Spasticity in Participants With Multiple Sclerosis
Trial to Evaluate the Effect of Nabiximols Oromucosal Spray on Clinical Measures of Spasticity in Participants With Multiple Sclerosis
This study will be conducted to evaluate the effect of multiple doses of nabiximols as adjunctive therapy compared with placebo on a clinical measure of velocity-dependent muscle tone in the lower limbs (Modified Ashworth Scale…
- Trial name
- RELEASE MSS1 (NCT04657666)
- Testing
- Nabiximols
- Where
- 16 sites in Czechia, Poland
- Volunteers
- 68 people
- Sponsor
- Jazz Pharmaceuticals
Spasticity, Muscle
Does ESWT With BoNTA Treatment Improve Outcomes When Compared to Standard Management for Upper Limb Spasticity Patient.
Background Effective management of spasticity, a debilitating and challenging condition afflicting many recovering from and living with neurological conditions, may reduce long term consequences such as limb contracture, skin…
- Trial name
- NCT05226637
- Testing
- ESWT (extra-corporeal shock wave therapy)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Alberta
Stroke, Spasticity, Muscle
REHABOTICS: Integrated Rehabilitation System for People With Motor Disabilities
The goal of the Rehabotics project is the development of a comprehensive rehabilitation system to provide highly individualized treatment of upper limb function in patients with motor disorders due to acquired brain damage (eg…
- Conditions
- Stroke, Spasticity, Muscle, Upper Extremity Dysfunction
- Trial name
- NCT06519630
- Testing
- Rehabotics Physiotherapy, Traditional Physiotherapy
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Pantelis Syringas
Hereditary Spastic Paraplegia
Effects of Botulinum Toxin Injections in Patients With Hereditary Spastic Paraplegia
Hereditary spastic paraplegias constitute a heterogeneous group of diseases with the common predominant feature of spasticity of the lower limbs.
- Trial name
- SPASTOX (NCT02604186)
- Testing
- Botulinum Toxin Injections
- Where
- Brazil
- Volunteers
- 55 people
- Sponsor
- University of Campinas, Brazil
Spasticity, Multiple Sclerosis, Stroke, Trauma
Antispastic Effect of Transcranial Magnetic Stimulation in Patients With Cerebral and Spinal Spasticity
Spasticity - movement disorder, which is part of the syndrome of defeat top motor-neuron, characterized by the rate-dependent increase in muscle tone and increased dry-core reflections from hyperexcitability of stretch receptors…
- Trial name
- ANTMS (NCT01786005)
- Testing
- Transcranial magnetic stimulation
- Where
- Russia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Russian Academy of Medical Sciences
Muscle Hypertonia
Effects of Long-term Foam Rolling Compared to Static Stretching on Hamstring Muscle Flexibility
The purpose of this study to to compare the long-term effects of foam rolling in comparison to static stretching and a control group on hamstring flexibility.
- Trial name
- NCT02808923
- Testing
- Foam Rolling, Static Stretching
- Volunteers
- 45 people
- Sponsor
- Creighton University