Clinical trials: Hyperthermic Intraperitoneal Chemotherapy (HIPEC)
Colorectal Cancer
Efficacy of HIPEC in Patients With Colorectal Cancer at High Risk of Peritoneal Carcinomatosis
The purpose of this study is to determine the efficacy of adjuvant HIPEC with Mitomycin C after colectomy in the treatment of colorectal cancer patients at high risk of peritoneal carcinomatosis.
- Trial name
- NCT04370925
- Testing
- Radical colectomy, HIPEC, Systemic chemotherapy
- Where
- 37 sites in China
- Volunteers
- 688 people
- Sponsor
- Affiliated Cancer Hospital & Institute of Guangzhou Medical University
Primary Peritoneal Neoplasm, Secondary Peritoneal Neoplasm
Goal Directed Therapy (GDT) in Cytoreductive Surgery (CRS) and Hyperthermic Intra Peritoneal Chemotherapy (Hipec)
The aim of the study is to assess whether in cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) the use of a protocol of intravenous fluid therapy combined with goal directed fluid therapy (GDT) is…
- Trial name
- NCT01882920
- Testing
- Goal Directed Intravenous Restrictive Fluid Therapy, Conventional Intravenous Fluid therapy
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Regina Elena Cancer Institute
Peritoneal Neoplasms, Neoplasm Metastasis
HIPEC For Peritoneal Surface Malignancies Including Carcinomatosis or Sarcomatosis - Data Registry
In this registry study the investigators will collect data about patients' disease, treatment, and response to treatment to include in both our local and national databases.
- Conditions
- Peritoneal Neoplasms, Neoplasm Metastasis, Adenocarcinoma, Sarcoma
- Trial name
- NCT02082886
- Where
- 2 sites in United States
- Volunteers
- 193 people
- Sponsor
- Edward-Elmhurst Health System
Colorectal Cancer
Anesthesia, TIVA, Balanced Anesthesia, NK Cell
Anesthetic method was reported to have an impact on postoperative long-term outcome in cancer patients. In this study, we will investigate the effect of different anesthetic methods on NK cell activity, cytokine response and…
- Trial name
- NCT05951842
- Testing
- anesthetic method
- Sponsor
- Gangnam Severance Hospital
Ovarian Cancer, Intraperitoneal Chemotherapy
Intensive Intraperitoneal Therapy in Advanced Ovarian Cancer
Clinicians postulate that it may be interesting to combine the two IntraPeritoneal (IP) treatments associated with a significant improvement of OC overall survival i.e.
- Trial name
- INTENS-IP (NCT04282356)
- Testing
- Intraperitoneal chemotherapy during surgery
- Where
- France
- Volunteers
- 55 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Stage III Ovarian Cancer, Stage IV Ovarian Cancer
Heated Intraperitoneal Chemotherapy Followed by Niraparib for Ovarian, Primary Peritoneal and Fallopian Tube Cancer
Patients will be registered prior to, during or at the completion of neoadjuvant chemotherapy given per standard institutional guidelines +/- bevacizumab on Day 1 every 21 days for 3-4 cycles.
- Conditions
- Stage III Ovarian Cancer, Stage IV Ovarian Cancer, Stage III Primary Peritoneal Cancer, Stage IV Primary Peritoneal Cancer
- Trial name
- HOTT (NCT05659381)
- Testing
- Cisplatin, No treatment
- Where
- 59 sites in United States
- Volunteers
- 220 people
- Sponsor
- GOG Foundation
Hepatocellular Carcinoma
Research on Effectiveness and Safety of the Treatment, Hyperthermic Intraperitoneal Chemotherapy Combined With Tislelizumab and Targeted Therapy, That is Used for High-risk Hepatocellular Carcinoma After R0 Resection
There are limited treatment options for HCC with high recurrence risk, and there is no consistent plan for adjuvant therapy after surgery. Hence an unmet clinical need.
- Trial name
- NCT05546619
- Testing
- HIPEC+tislelizumab + targeted therapy
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sulai Liu
Gastric Adenocarcinoma
PHASE II EVALUATION OF CYTOREDUCTION SURGERY AND HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY (CRS/HIPEC) IN GASTRIC CANCER
This is a Phase II treatment study analyzing the role of preoperative chemotherapy, preoperative laparoscopic HIPEC, and gastrectomy with CRS/HIPEC in gastric adenocarcinoma patients with cytology-positive only carcinomatosis…
- Trial name
- NCT07178808
- Testing
- Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Banner Health
Organ Failure, Multiple
Comparing the Prognosis of Lactate-directed and Goal-directed Therapy in Hyperthermic Intraperitoneal Chemotherapy.
Hyperthermic intraperitoneal chemotherapy is a major surgery for tumor peritoneal metastasis. For anesthesiologist, the intra-operative fluid control is always a big challenge.
- Trial name
- NCT03933930
- Testing
- Lactate-directed therapy, Goal-directed therapy
- Sponsor
- Taipei Medical University WanFang Hospital
Stomach Neoplasm
Cytoreductive Surgery Combined With HIPEC and Chemotherapy for Gastric Cancer With Peritoneal Metastasis
This study evaluates the survival benefit and safety of cytoreductive surgery(CRS) combined with HIPEC and chemotherapy in gastric cancer with peritoneal metastasis.
- Trial name
- NCT03023436
- Testing
- Cytoreductive surgery, Hyperthermic Intraperitoneal Chemotherapy, Fluoropyrimidine
- Where
- 13 sites in China
- Volunteers
- 220 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Long Term, Quality of Life
Long-Term Quality Of Life And Symptom Assessment Among Recurrence-Free Patients Who Underwent Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
To evaluate long-term quality of life (QoL) and participant reported symptom burden in disease-free survivors who have undergone cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) at MD Anderson…
- Conditions
- Long Term, Quality of Life, Recurrence Free, Cytoreductive Surgery
- Trial name
- NCT07871760
- Testing
- Questionnaire and Physical Exam
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- M.D. Anderson Cancer Center
Colorectal Cancer, Peritoneal Metastases
Prophylactic HIPEC for Colorectal Cancers at High Risk of Developing Peritoneal Metastases
The study investigators hypothesize that prophylactic HIPEC is feasible and well tolerated in patients with colorectal cancers with high-risk of developing peritoneal recurrence.
- Trial name
- NCT03422432
- Testing
- HIPEC
- Where
- Singapore
- Volunteers
- 17 people
- Sponsor
- National Cancer Centre, Singapore
Fallopian Tube Endometrioid Adenocarcinoma, Fallopian Tube Mucinous Adenocarcinoma
Hyperthermic Intraperitoneal Chemotherapy With Cisplatin During Surgery or Cisplatin Before Surgery for the Treatment of Stage III or IV Ovarian, Fallopian Tube or Peritoneal Cancer
This phase I trial studies the side effects of hyperthermic intraepithelial chemotherapy with cisplatin after surgery or cisplatin before surgery in treating patients with stage III or IV ovarian, fallopian tube or peritoneal…
- Conditions
- Fallopian Tube Endometrioid Adenocarcinoma, Fallopian Tube Mucinous Adenocarcinoma, Fallopian Tube Serous Adenocarcinoma, Ovarian Endometrioid Adenocarcinoma
- Trial name
- NCT05415709
- Testing
- Carboplatin, Cisplatin, Cytoreductive Surgery
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Hyperthermic Intraperitoneal Chemotherapy, Cytoreductive Surgery
Role of Magnetic Resonance Enterography for Predicting Peritoneal Cancer Index
This is a prospective observational study which will recruit 90 participants over a three-year period to investigate whether adding magnetic resonance imaging and enterography to routine computed tomography study can better…
- Conditions
- Hyperthermic Intraperitoneal Chemotherapy, Cytoreductive Surgery, Peritoneal Carcinomatosis
- Trial name
- NCT05063019
- Testing
- MRI
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Chang Gung Memorial Hospital
Gastric Cancer
HIPEC, Intravenous Chemotherapy and Surgery for the Treatment of Advanced GC With Peritoneal Metastasis
Explore the hyperthermic intraperitoneal chemotherapy (HIPEC) and intravenous chemotherapy for Creating the Operation Chance in advanced gastric cancer with peritoneal metastasis.
- Trial name
- NCT02549911
- Testing
- HIPEC,Chemotherapy AND surgery
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Zhejiang Cancer Hospital
Malignant Neoplasm of Stomach
Radical Gastrectomy and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Locally Advanced Gastric Cancer
The efficacy of HIPEC in prevention of local recurrence, distant metastasis or peritoneal metastasis in locally advanced gastric cancer is not definite.
- Trial name
- NCT02528110
- Testing
- Hyperthermic intraperitoneal chemotherapy (HIPEC), D2 radical gastrectomy, SOX postoperative chemotherapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Wuhan University
Ovarian Cancer
Tolerance of Intraperitoneal (IP) Nivolumab After Extensive Debulking Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Patients With Advanced Ovarian Carcinoma
Spread pattern, the lack of alternative treatments, and emerging data on the activity of anti-Programmed death ligand 1 (PDL1) targeted checkpoint inhibitor therapy in gynecological cancers provide the rationale for this…
- Trial name
- ICONIC (NCT03959761)
- Testing
- Intraperitoneal (IP) nivolumab infusion
- Where
- France
- Volunteers
- 22 people
- Sponsor
- Hospices Civils de Lyon
Stomach Neoplasms
Prophylactic Surgery Plus HIPEC With CO2 in Patients Affected by Gastric Carcinoma.GOETH Study
This is a phase III randomized, multicenter study with two different arm: experimental: prophylactic surgery plus HIPEC CO2 performed with mitomycin and cisplatin comparator: standard surgery Adjuvant treatment after surgery is…
- Trial name
- GOETH (NCT03917173)
- Testing
- Surgery plus HIPEC CO2, Standard surgery
- Where
- 13 sites in Italy
- Volunteers
- 240 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Mesothelioma; Peritoneum, Pseudomyxoma Peritonei
Thrombin Generation and Platelet Activation in CRS/HIPEC
Cytoreductive surgery (CRS) with hyperthermic intraperitoneal peroperative chemotherapy (HIPEC), indicated for patients with peritoneal metastases from digestive or gynecological malignancies alike, demonstrates a considerable…
- Conditions
- Mesothelioma; Peritoneum, Pseudomyxoma Peritonei, Peritoneal Carcinomatosis
- Trial name
- NCT03034850
- Testing
- CRS/HIPEC
- Volunteers
- 27 people
- Sponsor
- Ziekenhuis Oost-Limburg
Gastric Cancer
A Clinical Study Evaluating the Efficacy of Systemic Chemotherapy and Immune Checkpoint Inhibitors Combined With Hyperthermic Intraperitoneal Chemotherapy in the Treatment of Gastric Cancer Patients With Peritoneal Metastasis
This study is a single-center, prospective, phase II clinical trial aimed at assessing the impact of HIPEC combined with systemic chemotherapy and immune checkpoint inhibitors on the R0 resection rate in patients with peritoneal…
- Trial name
- NCT06685887
- Testing
- HIPEC, SOX, Immune Checkpoint Inhibitors
- Where
- China
- Volunteers
- 34 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology