Clinical trials: Hypertensive Emergency
Hypertension, Acute Severe Hypertension
Study of Efficacy and Safety of Tonlamarsen in Participants With a Recent Hospitalization and a Concurrent Episode of Acute Severe Hypertension
The purpose of this study is to evaluate the blood pressure-lowering effect of tonlamarsen in adult participants who were recently hospitalized and concurrently experienced an episode of acute severe hypertension.
- Conditions
- Hypertension, Acute Severe Hypertension, Hypertensive Emergency, Hypertensive Urgency
- Trial name
- KARDINAL-ASH (NCT07511361)
- Testing
- Tonlamarsen
- Where
- 13 sites in United States
- Volunteers
- 140 people
- Sponsor
- Kardigan, Inc.
Hypertensive Urgency, Primary Hypertension
The Use of Virtual Reality and Music Therapy for Hypertensive Urgency
This study aims to evaluate whether virtual reality (VR) and classical music therapy, when added to standard antihypertensive treatment, can improve blood pressure control and reduce anxiety in patients presenting to the…
- Trial name
- NCT07272486
- Testing
- Captopril 25Mg Tab, Virtual Reality Exposure, Classic Music Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people
- Sponsor
- Ankara City Hospital Bilkent
Postpartum Pregnancy-Induced Hypertension, Postpartum Preeclampsia
Postpartum Hypertension Study
The purpose of this study is to assess which blood pressure medication (intravenous labetalol or oral nifedipine) works better in treating severely elevated blood pressure in women who have just delivered a baby.
- Conditions
- Postpartum Pregnancy-Induced Hypertension, Postpartum Preeclampsia, Pregnancy-Induced Hypertension in Postpartum, Hypertensive Emergency
- Trial name
- NCT05139238
- Testing
- Labetalol, Nifedipine
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Columbia University
Hypertensive Emergency, Papilledema
Optic Nerve Sheath Diameter in Hypertensive Emergency
This prospective observational study investigates the potential of point-of-care ultrasonography of the optic nerve sheath diameter (ONSD) to rule out papilledema in patients with suspected hypertensive emergency.
- Conditions
- Hypertensive Emergency, Papilledema, Hypertension
- Trial name
- OpticUS (NCT06286696)
- Testing
- Optic Nerve Sheath Diameter
- Volunteers
- 375 people
- Sponsor
- Leiden University Medical Center
Hypoxemic Respiratory Failure, Side Effect
Clinical Relevance of Nicardipine Induced Hypoxemia in the Intensive Care Unit
In the context of postoperative hypertension in the intensive care units, or after resusitation of hypertensive patients, intravenous antihypertensive drugs are often used.
- Conditions
- Hypoxemic Respiratory Failure, Side Effect, Hypertensive Emergency
- Trial name
- ECRHIN-ICU (NCT05155202)
- Testing
- Antihypertensive Agents
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Caen
Hypertensive Emergency
The Value of TOI in Evaluating Renal Function Damage in Hypertensive Emergency Patients
TOI was used to measure heart rate, respiration, blood pressure, heart rate variability and psychological stress. At the same time, the patient's urine protein, creatinine, urea nitrogen and other indicators were detected.
- Trial name
- NCT06201572
- Testing
- The relationship between TOI composite index and renal function in hypertensive emergency patients was compared
- Volunteers
- 300 people
- Sponsor
- The Affiliated Hospital of Hangzhou Normal University
Hypertensive Emergency-associated Hemolytic Uremic Syndrome
Eculizumab in Hypertensive Emergency-associated Hemolytic Uremic Syndrome
Hemolytic and uremic syndrome (HUS) is a clinic-biological syndrome related to thrombotic microangiopathy affecting predominantly the kidney.
- Trial name
- HYPERSHU (NCT05726916)
- Testing
- Soliris®, Renin angiotensin system blockers
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypertensive Emergency
a Study Evaluating the Safety and Efficacy of Clevidipine for Patients Who With Hypertensive Emergency and Sub-emergency
A Multicentre, Randomized, Double-blind, Parallel Design Phase III Study to Evaluate the efficacy and safety of QLG2071 Versus Cleviprex® in the Treatment of Hypertensive Emergency and Sub-emergency
- Trial name
- NCT05922436
- Testing
- QLG2071, Cleviprex®
- Volunteers
- 378 people
- Sponsor
- Qilu Pharmaceutical (Hainan) Co., Ltd.
Hypertensive Emergency
A Study of Clevidipine Butyrate Injectable Emulsion in the Treatment of Hypertensive Emergency and Sub-emergency
A randomized, double-blind, active-compared phase Ш clinical trial to evaluate clevidipine butyrate injectable emulsion in the treatment of Hypertensive Emergency and Sub-emergency.
- Trial name
- NCT05783557
- Testing
- Clevidipine Butyrate Injectable Emulsion, Cleviprex®
- Volunteers
- 398 people
- Sponsor
- CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co., Ltd.
Hypertensive Emergency
Clinical Study of Clevidipine Butyrate Injection in the Treatment of Hypertensive Emergency and Sub-emergency
Emergency treatment warning of clevidipine butyrate butyrate injection or invalid medical treatment and verification of the effectiveness and safety of subacute.
- Trial name
- NCT05044364
- Testing
- This is a randomized, single-blind, parallel-controlled clinical study with the original research clevidipine butyrate injection as the positive control drug, which is an equivalence test.
- Where
- 2 sites in China
- Volunteers
- 10 people
- Sponsor
- Shenzhen People's Hospital
Hypertension, Hypertensive Crisis
Improving Acute Hypertension Management Through Emergency Department Checklist
The investigators hypothesize that the implementation of a checklist in acute severe hypertension would result in improving short and long-term outcomes of patients with acute severe hypertension treated in the emergency…
- Conditions
- Hypertension, Hypertensive Crisis, Hypertensive Emergency
- Trial name
- NCT04553653
- Testing
- checklist
- Where
- Pakistan
- Volunteers
- 1,161 people
- Sponsor
- Johns Hopkins University
Hypertensive Emergency
Safety and Efficacy Study of Clevidipine Butyrate Injection in Hypertensive Emergencies
The purpose of this study was to determine the efficacy and safety of clevidipine for treating Hypertensive emergencies（defined as systolic blood pressure >180 mmHg and/or diastolic blood pressure >120 mmHg, accompanied by acute…
- Trial name
- NCT04670809
- Testing
- Clevidipine Butyrate Injection, Ncardipine Hydrochloride Injection
- Where
- 2 sites in China
- Volunteers
- 262 people
- Sponsor
- Nanjing Yoko Biomedical Co., Ltd.
Hypertensive Urgency
Effect of Pursed-Lip Breathing on Blood Pressure and Heart Rate
Hypertensive urgency (HT urgency) is an alarm sign of uncontrolled hypertension. It can be aggravated by nonadherent to medication and psychosocial stress.
- Trial name
- NCT04572672
- Testing
- Non-pharmacologic treatment; Pursed-Lip Breathing Combined with Number Counting
- Where
- Thailand
- Volunteers
- 112 people
- Sponsor
- Khon Kaen University
Hypertensive Emergency, Hypertension
A ED-based Intervention to Improve Antihypertensive Adherence
Despite great strides, hypertension remains an incredibly important disease and public health problem. This study addresses this critical need among ED patients, a unique population of patients who are (a) likely to benefit from…
- Conditions
- Hypertensive Emergency, Hypertension, Blood Pressure
- Trial name
- NCT02672787
- Testing
- ED-based behavioral intervention, ED usual care plus education
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Vanderbilt University
Hypertensive Emergency, Hypertensive Urgency
Telemedical Versus Conventional Emergency Care of Hypertensive Emergencies
Comparison of telemedical prehospital emergency care and conventional on-scene physician based care of hypertensive emergencies and urgencies. The adherence to current Guidelines should be researched.
- Trial name
- NCT02924805
- Testing
- Telemedical care
- Where
- Germany
- Volunteers
- 331 people
- Sponsor
- RWTH Aachen University
Hypertensive Urgency
Evaluation of Intravenous Cardene(Nicardipine)and Labetalol Use in the Emergency Department
The purpose of this study is to compare the safety and efficacy of Cardene I.V. to labetalol administered intravenously for the management of hypertension in the emergency department setting.
- Trial name
- CLUE (NCT00765648)
- Testing
- nicardipine intravenous, Labetalol
- Where
- 2 sites in United States
- Volunteers
- 226 people
- Sponsor
- The Cleveland Clinic