Clinical trials: Hypertension, Systolic
Hypertension, Systolic, Metabolic Syndrome
Air Pollution and Cardiovascular Disease in Qatar: an Interventional Study to Reduce Blood Pressure
The main objective is to determine if in-home portable air cleaners provide persistent reductions in PM2.5 exposures and improvements in systolic blood pressure and biochemical parameters over one week in patients with metabolic…
- Conditions
- Hypertension, Systolic, Metabolic Syndrome, Typ 2 Diabetes
- Trial name
- APCIQ-BP (NCT05903950)
- Testing
- Air cleaners with HEPA filter, Air cleaners without HEPA filter
- Where
- Qatar
- Volunteers
- 100 people
- Sponsor
- Weill Cornell Medical College in Qatar
Hypertension, Hypertension, Systolic
BradycArdia paCemaKer With AV Interval Modulation for Blood prEssure treAtmenT
A prospective, multinational, randomized, double-blind, clinical trial evaluating the safety and effectiveness of a novel atrioventricular interval modulation (AVIM) algorithm downloaded into a dual-chamber Medtronic Astra/Azure…
- Conditions
- Hypertension, Hypertension, Systolic, Hypertension, Essential
- Trial name
- BACKBEAT (NCT06059638)
- Testing
- Medtronic Astra/Azure DR MRI IPG with AVIM therapy Activated, Medtronic Astra/Azure DR MRI IPG with AVIM therapy Deactivated
- Where
- 131 sites in United States, Australia and 13 more
- Volunteers
- 316 people
- Sponsor
- Orchestra BioMed, Inc
Uncontrolled Hypertension
A Study of Modified Release RTN-001 In Patients With Uncontrolled Hypertension
The purpose of this clinical trial is to measure the safety and efficacy of RTN-001 in adult participants with uncontrolled hypertension versus placebo.
- Trial name
- NCT07142356
- Testing
- RTN-001
- Where
- 34 sites in United States
- Volunteers
- 280 people
- Sponsor
- Retension Pharmaceuticals. Inc.
Elevated Triglycerides, Systolic Hypertension
A Pilot Study to Determine the Efficacy of a Low Carbohydrate Diet in Treatment of Adolescents With Metabolic Syndrome
The purpose of this study is to determine the effectiveness of two different non-energy restricted controlled carbohydrate programs with the American Diabetes Associations' diet on glycosylated hemoglobin and other diabetes risk…
- Conditions
- Elevated Triglycerides, Systolic Hypertension, Insulin Resistance, Abdominal Obesity
- Trial name
- NCT00940966
- Testing
- standard ADA diet, energy restricted very-low carbohydrate diet, low glycemic diet
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- CAMC Health System
Hypertension,Essential, Systolic Hypertension
Cardiac Neuromodulation Therapy (CNT) "Washout" Sub-Study
This washout protocol is structured as a sub-study for patients willing to participate after finishing the double blind randomised phase of the clinical trial, NCT02837445. Devices will be turned off for a week approximately.
- Trial name
- NCT05086523
- Testing
- Programmable Hypertension Control (BackBeat Moderato), Pacing (BackBeat Moderato)
- Where
- 6 sites in Czechia, Hungary and 1 more
- Volunteers
- 28 people
- Sponsor
- BackBeat Medical Inc
Bradycardia, Hypertension, Systolic
Preload and Autonomic Responses With Cardiac Neuromodulation Therapy (CNT) (CS-06)
This investigation will evaluate the effect of RV pacing lead position on cardiac function and the modulation of the autonomic nervous system with Cardiac Neuromodulation Therapy (CNT) pacing signals.
- Trial name
- CS-06 (NCT04463121)
- Testing
- Moderato IPG's CNT pacing signals, CD Leycom Pressure/Volume Combination Catheters
- Where
- Czechia
- Volunteers
- 22 people
- Sponsor
- BackBeat Medical Inc
Postoperative Complications
Effect of Different Anesthetic Techniques for Isolated Systolic Hypertensive Patients of Abdominal Surgery on Postoperative Hospital Stay and Morbidity
In General anesthesia, two main ways of pain control are used intra-operatively, one is opioids, the other is epidural. Many colleges prefer using epidural analgesia because it is potent and more effective , and also the benefits…
- Trial name
- NCT01884298
- Where
- China
- Sponsor
- Peking University First Hospital
Hypertension (HTN), Heart Failure With Preserved Ejection Fraction (HFpEF
Clinical Feasibility of Cardiac Neuromodulation Therapy for Heart Failure With Preserved Ejection Fraction
This is an open-label pilot study to evaluate the feasibility of Cardiac Neuromodulation Therapy (CNT) in patients with high blood pressure and heart failure who require dual-chamber pacemaker implantation or replacement.
- Conditions
- Hypertension (HTN), Heart Failure With Preserved Ejection Fraction (HFpEF, Hypertension, Systolic
- Trial name
- NCT07598760
- Testing
- Moderato Plus device with Cardiac Neuromodulation Therapy
- Where
- 2 sites in Georgia
- Volunteers
- 20 people
- Sponsor
- BackBeat Medical Inc
HFrEF - Heart Failure With Reduced Ejection Fraction, HFpEF - Heart Failure With Preserved Ejection Fraction
Study of JK07 in Patients With Heart Failure and WHO Group 2 Combined Post- and Pre-Capillary Pulmonary Hypertension
This is a Phase 2a, open-label, multiple-dose study to assess the safety, tolerability, and efficacy of JK07 in participants 18 to 85 years of age with diagnosed HF and cpcPH.
- Conditions
- HFrEF - Heart Failure With Reduced Ejection Fraction, HFpEF - Heart Failure With Preserved Ejection Fraction, Group 2 Pulmonary Hypertension
- Trial name
- RENEU-PH (NCT07221513)
- Testing
- JK07
- Where
- United States
- Sponsor
- Salubris Biotherapeutics Inc
Systolic Hypertension, Brachial Artery Flow-mediated Dilation
Dose-Response Effects of Inspiratory Muscle Strength Training on Blood Pressure and Vascular Function
This study will assess the dose-response effects of Inspiratory Muscle Strength Training (IMST) in adults with above-normal systolic blood pressure over a 6-week period.
- Trial name
- NCT07109739
- Testing
- POWERbreathe K5
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- University of Minnesota
Hypertension, Systolic, Stiffness, Aortic
Sympathetic Regulation of Large Artery Stiffness in Humans With ISH
Stiffening of your blood vessels, particularly the large vessels from your heart (called the aorta and carotids) you age contributes to the development of cardiovascular disease (CVD) such as heart attack and stroke.
- Trial name
- SELECT (NCT04423627)
- Testing
- Clonidine, Hydrochlorothiazide
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Hypertension Combined Diastolic and Systolic
A Study Protocol to Assess the Effectiveness of Nurse-Led Telehealth Intervention for Hypertension Control in Nepal
Despite being the leading cause of cardiovascular diseases and premature death worldwide, hypertension control remains a largely unmet challenge for public health systems even in developed countries.
- Trial name
- NCT07089290
- Testing
- Nurse-led Telehealth Intervention
- Where
- Nepal
- Volunteers
- 706 people
- Sponsor
- Kathmandu University School of Medical Sciences
Systolic Hypertension, Pregnancy Related
Effect of Labetalol, Atenolol, and Nifedipine on Maternal Hemodynamics Measured by ICG in Early Pregnancy
The purpose of the research is to characterize the effect of labetalol, atenolol, and nifedipine on maternal hemodynamics early in pregnancy.
- Conditions
- Systolic Hypertension, Pregnancy Related, Diastolic Hypertension, Cardiac Output, Low
- Trial name
- NCT04755764
- Testing
- Labetalol, Atenolol, Nifedipine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Marshall University
Hypertension, Hypertension, Systolic
Treatment of Hypertension During Sleep
On the basis of new evidence on the relationship between achieved office blood pressure (BP) measurements (OBPM) and the risk of cardiovascular disease (CVD) morbidity and mortality documented in the SPRINT trial, the recent 2017…
- Trial name
- THADEUS (NCT03457168)
- Testing
- Treatment of elevated asleep SBP mean
- Where
- 9 sites in Spain
- Volunteers
- 5,320 people
- Sponsor
- University of Vigo
Hypertension, Systolic
Olive Polyphenols in Cardiovascular Prevention
The aim of this study is to evaluate whether the use of a commercially available standardized olive extract (Tensiofytol®) in individuals with elevated blood pressure 1.
- Trial name
- NCT04874961
- Testing
- Tensiofytol®
- Where
- Belgium
- Volunteers
- 56 people
- Sponsor
- Nina Hermans
Aortic Stenosis, Mitral Regurgitation
Evaluating Infrasonic Hemodynography
This comparative diagnostic accuracy study will determine the accuracy of a noninvasive wearable infrasonic sensor to detect the mechanical, electrical, and hemodynamic function of the cardiovascular system.
- Conditions
- Aortic Stenosis, Mitral Regurgitation, Pulmonary Hypertension, Heart Failure, Systolic
- Trial name
- NCT04636892
- Testing
- MindMics earbud
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Scripps Health
Hypertension, Blood Pressure
Feasibility and Effectiveness of a Ring-type Blood Pressure Measurement Device
The goal of this clinical trial is to evaluate the feasibility and effectiveness of a ring-type blood pressure measurement device compared to a 24-hour ambulatory blood pressure monitoring device in patients with hypertension or…
- Conditions
- Hypertension, Blood Pressure, Systolic Hypertension, Diastolic Hypertension
- Trial name
- NCT06084065
- Testing
- CART-I Plus
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Seoul National University Hospital
Isolated Systolic Hypertension
Isolated Systolic Hypertension in the Elderly and Very Elderly
To evaluate the efficacy of long-term treatment of individually optimized doses of olmesartan medoxomil compared to nitrendipine in elderly and very elderly patients with isolated systolic hypertension.
- Trial name
- NCT00751829
- Testing
- olmesartan medoxomil + hydrochlorothiazide, if necessary, nitrendipine + hydrochlorothiazide, if necessary
- Where
- Germany
- Volunteers
- 417 people
- Sponsor
- Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company
Isolated Systolic Hypertension
Blood Pressure and Lipids Reduction in High Risk Elderly Patients With Isolated Systolic Hypertension
1. Study name: Blood Pressure and Lipids Reduction in High Risk Elderly Patients with Isolated Systolic Hypertension. 2. Medicine: amlodipine/atorvastatin tablet (5mg/10mg) and amlodipine (5mg). 3.
- Trial name
- NCT05165251
- Testing
- Amlodipine/Atorvastatin 5 Mg-10 Mg ORAL TABLET, Amlodipine 5mg, Lifestyle intervention
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Hypertension, Systolic
A Pivotal Study To Evaluate The Effectiveness of Isometric Handgrip Therapy In Prehypertensive And Hypertensive Patients
This is a double-blind, sham-controlled clinical trial assessing the effectiveness of personalized isometric handgrip device therapy.
- Trial name
- NCT04467879
- Testing
- Zona Plus Device, Control Device
- Where
- 5 sites in United States
- Volunteers
- 146 people
- Sponsor
- Zona Health, Inc