Clinical trials: Hyperpigmentation
Skin Aging
Evaluation of the Efficacy and Tolerance of a Light Therapy Mask on Mild to Moderate Brown Spots and Moderate to Severe Facial Wrinkles
This research study will test how well a light therapy mask works for women with mild to moderate hyperpigmentation (brown spots) and moderate to severe facial wrinkles, as compared to a "sham" or inactive investigational light…
- Trial name
- NCT03312543
- Testing
- Active Mask
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Johnson & Johnson Consumer Inc. (J&JCI)
Melanosis
A Pilot Study Testing 1064nm Q-switch Laser Versus Glycolic Acid Peels for the Treatment of Melasma
The purpose of this study is to find out the safety and effectiveness of 1064 Q-Switch Laser Therapy compared to Glycolic Acid Chemical Peels for the treatment of melasma.
- Trial name
- NCT01976273
- Testing
- 1064nm Q-switch Laser, Glycolic Acid Peels
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Headache, Cognitive Disturbance
Effects of IV-Administered Ca-DTPA and Zn-DTPA To Treat Patients With Gadolinium Deposition Disease
Purpose: There are two goals we have for this prospective single arm study; to see an increase in the amount of gadolinium in 24 hour urine collection following each infusion treatment with Calcium and Zinc DTPA, and to see a…
- Conditions
- Headache, Cognitive Disturbance, Skin Hyperpigmentation, Arthralgia
- Trial name
- NCT02947022
- Testing
- Calcium DTPA, Zinc DTPA
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of North Carolina, Chapel Hill
Pancreatic Cancer
Secretin (ChiRhoStim) Pancreas Perfusion for Pancreatic Adenocarcinoma
The purpose of this study is to test if secretin-enhanced CT is a useful noninvasive screening tool for pancreatic cancer in a high-risk population.
- Trial name
- NCT00587132
- Testing
- Synthetic Human Secretin
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Mayo Clinic
Melasma
Topical Composition Therapy (2013-MCN-333) for the Treatment of Melasma
The purpose of this research study is to gather information on the effectiveness and tolerability of a novel composition of existing U.S.
- Trial name
- NCT02730819
- Testing
- Illuminate Cream
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Mayo Clinic
Solar Lentigines
A Fixed Triple Combination Cream for Solar Lentigines Associated to Cryotherapy
To evaluate safety and efficacy of Tri-Luma® cream as an adjunctive treatment to cryotherapy when used in the pre- and post-procedure phases for the treatment of solar lentigines on the back of the hands and in the prevention of…
- Trial name
- NCT01778179
- Testing
- Tri-luma, Cryotherapy (CRY-AC3® device)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hexsel Dermatology Clinic
Melasma
Treatment w/ Tri-Luma® Cream & Intense Pulsed Light (IPL) vs a Mild Inactive Control Cream & Intense Pulsed Light (IPL) in Melasma
This study is to evaluate the efficacy and safety of Tri-Luma® Cream (fluocinolone acetonide 0.01%, hydroquinone 4%, tretinoin 0.05%) when used sequentially with a series of intense pulsed light (IPL) treatments in Subjects…
- Trial name
- NCT00669071
- Testing
- Fluocinolone acetonide 0.01%, hydroquinone 4%, tretinoin 0.05%, Cetaphil® Moisturizing Cream as Inactive Control
- Where
- 2 sites in United States
- Volunteers
- 56 people
- Sponsor
- Galderma R&D
Acne Vulgaris, Post Inflammatory Hyperpigmentation
The Use of Onexton in Moderate Acne Vulgaris for Patients With Skin of Color
This is a single-center, open label pilot study. The study is comprised of 5 study visits; Screening, Baseline, and Weeks 4, 8, and 16.
- Trial name
- NCT03402893
- Testing
- ONEXTON Topical Gel
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Derm Research, PLLC
Vitiligo
PHNA, Efficacy of Tretinoin Cream on Post-phototherapy Hyperpigmentation
A randomized controlled split-face pilot study was planned to investigate the preventive effect of tretinoin 0.05% cream on hyperpigmentation during phototherapy in patients with vitiligo.
- Trial name
- NCT03933774
- Testing
- Tretinoin 0.05% cream
- Where
- South Korea
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- The Catholic University of Korea
Acne Vulgaris, Post Inflammatory Hyperpigmentation
Efficacy and Safety Study of Finacea to Treat Acne Vulgaris and Post-Inflammatory Hyperpigmentation (PIH)
Residual post-inflammatory hyperpigmentation (PIH)from acne is disturbing to individuals with skin of color. Finacea has been anecdotally known to be beneficial in resolving PIH related to acne vulgaris.
- Trial name
- NCT01038869
- Testing
- Azelaic acid
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Derm Research, PLLC
Peutz-Jeghers Syndrome
Pilot Study of mTOR Inhibitor Therapy in Peutz-Jeghers Syndrome
Pilot study, Open-label, Phase II study of Everolimus. Objective: To determine if Everolimus can diminish large gastrointestinal polyps in patients with Peutz-Jeghers Syndrome.
- Trial name
- NCT00811590
- Testing
- Everolimus
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Utah
Diabetes Mellitus
Adjunctive Metformin Therapy in Double Diabetes
The significance of this project is to investigate the effects of adjunctive metformin therapy in children and adolescents with double diabetes.
- Trial name
- AMTIDD (NCT01334125)
- Testing
- Metformin
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Massachusetts, Worcester
Hyperpigmentation
Fractionated 1927nm Laser for Hyperpigmentation in Fitzpatrick Skin Phototypes V and VI
The primary objective of this study is to assess the efficacy of 1927nm non-ablative fractionated laser therapy to treat hyperpigmentation in patients ages 18-75 with Fitzpatrick Skin Phototypes V and VI and explore an effective…
- Trial name
- NCT05493280
- Testing
- MOXI
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Melasma
Salicylic Acid Peels Combined With 4% Hydroquinone in the Treatment of Moderate to Severe Melasma in Hispanic Women
This study will enroll 20 adult Hispanic women. Participants will apply 4% hydroquinone cream twice daily to affected areas on the face for 14 weeks and half the face will be peeled with 20-30% salicylic acid every two weeks for…
- Trial name
- NCT00616239
- Testing
- 20-30% Salicylic Acid peels to the right side of the face, 20-30% Salicylic Acid peels to the left side of the face
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Texas Southwestern Medical Center
Hyperpigmentation
Study to Evaluate the Effect of a Nu Skin Product and Device for Brown Spots
The purpose of this study is to determine whether a topical Nu Skin product with or without a galvanic spa device improves brown spots on the face.
- Trial name
- NCT01149876
- Testing
- Nu Skin Product, Cosmetic instrument, Tretinoin cream 0.05
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Lentigines
A Single-Center 2-Arm Study for Lentigines on the Hands
The purpose of this study is to evaluate the effectiveness and safety of two laser systems for improvement of lentigines on the hands.
- Trial name
- NCT02763072
- Testing
- Enlighten Laser, Excel V Laser
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cutera Inc.
Melasma
Split-face Study Comparing the Cosmetic Efficacy and Tolerability of Two Topical Products in Participants With Moderate Facial Melasma
The objective of this study is to evaluate the efficacy and tolerability of Lytera 2.0 versus 4% hydroquinone in the improvement of the appearance of moderate facial melasma.
- Trial name
- NCT02977507
- Testing
- Lytera 2.0, 4% Hydroquinone Topical Cream, SkinMedica Facial Cleanser
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Allergan
Acne, Post Inflammatory Hyperpigmentation
LiftActiv B3 in Post Inflammatory Hyperpigmentation (PIHP)
The purpose of this research study is to measure the depigmenting effect of a serum product called Liftactiv B3 in patients with mild to moderate facial PIHP (Post Inflammatory Hyper Pigmentation)
- Trial name
- NCT05327361
- Testing
- Liftactiv B3, Sunscreen
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Miami
Tattoo; Pigmentation, Melasma
Lutronic PicoPlus Exploratory Clinical Trial
This study will evaluate the use of the Lutronic PicoPlus for treatment of dermatological conditions such as unwanted tattoos and benign pigmented lesions.
- Conditions
- Tattoo; Pigmentation, Melasma, Benign Pigmented Lesion
- Trial name
- NCT03415685
- Testing
- PicoPlus laser system
- Where
- 4 sites in United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- CynosureLutronic
Acne Vulgaris
AkLief Evaluation in Acne-induced Post-Inflammatory Hyperpigmentation
The purpose of this study is to evaluate the efficacy and safety of Trifarotene 50 microgram per gram (mcg/g) cream compared to its vehicle cream in the treatment of moderate acne vulgaris with risk of acne-induced post…
- Trial name
- LEAP (NCT05089708)
- Testing
- Trifarotene Cream, Trifarotene Vehicle Cream
- Where
- 25 sites in United States, Spain
- Volunteers
- 123 people
- Sponsor
- Galderma R&D