Clinical trials: Hyperpigmentation
Morbid Obesity, Acanthosis Nigricans
The Effect of Laparoscopic Sleeve Gastrectomy on Insulin Secretion Pattern in Morbidly Obese Patients With Acanthosis Nigricans
Acanthosis nigricans (AN) is increasing in its prevalence and is the most prevalent cutaneous manifestation in individuals with obesity.
- Conditions
- Morbid Obesity, Acanthosis Nigricans, Insulin Resistance, Insulin Sensitivity
- Trial name
- NCT05529563
- Testing
- LSG
- Where
- China
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Shen Qu
Gut Microbiota, Hyperglycemia
Sustainable-psycho-nutritional Intervention Program and Its Effects on Health Outcomes and the Environment
Mexico is going through a major environmental and nutritional crisis, which is related to unsustainable dietary behaviors. Sustainable diets could solve both problems together.
- Conditions
- Gut Microbiota, Hyperglycemia, Hypercholesterolemia, HDLC
- Trial name
- NCT05457439
- Testing
- Sustainable diet promotion through behavioral change intervention
- Where
- Mexico
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University of Guadalajara
Melasma
Sylfirm X Radiofrequency Microneedling for the Treatment of Melasma
Microneedling radiofrequency technology has been shown in clinical studies to improve skin quality, tone, pigment, and to treat various skin conditions related to aging.
- Trial name
- NCT06415435
- Testing
- Radiofrequency Microneedling
- Where
- 3 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Benev Company, Inc.
Hyperpigmentation, Photodamaged Skin
A Multi-Center, Open-label Study Evaluate the Efficacy and Tolerability of a Dual Skincare Regimen Treatment for Facial Hyperpigmentation and Photodamaged Skin in Patients Exposed to Extrinsic Factors of Aging
This open-label, multi-center clinical trial was conducted to evaluate the dual skincare regimen of vitamin C serum and moisturizing sunscreen SPF 45 to improve facial hyperpigmentation and photodamage after 12 weeks of twice…
- Conditions
- Hyperpigmentation, Photodamaged Skin, Wrinkle, Fine Lines
- Trial name
- NCT05423873
- Testing
- Gentle Cleansing Lotion, Revision Skincare
- Where
- 3 sites in United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Revision Skincare
Melasma
Efficacy of Platelet-rich Plasma in Treatment of Melasma
The application of Platelet Rich Plasma (PRP) on three occasions with an interval of 15 days between each one, is related to a decrease in the intensity of the spots and improvement in the quality of the skin of patients with…
- Trial name
- NCT03674203
- Testing
- Platelet-Rich Plasma
- Where
- Mexico
- Volunteers
- 20 people
- Sponsor
- Instituto Mexicano del Seguro Social
Lentigines, Post Inflammatory Hyperpigmentation
Topical Corticosteroids on the Incidence of Postinflammatory Hyperpigmentation After QsNdYAG Laser
To investigate the benefit of the application of topical high potency steroid on the incidence of post inflammatory hyperpigmentation after laser treatment.
- Trial name
- NCT02492373
- Testing
- topical 0.05% Clobetasol propionate ointment, Q switched Nd:YAG laser 532 nm
- Where
- Thailand
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Skin Diseases, Skin Disorder
OneDoc Picopulse™ for the Treatment of Melasma Among Malaysian Women
OneDoc Picopulse™ is a radiopulse technology beauty grade device invented for treating melasma.
- Conditions
- Skin Diseases, Skin Disorder, Melanoma (Skin)
- Trial name
- NCT04834167
- Testing
- OneDoc Picopulse
- Where
- Malaysia
- Volunteers
- 32 people
- Sponsor
- Universiti Tunku Abdul Rahman
Melasma
Modified Jessner's Solution With Trichloroacetic Acid Versus Glycolic Acid With Trichloroacetic Acid
Melasma is a common acquired disorder of hyperpigmentation characterized by irregular light brown to dark brown patches of hyperpigmentation commonly affecting the face. The trunk and arms are also occasionally involved .
- Trial name
- NCT03153852
- Testing
- Modified Jessner's solution, Glycolic acid, Trichloroacetic acid
- Volunteers
- 30 people
- Sponsor
- Assiut University
Pancreatic Neoplasms, Peutz-Jegher's Syndrome
Pancreatic Cancer Screening of High-Risk Individuals in Arkansas
100 subjects who have a family history of pancreatic cancer (PC), or known genetic syndromes associated with increased risk of pancreatic cancer, will be followed for five years.
- Conditions
- Pancreatic Neoplasms, Peutz-Jegher's Syndrome, BRCA1 Gene Mutation, BRCA2 Gene Mutation
- Trial name
- NCT02309632
- Testing
- Pancreatic Cancer Screening Pathway 1, Pancreatic Cancer Screening Pathway 2
- Where
- United States
- Sponsor
- University of Arkansas
Melasma
Azelaic Acid Iontophoresis Versus Topical Azelaic Acid Cream in the Treatment of Melasma
The purpose of this prospective, randomized, controlled, single-blinded investigation is to study the efficacy, tolerability and safety of azelaic acid iontophoresis (AAI) versus topical treatment with azelaic acid cream in…
- Trial name
- AAI (NCT00848458)
- Testing
- Iontophoresis, Azelaic acid cream
- Where
- Austria
- Volunteers
- 70 people
- Sponsor
- Medical University of Vienna
Melasma
Prevention of Melasma Relapse During Summertime
Main objective is to show that a photoprotective sunscreen having a protection against the visible light is more effective than a sunscreen having the same UVA AND UVB protection but with a low (weak) protection against the…
- Trial name
- NCT02061839
- Testing
- Sunscream with visible light protection, Sunscream
- Volunteers
- 40 people
- Sponsor
- Centre de Pharmacologie Clinique Applique a la Dermatologie
Hyperpigmentation, Dark Spots
A 16-week Clinical Study Investigating a Dark Spot Corrector Serum in Women With Moderate Discrete Hyperpigmentation
This was a single-center, double-blinded, randomized, controlled cosmetic clinical trial to investigate the efficacy and tolerance of dark spot corrector serum and regimen skincare products when used over the course of 16 weeks…
- Trial name
- NCT07468175
- Testing
- Cosmetic dark spot corrector serum
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Revision Skincare
Lentigo Solar, Senile Lentigo
Tolerance and Performance (Mode of Administration) of Cyto-selective Difluoroethane-based Cryotherapy in the Treatment of Brown Spots
CS5_8 study aim to evaluate the tolerance and to adjust the mode of administration of 2 different conditions of cryotherapy treatments applied on the brown spots of the face with 1 prototype (816-v1).
- Trial name
- NCT05793619
- Testing
- Prototypes (816-v1 301) to (816-v1 355) every week, Prototypes (816-v1 301) to (816-v1 355) every two weeks
- Where
- Georgia
- Volunteers
- 20 people
- Sponsor
- Cryonove Pharma
Acanthosis Nigricans
Evaluating the Safety and Efficacy of Topical Sirolimus 0.2% to Treat Acanthosis Nigricans
The purpose of this study is to demonstrate the safety and efficacy of Sirolimus 0.2% topical gel for patients with Acanthosis Nigricans
- Trial name
- NCT06940895
- Testing
- Sirolimus 0.2%
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Narrows Institute for Biomedical Research
Melasma
Comparison Between Efficacy of Topical Tranexamic Acid Vs Topical Ethyl Ascorbic Acid In Treatment Of Melasma
This study is to compare the efficacy of topical tranexamic acid vs topical ethyl ascorbic acid in the treatment of melasma
- Trial name
- NCT07522788
- Testing
- Ethyl ascorbic acid topical application, Tranxemic acid topical application
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Hayatabad Medical Complex
Melasma, Chloasma
Oral and Topical Tranexamic Acid for the Treatment of Melasma
Tranexamic acid has been used for treating melasma due to its effect on decreasing the activity of tyrosinase and melanogenesis.
- Conditions
- Melasma, Chloasma, Melanosis
- Trial name
- TRANEXAMICO (NCT03585179)
- Testing
- Oral Tranexamic Acid, 5% topical tranexamic acid, 4% hydroquinone
- Where
- Mexico
- Volunteers
- 120 people
- Sponsor
- Centro Dermatológico Dr. Ladislao de la Pascua
Gingival Hyperpigmentation, Oral Pigmentation
Comparison of Er-YAG Laser, Air Polishing, and Surgical Excision for Gingival Hyperpigmentation
This randomized controlled clinical trial aimed to compare the effectiveness of different treatment approaches for physiologic gingival hyperpigmentation.
- Trial name
- APGH (NCT07672587)
- Testing
- Er:YAG Laser Therapy, Air Polishing with Erythritol Powder, Air Polishing with Sodium Bicarbonate Powder
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Melasma
Oral Tranexamic Acid and Laser for Treatment of Melasma
Tranexamic acid and 1927 diode laser non-ablative fractionated laser for the treatment of Melasma.
- Trial name
- NCT03686787
- Testing
- Tranexamic Acid
- Where
- 2 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Laser and Skin Surgery Center of New York
Skin Barrier to Water Loss, Skin Health
Apple Peptide Complex for Post-Surgical and Aesthetic Skin Recovery
This clinical study evaluates a topical botanical formulation for supporting skin recovery following invasive and non-invasive aesthetic procedures.
- Conditions
- Skin Barrier to Water Loss, Skin Health, Skin Discoloration, Skin Irritation
- Trial name
- APC-SKIN (NCT07807085)
- Testing
- Apple Peptide Complex Post-Aesthetic Care Protocol
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Grow Out Oils Clinical Aromatherapy Company
Melasma
COMPARISON OF TOPICAL VITAMIN C VS NIACINAMIDE IN TREATMENT OF MELASMA
Melasma is a common acquired hyperpigmentation disorder that significantly affects quality of life. Various topical agents are used in its treatment, including Vitamin C and Niacinamide, both of which possess depigmenting…
- Trial name
- NCT07890571
- Testing
- Ascorbic acid, niacinamide
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Pak Emirates Military Hospital