Clinical trials: Hyperparathyroidism
Chronic Kidney Disease, Renal Osteodystrophy
Serum Sclerostin Levels, Cardiovascular Parameters and Carpal Tunnel Syndrome in Maintenance Hemodialysis Patients
Sclerostin, the product of the SOST gene, located on chromosome 17, locus q11.2 in humans, was originally believed to be a non-classical Bone morphogenetic protein (BMP) antagonist.Sclerostin was recently identified as a…
- Conditions
- Chronic Kidney Disease, Renal Osteodystrophy, Left Ventricular Hypertrophy
- Trial name
- NCT01382966
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- RFM Renal Treatment Services
Phosphorus and Calcium Disorders, Parathyroid Diseases
Serum Calcium to Phosphorous (Ca/P) Ratio in the Diagnosis of Ca-P Metabolism Disorders: a Multicentre Study
Primary hyperparathyroidism (PHPT) and Hypoparathyroidism (HP) are two of the most frequent disorder of Calcium-Phosphorus (Ca-P) metabolism.
- Conditions
- Phosphorus and Calcium Disorders, Parathyroid Diseases, Hyperparathyroidism, Hypoparathyroidism
- Trial name
- NCT03747029
- Testing
- No intervention is provided
- Where
- Italy
- Volunteers
- 1,038 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero-Universitaria di Modena
Pulmonary Hypertension
Prognostic Value of Vitamin D and Intact Parathyroid Hormone (iPTH) in Pulmonary Hypertension
The aim of this observational study is to analyse the prognostic value of 25(OH)-vitamin D, iPTH and other serum biomarkers in patients with pulmonary hypertension.
- Trial name
- NBHAP (NCT06872710)
- Volunteers
- 345 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Familial Hypophosphatemic Rickets
Calcimimetics in Hypophosphatemic Rickets
Currently, large oral doses of phosphate and 1,25(OH)2D (calcitriol) are the standard treatment of patients with familial hypophosphatemic rickets (XLH).
- Trial name
- CHR (NCT00844740)
- Testing
- Cinacalcet
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Chronic Kidney Disease-Mineral and Bone Disorder
To Investigate the Bone and Muscle Abnormalities in Patients With Chronic Kidney Disease With MRI
Patients with chronic kidney disease (CKD) have a higher risk of fractures than those without. The purpose of this study is to develop a non-invasive Magnetic resonance imaging (MRI) method that can improve fracture risk…
- Trial name
- NCT04564924
- Testing
- DXA
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital
Hyperparathyroidism, Hypercalcemia
Oral Peptones Load in Normocalcemic and Hypercalcemic Primary Hyperparathyroidism and Healthy Subjects
The purpose of this study is to assess if subjects with hyperparathyroidism with normal serum calcium levels have different responses in the calcium regulating hormonal handling compared to a) patients with primary…
- Trial name
- NCT01042626
- Testing
- Oral peptones load
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Eastern Piedmont
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Parathyroid Hormone Suppression Test With Cinacalcet
Evaluation of a Cincalcet Suppression Test
The aim of the study is to compare the results of a parathyroid hormone (PTH)suppression test using a single oral tablet of cinacalcet in two groups of subjects: 1- a group of healthy adults in whom the results of the test with…
- Trial name
- NCT01103206
- Testing
- cinacalcet, cinacalcet dose 1, cinacalcet dose 2
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Hyperparathyroidism, Primary, Parathyroidectomy
Alterations in Muscle's Functional Characteristics After Parathyroid Surgery for Primary Hyperparathyroidism.
Protocol title: Alterations in functional characteristics of the muscle tissue following surgery for primary hyperparathyroidism.
- Trial name
- NCT03091140
- Where
- Greece
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Hyperparathyroidism, Secondary
Safety, Tolerability and Pharmacokinetics of Etelcalcetide in Healthy Male Volunteers
The purpose of this study is to characterize the safety and tolerability of etelcalcetide in healthy young males.
- Trial name
- NCT01134549
- Testing
- Etelcalcetide
- Where
- Australia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- KAI Pharmaceuticals
Neuroendocrine Neoplasm, Neuroendocrine Neoplasm of Gastrointestinal Tract
Genetic Bases of Neuroendocrine Neoplasms in Mexican Patients
Neuroendocrine neoplasms (NENs) are a heterogeneous group of lesions derived from cells with the ability to produce hormones that may arise from multiple different organs.
- Conditions
- Neuroendocrine Neoplasm, Neuroendocrine Neoplasm of Gastrointestinal Tract, Neuroendocrine Neoplasm of Lung, Thymic Neuroendocrine Neoplasm
- Trial name
- NCT06523582
- Where
- 3 sites in Mexico
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional Autonoma de Mexico
Vitamin D Deficiency, Secondary Hyperparathyroidism
Characterization of Hyperparathyroidism and Vitamin D Deficiency in Obesity
Obese persons are known to have elevated levels of parathyroid hormone (PTH) and low levels of vitamin D. These hormones are important in regulation of the body's calcium stores and bone health.
- Conditions
- Vitamin D Deficiency, Secondary Hyperparathyroidism, Obesity
- Trial name
- NCT00288873
- Testing
- Ergocalciferol, Cholecalciferol
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Primary Hyperparathyroidism
Effects of Parathyroidectomy on Cardiovascular Risk Factors in Primary Hyperparathyroidism
Primary hyperparathyroidism (PHPT) is associated with increased cardiovascular morbidity. The benefit of surgical treatment in this respect is unclear.
- Trial name
- NCT01057732
- Where
- Israel
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- HaEmek Medical Center, Israel
Osteoporosis, Hypercalcemia of Malignancy
One Week Comparison Study of PTH and PTHrP Infusions
This is a dose escalation study to determine the maximum tolerable dose of Parathyroid Hormone-related Protein, PTHrP, or Parathyroid Hormone, PTH, that can be given safely over one week in healthy African-American volunteers.
- Conditions
- Osteoporosis, Hypercalcemia of Malignancy, Hyperparathyroidism, Bone Diseases, Endocrine
- Trial name
- NCT01333267
- Testing
- Parathyroid Hormone-related Protein (1-36), parathyroid hormone (1-34), PTH (1-34) and PTHrP (1-36)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Chronic-kidney Disease Stage 5D on Stable Hemodialysis
A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of VS 105
The purpose of the study is to evaluate the safety, tolerability, and PK following single and multiple ascending dose administration of VS-105 in healthy subjects and patients with chronic kidney disease stage 5D (CKD-5D) on…
- Trial name
- NCT03043482
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Vidasym, Inc.
Osteoporosis, Bone Diseases, Endocrine
7 Day Continuous Parathyroid Hormone IV Infusion
Study consists of an eight day inpatient visit on the General Clinical Research Center. The investigators' specific aims are to: 1.
- Conditions
- Osteoporosis, Bone Diseases, Endocrine, Hyperparathyroidism
- Trial name
- NCT00377312
- Testing
- Parathyroid Hormone (1-34)
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Amino-Acid Transport Disorder, Primary Hyperparathyroidism
Amino Acid Transporter System PET/CT Imaging in AATS-Related Diseases
To evaluate the potential usefulness of 11C/18F-MET/FET positron emission tomography/ computed tomography (PET/CT) for the diagnosis of primary and metastatic lesions in various amino acid transporter system (AATS)-related…
- Conditions
- Amino-Acid Transport Disorder, Primary Hyperparathyroidism, Glioma
- Trial name
- NCT07379463
- Testing
- 11C/18F-MET/FET
- Where
- 3 sites in China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University
Heart Failure, Atrial Fibrillation (AF)
Cardiovascular Risk in Patients With Primary Hyperparathyroidism
Patients with primary hyperparathyroidism versus healthy controls assessed for their cardiovascular risk and overt CVD
- Conditions
- Heart Failure, Atrial Fibrillation (AF), Arrhythmia, Coronary Artery Disease
- Trial name
- CVD-PHPT (NCT07870369)
- Where
- Bulgaria
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Medical University of Sofia
Vitamin D Insufficiency, Secondary Hyperparathyroidism
Pharmacokinetics and Safety Study of CTAP101 Capsules in Japanese and Non-Japanese Healthy Subjects and Non-Japanese Healthy Subjects
Pharmacokinetics and Safety Study of CTAP101 Capsules in Japanese and non-Japanese Healthy Subjects
- Trial name
- NCT03660800
- Testing
- CTAP101 Capsules
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- OPKO Health, Inc.
Chronic Kidney Failure, Secondary Hyperparathyroidism
Paricalcitol Oral Therapy in Predialysis CKD Patients. The Greek Experience
The purpose of this study is to obtain data on the use of Zemplar (paricalcitol) capsules in real-life clinical practice in predialysis patients with chronic kidney disease (CKD) and secondary hyperparathyroidism.
- Trial name
- PROTECT (NCT01083186)
- Where
- 24 sites in Greece
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- AbbVie (prior sponsor, Abbott)