Clinical trials: Hyperoxemia
Hyperoxemia, Cerebrovascular Circulation
HYPER MIND - Hyperoxia Effects on Cerebral Hemodynamics
This study aims to better understand how short periods of exposure to high oxygen levels affect blood flow in the brain of patients who are intubated and mechanically ventilated in the Intensive Care Unit (ICU).
- Conditions
- Hyperoxemia, Cerebrovascular Circulation, Cerebral Autoregulation, Critical Illness
- Trial name
- HYPER-MIND (NCT07377162)
- Testing
- Normobaric Hyperoxic Stimulus (NBHO)
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Erasme University Hospital
High Flow Nasal Cannula, Oxygen Therapy
Closed-loop Oxygen Control for High Flow Nasal Therapy
In patients with acute hypoxemic respiratory failure (AHRF), High Flow Nasal Therapy (HFNT) improves oxygenation, tolerance, and decrease work of breathing as compared to standard oxygen therapy by facemask.
- Conditions
- High Flow Nasal Cannula, Oxygen Therapy, Hypoxemia, Hyperoxemia
- Trial name
- HILOOP (NCT04965844)
- Testing
- Oxygen close-loop, No intervention
- Where
- Spain
- Volunteers
- 53 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Hyperoxemia, Oxygen Reserve Index
Oxygen Reserve Index and Prevention of Hyperoxemia
In patients under general anesthesia, the oxygen level (FiO2) used in inspiration is usually adjusted by monitoring the peripheral oxygen saturation level (SpO2).
- Conditions
- Hyperoxemia, Oxygen Reserve Index, Hyperoxia, Fraction of Inspired Oxygen
- Trial name
- NCT05505032
- Testing
- Oxygen, Masimo Root Radical 7
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Baskent University Ankara Hospital
Respiratory Failure, Hypoxemia
Comparison of Pulse Oximetry (SpO2) With Different Oximeters and Arterial Saturation (SaO2): Oxygap2 Study
The oximeter is used to monitor intensive care patients undergoing oxygen therapy. It indicates pulsed oxygen saturation (SpO2), a reflection of arterial oxygen saturation (SaO2) which enables detection of hypoxemia and…
- Conditions
- Respiratory Failure, Hypoxemia, Hyperoxemia
- Trial name
- Oxygap 2 (NCT06102499)
- Testing
- SpO2 and SaO2 comparison
- Where
- 3 sites in Canada
- Volunteers
- 200 people
- Sponsor
- Laval University
Troponin
O2 Tension During TAVI
Hyperoxemia can produce various complications including oxidative stress and myocardial injury. We hypothesized that the normoxic group would have lower myocardial injury compared to hyperoxic group after transcatheter aortic…
- Trial name
- NCT03291210
- Testing
- normal inspired oxygen fraction, high inspired oxygen fraction
- Where
- South Korea
- Volunteers
- 72 people
- Sponsor
- Seoul National University Hospital
Oxygen, Hyperoxemia
Cerebral Hemodynamic Effects of Oxygen and Antioxidants (CHEOXANT)
This study is called CHE-OX-ANT (Cerebral Hemodynamic Effects of Oxygen and Antioxidants). It is a single-center, academic research project led by the Department of Intensive Care at Erasme Hospital (Université Libre de…
- Conditions
- Oxygen, Hyperoxemia, Antioxidant, Cerebral Autoregulation
- Trial name
- CHEOXANT (NCT07369232)
- Testing
- Oxygen, Vitamin C (Ascorbic Acid)
- Where
- Belgium
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Erasme University Hospital
Mechanical Ventilation
Hyperoxemia and Ventilator-associated Pneumonia
The aim of this prospective cohort single-center observational study is to determine the impact of hyperoxemia on ventilator-associated pneumonia (VAP) occurrence.
- Trial name
- SOH-VAP (NCT03434821)
- Where
- France
- Volunteers
- 534 people
- Sponsor
- University Hospital, Lille
Critical Illness, Wounds and Injury
Strategy to Avoid Excessive Oxygen in Major Burn Patients
The objective is to determine the effectiveness of a multimodal educational intervention to reduce supplemental oxygen use in major burn patients.
- Conditions
- Critical Illness, Wounds and Injury, Disease Attributes, Pathologic Processes
- Trial name
- SAVE-O2 (NCT04534972)
- Testing
- Targeting Normoxemia (SpO2 90-96%; PaO2 60-100 mmHg)
- Where
- 6 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- University of Colorado, Denver
Hyperoxemia
Oxygen Reserve Index to Reduce Hyperoxia
Excessive oxygen administration is known to cause oxidative stress, and absorption atelectasis. Hyperoxia is very common in general anesthesia settings.
- Trial name
- NCT04211246
- Testing
- Titration of fraction of inspired oxygen (FiO2) guided by SpO2, Titration of fraction of inspired oxygen (FiO2) guided by ORI and SpO2
- Where
- South Korea
- Volunteers
- 64 people
- Sponsor
- Eunah Cho, MD
Establish the Incidence Rate of Abdominal and Cerebral Hyperoxemia and Hypoxemia Events in Neonates at Birth
Monitoring of Cerebral and Abdominal Tissue Oxygen Saturation in Neonates
Near-infrared spectroscopy (NIRS) functions in a manner similar to pulse oximetry, using the difference in absorptive qualities of oxy- and deoxyhemoglobin to infrared light to quantify the percent saturation.
- Trial name
- NCT03149731
- Testing
- NIRS
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Xijing Hospital
Vascular Disease
Is Peri-operative Hyperoxemia a Risk Factor for Postoperative Complications?
Patients undergoing vascular surgery are at a significantly high risk of perioperative cardiovascular, cerebral and renal events compared to those undergoing non-vascular surgery.
- Trial name
- HYPEROXIA (NCT02562781)
- Testing
- Oxygen, Air
- Where
- 2 sites in Sweden
- Volunteers
- 184 people
- Sponsor
- Örebro University, Sweden
Healthy Volunteers
Effect of Hyperoxemia on Platelet Function in Healthy Volunteers
Prospective, controlled, randomized crossover volunteer study to investigate the effect of hyperoxemia due to inhalation of oxygen (80% inspiratory fraction) via reservoir-face-mask on blood coagulation, especially platelet…
- Trial name
- NCT01057420
- Testing
- oxygen inhalation
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Hyperoxemia
A Titration of Fractional Inspired Oxygen Using Oxygen Reserve Index in Child
The purpose of this prospective randomized controlled trial is to determine whether using the Oxygen Reserve Index can prevent hyperoxemia in pediatric patients receiving single-lung ventilation.
- Trial name
- NCT05912543
- Testing
- Titration of FiO2
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Seoul National University Hospital
Hyperoxia, Hyperoxemia
Hyperoxemia and Oxygen Reserve Index During Neurointerventional Anesthesia
The goal of this observational study is to learn how often high blood oxygen levels (hyperoxemia) occur in adults receiving general anesthesia for planned (elective) neurointerventional procedures, such as brain aneurysm coiling…
- Conditions
- Hyperoxia, Hyperoxemia, Cerebrovascular Disorders, Intracranial Aneurysms
- Trial name
- NCT07859982
- Testing
- Oxygen Reserve Index Monitoring (Observational)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Thoracic Surgery With One-lung Ventilation
ORI-Guided Oxygen Therapy During One-Lung Ventilation
High inspired oxygen concentrations (FiO₂) are commonly administered during general anesthesia to prevent hypoxemia. However, excessive oxygen administration may result in hyperoxemia, which has been associated with impaired…
- Trial name
- ORI-OLV (NCT07720778)
- Testing
- ORI-Guided FiO2 Titration, Conventional SpO₂-Guided FiO₂ Titration
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Konkuk University Medical Center
Critical Illness, Respiration, Artificial
Conservative Versus Conventional Oxygen Administration in Critically Ill Patients
Oxygen supplementation in the inspired mixture is commonly used in critically ill patients and observational studies highlight that those patients remain hyperoxemic for substantial periods during Intensive Care Unit stay.
- Conditions
- Critical Illness, Respiration, Artificial, Hyperoxia, Hyperoxemia
- Trial name
- NCT04198077
- Testing
- Oxygen
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- University of Modena and Reggio Emilia
Hyperoxemia, Intraoperative Oxygen Therapy
Oxygen Reserve Index-Guided Oxygen Titration During Surgery in the Beach Chair Position
This study aims to evaluate whether guidance by the Oxygen Reserve Index (ORi) improves inspiratory oxygen fraction (FiO₂) titration compared with conventional pulse oximetry (SpO₂)-guided oxygen administration in adult patients…
- Conditions
- Hyperoxemia, Intraoperative Oxygen Therapy, Beach Chair Position, Cerebral Oxygenation
- Trial name
- ORI-BCP (NCT07404267)
- Testing
- ORi-Guided FiO₂ Titration, SpO₂-Guided FiO₂ Titration
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Hyperoxemia, Intensive Care Unit (ICU)
Hyperoxemia in the Intensive Care Unit(ICU)
In our study, to research the prevalence of hyperoxemia in adult patients treated in the intensive care unit (ICU) and its relationship with clinical outcomes.
- Conditions
- Hyperoxemia, Intensive Care Unit (ICU), CPAP, Invasive Mechanical Ventilation
- Trial name
- ICU (NCT07549763)
- Where
- Turkey (Türkiye)
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Trakya University
Critical Illness, Wounds and Injury
Strategy to Avoid Excessive Oxygen for Critically Ill Trauma Patients
The objective is to determine the effectiveness of a multimodal educational intervention to reduce supplemental oxygen use in critically injured patients.
- Conditions
- Critical Illness, Wounds and Injury, Disease Attributes, Pathologic Processes
- Trial name
- SAVE-O2 (NCT04534959)
- Testing
- Targeting Normoxemia (SpO2 90-96%; PaO2 60-100 mmHg)
- Where
- 8 sites in United States
- Volunteers
- 6,000 people
- Sponsor
- University of Colorado, Denver
Critical Illness, Wounds and Injury
Strategy to Avoid Excessive Oxygen Using an Autonomous Oxygen Titration Intervention
This study is a multicenter randomized controlled trial to determine the effectiveness of a closed loop/autonomous oxygen titration system (O2matic PRO100) to maintain normoxemia (goal range SpO2 90-96%, target 93%) during the…
- Conditions
- Critical Illness, Wounds and Injury, Disease Attributes, Pathologic Processes
- Trial name
- SAVE-O2 AI (NCT06374225)
- Testing
- Automated Titration (O2matic)
- Where
- 4 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Colorado, Denver