Clinical trials: Hypermobility Spectrum Disorder
Hypermobile EDS (hEDS), Hypermobility Syndrome
Dyspnea in Hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorder
Individuals with hypermobile Ehlers-Danlos Syndrome (hEDS) and Hypermobility Spectrum Disorders (HSD) often experience dyspnea. Inspiratory Muscle Training (IMT) has been shown to improve dyspnea and respiratory muscle function…
- Trial name
- NCT04972565
- Testing
- Usual Care plus Inspiratory Muscle Training (IMT)
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- University Health Network, Toronto
Multidirectional Instability, Hypermobility Spectrum Disorder
Impact of Neuromuscular Control With and Without Electrical Stimulation and Long-term Effect of Kinetic Chain Exercises in Multidirectional Shoulder Instability Patients
Background: Shoulder instability is commonly observed in adolescents and young females, ranging from asymptomatic multidirectional instability (MDI) to symptomatic conditions.
- Conditions
- Multidirectional Instability, Hypermobility Spectrum Disorder, Electrical Stimulation, Neuromuscular Control
- Trial name
- NCT07611006
- Testing
- neuromuscular eletrical stimulation, neuromuscular control training
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Hypermobile Ehlers-Danlos Syndrome, Hypermobile Spectrum Disorder
Hypermobile Ehlers-Danlos Syndrome - Transcutaneous Auricular Neuromodulation
Investigate whether at-home transcutaneous auricular VNS (tAN: transcutaneous auricular neurostimulation) improves a battery of nine key physical and psychological symptoms of a group of hEDS (Hypermobile Ehlers-Danlos Syndrome…
- Conditions
- Hypermobile Ehlers-Danlos Syndrome, Hypermobile Spectrum Disorder, Ehlers-Danlos Syndrome
- Trial name
- hEDS-tAN (NCT06105541)
- Testing
- Transcutaneous Auricular Neurostimulation
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Medical University of South Carolina
Hypermobile EDS (hEDS), Hypermobile Ehlers-Danlos Syndrome
Hamstring Strengthening in Hypermobile Conditions
The goal of this clinical trial is to determine how strengthening the hamstring muscles affects the knee joint in people living with hypermobility spectrum disorders (HSD) and hypermobile Ehlers-Danlos syndrome (hEDS).
- Conditions
- Hypermobile EDS (hEDS), Hypermobile Ehlers-Danlos Syndrome, Hypermobile Spectrum Disorder, Hypermobility Type Ehlers-Danlos Syndrome
- Trial name
- NCT07626957
- Testing
- Progressive resistance exercise with an emphasis on eccentric hamstring loading.
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Ehlers-Danlos Syndrome (EDS), Hypermobile EDS (hEDS)
STABLE Pilates for Hypermobility
This study is looking at whether Pilates-based exercise can help with hypermobility-related symptoms, like pain.
- Conditions
- Ehlers-Danlos Syndrome (EDS), Hypermobile EDS (hEDS), Hypermobile Spectrum Disorder
- Trial name
- STABLE (NCT07464093)
- Testing
- Pilates, Education
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Brigham and Women's Hospital
Hypermobility Syndrome, Hypermobile Ehlers-Danlos Syndrome
Dynamic Stability Exercises in Patients With Hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorder
Background: Symptomatic hypermobility may lead to a number of restrictions in daily life. So far, there is a lack of effective treatments.
- Trial name
- NCT05800262
- Testing
- Dynamic stability exercises
- Where
- 2 sites in Sweden
- Volunteers
- 15 people
- Sponsor
- University Hospital, Linkoeping
Ehlers-Danlos Syndrome Hypermobility Type (hEDS), Ehlers-Danlos Syndrome (EDS)
Regenerative Medicine for Joint Hypermobility and Instability
This clinical trial is designed to evaluate whether a stepwise injection-based treatment approach can reduce pain and improve function in adults with joint hypermobility, connective tissue laxity, and joint instability.
- Conditions
- Ehlers-Danlos Syndrome Hypermobility Type (hEDS), Ehlers-Danlos Syndrome (EDS), Joint Hypermobility, Joint Instability
- Trial name
- NCT07688096
- Testing
- Dextrose 20% Prolotherapy, Autologous Platelet-Rich Plasma, Doxycycline Hyclate Injectable (Investigational)
- Volunteers
- 100 people
- Sponsor
- Manhattan Pain Medicine, PLLC
Joint Hypermobility
Characteristics of the Functional State of the Musculoskeletal System, Body Awareness, and Quality of Life in Individuals With Joint Hypermobility, Their Associations, and Guidelines for Intervention.
The goal of this observational study is to learn about the characteristics of the functional state of the musculoskeletal system, body awareness, and quality of life in individuals with joint hypermobility, their associations…
- Trial name
- NCT07476976
- Testing
- No intervention
- Where
- Lithuania
- Volunteers
- 511 people, healthy volunteers welcome
- Sponsor
- Lithuanian University of Health Sciences
Joint Hypermobility Syndrome, Hypermobile Ehlers-Danlos Syndrome
Central Sensitization and Physical Activity in Adolescents With HSD/hEDS
Hypermobility Spectrum Disorder and hypermobile Ehlers-Danlos Syndrome (HSD/hEDS) is under-recognized and poorly understood and its management is therefore not clear.
- Trial name
- NCT05633225
- Testing
- Submax exercise test on a bicycle ergometer
- Where
- 2 sites in Sweden
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vastra Gotaland Region
Hypermobile Ehlers-Danlos Syndrome, Hypermobile Spectrum Disorder
Online Pilates Exercise for People With Hypermobility
People with hypermobile Ehlers-Danlos Syndrome/Hypermobility Spectrum Disorder (hEDS/HSD) often have pain, coordination problems, and low tolerance to activity and exercise.
- Trial name
- NCT07118865
- Testing
- Online Pilates exercise
- Where
- United States
- Volunteers
- 440 people
- Sponsor
- Clarkson University
Hypermobility Syndrome Shoulder, Shoulder Pain Chronic
Shoulder Exercises in Hypermobile Patients With Shoulder Symptoms
Hypermobility Spectrum Disorder (HSD) is a recent diagnosis that covers generalised joint hypermobility with one or more secondary symptomatic musculoskeletal manifestations.
- Conditions
- Hypermobility Syndrome Shoulder, Shoulder Pain Chronic, Shoulder Luxation
- Trial name
- NCT03869307
- Testing
- Exercise
- Where
- 3 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- University of Southern Denmark
Hypermobile Ehlers-Danlos Syndrome, Hypermobility Syndrome
Patient-based Care Versus Standard Care for Patients With hEDS/HSD and Multidirectional Shoulder Instability
For hEDS or HSD patients with MDI, a multidisciplinary treatment approach is suggested. As follows, physiotherapy plays a key role in this integrative management.
- Conditions
- Hypermobile Ehlers-Danlos Syndrome, Hypermobility Syndrome, Multidirectional Subluxation of Shoulder
- Trial name
- NCT04666896
- Testing
- Tailored home-based exercise therapy, Standard home-based exercise therapy
- Where
- Belgium
- Volunteers
- 21 people
- Sponsor
- University Ghent
Ehlers-Danlos Syndrome, Irritable Bowel Syndrome
RCT of Gut-directed Hypnotherapy in Ehlers-Danlos Syndromes and Generalized Hypermobility Spectrum Disorders
This randomized, controlled trial (RCT) will evaluate the effectiveness of gut-directed hypnotherapy for management of Irritable Bowel Syndrome (IBS) in individuals diagnosed with Ehlers-Danlos Syndromes or Generalized…
- Conditions
- Ehlers-Danlos Syndrome, Irritable Bowel Syndrome, Hypermobility Syndrome, Gastrointestinal Dysfunction
- Trial name
- NCT06325345
- Testing
- Gut-directed hypnotherapy, Standard Medical Therapy
- Where
- Canada
- Volunteers
- 74 people
- Sponsor
- University Health Network, Toronto
Ehlers-Danlos Syndrome, Hypermobile EDS (hEDS)
Integrative Medicine for Hypermobility Spectrum Disorder and Ehlers-Danlos Syndromes (IMforHSDandEDS)
A feasibility study of an integrative medicine program among patients with Hypermobility Spectrum Disorder (HSD) or Ehlers-Danlos syndromes (EDS)
- Conditions
- Ehlers-Danlos Syndrome, Hypermobile EDS (hEDS), Hypermobility Syndrome, EDS
- Trial name
- NCT04734041
- Testing
- Anti-inflammatory (Mediterranean-style) diet, Behavioral and psychosocial support
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National University of Natural Medicine
Hypermobility Spectrum Disorder
Whole-Body Vibration and Postural Stability in Painful HSD
This randomized controlled trial aims to investigate the effects of adding whole-body vibration training to a conventional exercise program on postural stability and pain in painful women with hypermobility spectrum disorder.
- Trial name
- NCT07830589
- Testing
- Conventional Exercise Program, Whole-Body Vibration
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Gökalp Arif Utkugün
Hypermobile Ehlers-Danlos Syndrome, Postural Orthostatic Tachycardia Syndrome (POTS)
Presentation of Young Adults With and Without Joint Hypermobility
People with multiple hypermobile joints are diagnosed with Generalized Joint Hypermobility (GJH) when asymptomatic, or Hypermobile Ehlers-Danlos Syndrome (hEDS) and Hypermobility Spectrum Disorder (HSD) when symptomatic…
- Trial name
- NCT07657507
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Clarkson University
Hypermobility Syndrome Shoulder, Shoulder Pain Chronic
Resistance Training for Patients With Hypermobility Spectrum Disorders and Shoulder Symptoms: a Feasibility Study
Hypermobility Spectrum Disorders (HSD) is a recent diagnosis that covers joint hypermobility with one or more secondary symptomatic musculoskeletal manifestations.
- Trial name
- NCT03547570
- Testing
- Progressive heavy shoulder resistance training
- Where
- 3 sites in Denmark
- Volunteers
- 12 people
- Sponsor
- University of Southern Denmark